Volume 6, Issue 7 | Oncotarget

About The Cover

Because mitochondria evolved from bacteria that were originally engulfed by eukaryotic cells millions of years ago, many FDA-approved antibiotics target mitochondrial ribosomes, as a mild side-effect, which is well-tolerated. These four classes of drugs include: the erythromycins, chloramphenicol, the tetracyclines and glycylcyclines. In this issue of Oncotarget, Lamb et al., 2015 used these antibiotics as “investigational tools” to assess if mitochondrial biogenesis is required for the propagation of cancer stem cells, in 8 different cancer types. Based on their positive results, these FDA-approved antibiotics could be re-purposed for the treatment of cancer, to eradicate cancer stem cells, to prevent tumor recurrence and possibly treat metastatic disease. See Lamb et al.

Editorial

Senescence versus apoptosis in chemotherapy	Senescence versus apoptosis in chemotherapy
https://doi.org/10.18632/oncotarget.3114 StÃ©phane Ansieau, and Guillaume Collin
4551-4552

Abstract | PDF | How to cite

Reviews

Molecular landscape of pancreatic cancer: implications for current clinical trials	Molecular landscape of pancreatic cancer: implications for current clinical trials
https://doi.org/10.18632/oncotarget.2972 Gregory M. Heestand, and Razelle Kurzrock
4553-4561

MicroRNA dysregulation in uveal melanoma: a new player enters the game	MicroRNA dysregulation in uveal melanoma: a new player enters the game
https://doi.org/10.18632/oncotarget.2923 Zheng Li, Xin Yu, Jianxiong Shen, and Yang Jiang
4562-4568

Antibiotics that target mitochondria effectively eradicate cancer stem cells across multiple tumor types: Treating cancer like an infectious disease	Antibiotics that target mitochondria effectively eradicate cancer stem cells across multiple tumor types: Treating cancer like an infectious disease
https://doi.org/10.18632/oncotarget.3174 Rebecca Lamb, Bela Ozsvari, Camilla L. Lisanti, Herbert B. Tanowitz, Anthony Howell, Ubaldo E. Martinez-Outschoorn, Federica Sotgia, and Michael P. Lisanti
4569-4584

Targeting tumorinitiating cells: Eliminating anabolic cancer stem cells with inhibitors of protein synthesis or by mimicking caloric restriction	Targeting tumorinitiating cells: Eliminating anabolic cancer stem cells with inhibitors of protein synthesis or by mimicking caloric restriction
https://doi.org/10.18632/oncotarget.3278 Rebecca Lamb, Hannah Harrison, Duncan L. Smith, Paul A. Townsend, Thomas Jackson, Bela Ozsvari, Ubaldo E. Martinez-Outschoorn, Richard G. Pestell, Anthony Howell, Michael P. Lisanti, and Federica Sotgia
4585-4601

Activating transcription factor 5 enhances radioresistance and malignancy in cancer cells	Activating transcription factor 5 enhances radioresistance and malignancy in cancer cells
https://doi.org/10.18632/oncotarget.2912 Seiichiro Ishihara, Motoaki Yasuda, Akihiro Ishizu, Masayori Ishikawa, Hiroki Shirato, and Hisashi Haga
4602-4614

Norepinephrine promotes tumor microenvironment reactivity through Î²3adrenoreceptors during melanoma progression	Norepinephrine promotes tumor microenvironment reactivity through Î²3adrenoreceptors during melanoma progression
https://doi.org/10.18632/oncotarget.2652 Maura Calvani, Floriane Pelon, Giuseppina Comito, Maria Letizia Taddei, Silvia Moretti, Stefania Innocenti, Romina Nassini, Gianni Gerlini, Lorenzo Borgognoni, Franco Bambi, Elisa Giannoni, Luca Filippi, and Paola Chiarugi
4615-4632

