The Oncosearch | Oncotarget

Diverse transcriptional regulation and functional effects revealed by CRISPR/Cas9-directed epigenetic editing Research Paper

Miguel Vizoso, Jacco van Rheenen

Published Jul 29, 2021 · Vol. 12, No. 17 · pp. 1651-1662

Keywords: targeted DNA methylation, CRISPR/Cas9-based system, IGFBP2, epithelial-to-mesenchymal transition

Interactions of multidomain pro-apoptotic and anti-apoptotic proteins in cancer cell death Review

Alexander Chota, Blassan P. George, Heidi Abrahamse

Published Jul 19, 2021 · Vol. 12, No. 16 · pp. 1615-1626

Keywords: apoptosis, caspases, cancer, Bcl-2 family proteins, p53

MiR-7-5p inhibits thyroid cell proliferation by targeting the EGFR/MAPK and IRS2/PI3K signaling pathways Research Paper

Alice Augenlicht, Manuel Saiselet, Myriam Decaussin-Petrucci, Guy Andry, Jacques E. Dumont, Carine Maenhaut

Published Jul 17, 2021 · Vol. 12, No. 16 · pp. 1587-1599

Keywords: miRNA, papillary thyroid carcinoma, IRS2, MAPK, PI3K

High CD39 expression is associated with the non-muscle-invasive phenotype of human bladder cancer Research Paper

Janaina Mendes Ferreira, Luiz Henrique Gomes Matheus, Renato Vasconcelos Souza de Almeida, Petronio Augusto de Souza Melo, Kátia Ramos Moreira Leite, Claudio Bovolenta Murta, Joaquim Francisco de Almeida Claro, Cleber Pinto Camacho, José Pontes-Júnior, Humberto Dellê

Published Jul 16, 2021 · Vol. 12, No. 16 · pp. 1580-1586

Keywords: bladder cancer, purinergic signaling, ectonucleotidases, CD39

JunD accentuates arecoline-induced disruption of tight junctions and promotes epithelial-to-mesenchymal transition by association with NEAT1 lncRNA Research Paper

Subarna Ghosh, Priyanka Dey Talukdar, Abhinandan Bhattacharjee, Sarbani Giri, Nitai Pada Bhattacharyya, Urmi Chatterji

Published Jul 2, 2021 · Vol. 12, No. 15 · pp. 1520-1539

Keywords: arecoline, tight junction, head and neck cancer, lncRNA-NEAT1, JunD

The impact of neoadjuvant concurrent chemoradiation on exosomal markers (CD63 and CD9) expression and their prognostic significance in patients with rectal adenocarcinoma Research Paper

Moh’d Khushman, Pranitha Prodduturvar, Wadad Mneimneh, Valeria Dal Zotto, Shalla Akbar, Leander Grimm, Paul Rider, John Hunter, Omar Alkharabsheh, Girijesh Kumar Patel, Jesus C. Fabregas, Ajay P. Singh

Published Jun 30, 2021 · Vol. 12, No. 15 · pp. 1490-1498

Keywords: exosomes, exosomal markers, CD63, CD9, neoadjuvant chemoradiation

RNA expression differences in prostate tumors and tumor-adjacent stroma between Black and White Americans Research Paper

Farah Rahmatpanah, Gabriela De Robles, Michael Lilly, Thomas Keane, Vinay Kumar, Dan Mercola, Pavneet Randhawa, Michael McClelland

Published Jun 29, 2021 · Vol. 12, No. 15 · pp. 1457-1469

Keywords: prostate cancer, tumor-adjacent stroma, African ancestry, European ancestry, RNA-seq analysis

Actionability evaluation of biliary tract cancer by genome transcriptome analysis and Asian cancer knowledgebase Research Paper

Yuki Okawa, Nobutaka Ebata, Nayoung K.D. Kim, Masashi Fujita, Kazuhiro Maejima, Shota Sasagawa, Toru Nakamura, Woong-Yang Park, Satoshi Hirano, Hidewaki Nakagawa

Published Jun 28, 2021 · Vol. 12, No. 15 · pp. 1540-1552

Keywords: biliary tract cancer, mutation, immunotherapic biomarker, knowledgebase, molecular targeted therapy

Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells Priority Research Paper

Nikolai Petrov, Hee-Sheung Lee, Mikhail Liskovykh, Marie-Paule Teulade-Fichou, Hiroshi Masumoto, William C. Earnshaw, Yves Pommier, Vladimir Larionov, Natalay Kouprina

Published Jun 27, 2021 · Vol. 12, No. 15 · pp. 1444-1456

Keywords: chromosome instability, CIN, platinum-derived G4-quadruplexes, telomere dysfunction, human artificial chromosome

