The Oncosearch | Oncotarget

MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection Priority Research Paper

Lanlan Zhou, Kelsey Huntington, Shengliang Zhang, Lindsey Carlsen, Eui-Young So, Cassandra Parker, Ilyas Sahin, Howard Safran, Suchitra Kamle, Chang-Min Lee, Chun Geun Lee, Jack A. Elias, Kerry S. Campbell, Mandar T. Naik, Walter J. Atwood, Emile Youssef, Jonathan A. Pachter, Arunasalam Navaraj, Attila A. Seyhan, Olin Liang, Wafik S. El-Deiry

Published Oct 28, 2020

Keywords: ACE2, TMPRSS2, SARS-CoV-2, COVID-19, pseudovirus

Expression profiling on subclasses of primary parotid gland carcinomas Research Paper

Jeannine Meinrath, Anja Haak, Nesrin Igci, Priya Dalvi, Christoph Arolt, Sonja Meemboor, Udo Siebolts, Hannah Eischeidt-Scholz, Claudia Wickenhauser, Inga Grünewald, Uta Drebber, Reinhard Büttner, Alexander Quaas, Jens-Peter Klußmann, Margarete Odenthal, Dirk Beutner, Moritz Meyer

Published Oct 27, 2020 · Vol. 11, No. 45 · pp. 4123-4137

Keywords: cancer, salivary gland, nanostring, pancancer pathway, gene expression

The impact of the RASSF1C and PIWIL1 on DNA methylation: the identification of GMIP as a tumor suppressor Research Paper

Yousef G. Amaar, Mark E. Reeves

Published Oct 26, 2020 · Vol. 11, No. 45 · pp. 4082-4092

Keywords: lung cancer, RASSF1C, PIWIL1, DNA metylation,

Baseline CD44v6-positive circulating tumor cells to predict first-line treatment failure in patients with metastatic colorectal cancer Research Paper

Chiara Nicolazzo, Flavia Loreni, Salvatore Caponnetto, Valentina Magri, Anna Rita Vestri, Rita Zamarchi, Angela Gradilone, Antonella Facchinetti, Elisabetta Rossi, Enrico Cortesi, Paola Gazzaniga

Published Oct 24, 2020 · Vol. 11, No. 45 · pp. 4115-4122

Keywords: cancer stem cells, CD44v6, circulating tumor cells, colorectal cancer, CellSearch^®

Liquid biopsy and multi-analyte testing guided treatment of HER2 positive periampullary adenocarcinoma with durable complete response after trastuzumab based therapy Case Report

Rajnish Nagarkar, Darshana Patil, Sewanti Limaye, Pradip Devhare, Ashwini Ghaisas, Navin Srivastava, Sachin Apurwa, Sanket Patil, Jinumary John, Zarrine Raazi, Aditya Shreenivas, Janani Sambath, Ajay Srinivasan, Prashant Kumar, Dadasaheb Akolkar, Rajan Datar

Published Oct 24, 2020 · Vol. 11, No. 45 · pp. 4195-4200

Keywords: periampullary adenocarcinoma, ETA, HER2, trastuzumab

T-cell redirecting bispecific antibodies targeting BCMA for the treatment of multiple myeloma Research Perspective

Christie P.M. Verkleij, Kristine A. Frerichs, Marloes Broekmans, Saida Absalah, Patricia W.C. Maas-Bosman, Sandy Kruyswijk, Inger S. Nijhof, Tuna Mutis, Sonja Zweegman, Niels W.C.J. van de Donk

Published Oct 24, 2020 · Vol. 11, No. 45 · pp. 4076-4081

Keywords: multiple myeloma, bispecific antibody, immunotherapy, BCMA, CD38

Histo-molecular differentiation of renal cancer subtypes by mass spectrometry imaging and rapid proteome profiling of formalin-fixed paraffin-embedded tumor tissue sections Research Paper

