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A squalamine derivative, NV669, as a novel PTP1B inhibitor: in vitro and in vivo effects on pancreatic and hepatic tumor growth Research Paper

Sylvie Carmona, Jean-Michel Brunel, Rénaté Bonier, Véronique Sbarra, Stéphane Robert, Patrick Borentain, Dominique Lombardo, Eric Mas, René Gerolami

Published Nov 19, 2019 · Vol. 10, No. 62 · pp. 6651-6667

Keywords: aminosterol, pancreas, liver, PTP1B, cancer

The long non-coding RNA PCA3: an update of its functions and clinical applications as a biomarker in prostate cancer Review

Ana Emília Goulart Lemos, Aline da Rocha Matos, Luciana Bueno Ferreira, Etel Rodrigues Pereira Gimba

Published Nov 12, 2019 · Vol. 10, No. 61 · pp. 6589-6603

Keywords: PCA3, prostate cancer, biomarker, long non-coding RNA (lncRNA), clinical applications

MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma Priority Research Paper

David King, Xiao Dun Li, Gilberto S. Almeida, Colin Kwok, Polly Gravells, Daniel Harrison, Saoirse Burke, Albert Hallsworth, Yann Jamin, Sally George, Simon P. Robinson, Christopher J. Lord, Evon Poon, Daniel Yeomanson, Louis Chesler, Helen E. Bryant

Published Nov 6, 2019 · Vol. 11, No. 23 · pp. 2141-2159

Keywords: PARP inhibitor, neuroblastoma, MYCN, replication stress, replication fork stalling

SNiPER: a novel hypermethylation biomarker panel for liquid biopsy based early breast cancer detection Research Paper

Jolein Mijnes, Janina Tiedemann, Julian Eschenbruch, Janina Gasthaus, Sarah Bringezu, Dirk Bauerschlag, Nicolai Maass, Norbert Arnold, Jörg Weimer, Tobias Anzeneder, Peter A. Fasching, Matthias Rübner, Benjamin Bruno, Uwe Heindrichs, Jennifer Freres, Hanna Schulz, Ralf-Dieter Hilgers, Nadina Ortiz-Brüchle, Sonja von Serenyi, Ruth Knüchel, Vera Kloten, Edgar Dahl

Published Nov 5, 2019 · Vol. 10, No. 60 · pp. 6494-6508

Keywords: liquid biopsy, breast cancer, early detection, hypermethylation, discriminative CpG dinucleotides

Volasertib preclinical activity in high-risk hepatoblastoma Research Paper

Dina Kats, Cora A. Ricker, Noah E. Berlow, Bénédicte Noblet, Delphine Nicolle, Katell Mevel, Sophie Branchereau, Jean-Gabriel Judde, Cody D. Stiverson, Christina L. Stiverson, Matthew N. Svalina, Teagan Settelmeyer, Kevin Matlock, Melvin Lathara, Charlotte Mussini, James I. Geller, Christopher Noakes, Ido Sloma, Narendra Bharathy, Stefano Cairo, Charles Keller

Published Nov 5, 2019 · Vol. 10, No. 60 · pp. 6403-6417

Keywords: hepatoblastoma, PLK1, volasertib, liver, cell cycle

The multikinase inhibitor RXDX-105 is effective against neuroblastoma in vitro and in vivo Research Paper

Sean M. Flynn, Jacqueline Lesperance, Andrew Macias, Nikki Phanhthilath, Megan Rose Paul, Jong Wook Kim, Pablo Tamayo, Peter E. Zage

Published Oct 29, 2019 · Vol. 10, No. 59 · pp. 6323-6333

Keywords: neuroblastoma, RXDX-105, CEP-32496, RET, BRAF

Correction: Pharmacological treatment with inhibitors of nuclear export enhances the antitumor activity of docetaxel in human prostate cancer Correction

Giovanni Luca Gravina, Andrea Mancini, Alessandro Colapietro, Francesco Marampon, Roberta Sferra, Simona Pompili, Leda Assunta Biordi, Roberto Iorio, Vincenzo Flati, Christian Argueta, Yosef Landesman, Michael Kauffman, Sharon Shacham, Claudio Festuccia

