The Oncosearch | Oncotarget

Targeted therapy for hepatocellular carcinoma: novel agents on the horizon Review

Melchiorre Cervello, James A McCubrey, Antonella Cusimano, Nadia Lampiasi, Antonina Azzolina, Giuseppe Montalto

Published Mar 31, 2012 · Vol. 3, No. 3 · pp. 236-260

Keywords: HCC, signaling pathways, EGF/EGFR, Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR, Wnt/Î²-catenin

Stratification of Wilms tumor by genetic and epigenetic analysis Research Paper

Richard H. Scott, Anne Murray, Linda Baskcomb, Clare Turnbull, Chey Loveday, Reem Al-Saadi, Richard Williams, Fin Breatnach, Mary Gerrard, Juliet Hale, Janice Kohler, Pablo Lapunzina, Gill A. Levitt, Sue Picton, Barry Pizer, Milind D. Ronghe, Heidi Traunecker, Denise Williams, Anna Kelsey, Gordan M. Vujanic, Neil J. Sebire, Paul Grundy, Charles A. Stiller, Kathy Pritchard-Jones, Jenny Douglas, Nazneen Rahman

Published Mar 31, 2012 · Vol. 3, No. 3 · pp. 327-335

Keywords: Wilms tumor, WT1, WTX, CTNNB1, TP53, 11p15, somatic genetic mutation, epigenetic

Essential role for telomerase in chronic myeloid leukemia induced by BCR-ABL in mice Brief Reports

Carolina Vicente-DueÃ±as, Marcos Barajas-Diego, Isabel Romero-Camarero, Ines Gonzalez-Herrero, Teresa Flores, Isidro Sanchez-Garcia

Published Mar 8, 2012 · Vol. 3, No. 3 · pp. 261-266

Keywords: cancer, cancer stem cells (CSC), stem cells, mouse models, Telomerase inhibitors, drug discovery

Single Enantiomer of YK-4-279 Demonstrates Specificity in Targeting the Oncogene EWS-FLI1 Research Paper

Julie S. Barber-Rotenberg, Saravana P. Selvanathan, Yali Kong, Hayriye V. Erkizan, Tara M. Snyder, S. Peter Hong, Christina L. Kobs, Natalie L. South, Steven Summer, Philip J. Monroe, Maksymilian Chruszcz, Veselin Dobrev, Perrer N. Tosso, Lauren J. Scher, Wladek Minor, Milton L. Brown, Steven J. Metallo, Aykut Ãœren, Jeffrey A. Toretsky

Published Feb 29, 2012 · Vol. 3, No. 2 · pp. 172-182

Engineering the First Chimeric Antibody in Targeting Intracellular PRL-3 Oncoprotein for Cancer Therapy in Mice Research Paper

Ke Guo, Jing Ping Tang, Jie Li, Cheng Peow Tan, Abdul Qader O. Al-Aidaroos, Cheng William Hong, Leyon Varghese, Zhi Wei Feng, Jung Eun Park, Jian Biao Zhou, Wee Joo Chng, Qi Zeng

Published Feb 27, 2012 · Vol. 3, No. 2 · pp. 158-171

Keywords: cancer therapy with chimeric antibody, animal model, intracellular oncotarget, PRL-3 phosphatase

MiR-181b: new perspective to evaluate disease progression in chronic lymphocytic leukemia Research Perspective

Carlo Maria Croce, Rosa Visone, Angelo Veronese, Veronica Balatti

Published Feb 18, 2012 · Vol. 3, No. 2 · pp. 195-202

Keywords: miR-181b, diagnosis, CLL

Tumor suppressive microRNA-1285 regulates novel molecular targets: Aberrant expression and functional significance in renal cell carcinoma Research Paper

Hideo Hidaka, Naohiko Seki, Hirofumi Yoshino, Takeshi Yamasaki, Yasutoshi Yamada, Nijiro Nohata, Miki Fuse, Masayuki Nakagawa, Hideki Enokida

Published Jan 30, 2012 · Vol. 3, No. 1 · pp. 44-57

Keywords: microRNA, expression signature, miR-1285, tumor suppressor, renal cell carcinoma, transglutaminase 2

Neoplastic cells are a rare component in human glioblastoma microvasculature Research Perspective

Fausto J. Rodriguez, Brent A. Orr, Keith L. Ligon, Charles G. Eberhart

Published Jan 30, 2012 · Vol. 3, No. 1 · pp. 98-106

Keywords: Glioblastoma, microvascular proliferation, endothelium, stem cells, FISH

Recent Developments in Targeting Carbonic Anhydrase IX for Cancer Therapeutics Research Perspective

