The Oncosearch | Oncotarget

Inactivation of beta1 integrin induces proteasomal degradation of Myc oncoproteins Research Paper

Manabu Sasada, Takuya Iyoda, Tatsufumi Asayama, Yusuke Suenaga, Shunsuke Sakai, Naoya Kase, Hiroaki Kodama, Sana Yokoi, Yoichiro Isohama, Fumio Fukai

Published Aug 13, 2019 · Vol. 10, No. 48 · pp. 4960-4972

Keywords: integrin, Myc, proteasomal degradation, fibronectin, neuroblastoma

Combinatorial drug screening of mammary cells with induced mesenchymal transformation to identify drug combinations for triple-negative breast cancer Research Paper

Sierra A. Colavito, James T. Platt, Matthew A. Held, Zongzhi Liu, Ryan Sokup, David F. Stern

Published Aug 6, 2019 · Vol. 10, No. 47 · pp. 4822-4839

Keywords: epithelial-mesenchymal transition, triple-negative breast cancer, targeted drug combination screen, claudin-low breast cancer, CHK1

The p21 levels have the potential to be a monitoring marker for ribociclib in breast cancer Research Paper

Masafumi Iida, Misato Nakamura, Emi Tokuda, Daichi Toyosawa, Toshifumi Niwa, Noriaki Ohuchi, Takanori Ishida, Shin-ichi Hayashi

Published Aug 6, 2019 · Vol. 10, No. 47 · pp. 4907-4918

Keywords: breast cancer, CDK4/6 inhibitor, resistance, CDK6, p21

Somatostatin receptor 2 targeting in small cell lung carcinoma: perspectives Research Perspective

Jonathan M. Lehman, Pierre P. aMassion

Published Jul 30, 2019 · Vol. 10, No. 46 · pp. 4727-4730

Keywords: small cell lung cancer, somatostatin receptor 2, antibody-drug conjugate, peptide drug conjugate, perspectives

Precision delivery of RAS-inhibiting siRNA to KRAS driven cancer via peptide-based nanoparticles Research Paper

Matthew S. Strand, Bradley A. Krasnick, Hua Pan, Xiuli Zhang, Ye Bi, Candace Brooks, Christopher Wetzel, Narendra Sankpal, Timothy Fleming, S. Peter Goedegebuure, David G. DeNardo, William E. Gillanders, William G. Hawkins, Samuel A. Wickline, Ryan C. Fields

Published Jul 30, 2019 · Vol. 10, No. 46 · pp. 4761-4775

Keywords: nanoparticle agents, pancreatic cancer, gastrointestinal cancer, oncoprotein

Targeting cyclin-dependent kinase 9 by a novel inhibitor enhances radiosensitization and identifies Axl as a novel downstream target in esophageal adenocarcinoma Research Paper

Omkara Lakshmi Veeranki, Zhimin Tong, Rashmi Dokey, Alicia Mejia, Jianhu Zhang, Yawei Qiao, Pankaj Kumar Singh, Riham Katkhuda, Barbara Mino, Ramesh Tailor, Jaime Rodriguez Canales, Roland Bassett, Jaffer Ajani, Ji Yuan Wu, Scott Kopetz, Mariela Blum, Wayne Hofstetter, Michael Tetzlaff, Sunil Krishnan, Steven H. Lin, Dipen Maru

Published Jul 23, 2019 · Vol. 10, No. 45 · pp. 4703-4718

Keywords: CDK 9 Inhibitor, esophageal adenocarcinoma, radiation, Axl

Real-world evidence to guide healthcare policies in oncology Research Perspective

Marco Donia, Steen Werner Hansen, Inge Marie Svane

Published Jul 16, 2019 · Vol. 10, No. 44 · pp. 4513-4515

Keywords: real-world evidence, real-world data, clinical trial eligibility

Tris DBA palladium is an orally available inhibitor of GNAQ mutant uveal melanoma in vivo Research Paper