Neddylation and anti-tumor immunity Research Perspective

Xiaoguang Wang, Scott Best, Alexey V. Danilov

Published Jun 27, 2021 · Vol. 12, No. 21 · pp. 2227-2230

Keywords: neddylation, T cell, pevonedistat

Prokineticin-1 induces normal lymphangiogenic activity and is involved in lymphangiogenesis and lymph node metastasis in colorectal cancer Research Paper

Takayuki Naruse, Takanori Goi, Akio Yamaguchi

Published Jun 23, 2021 · Vol. 12, No. 14 · pp. 1388-1397

Keywords: prokineticin-1, lymphangiogenic activity, colorectal cancer

Mebendazole disrupts stromal desmoplasia and tumorigenesis in two models of pancreatic cancer Research Paper

Tara Williamson, Michelle Carvalho de Abreu, Dimitri G. Trembath, Cory Brayton, Byunghak Kang, Thais Biude Mendes, Paulo Pimentel de Assumpção, Janete M. Cerutti, Gregory J. Riggins

Published Jun 22, 2021 · Vol. 12, No. 14 · pp. 1326-1338

Keywords: mebendazole, pancreatic cancer, cancer prevention, metastasis, mouse models

The use of a uPAR-targeted probe for photothermal cancer therapy prolongs survival in a xenograft mouse model of glioblastoma Research Paper

Marina Simón, Jesper Tranekjær Jørgensen, Karina Juhl, Andreas Kjaer

Published Jun 22, 2021 · Vol. 12, No. 14 · pp. 1366-1376

Keywords: photothermal therapy (PTT), indocyanine green (ICG), urokinase plasminogen activator receptor (uPAR), cancer, hyperthermia

Next-generation multimodality of nutrigenomic cancer therapy: sulforaphane in combination with acetazolamide actively target bronchial carcinoid cancer in disabling the PI3K/Akt/mTOR survival pathway and inducing apoptosis Research Paper

Reza Bayat Mokhtari, Bessi Qorri, Narges Baluch, Angelo Sparaneo, Federico Pio Fabrizio, Lucia Anna Muscarella, Albina Tyker, Sushil Kumar, Hai-Ling Margaret Cheng, Myron R. Szewczuk, Bikul Das, Herman Yeger

Published Jun 22, 2021 · Vol. 12, No. 15 · pp. 1470-1489

Keywords: sulforaphane, acetazolamide, bronchial carcinoid tumors, serotonin, carbonic anhydrase

Multifaceted effect of chlorpromazine in cancer: implications for cancer treatment Review

Pareesa Kamgar-Dayhoff, Tinatin I. Brelidze

Published Jun 19, 2021 · Vol. 12, No. 14 · pp. 1406-1426

Keywords: chlorpromazine, repurposing

Esomeprazole enhances the effect of ionizing radiation to improve tumor control Research Paper

Kassidy A. Hebert, Sergio Jaramillo, Wangjie Yu, Min Wang, Ratna Veeramachaneni, Vlad C. Sandulache, Andrew G. Sikora, Mark D. Bonnen, Ananth V. Annapragada, David Corry, Farrah Kheradmand, Raj K. Pandita, Michelle S. Ludwig, Tej K. Pandita, Shixia Huang, Cristian Coarfa, Sandra L. Grimm, Dimuthu Perera, George Miles, Yohannes T. Ghebre

Published Jun 19, 2021 · Vol. 12, No. 14 · pp. 1339-1353

Keywords: esomeprazole, proton pump inhibitors, ionizing radiation, radiosensitization, tumor control

The role of dynamic phenotypes in cancer Research Perspective

Luana S. Lenz, Guido Lenz

Published Jun 19, 2021 · Vol. 12, No. 19 · pp. 1962-1965

Keywords: dynamic phenotype, fitness, tumor resistance, tumor evolution, single cell

MRI texture features from tumor core and margin in the prediction of response to neoadjuvant chemotherapy in patients with locally advanced breast cancer Research Paper

Christopher Kolios, Lakshmanan Sannachi, Archya Dasgupta, Harini Suraweera, Daniel DiCenzo, Gregory Stanisz, Arjun Sahgal, Frances Wright, Nicole Look-Hong, Belinda Curpen, Ali Sadeghi-Naini, Maureen Trudeau, Sonal Gandhi, Michael C. Kolios, Gregory J. Czarnota

Published Jun 16, 2021 · Vol. 12, No. 14 · pp. 1354-1365

Keywords: radiomics, MRI, breast cancer, neoadjuvant chemotherapy, biomarkers

Targeting AP-1 transcription factors by CRISPR in the prostate Research Perspective

Maria Riedel, Huiqiang Cai, Iben C. Stoltze, Mikkel H. Vendelbo, Erwin F. Wagner, Latifa Bakiri, Martin K. Thomsen

Published Jun 15, 2021 · Vol. 12, No. 19 · pp. 1956-1961

Keywords: AP-1, prostate cancer, CRISPR, mouse models, AAV

Towards precision oncology in angiosarcomas using next generation “omic” technologies Research Perspective