The broadspectrum antiDNA virus agent cidofovir inhibits lung metastasis of virusindependent FGF2driven tumors	The broadspectrum antiDNA virus agent cidofovir inhibits lung metastasis of virusindependent FGF2driven tumors
https://doi.org/10.18632/oncotarget.3079 Sandra Liekens, Sam Noppen, Sofie Gijsbers, Rebecca Sienaert, Roberto Ronca, Chiara Tobia, and Marco Presta
4633-4648

The soybeanderived peptide lunasin inhibits nonsmall cell lung cancer cell proliferation by suppressing phosphorylation of the retinoblastoma protein	The soybeanderived peptide lunasin inhibits nonsmall cell lung cancer cell proliferation by suppressing phosphorylation of the retinoblastoma protein
https://doi.org/10.18632/oncotarget.3080 Elizabeth J. McConnell, Bharat Devapatla, Kavitha Yaddanapudi, and Keith R. Davis
4649-4662

Radiotherapy combined with TLR7/8 activation induces strong immune responses against gastrointestinal tumors	Radiotherapy combined with TLR7/8 activation induces strong immune responses against gastrointestinal tumors
https://doi.org/10.18632/oncotarget.3081 Sebastian SchÃ¶lch, Conrad Rauber, Alexandra Tietz, Nuh N. Rahbari, Ulrich Bork, Thomas Schmidt, Christoph Kahlert, Uwe Haberkorn, Mark A. Tomai, Kenneth E. Lipson, Rafael Carretero, JÃ¼rgen Weitz, Moritz Koch, and Peter E. Huber
4663-4676

Small noncoding RNA deregulation in endometrial carcinogenesis	Small noncoding RNA deregulation in endometrial carcinogenesis
https://doi.org/10.18632/oncotarget.2911 Maria Ravo, Angela Cordella, Antonio Rinaldi, Giuseppina Bruno, Elena Alexandrova, Pasquale Saggese, Giovanni Nassa, Giorgio Giurato, Roberta Tarallo, Giovanna Marchese, Francesca Rizzo, Claudia Stellato, Rossella Biancardi, Jacopo Troisi, Attilio Di Spiezio Sardo, Fulvio Zullo, Alessandro Weisz, and Maurizio Guida
4677-4691

Î±Radioimmunotherapy with ²¹³BiantiCD38 immunoconjugates is effective in a mouse model of human multiple myeloma	Î±Radioimmunotherapy with ²¹³BiantiCD38 immunoconjugates is effective in a mouse model of human multiple myeloma
https://doi.org/10.18632/oncotarget.2986 Katharina Teiluf, Christof Seidl, Birgit Blechert, Florian C. Gaertner, Klaus-Peter Gilbertz, Vanesa Fernandez, Florian Bassermann, Jan Endell, Rainer Boxhammer, Stephane Leclair, Mario Vallon, Michaela Aichler, Annette Feuchtinger, Frank Bruchertseifer, Alfred Morgenstern, and Markus Essler
4692-4703

Increased expression of the immune modulatory molecule PDL1 CD274 in anaplastic meningioma	Increased expression of the immune modulatory molecule PDL1 CD274 in anaplastic meningioma
https://doi.org/10.18632/oncotarget.3082 Ziming Du, Malak Abedalthagafi, Ayal A. Aizer, Allison R. McHenry, Heather H. Sun, Mark-Anthony Bray, Omar Viramontes, Revaz Machaidze, Priscilla K. Brastianos, David A. Reardon, Ian F. Dunn, Gordon J. Freeman, Keith L. Ligon, Anne E. Carpenter, Brian M. Alexander, Nathalie Y. Agar, Scott J. Rodig, Elizabeth M. Bradshaw, and Sandro Santagata
4704-4716

Stromalderived factor1Î±/CXCL12CXCR4 chemotactic pathway promotes perineural invasion in pancreatic cancer	Stromalderived factor1Î±/CXCL12CXCR4 chemotactic pathway promotes perineural invasion in pancreatic cancer
https://doi.org/10.18632/oncotarget.3069 Qinhong Xu, Zheng Wang, Xin Chen, Wanxing Duan, Jianjun Lei, Liang Zong, Xuqi Li, Liang Sheng, Jiguang Ma, Liang Han, Wei Li, Lun Zhang, Kun Guo, Zhenhua Ma, Zheng Wu, Erxi Wu, and Qingyong Ma
4717-4732

