The Oncosearch | Oncotarget

Effect of cell microenvironment on the drug sensitivity of hepatocellular cancer cells Research Paper

Bhaskar Bhattacharya, Daniel Q. Huang, Sarah Hong Hui Low, Gim Hwa Tan, Min Ji Han, Sanamerjit Singh, Benny Tang, Sheng Chun Chang, Joey Sze Yun Lim, Mohd Feroz Mohd Omar, Yock Young Dan, Richie Soong

Published Mar 3, 2021 · Vol. 12, No. 7 · pp. 674-685

Keywords: drug development, microenvironment, glycolysis

Landscape of somatic mutations in breast cancer: new opportunities for targeted therapies in Saudi Arabian patients Research Paper

Duna H. Barakeh, Rasha Aljelaify, Yara Bashawri, Amal Almutairi, Fatimah Alqubaishi, Mohammed Alnamnakani, Latifa Almubarak, Abdulrahman Al Naeem, Fatema Almushawah, May Alrashed, Malak Abedalthagafi

Published Feb 27, 2021 · Vol. 12, No. 7 · pp. 686-697

Keywords: breast cancer, PIK3CA, BCa, Saudi Arabia, BRCA

A high-content AlphaScreen™ identifies E6-specific small molecule inhibitors as potential therapeutics for HPV⁺ head and neck squamous cell carcinomas Research Paper

Lennox Chitsike, Chung-Hsiang Yuan, Anuradha Roy, Kristopher Boyle, Penelope J. Duerksen-Hughes

Published Feb 22, 2021 · Vol. 12, No. 6 · pp. 549-561

Keywords: HNSCC, HPV, E6, AlphaScreen™, 30-hydroxygambogic acid

Genomic and neoantigen evolution from primary tumor to first metastases in head and neck squamous cell carcinoma Research Paper

Charles R. Schutt, Hua Sun, Jaya Sarin Pradhan, Yvonne Saenger, Jessica Ley, Douglas Adkins, Matthew Ingham, Li Ding, Brian A. Van Tine

Published Feb 21, 2021 · Vol. 12, No. 6 · pp. 534-548

Keywords: head and neck squamous cell carcinoma, neoantigens, mutational evolution, tumor relapse, immune cell infiltration

Characterization of the inflammatory microenvironment and hepatic macrophage subsets in experimental hepatocellular carcinoma models Research Paper

Helena Degroote, Sander Lefere, Astrid Vandierendonck, Bart Vanderborght, Tim Meese, Filip Van Nieuwerburgh, Xavier Verhelst, Anja Geerts, Hans Van Vlierberghe, Lindsey Devisscher

Published Feb 20, 2021 · Vol. 12, No. 6 · pp. 562-577

Keywords: hepatocellular carcinoma, macrophage subsets, tumor microenvironment, tumor associated macrophages, inflammation

Molecular characterization of lung squamous cell carcinoma tumors reveals therapeutically relevant alterations Research Paper

Asim Joshi, Rohit Mishra, Sanket Desai, Pratik Chandrani, Hitesh Kore, Roma Sunder, Supriya Hait, Prajish Iyer, Vaishakhi Trivedi, Anuradha Choughule, Vanita Noronha, Amit Joshi, Vijay Patil, Nandini Menon, Rajiv Kumar, Kumar Prabhash, Amit Dutt

Published Feb 19, 2021 · Vol. 12, No. 6 · pp. 578-588

Keywords: lung squamous carcinoma, genetic alterations, druggable mutations, whole exome sequencing, mass spectrometry

Pancreatic cancer driver mutations are targetable through distant alternative RNA splicing dependencies Research Perspective

Ryan R. Kawalerski, Steven D. Leach, Luisa F. Escobar-Hoyos

Published Feb 12, 2021 · Vol. 12, No. 6 · pp. 525-533

Keywords: pancreatic cancer, RNA splicing, targeted therapy, KRAS, TP53

The role of immune surveillance in malignant transformation of benign salivary gland tumors Research Perspective

