Research Papers:

Circadian genes Per1 and Per2 increase radiosensitivity of glioma in vivo

Niu Zhanfeng, Li Yanhui, Fei Zhou, Hao Shaocai, Li Guangxing and Xia Hechun _

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Oncotarget. 2015; 6:9951-9958. https://doi.org/10.18632/oncotarget.3179

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Niu Zhanfeng1,2, Li Yanhui3, Fei Zhou2, Hao Shaocai1, Li Guangxing1, Xia Hechun1,4

1Department of Neurosurgery, The General Hospital of Ningxia Medical University, Yinchuan, China

2Department of Neurosurgery, The Xijing Hospital of The Fourth Miltary Medical University, Xi'an, China

3Graduate School of Ningxia Medical University, Yinchuan, China

4Incubation Base of National Key Laboratory for Cerebrocranial Diseases, Ningxia Medical University, Yinchuan, China

Correspondence to:

Xia Hechun, e-mail: [email protected]

Keywords: Per1, Per2, glioma, radiotherapeutic sensitivity

Received: September 24, 2014     Accepted: January 23, 2015     Published: February 07, 2015


Per1 and Per2 play a key role in regulating the circadian rhythm in mammals. We report here that although both genes were expressed with a circadian rhythm in glioma and normal brain tissue in rats, their expression profiles differed in the two types of tissue. In addition, high expression of Per1 and Per2 in glioma tissue was associated with increased sensitivity to x-irradiation. No such sensitizing effect was observed in normal tissue. Our results suggest that Per1 and Per2 expression may increase the efficacy of radiotherapy against glioma by promoting apoptosis.

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