Elgilda Musi, Gary K. Schwartz, Jae Hyuk Yoo, Shannon J. Odelberg, Dean Y. Li, Michael Y. Bonner, Ponniah Selvakumar, Shikha Rao, Linda C. Gilbert, Justin Elsey, Jack L. Arbiser

Published Jul 9, 2019 · Vol. 10, No. 43 · pp. 4424-4436

Keywords: melanoma, chemotherapy

AGR2, a unique tumor-associated antigen, is a promising candidate for antibody targeting Research Paper

Alvin Y. Liu, Adelle D. Kanan, Tomasz P. Radon, Siama Shah, Mark E. Weeks, Julie M. Foster, Jane K. Sosabowski, Laurent Dumartin, Tatjana Crnogorac-Jurcevic

Published Jul 2, 2019 · Vol. 10, No. 42 · pp. 4276-4289

Keywords: pancreatic cancer, eAGR2, chimeric antibody, prostate cancer, tumor localization

Olfactory ensheathing cells travel their natural nasal pathway to deliver therapeutics to brain tumors Editorial

Litia A. Carvalho, Bakhos A. Tannous

Published Jun 19, 2019 · Vol. 10, No. 43 · pp. 4351-4353

Keywords: olfactory ensheathing cells, glioma, gene therapy

Mutations of the MAPK/TSC/mTOR pathway characterize periventricular glioblastoma with epithelioid SEGA-like morphology–morphological and therapeutic implications Research Paper

Maria-Magdalena Georgescu, Yan Li, Mohammad Zahidul Islam, Christina Notarianni, Hai Sun, Adriana Olar, Gregory N. Fuller

Published Jun 18, 2019 · Vol. 10, No. 40 · pp. 4038-4052

Keywords: epithelioid glioblastoma, SEGA-like, mTOR, MAPK, 4E-BP1

Investigating the role of LSD2 as an epigenetic regulator in Ewing sarcoma Research Paper

Priyal O. Patel, Kathleen I. Pishas, Cenny Taslim, Julia Selich-Anderson, Emily R. Theisen, Stephen L. Lessnick

Published Jun 11, 2019 · Vol. 10, No. 39 · pp. 3865-3878

Keywords: LSD2/KDM1B, Ewing sarcoma, SP-2509, LSD1/KDM1A

Prioritization of metabolic genes as novel therapeutic targets in estrogen-receptor negative breast tumors using multi-omics data and text mining Research Paper

Dinesh Kumar Barupal, Bei Gao, Jan Budczies, Brett S. Phinney, Bertrand Perroud, Carsten Denkert, Oliver Fiehn

Published Jun 11, 2019 · Vol. 10, No. 39 · pp. 3894-3909

Keywords: set-enrichment, ChemRICH, multi-omics, metabolic networks, candidate gene prioritization

1,4-dihydroxy quininib attenuates growth of colorectal cancer cells and xenografts and regulates the TIE-2 signaling pathway in patient tumours Research Paper

Clare T. Butler, Susan A. Kennedy, Amy Buckley, Ronan Doyle, Emer Conroy, William M. Gallagher, Jacintha O’Sullivan, Breandán N. Kennedy

Published Jun 4, 2019 · Vol. 10, No. 38 · pp. 3725-3744

Keywords: colorectal cancer, angiogenesis, cysteinyl leukotriene, drug discovery, xenograft

Comparing progression molecular mechanisms between lung adenocarcinoma and lung squamous cell carcinoma based on genetic and epigenetic networks: big data mining and genome-wide systems identification Research Paper

Shan-Ju Yeh, Chien-An Chang, Cheng-Wei Li, Lily Hui-Ching Wang, Bor-Sen Chen

Published Jun 4, 2019 · Vol. 10, No. 38 · pp. 3760-3806

Keywords: lung adenocarcinoma, lung squamous cell carcinoma, NSCLC, genetic and epigenetic network, potential drug target

Regression of BRAF^V600E mutant adult glioblastoma after primary combined BRAF-MEK inhibitor targeted therapy: a report of two cases Case Report

