The Oncosearch | Oncotarget

A Chemical Biology Approach to Developing STAT Inhibitors: Molecular Strategies for Accelerating Clinical Translation Research Perspective

Erik A. Nelson, Sreenath V. Sharma, Jeffrey Settleman, David A. Frank

Published Jun 15, 2011 · Vol. 2, No. 6 · pp. 518-524

Keywords: STAT transcription factors, signal transduction, cancer therapy

Phosphorylation of AKT: a Mutational Analysis. Research Paper

Jonathan R. Hart, Peter K. Vogt

Published Jun 10, 2011 · Vol. 2, No. 6 · pp. 467-476

Keywords: Oncogenic transformation, signaling, myristylation, phosphomimetic

p21-activated kinase 1: PAKâ€™ed with potential Research Perspective

Christy Ong, Adrian Jubb, Wei Zhou, Peter Haverty, Adrian Harris, Marcia Belvin, Lori Friedman, Hartmut Koeppen, Klaus Hoeflich

Published Jun 7, 2011 · Vol. 2, No. 6 · pp. 491-496

Keywords: PAK1, apoptosis, squamous, lung cancer, breast cancer

The direct Myc target Pim3 cooperates with other Pim kinases in supporting viability of Myc-induced B-cell lymphomas Research Paper

Linus Plym Forshell, Yongmei Li, Tacha Zi Plym Forshell, Martina Rudelius, Lisa Nilsson, Ulrich Keller, Jonas Nilsson

Published Jun 5, 2011 · Vol. 2, No. 6 · pp. 448-460

Keywords: Pim kinase, Myc, B-cell lymphoma

Elevated PI3K signaling drives multiple Breast Cancer subtypes Review

Jessica Adams, Nathan F. Schachter, Jeff C. Liu, Eldad Zacksenhaus, Sean Eoin Egan

Published Jun 5, 2011 · Vol. 2, No. 6 · pp. 435-447

Keywords: PIK3CA, Mouse models, Breast Cancer, PTEN, Akt, Metastasis

Molecular signature induced by RNASET2, a tumor antagonizing gene, in ovarian cancer cells Research Perspective

Francesco Acquati, Laura Monti, Marta Lualdi, Marco Fabbri, Maria Grazia Sacco, Laura Gribaldo, Roberto Taramelli

Published Jun 4, 2011 · Vol. 2, No. 6 · pp. 477-484

Keywords: RNases, cancer microenvironment, transcriptional profile.

No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis Research Paper

Katharina Bluemlein, Nana-Maria GrÃ¼ning, RenÃ© G. Feichtinger, Hans Lehrach, Barbara Kofler, Markus Ralser

Published May 22, 2011 · Vol. 2, No. 5 · pp. 393-400

Keywords: pyruvate kinase, proteomics, cancer metabolism, alternative splicing, Warburg effect.

Novel insights into the synergistic interaction of Bortezomib and TRAIL: tBid provides the link Research Perspective

Simone Fulda

Published May 16, 2011 · Vol. 2, No. 5 · pp. 418-421

Keywords: cancer, apoptosis, chemotherapy, proteasome inhibitor, TRAIL

Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity Research Perspective

Mehdi Mollapour, Shinji Tsutsumi, Yeong Sang Kim, Jane Trepel, Len Neckers

Published May 14, 2011 · Vol. 2, No. 5 · pp. 407-417

Keywords: heat shock protein 90, phosphorylation, casein kinase 2, Hsp90 inhibitors, heat shock response, oncotargets, cancer

Mitochondrial Compartmentalized Protein Folding and Tumor Cell Survival Research Perspective

Dario C. Altieri

Published May 7, 2011 · Vol. 2, No. 4 · pp. 347-351

Keywords: Hsp90, mitochondria, chaperone, unfolded protein response, cancer therapy

Thioaptamer Conjugated Liposomes for Tumor Vasculature Targeting Research Paper

Aman P. Mann, Rohan C. Bhavane, Anoma Somasunderam, Brenda Liz Montalvo-Ortiz, Ketan B. Ghaghada, David Volk, RenÃ© Nieves-Alicea, K. Stephen Suh, Mauro Ferrari, Ananth Annapragada, David G. Gorenstein, Takemi Tanaka

Published May 7, 2011 · Vol. 2, No. 4 · pp. 298-304

Keywords: drug delivery, aptamer, E-selectin

A stressful life (or death): Combinatorial proteotoxic approaches to cancer-selective therapeutic vulnerability Commentary

Paul Workman, Faith E. Davies

Published Apr 21, 2011 · Vol. 2, No. 4 · pp. 277-280

Pharmacological manipulation of the cell cycle and metabolism to protect normal tissues against conventional anticancer drugs Commentary

Ingeborg M.M. van Leeuwen, Sonia LaÃn

Published Apr 20, 2011 · Vol. 2, No. 4 · pp. 274-276

Mycoplasma and cancer: in search of the link Commentary

Melissa B. Rogers

Published Apr 19, 2011 · Vol. 2, No. 4 · pp. 271-273

Using quantitative proteomic analysis to understand genotype specific intrinsic drug resistance in melanoma Research Perspective

John M. Koomen, Keiran S. M. Smalley

Published Apr 15, 2011 · Vol. 2, No. 4 · pp. 329-335

Keywords: Oncogene, cancer, kinase, BRAF V600E, drug resistance, proteomics

The beating heart of melanomas: a minor subset of cancer cells sustains tumor growth Research Perspective