Maximilian Linxweiler, Jingming Wang, Luc G.T. Morris

Published Feb 10, 2021 · Vol. 12, No. 7 · pp. 592-595

Keywords: salivary tumor, salivary cancer, pleomorphic adenoma, immune surveillance

The cancer testis antigens CABYR-a/b and CABYR-c are expressed in a subset of colorectal cancers and hold promise as targets for specific immunotherapy Research Paper

H.M.C. Shantha Kumara, Elie Sutton, Otavia L. Caballero, Tao Su, Xiaohong Yan, Aqeel Ahmed, Sonali A.C. Herath, Vesna Cekic, Linda Njoh, Daniel D. Kirchoff, Richard L. Whelan

Published Feb 9, 2021 · Vol. 12, No. 5 · pp. 412-421

Keywords: cancer testis antigens, colorectal cancer, CABYR a/b, c

Reg4 and its downstream transcriptional activator CD44ICD in stage II and III colorectal cancer Research Paper

Jared A. Sninsky, Kumar S. Bishnupuri, Iván González, Nikolaos A. Trikalinos, Ling Chen, Brian K. Dieckgraefe

Published Feb 8, 2021 · Vol. 12, No. 4 · pp. 278-291

Keywords: Reg4, CD44, CD44ICD, colorectal cancer

Development of a ghrelin receptor inverse agonist for positron emission tomography Research Paper

Ralf Bergmann, Constance Chollet, Sylvia Els-Heindl, Martin Ullrich, Nicole Berndt, Jens Pietzsch, Domokos Máthé, Michael Bachmann, Annette G. Beck-Sickinger

Published Feb 7, 2021 · Vol. 12, No. 5 · pp. 450-474

Keywords: cancer, prostate cancer, growth hormone secretagogue receptor (GHS-R), small animal imaging, copper-64

Multi-modal effects of 1B3, a novel synthetic miR-193a-3p mimic, support strong potential for therapeutic intervention in oncology Research Paper

Bryony J. Telford, Sanaz Yahyanejad, Thijs de Gunst, Harm C. den Boer, Rogier M. Vos, Marieke Stegink, Marion T.J. van den Bosch, Mir Farshid Alemdehy, Laurens A.H. van Pinxteren, Roel Q.J. Schaapveld, Michel Janicot

Published Feb 7, 2021 · Vol. 12, No. 5 · pp. 422-439

Keywords: miR-193a-3p, microRNA mimic, microRNA delivery in vivo, pleiotropic mechanism of microRNA,

Low concentrations of vorinostat decrease EB1 expression in GBM cells and affect microtubule dynamics, cell survival and migration Research Paper

Thomas Perez, Raphaël Bergès, Hélène Maccario, Sarah Oddoux, Stéphane Honoré

Published Feb 5, 2021 · Vol. 12, No. 4 · pp. 304-315

Keywords: vorinostat, glioblastoma, EB1, microtubule, tubulin

Quantitative proteome profiling stratifies fibroepithelial lesions of the breast Research Paper

Aviral Kumar, David S. Nayakanti, Kiran K. Mangalaparthi, Veena Gopinath, Nandyala Venkat Narsimha Reddy, Krishna Govindan, Geeta Voolapalli, Prashant Kumar, Lekha Dinesh Kumar

Published Feb 3, 2021 · Vol. 12, No. 5 · pp. 507-518

Keywords: breast tumors, fibroepithelial lesions, phyllodes, iTRAQ, quantitative proteomics

Phase 1 study of Z-endoxifen in patients with advanced gynecologic, desmoid, and hormone receptor-positive solid tumors Research Paper

Naoko Takebe, Geraldine O'Sullivan Coyne, Shivaani Kummar, Jerry Collins, Joel M. Reid, Richard Piekarz, Nancy Moore, Lamin Juwara, Barry C. Johnson, Rachel Bishop, Frank I. Lin, Esther Mena, Peter L. Choyke, M. Liza Lindenberg, Larry V. Rubinstein, Cecilia Monge Bonilla, Matthew P. Goetz, Matthew M. Ames, Renee M. McGovern, Howard Streicher, Joseph M. Covey, James H. Doroshow, Alice P. Chen

