Vol 5, No 13

Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention

Identification of kit^M541L somatic mutation in chronic eosinophilic leukemia, not otherwise specified and its implication in low-dose imatinib response

Investigation of IL-23 (p19, p40) and IL-23R identifies nuclear expression of IL-23 p19 as a favorable prognostic factor in colorectal cancer: a retrospective multicenter study of 675 patients

A radiosensitivity gene signature in predicting glioma prognostic via EMT pathway

Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor.

Capturing the metabolomic diversity of KRAS mutants in non-small-cell lung cancer cells

Adiponectin promotes pancreatic cancer progression by inhibiting apoptosis via the activation of AMPK/Sirt1/PGC-1α signaling

Metformin limits the adipocyte tumor-promoting effect on ovarian cancer

Combining AKT inhibition with chloroquine and gefitinib prevents compensatory autophagy and induces cell death in EGFR mutated NSCLC cells

A polymorphism in JMJD2C alters the cleavage by caspase-3 and the prognosis of human breast cancer

Nicotine and oxidative stress induced exomic variations are concordant and overrepresented in cancer-associated genes

Enhanced Orai1 and STIM1 expression as well as store operated Ca²⁺ entry in therapy resistant ovary carcinoma cells

Anti-tumor activity of fenretinide complexed with human serum albumin in lung cancer xenograft mouse model

MicroRNA-31 suppresses medulloblastoma cell growth by inhibiting DNA replication through minichromosome maintenance 2

Tumor suppressor FOXO3 regulates ribonucleotide reductase subunit RRM2B and impacts on survival of cancer patients

Lapatinib induces autophagic cell death and inhibits growth of human hepatocellular carcinoma

HGF/c-Met axis drives cancer aggressiveness in the neo-adjuvant setting of ovarian cancer

Afatinib and its encapsulated polymeric micelles inhibits HER2-overexpressed colorectal tumor cell growth in vitro and in vivo

Selective inhibition of unfolded protein response induces apoptosis in pancreatic cancer cells

Tumor-derived CXCL8 signaling augments stroma-derived CCL2-promoted proliferation and CXCL12-mediated invasion of PTEN-deficient prostate cancer cells

RFX1–dependent activation of SHP-1 induces autophagy by a novel obatoclax derivative in hepatocellular carcinoma cells

Receptor ligand-triggered resistance to alectinib and its circumvention by Hsp90 inhibition in EML4-ALK lung cancer cells

Thioridazine inhibits angiogenesis and tumor growth by targeting the VEGFR-2/PI3K/mTOR pathway in ovarian cancer xenografts

The antihypertension drug doxazosin inhibits tumor growth and angiogenesis by decreasing VEGFR-2/Akt/mTOR signaling and VEGF and HIF-1α expression

Engineered ubiquitin ligase PTB-U-box targets insulin/insulin-like growth factor receptor for degradation and coordinately inhibits cancer malignancy

miR-942 decreases TRAIL-induced apoptosis through ISG12a downregulation and is regulated by AKT

Silibinin strongly inhibits the growth kinetics of colon cancer stem cell-enriched spheroids by modulating interleukin 4/6-mediated survival signals

Synergistic induction of apoptosis by combination of BTK and dual mTORC1/2 inhibitors in diffuse large B cell lymphoma

Yin Yang 1 is a target of microRNA-34 family and contributes to gastric carcinogenesis

GCIP functions as a tumor suppressor in non-small cell lung cancer by suppressing Id1-mediated tumor promotion

Sulfatase 1 (hSulf-1) reverses basic fibroblast growth factor-stimulated signaling and inhibits growth of hepatocellular carcinoma in animal model

The MAPK pathway as an apoptosis enhancer in melanoma

Insights from yeast into whether the rapamycin inhibition of heat shock transcription factor (Hsf1) can prevent the Hsf1 activation that results from treatment with an Hsp90 inhibitor

Mutational analysis of primary central nervous system lymphoma

Niraparib (MK-4827), a novel poly(ADP-Ribose) polymerase inhibitor, radiosensitizes human lung and breast cancer cells

Visfatin promotes cell and tumor growth by upregulating Notch1 in breast cancer

Targeting the K-Ras - JNK axis eliminates cancer stem-like cells and prevents pancreatic tumor formation

FoxD3-regulated microRNA-137 suppresses tumour growth and metastasis in human hepatocellular carcinoma by targeting AKT2

H-Ras regulation of TRAIL death receptor mediated apoptosis

ERBB3 knockdown induces cell cycle arrest and activation of Bak and Bax-dependent apoptosis in colon cancer cells

The subcellular distribution and function of MTA1 in cancer differentiation

RPL24: a potential therapeutic target whose depletion or acetylation inhibits polysome assembly and cancer cell growth

Inhibition of glucose turnover by 3-bromopyruvate counteracts pancreatic cancer stem cell features and sensitizes cells to gemcitabine