Uwe Möginger, Niels Marcussen, Ole N. Jensen

Published Oct 21, 2020 · Vol. 11, No. 44 · pp. 3998-4015

Keywords: renal cell cancer, MALDI mass spectrometry imaging (MALDI MSI), microproteomics, statistical classification, liquid chromatography mass spectrometry (LC-MS)

HIC1 (Hypermethylated in Cancer 1) modulates the contractile activity of prostate stromal fibroblasts and directly regulates CXCL12 expression Research Paper

Marion Dubuissez, Sonia Paget, Souhila Abdelfettah, Nathalie Spruyt, Vanessa Dehennaut, Gaylor Boulay, Ingrid Loison, Clementine de Schutter, Brian R. Rood, Martine Duterque-Coquillaud, Xavier Leroy, Dominique Leprince

Published Oct 21, 2020 · Vol. 11, No. 45 · pp. 4138-4154

Keywords: HIC1, CXCL12, SDF1, α-SMA, Acta2

Biomarkers and novel therapeutic approaches for diffuse large B-cell lymphoma in the era of precision medicine Review

Niraj Lodhi, Moe Tun, Poonam Nagpal, Arati A. Inamdar, Nehad M. Ayoub, Noor Siyam, Lucia Oton-Gonzalez, Angela Gerona, Dainelle Morris, Rana Sandhu, Kwangsun Stephen Suh

Published Oct 20, 2020 · Vol. 11, No. 44 · pp. 4045-4073

Keywords: DLBCL, diagnosis, R-CHOP, precision medicine, prognosis

Phase I trial of TRC102 (methoxyamine HCl) in combination with temozolomide in patients with relapsed solid tumors and lymphomas Research Paper

Geraldine O'Sullivan Coyne, Shivaani Kummar, Robert S. Meehan, Khanh Do, Jerry M. Collins, Larry Anderson, Kazusa Ishii, Naoko Takebe, Jennifer Zlott, Lamin Juwara, Richard Piekarz, Howard Streicher, Elad Sharon, Larry Rubinstein, Andrea Regier Voth, Jay Lozier, Angie B. Dull, Deborah Wilsker, Toshinori Hinoue, Peter W. Laird, Katherine V. Ferry-Galow, Robert J. Kinders, Ralph E. Parchment, James H. Doroshow, Alice P. Chen

Published Oct 12, 2020 · Vol. 11, No. 44 · pp. 3959-3971

Keywords: DNA damage repair, base excision repair, MGMT, rational combination therapy, molecular pharmacodynamics

Effect of eflornithine on mutation frequency in temozolomide-treated U87MG cells Research Paper

Noymi Yam, Jason Levin, Zhengzheng Bao, Wubin Qian, Victor A. Levin

Published Oct 9, 2020 · Vol. 11, No. 44 · pp. 3933-3942

Keywords: glioma, eflornithine, temozolomide, chemotherapy, secondary mutations

Correction: Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma Correction

Ke Hu, Savalan Babapoor-Farrokhran, Murilo Rodrigues, Monika Deshpande, Brooks Puchner, Fabiana Kashiwabuchi, Syed Junaid Hassan, Laura Asnaghi, James T. Handa, Shannath Merbs, Charles G. Eberhart, Gregg L. Semenza, Silvia Montaner, Akrit Sodhi

Published Oct 9, 2020 · Vol. 12, No. 5 · pp. 519-520

Heterogeneity of CEACAM5 in breast cancer Research Paper

Marc B. Bechmann, Andreas V. Brydholm, Victoria L. Codony, Jiyoung Kim, René Villadsen

Published Oct 7, 2020 · Vol. 11, No. 43 · pp. 3886-3899

Keywords: CEACAM5, CEA, immunohistochemistry, breast cancer, invasion

Polymerized human hemoglobin increases the effectiveness of cisplatin-based chemotherapy in non-small cell lung cancer Research Paper

Alfredo Lucas, Donald A. Belcher, Carlos Munoz, Alexander T. Williams, Andre F. Palmer, Pedro Cabrales