Published Oct 22, 2019 · Vol. 10, No. 59 · pp. 6393-6395

Esophageal 3D organoids of MPV17^-/- mouse model of mitochondrial DNA depletion show epithelial cell plasticity and telomere attrition Research Paper

Manti Guha, Satish Srinivasan, Maura M. Sheehan, Takashi Kijima, Gordon Ruthel, Kelly Whelan, Koji Tanaka, Andres Klein-Szanto, Prasanna M. Chandramouleeswaran, Hiroshi Nakagawa, Narayan G. Avadhani

Published Oct 22, 2019 · Vol. 10, No. 58 · pp. 6245-6259

Keywords: mitochondrial DNA, MPV17, ESCC, telomere, 3D organoid

The predictive capability of immunohistochemistry and DNA sequencing for determining TP53 functional mutation status: a comparative study of 41 glioblastoma patients Research Paper

Aarash K. Roshandel, Christopher M. Busch, Jennifer Van Mullekom, Joshua A. Cuoco, Cara M. Rogers, Lisa S. Apfel, Eric A. Marvin, Harald W. Sontheimer, Robyn A. Umans

Published Oct 22, 2019 · Vol. 10, No. 58 · pp. 6204-6218

Keywords: p53, TP53, immunohistochemistry, gene sequencing, glioblastoma multiforme

Multiplatform profiling of pancreatic neuroendocrine tumors: Correlative analyses of clinicopathologic factors and identification of co-occurring pathogenic alterations Research Paper

Jun Gong, Edik M. Blais, Joseph R. Bender, Michelle Guan, Veronica Placencio-Hickok, Emanuel F. Petricoin, Michael J. Pishvaian, Gary Gregory, Richard Tuli, Andrew E. Hendifar

Published Oct 22, 2019 · Vol. 10, No. 58 · pp. 6260-6268

Keywords: pancreatic neuroendocrine tumors, genomic profiling, proteomic profiling, molecular pathways, co-occurring alterations

Splicing regulatory factors in breast cancer hallmarks and disease progression Review

Esmee Koedoot, Liesanne Wolters, Bob van de Water, Sylvia E. Le Dévédec

Published Oct 15, 2019 · Vol. 10, No. 57 · pp. 6021-6037

Keywords: hallmarks of cancer, breast cancer, alternative splicing, splice factors, RNA sequencing

Mutational profile and genotype/phenotype correlation of non-familial pheochromocytoma and paraganglioma Research Paper

Shatha Albattal, Meshael Alswailem, Yosra Moria, Hindi Al-Hindi, Majed Dasouki, Mohamed Abouelhoda, Hala Aba Alkhail, Entissar Alsuhaibani, Ali S. Alzahrani

Published Oct 15, 2019 · Vol. 10, No. 57 · pp. 5919-5931

Keywords: pheochromocytoma, paraganglioma, mutations, NGS, SDHB

Two novel ligand-independent variants of the VEGFR-1 receptor are expressed in human testis and spermatozoa, one of them with the ability to activate SRC proto-oncogene tyrosine kinases Research Paper

Belen Alvarez-Palomo, Carme Barrot-Feixat, Helena Sarret, Jordi Requena, Montserrat Pau, Jose-Manuel Vidal-Taboada, Rafael Oliva, Josep-Lluis Ballesca, Michael J. Edel, Jovita Mezquita-Pla

Published Oct 8, 2019 · Vol. 10, No. 56 · pp. 5871-5887

Keywords: ligand-independent intracellular iVEGFR-1 isoforms, mature testis, spermiogenesis, SRC activation, fertility

Comparison of different semi-automated cfDNA extraction methods in combination with UMI-based targeted sequencing Research Paper

Anna Streubel, Albrecht Stenzinger, Susann Stephan-Falkenau, Jens Kollmeier, Daniel Misch, Torsten Gerriet Blum, Torsten Bauer, Olfert Landt, Alexander Am Ende, Peter Schirmacher, Thomas Mairinger, Volker Endris

Published Oct 1, 2019 · Vol. 10, No. 55 · pp. 5690-5702

Keywords: lung cancer, liquid biopsy, cfDNA, molecular diagnostics, T790M

Excision repair cross-complementing group-1 (ERCC1) induction kinetics and polymorphism are markers of inferior outcome in patients with colorectal cancer treated with oxaliplatin Research Paper