CSIG promotes hepatocellular carcinoma proliferation by activating cMYC expression	CSIG promotes hepatocellular carcinoma proliferation by activating cMYC expression
https://doi.org/10.18632/oncotarget.2900 Qian Cheng, Fuwen Yuan, Fengmin Lu, Bo Zhang, Tianda Chen, Xiangmei Chen, Yuan Cheng, Na Li, Liwei Ma, and Tanjun Tong
4733-4744

The cytotoxic effects of regorafenib in combination with protein kinase D inhibition in human colorectal cancer cells	The cytotoxic effects of regorafenib in combination with protein kinase D inhibition in human colorectal cancer cells
https://doi.org/10.18632/oncotarget.2938 Ning Wei, Edward Chu, Shao-yu Wu, Peter Wipf, and John C. Schmitz
4745-4756

FAK activation is required for IGF1Rmediated regulation of EMT migration and invasion in mesenchymal triple negative breast cancer cells	FAK activation is required for IGF1Rmediated regulation of EMT migration and invasion in mesenchymal triple negative breast cancer cells
https://doi.org/10.18632/oncotarget.3023 LaTonia Taliaferro-Smith, Elaine Oberlick, Tongrui Liu, Tanisha McGlothen, Tiffanie Alcaide, Rachel Tobin, Siobhan Donnelly, Rachel Commander, Erik Kline, Ganji Purnachandra Nagaraju, Lauren Havel, Adam Marcus, Rita Nahta, and Ruth O'Regan
4757-4772

The histone code reader SPIN1 controls RET signaling in liposarcoma	The histone code reader SPIN1 controls RET signaling in liposarcoma
https://doi.org/10.18632/oncotarget.3000 Henriette Franz, Holger Greschik, Dominica Willmann, Luka OzretiÄ‡, Cordula Annette Jilg, Eva Wardelmann, Manfred Jung, Reinhard Buettner, and Roland SchÃ¼le
4773-4789

PARP targeting counteracts gliomagenesis through induction of mitotic catastrophe and aggravation of deficiency in homologous recombination in PTENmutant glioma	PARP targeting counteracts gliomagenesis through induction of mitotic catastrophe and aggravation of deficiency in homologous recombination in PTENmutant glioma
https://doi.org/10.18632/oncotarget.2993 Jara Majuelos-Melguizo, MarÃa Isabel RodrÃguez, Laura LÃ³pez-JimÃ©nez, Jose M. RodrÃguez-Vargas, Juan M. MartÃ MartÃn-Consuegra, Santiago Serrano-SÃ¡enz, Julie Gavard, J. Mariano Ruiz de AlmodÃ³var, and F. Javier Oliver
4790-4803

p53 activates G₁ checkpoint following DNA damage by doxorubicin during transient mitotic arrest	p53 activates G₁ checkpoint following DNA damage by doxorubicin during transient mitotic arrest
https://doi.org/10.18632/oncotarget.3103 Sun-Yi Hyun, and Young-Joo Jang
4804-4815

Insilico identification and functional validation of alleledependent AR enhancers	Insilico identification and functional validation of alleledependent AR enhancers
https://doi.org/10.18632/oncotarget.3019 Sonia Garritano, Alessandro Romanel, Yari Ciribilli, Alessandra Bisio, Antoneta Gavoci, Alberto Inga, and Francesca Demichelis
4816-4828

Inhibition of EP2/EP4 signaling abrogates IGF1Rmediated cancer cell growth: Involvement of protein kinase CÎ¸ activation	Inhibition of EP2/EP4 signaling abrogates IGF1Rmediated cancer cell growth: Involvement of protein kinase CÎ¸ activation
https://doi.org/10.18632/oncotarget.3104 Tetsuyuki Takahashi, Hisanori Uehara, Hirohisa Ogawa, Hitomi Umemoto, Yoshimi Bando, and Keisuke Izumi
4829-4844