Paul C. McDonald, Jean-Yves Winum, Claudiu T. Supuran, Shoukat Dedhar

Published Jan 28, 2012 · Vol. 3, No. 1 · pp. 84-97

Keywords: cancer, hypoxia, carbonic anhydrase IX, metastasis, targeted therapeutics

A combination of a ribonucleotide reductase inhibitor and histone deacetylase inhibitors downregulates EGFR and triggers BIM-dependent apoptosis in head and neck cancer Research Paper

Roland H. Stauber, Shirley K. Knauer, Negusse Habtemichael, Carolin Bier, Britta Unruhe, Simona Weisheit, Stephanie Spange, Frank Nonnenmacher, Verena Fetz, Torsten Ginter, Sigrid Reichardt, Claus Liebmann, GÃ¼nter Schneider, Oliver H. KrÃ¤mer

Published Jan 28, 2012 · Vol. 3, No. 1 · pp. 31-43

Keywords: apoptosis, BH3-only protein, chemotherapy, hydroxyurea, oral cancer, therapy resistance, tumor xenograft, valproic acid

Regression of metastatic melanoma by targeting cancer stem cells Brief Reports

Max Schlaak, Patrick Schmidt, Christopher Bangard, Peter Kurschat, Cornelia Mauch, Hinrich Abken

Published Jan 28, 2012 · Vol. 3, No. 1 · pp. 22-30

Keywords: cancer stem cell, melanoma, CD20, rituximab

Capturing the Molecular and Biological Diversity of High-Grade Astrocytoma in Genetically Engineered Mouse Models Research Perspective

Lionel M.L. Chow, Suzanne J. Baker

Published Jan 25, 2012 · Vol. 3, No. 1 · pp. 67-77

Keywords: glioblastoma, astrocytoma, mouse model, PI3K pathway

Resistance to EGFR inhibitors: Molecular determinants and the enigma of head and neck cancer Editorial Comments

Luc G.T. Morris, Timothy A. Chan

Published Dec 31, 2011 · Vol. 2, No. 12 · pp. 894-895

Frizzled receptor 6 marks rare, highly tumourigenic stem-like cells in mouse and human neuroblastomas. Brief Reports

Sandra Cantilena, Fabio Pastorino, Olesya Chayka, Annalisa Pezzolo, Vito Pistoia, Mirco Ponzoni, Arturo Sala

Published Dec 31, 2011 · Vol. 2, No. 12 · pp. 976-983

Keywords: HIF, hypoxia, metastasis, neuroblastoma, stem cell

Is human cytomegalovirus a target in cancer therapy? Research Perspective

Published Dec 31, 2011 · Vol. 2, No. 12 · pp. 1329-1338

Keywords: cancer, human cytomegalovirus

Identification of a chrXq27.3 microRNA cluster associated with early relapse in advanced stage ovarian cancer patients Research Paper

Marina Bagnoli, Loris De Cecco, Anna Granata, Roberta Nicoletti, Edoardo Marchesi, Paola Alberti, Barbara Valeri, Massimo Libra, Mattia Barbareschi, Francesco Raspagliesi, Delia Mezzanzanica, Silvana Canevari

Published Dec 31, 2011 · Vol. 2, No. 12 · pp. 1265-1278

Keywords: advanced-stage ovarian cancer, early relapse, microRNA profiling, miR-506, cisplatin, miR-513a-5p, miR-513b.

Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein, BMAL1 Research Paper

Yan Hu, Mary L. Spengler, Karen K. Kuropatwinski, Maria Comas, Marilyn Jackson, Mikhail V. Chernov, Anatoly S. Gleiberman, Natalia Fedtsova, Youcef M. Rustum, Andrei V. Gudkov, Marina Antoch

Published Dec 31, 2011 · Vol. 2, No. 12 · pp. 1279-1290

Keywords: L-Methyl-selenocysteine, TIEG1, circadian rhythms, cyclophosphamide, anticancer treatment, liver, transcription

Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target Review

Mourad Sanhaji, Claire T Friel, Linda Wordeman, Frank Louwen, Juping Yuan

Published Dec 31, 2011 · Vol. 2, No. 12 · pp. 935-947

Keywords: MCAK, mitotic kinases, chromosome instability, drug resistance, invasiveness

Regulation of glucose metabolism by p53: Emerging new roles for the tumor suppressor Review

Esha Madan, Rajan Gogna, Madan Bhatt, Uttam Pati, Periannan Kuppusamy, Abbas Ali Mahdi