Devika Rao, Atrayee Basu Mallick, Titto Augustine, Cecilia Daroqui, Jeeshan Jiffry, Amartej Merla, Imran Chaudhary, Raviraja Seetharam, Arjun Sood, Srikanth Gajavelli, Santiago Aparo, Lakshmi Rajdev, Andreas Kaubisch, Jennifer Chuy, Abdissa Negassa, John M. Mariadason, Radhashree Maitra, Sanjay Goel

Published Sep 17, 2019 · Vol. 10, No. 53 · pp. 5510-5522

Keywords: oxaliplatin, colorectal cancer, ERCC1, FOLFOX, resistance

Retraction: DNA-PK_CS binding to p53 on the p21^WAF1/CIP1 promoter blocks transcription resulting in cell death Retraction

Richard Hill, Patricia A. Madureira, David. M. Waisman, Patrick W.K. Lee

Published Sep 13, 2019 · Vol. 10, No. 53 · pp. 5572-5572

Drivers of topoisomerase II poisoning mimic and complement cytotoxicity in AML cells Research Paper

Piyush More, Ute Goedtel-Armbrust, Viral Shah, Marianne Mathaes, Thomas Kindler, Miguel A. Andrade-Navarro, Leszek Wojnowski

Published Sep 3, 2019 · Vol. 10, No. 51 · pp. 5298-5312

Keywords: topoisomerase II poisons, DNA damage, gene expression, combination therapy, cancer essentiality

Safety evaluation of conditionally immortalized cells for renal replacement therapy Research Paper

Milos Mihajlovic, Sam Hariri, Koen C.G. Westphal, Manoe J. Janssen, Miriam J. Oost, Laura Bongiovanni, Lambertus P. van den Heuvel, Alain de Bruin, Luuk B. Hilbrands, Rosalinde Masereeuw

Published Sep 3, 2019 · Vol. 10, No. 51 · pp. 5332-5348

Keywords: bioartificial kidney, cell therapy safety, conditionally immortalized proximal tubule epithelial cells, tumorigenicity, viral integration

Development and analytical validation of a next-generation sequencing based microsatellite instability (MSI) assay Research Paper

Sarabjot Pabla, Jonathan Andreas, Felicia L. Lenzo, Blake Burgher, Jacob Hagen, Vincent Giamo, Mary K. Nesline, Yirong Wang, Mark Gardner, Jeffrey M. Conroy, Antonios Papanicolau-Sengos, Carl Morrison, Sean T. Glenn

Published Aug 27, 2019 · Vol. 10, No. 50 · pp. 5181-5193

Keywords: next-generation sequencing, NGS, microsatellite instability, MSI

Repurposed quinacrine synergizes with cisplatin, reducing the effective dose required for treatment of head and neck squamous cell carcinoma Research Paper

Jennifer Bryant, Nikolaos Batis, Anna Clara Franke, Gabriella Clancey, Margaret Hartley, Gordon Ryan, Jill Brooks, Andrew D. Southam, Nicholas Barnes, Joanna Parish, Sally Roberts, Farhat Khanim, Rachel Spruce, Hisham Mehanna

Published Aug 27, 2019 · Vol. 10, No. 50 · pp. 5229-5244

Keywords: head and neck cancer, drug repurposing, drug repositioning, quinacrine, mepacrine

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A squalamine derivative, NV669, as a novel PTP1B inhibitor: in vitro and in vivo effects on pancreatic and hepatic tumor growth Research Paper

The long non-coding RNA PCA3: an update of its functions and clinical applications as a biomarker in prostate cancer Review

MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma Priority Research Paper

SNiPER: a novel hypermethylation biomarker panel for liquid biopsy based early breast cancer detection Research Paper

Volasertib preclinical activity in high-risk hepatoblastoma Research Paper

The multikinase inhibitor RXDX-105 is effective against neuroblastoma in vitro and in vivo Research Paper

Correction: Pharmacological treatment with inhibitors of nuclear export enhances the antitumor activity of docetaxel in human prostate cancer Correction

Esophageal 3D organoids of MPV17^-/- mouse model of mitochondrial DNA depletion show epithelial cell plasticity and telomere attrition Research Paper