The IgH 3â€² regulatory region governs Î¼ chain transcription in mature B lymphocytes and the B cell fate	The IgH 3â€² regulatory region governs Î¼ chain transcription in mature B lymphocytes and the B cell fate
https://doi.org/10.18632/oncotarget.3010 Alexis Saintamand, Pauline Rouaud, Armand Garot, Faten Saad, Claire Carrion, Christelle Oblet, Michel CognÃ©, Eric Pinaud, and Yves Denizot
4845-4852

Aberrant expression of the embryonic transcription factor brachyury in human tumors detected with a novel rabbit monoclonal antibody	Aberrant expression of the embryonic transcription factor brachyury in human tumors detected with a novel rabbit monoclonal antibody
https://doi.org/10.18632/oncotarget.3086 Duane H. Hamilton, Romaine I. Fernando, Jeffrey Schlom, and Claudia Palena
4853-4862

HDAC12 inhibition impairs EZH2 and BBAP mediated DNA repair to overcome chemoresistance in EZH2 gainoffunction mutant diffuse large Bcell lymphoma	HDAC12 inhibition impairs EZH2 and BBAP mediated DNA repair to overcome chemoresistance in EZH2 gainoffunction mutant diffuse large Bcell lymphoma
https://doi.org/10.18632/oncotarget.3120 Danielle P. Johnson, Gabriella S. Spitz, Shweta Tharkar, Steven N. Quayle, Jeffrey R. Shearstone, Simon Jones, Maria E. McDowell, Hannah Wellman, Jessica K. Tyler, Bradley R. Cairns, Mahesh B. Chandrasekharan, and Srividya Bhaskara
4863-4887

The DNA methylation inhibitor induces telomere dysfunction and apoptosis of leukemia cells that is attenuated by telomerase overexpression	The DNA methylation inhibitor induces telomere dysfunction and apoptosis of leukemia cells that is attenuated by telomerase overexpression
https://doi.org/10.18632/oncotarget.2917 Xiaolu Zhang, Bingnan Li, Nick de Jonge, Magnus BjÃ¶rkholm, and Dawei Xu
4888-4900

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About The Cover

Table of Contents

Editorial

Reviews

Priority Research Papers

Research Papers

Clinical Research Papers

High expression of Nmyc and STAT interactor predicts poor prognosis and promotes tumor growth in human glioblastoma	High expression of Nmyc and STAT interactor predicts poor prognosis and promotes tumor growth in human glioblastoma
https://doi.org/10.18632/oncotarget.3208 Delong Meng, Yuanyuan Chen, Dapeng Yun, Yingjie Zhao, Jingkun Wang, Tao Xu, Xiaoying Li, Yuqi Wang, Li Yuan, Ruochuan Sun, Xiao Song, Cong Huai, Lingna Hu, Song Yang, Taishan Min, Juxiang Chen, Hongyan Chen, and Daru Lu
4901-4919

miR27a and miR27a* contribute to metastatic properties of osteosarcoma cells	miR27a and miR27a* contribute to metastatic properties of osteosarcoma cells
https://doi.org/10.18632/oncotarget.3025 Zaidoun Salah, Rand Arafeh, Vadim Maximov, Marco Galasso, Saleh Khawaled, Samah Abou-Sharieha, Stefano Volinia, Kevin B. Jones, Carlo M. Croce, and Rami I. Aqeilan
4920-4935

Galectin3 augments tumor initiating property and tumorigenicity of lung cancer through interaction with Î²catenin	Galectin3 augments tumor initiating property and tumorigenicity of lung cancer through interaction with Î²catenin
https://doi.org/10.18632/oncotarget.3210 Ling-Yen Chung, Shye-Jye Tang, Yi-Ching Wu, Guang-Huan Sun, Huan-Yun Liu, and Kuang-Hui Sun
4936-4952