Published Oct 7, 2020 · Vol. 11, No. 42 · pp. 3770-3781

Keywords: chemotherapy, cisplatin, polymerized hemoglobin, non-small cell lung cancer, hypoxia

Anti-tumor activities of the new oral pan-RAF inhibitor, TAK-580, used as monotherapy or in combination with novel agents in multiple myeloma Research Paper

Rikio Suzuki, Yuka Kitamura, Yoshihiko Nakamura, Hibiki Akashi, Yoshiaki Ogawa, Hiroshi Kawada, Kiyoshi Ando

Published Oct 7, 2020 · Vol. 11, No. 44 · pp. 3984-3997

Keywords: pan-RAF inhibitor, Bim, FOXO3a, bortezomib, lenalidomide

Significance of mesothelin expression in preoperative endoscopic biopsy specimens for colorectal cancer prognosis Research Paper

Takehiro Shiraishi, Eiji Shinto, Masato Yamadera, Ken Nagata, Hitoshi Tsuda, Satsuki Mochizuki, Yoshiki Kajiwara, Koichi Okamoto, Takahiro Einama, Yoji Kishi, Hideki Ueno

Published Oct 6, 2020 · Vol. 11, No. 43 · pp. 3807-3817

Keywords: colorectal cancer, mesothelin, endoscopic biopsy specimen, immunohistochemistry, Pathology

TRAIL receptor agonists convert the response of breast cancer cells to ONC201 from anti-proliferative to apoptotic Priority Research Paper

Marie D. Ralff, Aakash Jhaveri, Jocelyn E. Ray, Lanlan Zhou, Avital Lev, Kerry S. Campbell, David T. Dicker, Eric A. Ross, Wafik S. El-Deiry

Published Oct 6, 2020 · Vol. 11, No. 42 · pp. 3753-3769

Keywords: ONC201, TRAIL, breast cancer, death receptors, apoptosis

Targeting an engineered cytokine with interleukin-2 and interleukin-15 activity to the neovasculature of solid tumors Research Paper

Michael R. Mortensen, Jacqueline Mock, Marco Bertolini, Marco Stringhini, Marco Catalano, Dario Neri

Published Oct 6, 2020 · Vol. 11, No. 44 · pp. 3972-3983

Keywords: immunotherapy, immunocytokines, EDB of fibronectin, antibody-cytokine fusion proteins, engineered cytokine

Laser speckle flowgraphy in juxtapapillary retinal capillary hemangioblastoma: a case report on natural course and therapeutic effect Case Report

Mizuho Mitamura, Satoru Kase, Kiriko Hirooka, Susumu Ishida

Published Oct 6, 2020 · Vol. 11, No. 42 · pp. 3800-3804

Keywords: juxtapapillary retinal capillary hemangioblastoma, laser photocoagulation, laser speckle flowgraphy, fluorescein angiography, von Hippel-Lindau disease

A systematic review and meta-analysis of selected toxicity endpoints of alpelisib Review

Misty Shields, Qianxing Mo, Melissa Armitage, Susan C. Sharpe, Ricardo L.B. Costa

Published Oct 5, 2020 · Vol. 11, No. 42 · pp. 3793-3799

Keywords: alpelisib, adverse event, hyperglycemia, rash, diarrhea

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MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection Priority Research Paper

Expression profiling on subclasses of primary parotid gland carcinomas Research Paper

The impact of the RASSF1C and PIWIL1 on DNA methylation: the identification of GMIP as a tumor suppressor Research Paper

Baseline CD44v6-positive circulating tumor cells to predict first-line treatment failure in patients with metastatic colorectal cancer Research Paper

Liquid biopsy and multi-analyte testing guided treatment of HER2 positive periampullary adenocarcinoma with durable complete response after trastuzumab based therapy Case Report

T-cell redirecting bispecific antibodies targeting BCMA for the treatment of multiple myeloma Research Perspective