Published Feb 1, 2021 · Vol. 12, No. 4 · pp. 268-277

Keywords: Z-endoxifen, phase 1, tamoxifen, pharmacokinetics

Intratumoral immunotherapy with STING agonist, ADU-S100, induces CD8+ T-cell mediated anti-tumor immunity in an esophageal adenocarcinoma model Research Paper

Ali H. Zaidi, Ronan J. Kelly, Anastasia Gorbunova, Ashten N. Omstead, Madison S. Salvitti, Ping Zheng, Juliann E. Kosovec, Soyoung Lee, Shahin Ayazi, Laila Babar, Gene G. Finley, Ajay Goel, Blair A. Jobe

Published Feb 1, 2021 · Vol. 12, No. 4 · pp. 292-303

Keywords: esophageal adenocarcinoma, STING, PD-L1, CD8+ T-cells, IFNβ

Quercetin shortened survival of radio-resistant B-1 cells in vitro and in vivo by restoring miR15a/16 expression Research Paper

Yasmim Alefe Leuzzi Ramos, Olivia Fonseca Souza, Marilia Campos Tavares Novo, Caroline Ferreira Cunha Guimarães, Ana Flavia Popi

Published Jan 29, 2021 · Vol. 12, No. 4 · pp. 355-365

Keywords: B-1 cells, chronic lymphocytic leukemia, quercetin, Wnt, miRNA

The interaction between cancer associated fibroblasts and tumor associated macrophages via the osteopontin pathway in the tumor microenvironment of hepatocellular carcinoma Research Paper

Kazunori Tokuda, Yuji Morine, Katsuki Miyazaki, Shinichiro Yamada, Yu Saito, Masaaki Nishi, Takuya Tokunaga, Tetsuya Ikemoto, Satoru Imura, Mitsuo Shimada

Published Jan 27, 2021 · Vol. 12, No. 4 · pp. 333-343

Keywords: hepatocellular carcinoma, osteopontin, cancer associated fibroblast, tumor associated macrophage, tumor microenvironment

Cancer stem cells and macrophages: molecular connections and future perspectives against cancer Review

Beatrice Aramini, Valentina Masciale, Giulia Grisendi, Federico Banchelli, Roberto D’Amico, Antonino Maiorana, Uliano Morandi, Massimo Dominici, Khawaja Husnain Haider

Published Jan 27, 2021 · Vol. 12, No. 3 · pp. 230-250

Keywords: cancer stem cells, macrophages, future perspectives, cancer, target treatments

High mRNA expression of LY6 gene family is associated with overall survival outcome in pancreatic ductal adenocarcinoma Research Paper

Eric Russ, Krithika Bhuvaneshwar, Guisong Wang, Benjamin Jin, Michele M. Gage, Subha Madhavan, Yuriy Gusev, Geeta Upadhyay

Published Jan 26, 2021 · Vol. 12, No. 3 · pp. 145-159

Keywords: LY6 genes, pancreatic cancer, immune cells, survival outcome

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Effect of cell microenvironment on the drug sensitivity of hepatocellular cancer cells Research Paper

Landscape of somatic mutations in breast cancer: new opportunities for targeted therapies in Saudi Arabian patients Research Paper

A high-content AlphaScreen™ identifies E6-specific small molecule inhibitors as potential therapeutics for HPV⁺ head and neck squamous cell carcinomas Research Paper

Genomic and neoantigen evolution from primary tumor to first metastases in head and neck squamous cell carcinoma Research Paper

Characterization of the inflammatory microenvironment and hepatic macrophage subsets in experimental hepatocellular carcinoma models Research Paper

Molecular characterization of lung squamous cell carcinoma tumors reveals therapeutically relevant alterations Research Paper

Pancreatic cancer driver mutations are targetable through distant alternative RNA splicing dependencies Research Perspective

The role of immune surveillance in malignant transformation of benign salivary gland tumors Research Perspective