Peter Y.M. Woo, Tai-Chung Lam, Jenny K.S. Pu, Lai-Fung Li, Roland C.Y. Leung, Jason M.K. Ho, James T.F. Zhung, Belinda Wong, Timonthy S.K. Chan, Herbert H.F. Loong, Ho-Keung Ng

Published Jun 4, 2019 · Vol. 10, No. 38 · pp. 3818-3826

Keywords: glioblastoma, BRAF^V600E mutation, targeted therapies, BRAF-MEK inhibitors

PI3K inhibition enhances the anti-tumor effect of eribulin in triple negative breast cancer Research Paper

Sandeep Rajput, Zhanfang Guo, Shunqiang Li, Cynthia X. Ma

Published Jun 4, 2019 · Vol. 10, No. 38 · pp. 3667-3680

Keywords: PI3K inhibitor, BKM120, eribulin, triple-negative breast cancer, patient-derived xenograft

Evaluation of 6-mercaptopurine in a cell culture model of adaptable triple-negative breast cancer with metastatic potential Research Paper

Balraj Singh, Vanessa N. Sarli, Hannah E. Kinne, Anna Shamsnia, Anthony Lucci

Published Jun 4, 2019 · Vol. 10, No. 38 · pp. 3681-3693

Keywords: cancer evolution, metabolic adaptability in cancer, inflammatory breast cancer, minimal residual disease, TET2

Frankincense essential oil suppresses melanoma cancer through down regulation of Bcl-2/Bax cascade signaling and ameliorates heptotoxicity via phase I and II drug metabolizing enzymes Research Paper

Faruck L. Hakkim, Hamid A. Bakshi, Shabia Khan, Mohamad Nasef, Rabia Farzand, Smitha Sam, Luay Rashan, Mohammed S. Al-Baloshi, Sidgi Syed Anwar Abdo Hasson, Ali Al Jabri, Paul A. McCarron, Murtaza M. Tambuwala

Published May 28, 2019 · Vol. 10, No. 37 · pp. 3472-3490

Keywords: melanoma, frankincense, essential oil, apoptosis, tumor remission

In vitro and in vivo anti-tumor effects of brexpiprazole, a newly-developed serotonin-dopamine activity modulator with an improved safety profile Research Paper

Shuhei Suzuki, Masahiro Yamamoto, Keita Togashi, Tomomi Sanomachi, Asuka Sugai, Shizuka Seino, Takashi Yoshioka, Chifumi Kitanaka, Masashi Okada

Published May 28, 2019 · Vol. 10, No. 37 · pp. 3547-3558

Keywords: brexpiprazole, serotonin-dopamine activity modulator, drug repositioning, drug repurposing, survivin

Publication Alerts

European Cancer and Oncology Congress

Post-Publication Promotion

Search Oncotarget

Inactivation of beta1 integrin induces proteasomal degradation of Myc oncoproteins Research Paper

Combinatorial drug screening of mammary cells with induced mesenchymal transformation to identify drug combinations for triple-negative breast cancer Research Paper

The p21 levels have the potential to be a monitoring marker for ribociclib in breast cancer Research Paper

Somatostatin receptor 2 targeting in small cell lung carcinoma: perspectives Research Perspective

Precision delivery of RAS-inhibiting siRNA to KRAS driven cancer via peptide-based nanoparticles Research Paper

Targeting cyclin-dependent kinase 9 by a novel inhibitor enhances radiosensitization and identifies Axl as a novel downstream target in esophageal adenocarcinoma Research Paper

Real-world evidence to guide healthcare policies in oncology Research Perspective

Tris DBA palladium is an orally available inhibitor of GNAQ mutant uveal melanoma in vivo Research Paper

AGR2, a unique tumor-associated antigen, is a promising candidate for antibody targeting Research Paper

Olfactory ensheathing cells travel their natural nasal pathway to deliver therapeutics to brain tumors Editorial

Mutations of the MAPK/TSC/mTOR pathway characterize periventricular glioblastoma with epithelioid SEGA-like morphology–morphological and therapeutic implications Research Paper