Patrick Schmidt, Hinrich Abken

Published Apr 10, 2011 · Vol. 2, No. 4 · pp. 313-320

Keywords: melanoma, cancer stem cell, adoptive cell therapy

Caveolin-1 in sarcomas: friend or foe? Research Perspective

Miguel SÃ¡inz-Jaspeado, Juan Martin-Liberal, Laura Lagares-Tena, Silvia Mateo-Lozano, Xavier Garcia del Muro, Oscar M. Tirado

Published Apr 2, 2011 · Vol. 2, No. 4 · pp. 305-312

Keywords: Caveolin-1, Sarcomas, Oncogene, Tumor suppressor

Personalizing Therapy with Targeted Agents in Non-Small Cell Lung Cancer Review

Rodrigo Dienstmann, Pablo Martinez, Enriqueta Felip

Published Mar 23, 2011 · Vol. 2, No. 3 · pp. 165-177

Keywords: ALK, EGFR, KRAS, lung cancer, targeted therapy

Mutant Cbl proteins as oncogenic drivers in myeloproliferative disorders Research Perspective

Mayumi Naramura, Scott Nadeau, Bhopal Mohapatra, Gulzar Ahmad, Chandrani Mukhopadhay, Martin Sattler, Srikumar M. Raja, Amarnath Natarajan, Vimla Band, Hamid Band

Published Mar 20, 2011 · Vol. 2, No. 3 · pp. 245-250

Keywords: Cbl, E3 ubiquitin ligase, leukemia, protein tyrosine kinase, signal transduction

Mcl-1 Ubiquitination and Destruction Research Perspective

Hiroyuki Inuzuka, Hidefumi Fukushima, Shavali Shaik, Pengda Liu, Alan W. Lau, Wenyi Wei

Published Mar 19, 2011 · Vol. 2, No. 3 · pp. 239-244

Keywords: Ubiquitination, SCF, Fbw7, GSK3, Mcl-1, Apoptosis, Tumor Suppressor, Phosphorylation, Cell Cycle

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A Chemical Biology Approach to Developing STAT Inhibitors: Molecular Strategies for Accelerating Clinical Translation Research Perspective

Phosphorylation of AKT: a Mutational Analysis. Research Paper

p21-activated kinase 1: PAKâ€™ed with potential Research Perspective

The direct Myc target Pim3 cooperates with other Pim kinases in supporting viability of Myc-induced B-cell lymphomas Research Paper

Elevated PI3K signaling drives multiple Breast Cancer subtypes Review

Molecular signature induced by RNASET2, a tumor antagonizing gene, in ovarian cancer cells Research Perspective

No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis Research Paper

Novel insights into the synergistic interaction of Bortezomib and TRAIL: tBid provides the link Research Perspective

Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity Research Perspective

Mitochondrial Compartmentalized Protein Folding and Tumor Cell Survival Research Perspective

Thioaptamer Conjugated Liposomes for Tumor Vasculature Targeting Research Paper

A stressful life (or death): Combinatorial proteotoxic approaches to cancer-selective therapeutic vulnerability Commentary

Pharmacological manipulation of the cell cycle and metabolism to protect normal tissues against conventional anticancer drugs Commentary

Mycoplasma and cancer: in search of the link Commentary

Using quantitative proteomic analysis to understand genotype specific intrinsic drug resistance in melanoma Research Perspective

The beating heart of melanomas: a minor subset of cancer cells sustains tumor growth Research Perspective

Caveolin-1 in sarcomas: friend or foe? Research Perspective

Personalizing Therapy with Targeted Agents in Non-Small Cell Lung Cancer Review

Mutant Cbl proteins as oncogenic drivers in myeloproliferative disorders Research Perspective

Mcl-1 Ubiquitination and Destruction Research Perspective

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

A Chemical Biology Approach to Developing STAT Inhibitors: Molecular Strategies for Accelerating Clinical Translation Research Perspective

Phosphorylation of AKT: a Mutational Analysis. Research Paper

p21-activated kinase 1: PAKâ€™ed with potential Research Perspective

The direct Myc target Pim3 cooperates with other Pim kinases in supporting viability of Myc-induced B-cell lymphomas Research Paper

Elevated PI3K signaling drives multiple Breast Cancer subtypes Review

Molecular signature induced by RNASET2, a tumor antagonizing gene, in ovarian cancer cells Research Perspective

No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis Research Paper

Novel insights into the synergistic interaction of Bortezomib and TRAIL: tBid provides the link Research Perspective

Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity Research Perspective

Mitochondrial Compartmentalized Protein Folding and Tumor Cell Survival Research Perspective

Thioaptamer Conjugated Liposomes for Tumor Vasculature Targeting Research Paper

A stressful life (or death): Combinatorial proteotoxic approaches to cancer-selective therapeutic vulnerability Commentary

Pharmacological manipulation of the cell cycle and metabolism to protect normal tissues against conventional anticancer drugs Commentary

Mycoplasma and cancer: in search of the link Commentary

Using quantitative proteomic analysis to understand genotype specific intrinsic drug resistance in melanoma Research Perspective

The beating heart of melanomas: a minor subset of cancer cells sustains tumor growth Research Perspective

Caveolin-1 in sarcomas: friend or foe? Research Perspective

Personalizing Therapy with Targeted Agents in Non-Small Cell Lung Cancer Review

Mutant Cbl proteins as oncogenic drivers in myeloproliferative disorders Research Perspective

Mcl-1 Ubiquitination and Destruction Research Perspective