Volume 6, Issue 7 | Oncotarget

About The Cover

Because mitochondria evolved from bacteria that were originally engulfed by eukaryotic cells millions of years ago, many FDA-approved antibiotics target mitochondrial ribosomes, as a mild side-effect, which is well-tolerated. These four classes of drugs include: the erythromycins, chloramphenicol, the tetracyclines and glycylcyclines. In this issue of Oncotarget, Lamb et al., 2015 used these antibiotics as “investigational tools” to assess if mitochondrial biogenesis is required for the propagation of cancer stem cells, in 8 different cancer types. Based on their positive results, these FDA-approved antibiotics could be re-purposed for the treatment of cancer, to eradicate cancer stem cells, to prevent tumor recurrence and possibly treat metastatic disease. See Lamb et al.

Editorial

Senescence versus apoptosis in chemotherapy	Senescence versus apoptosis in chemotherapy
https://doi.org/10.18632/oncotarget.3114
4551-4552

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Reviews

Molecular landscape of pancreatic cancer: implications for current clinical trials	Molecular landscape of pancreatic cancer: implications for current clinical trials
https://doi.org/10.18632/oncotarget.2972
4553-4561

MicroRNA dysregulation in uveal melanoma: a new player enters the game	MicroRNA dysregulation in uveal melanoma: a new player enters the game
https://doi.org/10.18632/oncotarget.2923
4562-4568

Antibiotics that target mitochondria effectively eradicate cancer stem cells across multiple tumor types: Treating cancer like an infectious disease	Antibiotics that target mitochondria effectively eradicate cancer stem cells across multiple tumor types: Treating cancer like an infectious disease
https://doi.org/10.18632/oncotarget.3174
4569-4584

Targeting tumorinitiating cells: Eliminating anabolic cancer stem cells with inhibitors of protein synthesis or by mimicking caloric restriction	Targeting tumorinitiating cells: Eliminating anabolic cancer stem cells with inhibitors of protein synthesis or by mimicking caloric restriction
https://doi.org/10.18632/oncotarget.3278
4585-4601

Activating transcription factor 5 enhances radioresistance and malignancy in cancer cells	Activating transcription factor 5 enhances radioresistance and malignancy in cancer cells
https://doi.org/10.18632/oncotarget.2912
4602-4614

Norepinephrine promotes tumor microenvironment reactivity through Î²3adrenoreceptors during melanoma progression	Norepinephrine promotes tumor microenvironment reactivity through Î²3adrenoreceptors during melanoma progression
https://doi.org/10.18632/oncotarget.2652
4615-4632

The broadspectrum antiDNA virus agent cidofovir inhibits lung metastasis of virusindependent FGF2driven tumors	The broadspectrum antiDNA virus agent cidofovir inhibits lung metastasis of virusindependent FGF2driven tumors
https://doi.org/10.18632/oncotarget.3079
4633-4648

The soybeanderived peptide lunasin inhibits nonsmall cell lung cancer cell proliferation by suppressing phosphorylation of the retinoblastoma protein	The soybeanderived peptide lunasin inhibits nonsmall cell lung cancer cell proliferation by suppressing phosphorylation of the retinoblastoma protein
https://doi.org/10.18632/oncotarget.3080
4649-4662

Radiotherapy combined with TLR7/8 activation induces strong immune responses against gastrointestinal tumors	Radiotherapy combined with TLR7/8 activation induces strong immune responses against gastrointestinal tumors
https://doi.org/10.18632/oncotarget.3081
4663-4676

Small noncoding RNA deregulation in endometrial carcinogenesis	Small noncoding RNA deregulation in endometrial carcinogenesis
https://doi.org/10.18632/oncotarget.2911
4677-4691

Î±Radioimmunotherapy with ²¹³BiantiCD38 immunoconjugates is effective in a mouse model of human multiple myeloma	Î±Radioimmunotherapy with ²¹³BiantiCD38 immunoconjugates is effective in a mouse model of human multiple myeloma
https://doi.org/10.18632/oncotarget.2986
4692-4703

Increased expression of the immune modulatory molecule PDL1 CD274 in anaplastic meningioma	Increased expression of the immune modulatory molecule PDL1 CD274 in anaplastic meningioma
https://doi.org/10.18632/oncotarget.3082
4704-4716

Stromalderived factor1Î±/CXCL12CXCR4 chemotactic pathway promotes perineural invasion in pancreatic cancer	Stromalderived factor1Î±/CXCL12CXCR4 chemotactic pathway promotes perineural invasion in pancreatic cancer
https://doi.org/10.18632/oncotarget.3069
4717-4732

CSIG promotes hepatocellular carcinoma proliferation by activating cMYC expression	CSIG promotes hepatocellular carcinoma proliferation by activating cMYC expression
https://doi.org/10.18632/oncotarget.2900
4733-4744

The cytotoxic effects of regorafenib in combination with protein kinase D inhibition in human colorectal cancer cells	The cytotoxic effects of regorafenib in combination with protein kinase D inhibition in human colorectal cancer cells
https://doi.org/10.18632/oncotarget.2938
4745-4756

FAK activation is required for IGF1Rmediated regulation of EMT migration and invasion in mesenchymal triple negative breast cancer cells	FAK activation is required for IGF1Rmediated regulation of EMT migration and invasion in mesenchymal triple negative breast cancer cells
https://doi.org/10.18632/oncotarget.3023
4757-4772

The histone code reader SPIN1 controls RET signaling in liposarcoma	The histone code reader SPIN1 controls RET signaling in liposarcoma
https://doi.org/10.18632/oncotarget.3000
4773-4789