The cancer testis antigens CABYR-a/b and CABYR-c are expressed in a subset of colorectal cancers and hold promise as targets for specific immunotherapy Research Paper

Reg4 and its downstream transcriptional activator CD44ICD in stage II and III colorectal cancer Research Paper

Development of a ghrelin receptor inverse agonist for positron emission tomography Research Paper

Multi-modal effects of 1B3, a novel synthetic miR-193a-3p mimic, support strong potential for therapeutic intervention in oncology Research Paper

Low concentrations of vorinostat decrease EB1 expression in GBM cells and affect microtubule dynamics, cell survival and migration Research Paper

Quantitative proteome profiling stratifies fibroepithelial lesions of the breast Research Paper

Phase 1 study of Z-endoxifen in patients with advanced gynecologic, desmoid, and hormone receptor-positive solid tumors Research Paper

Intratumoral immunotherapy with STING agonist, ADU-S100, induces CD8+ T-cell mediated anti-tumor immunity in an esophageal adenocarcinoma model Research Paper

Quercetin shortened survival of radio-resistant B-1 cells in vitro and in vivo by restoring miR15a/16 expression Research Paper

The interaction between cancer associated fibroblasts and tumor associated macrophages via the osteopontin pathway in the tumor microenvironment of hepatocellular carcinoma Research Paper

Cancer stem cells and macrophages: molecular connections and future perspectives against cancer Review

High mRNA expression of LY6 gene family is associated with overall survival outcome in pancreatic ductal adenocarcinoma Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Effect of cell microenvironment on the drug sensitivity of hepatocellular cancer cells Research Paper

Landscape of somatic mutations in breast cancer: new opportunities for targeted therapies in Saudi Arabian patients Research Paper

A high-content AlphaScreen™ identifies E6-specific small molecule inhibitors as potential therapeutics for HPV+ head and neck squamous cell carcinomas Research Paper

Genomic and neoantigen evolution from primary tumor to first metastases in head and neck squamous cell carcinoma Research Paper

Characterization of the inflammatory microenvironment and hepatic macrophage subsets in experimental hepatocellular carcinoma models Research Paper

Molecular characterization of lung squamous cell carcinoma tumors reveals therapeutically relevant alterations Research Paper

Pancreatic cancer driver mutations are targetable through distant alternative RNA splicing dependencies Research Perspective

The role of immune surveillance in malignant transformation of benign salivary gland tumors Research Perspective

The cancer testis antigens CABYR-a/b and CABYR-c are expressed in a subset of colorectal cancers and hold promise as targets for specific immunotherapy Research Paper

Reg4 and its downstream transcriptional activator CD44ICD in stage II and III colorectal cancer Research Paper

Development of a ghrelin receptor inverse agonist for positron emission tomography Research Paper

Multi-modal effects of 1B3, a novel synthetic miR-193a-3p mimic, support strong potential for therapeutic intervention in oncology Research Paper

Low concentrations of vorinostat decrease EB1 expression in GBM cells and affect microtubule dynamics, cell survival and migration Research Paper

Quantitative proteome profiling stratifies fibroepithelial lesions of the breast Research Paper

Phase 1 study of Z-endoxifen in patients with advanced gynecologic, desmoid, and hormone receptor-positive solid tumors Research Paper

Intratumoral immunotherapy with STING agonist, ADU-S100, induces CD8+ T-cell mediated anti-tumor immunity in an esophageal adenocarcinoma model Research Paper

Quercetin shortened survival of radio-resistant B-1 cells in vitro and in vivo by restoring miR15a/16 expression Research Paper

The interaction between cancer associated fibroblasts and tumor associated macrophages via the osteopontin pathway in the tumor microenvironment of hepatocellular carcinoma Research Paper

Cancer stem cells and macrophages: molecular connections and future perspectives against cancer Review

High mRNA expression of LY6 gene family is associated with overall survival outcome in pancreatic ductal adenocarcinoma Research Paper

A high-content AlphaScreen™ identifies E6-specific small molecule inhibitors as potential therapeutics for HPV⁺ head and neck squamous cell carcinomas Research Paper