Extracellular vesicles from bone marrow mesenchymal stem/stromal cells transport tumor regulatory microRNA proteins and metabolites	Extracellular vesicles from bone marrow mesenchymal stem/stromal cells transport tumor regulatory microRNA proteins and metabolites
https://doi.org/10.18632/oncotarget.3211 Krishna C. Vallabhaneni, Patrice Penfornis, Santosh Dhule, Francois Guillonneau, Kristen V. Adams, Yin Yuan Mo, Rui Xu, Yiming Liu, Kounosuke Watabe, Mohan C. Vemuri, and Radhika Pochampally
4953-4967

Comprehensive analysis of targetable oncogenic mutations in chinese cervical cancers	Comprehensive analysis of targetable oncogenic mutations in chinese cervical cancers
https://doi.org/10.18632/oncotarget.3212 Libing Xiang, Jiajia Li, Wei Jiang, Xuxia Shen, Wentao Yang, Xiaohua Wu, and Huijuan Yang
4968-4975

Novel oral histone deacetylase inhibitor MPT0E028 displays potent growthinhibitory activity against human Bcell lymphoma in vitro and in vivo	Novel oral histone deacetylase inhibitor MPT0E028 displays potent growthinhibitory activity against human Bcell lymphoma in vitro and in vivo
https://doi.org/10.18632/oncotarget.3213 Han-Li Huang, Chieh-Yu Peng, Mei-Jung Lai, Chun-Han Chen, Hsueh-Yun Lee, Jing-Chi Wang, Jing-Ping Liou, Shiow-Lin Pan, and Che-Ming Teng
4976-4991

The heparan sulfate mimetic PG545 interferes with Wnt/Î²catenin signaling and significantly suppresses pancreatic tumorigenesis alone and in combination with gemcitabine	The heparan sulfate mimetic PG545 interferes with Wnt/Î²catenin signaling and significantly suppresses pancreatic tumorigenesis alone and in combination with gemcitabine
https://doi.org/10.18632/oncotarget.3214 Deok-Beom Jung, Miyong Yun, Eun-Ok Kim, Jaekwang Kim, Bonglee Kim, Ji Hoon Jung, Enfeng Wang, Debabrata Mukhopadhyay, Edward Hammond, Keith Dredge, Viji Shridhar, and Sung-Hoon Kim
4992-5004

Activating enhancerbinding protein2Î± induces cyclooxygenase2 expression and promotes nasopharyngeal carcinoma growth	Activating enhancerbinding protein2Î± induces cyclooxygenase2 expression and promotes nasopharyngeal carcinoma growth
https://doi.org/10.18632/oncotarget.3215 Dingbo Shi, Xiangsheng Xiao, Yun Tian, Lijun Qin, Fangyun Xie, Rui Sun, Jingshu Wang, Wenbin Li, Tianze Liu, Yao Xiao, Wendan Yu, Wei Guo, Yuqing Xiong, Huijuan Qiu, Tiebang Kang, Wenlin Huang, Chong Zhao, and Wuguo Deng
5005-5021

CXCR4 overexpression and survival in cancer: A system review and metaanalysis	CXCR4 overexpression and survival in cancer: A system review and metaanalysis
https://doi.org/10.18632/oncotarget.3217 Hongli Zhao, Liyuan Guo, Hong Zhao, Jiaxin Zhao, Hao Weng, and Bin Zhao
5022-5040

Advances in dynamic modeling of colorectal cancer signalingnetwork regions a path toward targeted therapies	Advances in dynamic modeling of colorectal cancer signalingnetwork regions a path toward targeted therapies
https://doi.org/10.18632/oncotarget.3238 Lorenzo Tortolina, David J. Duffy, Massimo Maffei, Nicoletta Castagnino, AimÃ©e M. Carmody, Walter Kolch, Boris N. Kholodenko, Cristina De Ambrosi, Annalisa Barla, Elia M. Biganzoli, Alessio Nencioni, Franco Patrone, Alberto Ballestrero, Gabriele Zoppoli, Alessandro Verri, and Silvio Parodi
5041-5058