Grace Fangmin Tan, Jason Yongsheng Chan

Published Jun 14, 2021 · Vol. 12, No. 19 · pp. 1953-1955

Keywords: rare cancer, single cell sequencing, chemoresistance, spatial transcriptomics

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Diverse transcriptional regulation and functional effects revealed by CRISPR/Cas9-directed epigenetic editing Research Paper

Interactions of multidomain pro-apoptotic and anti-apoptotic proteins in cancer cell death Review

MiR-7-5p inhibits thyroid cell proliferation by targeting the EGFR/MAPK and IRS2/PI3K signaling pathways Research Paper

High CD39 expression is associated with the non-muscle-invasive phenotype of human bladder cancer Research Paper

JunD accentuates arecoline-induced disruption of tight junctions and promotes epithelial-to-mesenchymal transition by association with NEAT1 lncRNA Research Paper

The impact of neoadjuvant concurrent chemoradiation on exosomal markers (CD63 and CD9) expression and their prognostic significance in patients with rectal adenocarcinoma Research Paper

RNA expression differences in prostate tumors and tumor-adjacent stroma between Black and White Americans Research Paper

Actionability evaluation of biliary tract cancer by genome transcriptome analysis and Asian cancer knowledgebase Research Paper

Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells Priority Research Paper

Neddylation and anti-tumor immunity Research Perspective

Prokineticin-1 induces normal lymphangiogenic activity and is involved in lymphangiogenesis and lymph node metastasis in colorectal cancer Research Paper

Mebendazole disrupts stromal desmoplasia and tumorigenesis in two models of pancreatic cancer Research Paper

The use of a uPAR-targeted probe for photothermal cancer therapy prolongs survival in a xenograft mouse model of glioblastoma Research Paper

Next-generation multimodality of nutrigenomic cancer therapy: sulforaphane in combination with acetazolamide actively target bronchial carcinoid cancer in disabling the PI3K/Akt/mTOR survival pathway and inducing apoptosis Research Paper

Multifaceted effect of chlorpromazine in cancer: implications for cancer treatment Review

Esomeprazole enhances the effect of ionizing radiation to improve tumor control Research Paper

The role of dynamic phenotypes in cancer Research Perspective

MRI texture features from tumor core and margin in the prediction of response to neoadjuvant chemotherapy in patients with locally advanced breast cancer Research Paper

Targeting AP-1 transcription factors by CRISPR in the prostate Research Perspective

Towards precision oncology in angiosarcomas using next generation “omic” technologies Research Perspective

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Diverse transcriptional regulation and functional effects revealed by CRISPR/Cas9-directed epigenetic editing Research Paper

Interactions of multidomain pro-apoptotic and anti-apoptotic proteins in cancer cell death Review

MiR-7-5p inhibits thyroid cell proliferation by targeting the EGFR/MAPK and IRS2/PI3K signaling pathways Research Paper

High CD39 expression is associated with the non-muscle-invasive phenotype of human bladder cancer Research Paper

JunD accentuates arecoline-induced disruption of tight junctions and promotes epithelial-to-mesenchymal transition by association with NEAT1 lncRNA Research Paper

The impact of neoadjuvant concurrent chemoradiation on exosomal markers (CD63 and CD9) expression and their prognostic significance in patients with rectal adenocarcinoma Research Paper

RNA expression differences in prostate tumors and tumor-adjacent stroma between Black and White Americans Research Paper

Actionability evaluation of biliary tract cancer by genome transcriptome analysis and Asian cancer knowledgebase Research Paper

Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells Priority Research Paper

Neddylation and anti-tumor immunity Research Perspective

Prokineticin-1 induces normal lymphangiogenic activity and is involved in lymphangiogenesis and lymph node metastasis in colorectal cancer Research Paper

Mebendazole disrupts stromal desmoplasia and tumorigenesis in two models of pancreatic cancer Research Paper

The use of a uPAR-targeted probe for photothermal cancer therapy prolongs survival in a xenograft mouse model of glioblastoma Research Paper

Next-generation multimodality of nutrigenomic cancer therapy: sulforaphane in combination with acetazolamide actively target bronchial carcinoid cancer in disabling the PI3K/Akt/mTOR survival pathway and inducing apoptosis Research Paper

Multifaceted effect of chlorpromazine in cancer: implications for cancer treatment Review

Esomeprazole enhances the effect of ionizing radiation to improve tumor control Research Paper

The role of dynamic phenotypes in cancer Research Perspective

MRI texture features from tumor core and margin in the prediction of response to neoadjuvant chemotherapy in patients with locally advanced breast cancer Research Paper

Targeting AP-1 transcription factors by CRISPR in the prostate Research Perspective

Towards precision oncology in angiosarcomas using next generation “omic” technologies Research Perspective