The predictive capability of immunohistochemistry and DNA sequencing for determining TP53 functional mutation status: a comparative study of 41 glioblastoma patients Research Paper

Multiplatform profiling of pancreatic neuroendocrine tumors: Correlative analyses of clinicopathologic factors and identification of co-occurring pathogenic alterations Research Paper

Splicing regulatory factors in breast cancer hallmarks and disease progression Review

Mutational profile and genotype/phenotype correlation of non-familial pheochromocytoma and paraganglioma Research Paper

Two novel ligand-independent variants of the VEGFR-1 receptor are expressed in human testis and spermatozoa, one of them with the ability to activate SRC proto-oncogene tyrosine kinases Research Paper

Comparison of different semi-automated cfDNA extraction methods in combination with UMI-based targeted sequencing Research Paper

Excision repair cross-complementing group-1 (ERCC1) induction kinetics and polymorphism are markers of inferior outcome in patients with colorectal cancer treated with oxaliplatin Research Paper

Retraction: DNA-PK_CS binding to p53 on the p21^WAF1/CIP1 promoter blocks transcription resulting in cell death Retraction

Drivers of topoisomerase II poisoning mimic and complement cytotoxicity in AML cells Research Paper

Safety evaluation of conditionally immortalized cells for renal replacement therapy Research Paper

Development and analytical validation of a next-generation sequencing based microsatellite instability (MSI) assay Research Paper

Repurposed quinacrine synergizes with cisplatin, reducing the effective dose required for treatment of head and neck squamous cell carcinoma Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

A squalamine derivative, NV669, as a novel PTP1B inhibitor: in vitro and in vivo effects on pancreatic and hepatic tumor growth Research Paper

The long non-coding RNA PCA3: an update of its functions and clinical applications as a biomarker in prostate cancer Review

MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma Priority Research Paper

SNiPER: a novel hypermethylation biomarker panel for liquid biopsy based early breast cancer detection Research Paper

Volasertib preclinical activity in high-risk hepatoblastoma Research Paper

The multikinase inhibitor RXDX-105 is effective against neuroblastoma in vitro and in vivo Research Paper

Correction: Pharmacological treatment with inhibitors of nuclear export enhances the antitumor activity of docetaxel in human prostate cancer Correction

Esophageal 3D organoids of MPV17-/- mouse model of mitochondrial DNA depletion show epithelial cell plasticity and telomere attrition Research Paper

The predictive capability of immunohistochemistry and DNA sequencing for determining TP53 functional mutation status: a comparative study of 41 glioblastoma patients Research Paper

Multiplatform profiling of pancreatic neuroendocrine tumors: Correlative analyses of clinicopathologic factors and identification of co-occurring pathogenic alterations Research Paper

Splicing regulatory factors in breast cancer hallmarks and disease progression Review

Mutational profile and genotype/phenotype correlation of non-familial pheochromocytoma and paraganglioma Research Paper

Two novel ligand-independent variants of the VEGFR-1 receptor are expressed in human testis and spermatozoa, one of them with the ability to activate SRC proto-oncogene tyrosine kinases Research Paper

Comparison of different semi-automated cfDNA extraction methods in combination with UMI-based targeted sequencing Research Paper

Excision repair cross-complementing group-1 (ERCC1) induction kinetics and polymorphism are markers of inferior outcome in patients with colorectal cancer treated with oxaliplatin Research Paper

Retraction: DNA-PKCS binding to p53 on the p21WAF1/CIP1 promoter blocks transcription resulting in cell death Retraction

Drivers of topoisomerase II poisoning mimic and complement cytotoxicity in AML cells Research Paper

Safety evaluation of conditionally immortalized cells for renal replacement therapy Research Paper

Development and analytical validation of a next-generation sequencing based microsatellite instability (MSI) assay Research Paper

Repurposed quinacrine synergizes with cisplatin, reducing the effective dose required for treatment of head and neck squamous cell carcinoma Research Paper

Esophageal 3D organoids of MPV17^-/- mouse model of mitochondrial DNA depletion show epithelial cell plasticity and telomere attrition Research Paper

Retraction: DNA-PK_CS binding to p53 on the p21^WAF1/CIP1 promoter blocks transcription resulting in cell death Retraction