Deubiquitinating enzymes as oncotargets

Ecology meets cancer biology: the cancer swamp promotes the lethal cancer phenotype

Forced expression of fibroblast growth factor 21 reverses the sustained impairment of liver regeneration in hPPARα^PAC mice due to dysregulated bile acid synthesis

Rapatar, a nanoformulation of rapamycin, decreases chemically-induced benign prostate hyperplasia in rats

New therapeutic approach to heart failure due to myocardial infarction based on targeting growth hormone-releasing hormone receptor

Silencing of R-Spondin1 increases radiosensitivity of glioma cells

EMMPRIN/CD147 is a novel coreceptor of VEGFR-2 mediating its activation by VEGF

Flotillin-2 promotes nasopharyngeal carcinoma metastasis and is necessary for the epithelial-mesenchymal transition induced by transforming growth factor-β

Netrin-4 as a biomarker promotes cell proliferation and invasion in gastric cancer

NGF-induced TrkA/CD44 association is involved in tumor aggressiveness and resistance to lestaurtinib

Hypoxia/reoxygenation-experienced cancer cell migration and metastasis are regulated by Rap1- and Rac1-GTPase activation via the expression of thymosin beta-4

Cordycepin (3’-deoxyadenosine) suppressed HMGA2, Twist1 and ZEB1-dependent melanoma invasion and metastasis by targeting miR-33b

Dietary compound isoliquiritigenin prevents mammary carcinogenesis by inhibiting breast cancer stem cells through WIF1 demethylation

PAK1-mediated MORC2 phosphorylation promotes gastric tumorigenesis

Cisplatin fails to induce puma mediated apoptosis in mucosal melanomas

Targeting Toll-like receptor 2 inhibits growth of head and neck squamous cell carcinoma

Interleukin-21 sustains inflammatory signals that contribute to sporadic colon tumorigenesis

HSPA12B: a novel facilitator of lung tumor growth

A suppressive role of ionizing radiation-responsive miR-29c in the development of liver carcinoma via targeting WIP1

Circadian genes Per1 and Per2 increase radiosensitivity of glioma in vivo

Valproic acid promotes radiosensitization in meningioma stem-like cells

Delphinidin sensitizes prostate cancer cells to TRAIL-induced apoptosis, by inducing DR5 and causing caspase-mediated HDAC3 cleavage

CXCR6 expression in non-small cell lung carcinoma supports metastatic process via modulating metalloproteinases

Aspirin counteracts cancer stem cell features, desmoplasia and gemcitabine resistance in pancreatic cancer

Stat3 orchestrates interaction between endothelial and tumor cells and inhibition of Stat3 suppresses brain metastasis of breast cancer cells

Manipulation of prostate cancer metastasis by locus-specific modification of the CRMP4 promoter region using chimeric TALE DNA methyltransferase and demethylase

Vasorin is a potential serum biomarker and drug target of hepatocarcinoma screened by subtractive-EMSA-SELEX to clinic patient serum

XPC inhibits NSCLC cell proliferation and migration by enhancing E-Cadherin expression

NF2 blocks Snail-mediated p53 suppression in mesothelioma

MET receptor is a potential therapeutic target in high grade cervical cancer

Co-activation of PIK3CA and Yap promotes development of hepatocellular and cholangiocellular tumors in mouse and human liver

Connexin32 regulates hepatoma cell metastasis and proliferation via the p53 and Akt pathways

Glucose starvation-mediated inhibition of salinomycin induced autophagy amplifies cancer cell specific cell death

Targeting the degradation of AXL receptor tyrosine kinase to overcome resistance in gefitinib-resistant non-small cell lung cancer

Critical role of gap junction communication, calcium and nitric oxide signaling in bystander responses to focal photodynamic injury

Yes-mediated phosphorylation of focal adhesion kinase at tyrosine 861 increases metastatic potential of prostate cancer cells

The miR-193a-3p-regulated ING5 gene activates the DNA damage response pathway and inhibits multi-chemoresistance in bladder cancer

Pre-clinical evaluation of the MDM2-p53 antagonist RG7388 alone and in combination with chemotherapy in neuroblastoma

Lung tumorigenesis induced by human vascular endothelial growth factor (hVEGF)-A165 overexpression in transgenic mice and amelioration of tumor formation by miR-16

WNT5A promotes stemness characteristics in nasopharyngeal carcinoma cells leading to metastasis and tumorigenesis

Endothelial exosomes contribute to the antitumor response during breast cancer neoadjuvant chemotherapy via microRNA transfer

Oncogenic extracellular HSP70 disrupts the gap-junctional coupling between capillary cells

MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer

MicroRNA-144 suppresses osteosarcoma growth and metastasis by targeting ROCK1 and ROCK2

Chorein addiction in VPS13A overexpressing rhabdomyosarcoma cells

HIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicity

Molecular signatures of sanguinarine in human pancreatic cancer cells: A large scale label-free comparative proteomics approach

Salinomycin decreases doxorubicin resistance in hepatocellular carcinoma cells by inhibiting the β-catenin/TCF complex association via FOXO3a activation

Triple negative breast cancers comprise a highly tumorigenic cell subpopulation detectable by its high responsiveness to a Sox2 regulatory region 2 (SRR2) reporter

Potentiating the cellular targeting and anti-tumor activity of Dp44mT via binding to human serum albumin: two saturable mechanisms of Dp44mT uptake by cells

PI3K pan-inhibition impairs more efficiently proliferation and survival of T-cell acute lymphoblastic leukemia cell lines when compared to isoform-selective PI3K inhibitors

IL-8 confers resistance to EGFR inhibitors by inducing stem cell properties in lung cancer

Dysregulation of the miR-34a-SIRT1 axis inhibits breast cancer stemness

Novel agents that downregulate EGFR, HER2, and HER3 in parallel

Icaritin suppresses multiple myeloma, by inhibiting IL-6/JAK2/STAT3

Sortilin is associated with breast cancer aggressiveness and contributes to tumor cell adhesion and invasion

Rampant centrosome amplification underlies more aggressive disease course of triple negative breast cancers

Loss of Cbl and Cbl-b ubiquitin ligases abrogates hematopoietic stem cell quiescence and sensitizes leukemic disease to chemotherapy

HDACi inhibits liposarcoma via targeting of the MDM2-p53 signaling axis and PTEN, irrespective of p53 mutational status

Integrated genomic analysis identifies subclasses and prognosis signatures of kidney cancer

Multiple myeloma induces Mcl-1 expression and survival of myeloid-derived suppressor cells

Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment

Powerful anti-tumor and anti-angiogenic activity of a new anti-vascular endothelial growth factor receptor 1 peptide in colorectal cancer models

Deregulation of dicer and mir-155 expression in liposarcoma

CD163+ tumor-associated macrophage is a prognostic biomarker and is associated with therapeutic effect on malignant pleural effusion of lung cancer patients

Molecular profiling of peripheral blood is associated with circulating tumor cells content and poor survival in metastatic castration-resistant prostate cancer

TERT promoter mutations and telomere length in adult malignant gliomas and recurrences

Increased angiogenesis is associated with a 32-gene expression signature and 6p21 amplification in aggressive endometrial cancer

High expression of cAMP-responsive element-binding protein 1 (CREB1) is associated with metastasis, tumor stage and poor outcome in gastric cancer

Expression and clinicopathological significance of FSIP1 in breast cancer