PARP targeting counteracts gliomagenesis through induction of mitotic catastrophe and aggravation of deficiency in homologous recombination in PTENmutant glioma	PARP targeting counteracts gliomagenesis through induction of mitotic catastrophe and aggravation of deficiency in homologous recombination in PTENmutant glioma
https://doi.org/10.18632/oncotarget.2993
4790-4803

p53 activates G₁ checkpoint following DNA damage by doxorubicin during transient mitotic arrest	p53 activates G₁ checkpoint following DNA damage by doxorubicin during transient mitotic arrest
https://doi.org/10.18632/oncotarget.3103
4804-4815

Insilico identification and functional validation of alleledependent AR enhancers	Insilico identification and functional validation of alleledependent AR enhancers
https://doi.org/10.18632/oncotarget.3019
4816-4828

Inhibition of EP2/EP4 signaling abrogates IGF1Rmediated cancer cell growth: Involvement of protein kinase CÎ¸ activation	Inhibition of EP2/EP4 signaling abrogates IGF1Rmediated cancer cell growth: Involvement of protein kinase CÎ¸ activation
https://doi.org/10.18632/oncotarget.3104
4829-4844

The IgH 3â€² regulatory region governs Î¼ chain transcription in mature B lymphocytes and the B cell fate	The IgH 3â€² regulatory region governs Î¼ chain transcription in mature B lymphocytes and the B cell fate
https://doi.org/10.18632/oncotarget.3010
4845-4852

Aberrant expression of the embryonic transcription factor brachyury in human tumors detected with a novel rabbit monoclonal antibody	Aberrant expression of the embryonic transcription factor brachyury in human tumors detected with a novel rabbit monoclonal antibody
https://doi.org/10.18632/oncotarget.3086
4853-4862

HDAC12 inhibition impairs EZH2 and BBAP mediated DNA repair to overcome chemoresistance in EZH2 gainoffunction mutant diffuse large Bcell lymphoma	HDAC12 inhibition impairs EZH2 and BBAP mediated DNA repair to overcome chemoresistance in EZH2 gainoffunction mutant diffuse large Bcell lymphoma
https://doi.org/10.18632/oncotarget.3120
4863-4887

The DNA methylation inhibitor induces telomere dysfunction and apoptosis of leukemia cells that is attenuated by telomerase overexpression	The DNA methylation inhibitor induces telomere dysfunction and apoptosis of leukemia cells that is attenuated by telomerase overexpression
https://doi.org/10.18632/oncotarget.2917
4888-4900

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About The Cover

Table of Contents

Editorial

Reviews

Priority Research Papers

Research Papers

Clinical Research Papers

High expression of Nmyc and STAT interactor predicts poor prognosis and promotes tumor growth in human glioblastoma	High expression of Nmyc and STAT interactor predicts poor prognosis and promotes tumor growth in human glioblastoma
https://doi.org/10.18632/oncotarget.3208
4901-4919

miR27a and miR27a* contribute to metastatic properties of osteosarcoma cells	miR27a and miR27a* contribute to metastatic properties of osteosarcoma cells
https://doi.org/10.18632/oncotarget.3025
4920-4935

Galectin3 augments tumor initiating property and tumorigenicity of lung cancer through interaction with Î²catenin	Galectin3 augments tumor initiating property and tumorigenicity of lung cancer through interaction with Î²catenin
https://doi.org/10.18632/oncotarget.3210
4936-4952

Extracellular vesicles from bone marrow mesenchymal stem/stromal cells transport tumor regulatory microRNA proteins and metabolites	Extracellular vesicles from bone marrow mesenchymal stem/stromal cells transport tumor regulatory microRNA proteins and metabolites
https://doi.org/10.18632/oncotarget.3211
4953-4967

Comprehensive analysis of targetable oncogenic mutations in chinese cervical cancers	Comprehensive analysis of targetable oncogenic mutations in chinese cervical cancers
https://doi.org/10.18632/oncotarget.3212
4968-4975

Novel oral histone deacetylase inhibitor MPT0E028 displays potent growthinhibitory activity against human Bcell lymphoma in vitro and in vivo	Novel oral histone deacetylase inhibitor MPT0E028 displays potent growthinhibitory activity against human Bcell lymphoma in vitro and in vivo
https://doi.org/10.18632/oncotarget.3213
4976-4991

The heparan sulfate mimetic PG545 interferes with Wnt/Î²catenin signaling and significantly suppresses pancreatic tumorigenesis alone and in combination with gemcitabine	The heparan sulfate mimetic PG545 interferes with Wnt/Î²catenin signaling and significantly suppresses pancreatic tumorigenesis alone and in combination with gemcitabine
https://doi.org/10.18632/oncotarget.3214
4992-5004

Activating enhancerbinding protein2Î± induces cyclooxygenase2 expression and promotes nasopharyngeal carcinoma growth	Activating enhancerbinding protein2Î± induces cyclooxygenase2 expression and promotes nasopharyngeal carcinoma growth
https://doi.org/10.18632/oncotarget.3215
5005-5021

CXCR4 overexpression and survival in cancer: A system review and metaanalysis	CXCR4 overexpression and survival in cancer: A system review and metaanalysis
https://doi.org/10.18632/oncotarget.3217
5022-5040

Advances in dynamic modeling of colorectal cancer signalingnetwork regions a path toward targeted therapies	Advances in dynamic modeling of colorectal cancer signalingnetwork regions a path toward targeted therapies
https://doi.org/10.18632/oncotarget.3238
5041-5058