Published Dec 31, 2011 · Vol. 2, No. 12 · pp. 948-957

Keywords: p53, TIGAR, SCO2, metabolism, senescence, aging

AHI-1: a novel signaling protein and potential therapeutic target in human leukemia and brain disorders Review

Sharmin Esmailzadeh, Xiaoyan Jiang

Published Dec 30, 2011 · Vol. 2, No. 12 · pp. 918-934

Keywords: AHI-1, oncogene, CML, CTCL, AHI-1-BCR-ABL-JAK2 interaction complex, tyrosine kinase inhibitors, leukemic stem cells, TKI resistance

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Targeted therapy for hepatocellular carcinoma: novel agents on the horizon Review

Stratification of Wilms tumor by genetic and epigenetic analysis Research Paper

Essential role for telomerase in chronic myeloid leukemia induced by BCR-ABL in mice Brief Reports

Single Enantiomer of YK-4-279 Demonstrates Specificity in Targeting the Oncogene EWS-FLI1 Research Paper

Engineering the First Chimeric Antibody in Targeting Intracellular PRL-3 Oncoprotein for Cancer Therapy in Mice Research Paper

MiR-181b: new perspective to evaluate disease progression in chronic lymphocytic leukemia Research Perspective

Tumor suppressive microRNA-1285 regulates novel molecular targets: Aberrant expression and functional significance in renal cell carcinoma Research Paper

Neoplastic cells are a rare component in human glioblastoma microvasculature Research Perspective

Recent Developments in Targeting Carbonic Anhydrase IX for Cancer Therapeutics Research Perspective

A combination of a ribonucleotide reductase inhibitor and histone deacetylase inhibitors downregulates EGFR and triggers BIM-dependent apoptosis in head and neck cancer Research Paper

Regression of metastatic melanoma by targeting cancer stem cells Brief Reports

Capturing the Molecular and Biological Diversity of High-Grade Astrocytoma in Genetically Engineered Mouse Models Research Perspective

Resistance to EGFR inhibitors: Molecular determinants and the enigma of head and neck cancer Editorial Comments

Frizzled receptor 6 marks rare, highly tumourigenic stem-like cells in mouse and human neuroblastomas. Brief Reports

Is human cytomegalovirus a target in cancer therapy? Research Perspective

Identification of a chrXq27.3 microRNA cluster associated with early relapse in advanced stage ovarian cancer patients Research Paper

Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein, BMAL1 Research Paper

Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target Review

Regulation of glucose metabolism by p53: Emerging new roles for the tumor suppressor Review

AHI-1: a novel signaling protein and potential therapeutic target in human leukemia and brain disorders Review

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Targeted therapy for hepatocellular carcinoma: novel agents on the horizon Review

Stratification of Wilms tumor by genetic and epigenetic analysis Research Paper

Essential role for telomerase in chronic myeloid leukemia induced by BCR-ABL in mice Brief Reports

Single Enantiomer of YK-4-279 Demonstrates Specificity in Targeting the Oncogene EWS-FLI1 Research Paper

Engineering the First Chimeric Antibody in Targeting Intracellular PRL-3 Oncoprotein for Cancer Therapy in Mice Research Paper

MiR-181b: new perspective to evaluate disease progression in chronic lymphocytic leukemia Research Perspective

Tumor suppressive microRNA-1285 regulates novel molecular targets: Aberrant expression and functional significance in renal cell carcinoma Research Paper

Neoplastic cells are a rare component in human glioblastoma microvasculature Research Perspective

Recent Developments in Targeting Carbonic Anhydrase IX for Cancer Therapeutics Research Perspective

A combination of a ribonucleotide reductase inhibitor and histone deacetylase inhibitors downregulates EGFR and triggers BIM-dependent apoptosis in head and neck cancer Research Paper

Regression of metastatic melanoma by targeting cancer stem cells Brief Reports

Capturing the Molecular and Biological Diversity of High-Grade Astrocytoma in Genetically Engineered Mouse Models Research Perspective

Resistance to EGFR inhibitors: Molecular determinants and the enigma of head and neck cancer Editorial Comments

Frizzled receptor 6 marks rare, highly tumourigenic stem-like cells in mouse and human neuroblastomas. Brief Reports

Is human cytomegalovirus a target in cancer therapy? Research Perspective

Identification of a chrXq27.3 microRNA cluster associated with early relapse in advanced stage ovarian cancer patients Research Paper

Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein, BMAL1 Research Paper

Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target Review

Regulation of glucose metabolism by p53: Emerging new roles for the tumor suppressor Review

AHI-1: a novel signaling protein and potential therapeutic target in human leukemia and brain disorders Review