Investigating the role of LSD2 as an epigenetic regulator in Ewing sarcoma Research Paper

Prioritization of metabolic genes as novel therapeutic targets in estrogen-receptor negative breast tumors using multi-omics data and text mining Research Paper

1,4-dihydroxy quininib attenuates growth of colorectal cancer cells and xenografts and regulates the TIE-2 signaling pathway in patient tumours Research Paper

Comparing progression molecular mechanisms between lung adenocarcinoma and lung squamous cell carcinoma based on genetic and epigenetic networks: big data mining and genome-wide systems identification Research Paper

Regression of BRAF^V600E mutant adult glioblastoma after primary combined BRAF-MEK inhibitor targeted therapy: a report of two cases Case Report

PI3K inhibition enhances the anti-tumor effect of eribulin in triple negative breast cancer Research Paper

Evaluation of 6-mercaptopurine in a cell culture model of adaptable triple-negative breast cancer with metastatic potential Research Paper

Frankincense essential oil suppresses melanoma cancer through down regulation of Bcl-2/Bax cascade signaling and ameliorates heptotoxicity via phase I and II drug metabolizing enzymes Research Paper

In vitro and in vivo anti-tumor effects of brexpiprazole, a newly-developed serotonin-dopamine activity modulator with an improved safety profile Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Inactivation of beta1 integrin induces proteasomal degradation of Myc oncoproteins Research Paper

Combinatorial drug screening of mammary cells with induced mesenchymal transformation to identify drug combinations for triple-negative breast cancer Research Paper

The p21 levels have the potential to be a monitoring marker for ribociclib in breast cancer Research Paper

Somatostatin receptor 2 targeting in small cell lung carcinoma: perspectives Research Perspective

Precision delivery of RAS-inhibiting siRNA to KRAS driven cancer via peptide-based nanoparticles Research Paper

Targeting cyclin-dependent kinase 9 by a novel inhibitor enhances radiosensitization and identifies Axl as a novel downstream target in esophageal adenocarcinoma Research Paper

Real-world evidence to guide healthcare policies in oncology Research Perspective

Tris DBA palladium is an orally available inhibitor of GNAQ mutant uveal melanoma in vivo Research Paper

AGR2, a unique tumor-associated antigen, is a promising candidate for antibody targeting Research Paper

Olfactory ensheathing cells travel their natural nasal pathway to deliver therapeutics to brain tumors Editorial

Mutations of the MAPK/TSC/mTOR pathway characterize periventricular glioblastoma with epithelioid SEGA-like morphology–morphological and therapeutic implications Research Paper

Investigating the role of LSD2 as an epigenetic regulator in Ewing sarcoma Research Paper

Prioritization of metabolic genes as novel therapeutic targets in estrogen-receptor negative breast tumors using multi-omics data and text mining Research Paper

1,4-dihydroxy quininib attenuates growth of colorectal cancer cells and xenografts and regulates the TIE-2 signaling pathway in patient tumours Research Paper

Comparing progression molecular mechanisms between lung adenocarcinoma and lung squamous cell carcinoma based on genetic and epigenetic networks: big data mining and genome-wide systems identification Research Paper

Regression of BRAFV600E mutant adult glioblastoma after primary combined BRAF-MEK inhibitor targeted therapy: a report of two cases Case Report

PI3K inhibition enhances the anti-tumor effect of eribulin in triple negative breast cancer Research Paper

Evaluation of 6-mercaptopurine in a cell culture model of adaptable triple-negative breast cancer with metastatic potential Research Paper

Frankincense essential oil suppresses melanoma cancer through down regulation of Bcl-2/Bax cascade signaling and ameliorates heptotoxicity via phase I and II drug metabolizing enzymes Research Paper

In vitro and in vivo anti-tumor effects of brexpiprazole, a newly-developed serotonin-dopamine activity modulator with an improved safety profile Research Paper

Regression of BRAF^V600E mutant adult glioblastoma after primary combined BRAF-MEK inhibitor targeted therapy: a report of two cases Case Report