Histo-molecular differentiation of renal cancer subtypes by mass spectrometry imaging and rapid proteome profiling of formalin-fixed paraffin-embedded tumor tissue sections Research Paper

HIC1 (Hypermethylated in Cancer 1) modulates the contractile activity of prostate stromal fibroblasts and directly regulates CXCL12 expression Research Paper

Biomarkers and novel therapeutic approaches for diffuse large B-cell lymphoma in the era of precision medicine Review

Phase I trial of TRC102 (methoxyamine HCl) in combination with temozolomide in patients with relapsed solid tumors and lymphomas Research Paper

Effect of eflornithine on mutation frequency in temozolomide-treated U87MG cells Research Paper

Correction: Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma Correction

Heterogeneity of CEACAM5 in breast cancer Research Paper

Polymerized human hemoglobin increases the effectiveness of cisplatin-based chemotherapy in non-small cell lung cancer Research Paper

Anti-tumor activities of the new oral pan-RAF inhibitor, TAK-580, used as monotherapy or in combination with novel agents in multiple myeloma Research Paper

Significance of mesothelin expression in preoperative endoscopic biopsy specimens for colorectal cancer prognosis Research Paper

TRAIL receptor agonists convert the response of breast cancer cells to ONC201 from anti-proliferative to apoptotic Priority Research Paper

Targeting an engineered cytokine with interleukin-2 and interleukin-15 activity to the neovasculature of solid tumors Research Paper

Laser speckle flowgraphy in juxtapapillary retinal capillary hemangioblastoma: a case report on natural course and therapeutic effect Case Report

A systematic review and meta-analysis of selected toxicity endpoints of alpelisib Review

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection Priority Research Paper

Expression profiling on subclasses of primary parotid gland carcinomas Research Paper

The impact of the RASSF1C and PIWIL1 on DNA methylation: the identification of GMIP as a tumor suppressor Research Paper

Baseline CD44v6-positive circulating tumor cells to predict first-line treatment failure in patients with metastatic colorectal cancer Research Paper

Liquid biopsy and multi-analyte testing guided treatment of HER2 positive periampullary adenocarcinoma with durable complete response after trastuzumab based therapy Case Report

T-cell redirecting bispecific antibodies targeting BCMA for the treatment of multiple myeloma Research Perspective

Histo-molecular differentiation of renal cancer subtypes by mass spectrometry imaging and rapid proteome profiling of formalin-fixed paraffin-embedded tumor tissue sections Research Paper

HIC1 (Hypermethylated in Cancer 1) modulates the contractile activity of prostate stromal fibroblasts and directly regulates CXCL12 expression Research Paper

Biomarkers and novel therapeutic approaches for diffuse large B-cell lymphoma in the era of precision medicine Review

Phase I trial of TRC102 (methoxyamine HCl) in combination with temozolomide in patients with relapsed solid tumors and lymphomas Research Paper

Effect of eflornithine on mutation frequency in temozolomide-treated U87MG cells Research Paper

Correction: Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma Correction

Heterogeneity of CEACAM5 in breast cancer Research Paper

Polymerized human hemoglobin increases the effectiveness of cisplatin-based chemotherapy in non-small cell lung cancer Research Paper

Anti-tumor activities of the new oral pan-RAF inhibitor, TAK-580, used as monotherapy or in combination with novel agents in multiple myeloma Research Paper

Significance of mesothelin expression in preoperative endoscopic biopsy specimens for colorectal cancer prognosis Research Paper

TRAIL receptor agonists convert the response of breast cancer cells to ONC201 from anti-proliferative to apoptotic Priority Research Paper

Targeting an engineered cytokine with interleukin-2 and interleukin-15 activity to the neovasculature of solid tumors Research Paper

Laser speckle flowgraphy in juxtapapillary retinal capillary hemangioblastoma: a case report on natural course and therapeutic effect Case Report

A systematic review and meta-analysis of selected toxicity endpoints of alpelisib Review