The Oncosearch | Oncotarget

A novel immunomodulatory and molecularly targeted strategy for refractory Hodgkinâ€™s lymphoma Brief Reports

Vivek Subbiah, Robert E. Brown, Mary F. McGuire, Jamie Buryanek, Filip Janku, Anas Younes, David Hong

Published Nov 19, 2013 · Vol. 5, No. 1 · pp. 95-102

Keywords: Hodgkin's lymphoma, mTOR, HDAC, Sirolimus, Vorinostat, Targeted therapy

Apoptosis inducers in chronic lymphocytic leukemia Review

Christian Billard

Published Nov 19, 2013 · Vol. 5, No. 2 · pp. 309-325

Keywords: CLL, impaired cell death program, apoptosis-targeted therapies, apoptosis inducers, Bcl-2 family proteins

Pharmacokinetic modeling optimizes inhibition of the â€˜undruggableâ€™ EWS-FLI1 transcription factor in Ewing Sarcoma Research Paper

Sung-Hyeok Hong, Sarah E. Youbi, S. Peter Hong, Bhaskar Kallakury, Phillip Monroe, Hayriye V. Erkizan, Julie S. Barber-Rotenberg, Peter Houghton, Aykut Ãœren, Jeffrey A. Toretsky

Published Nov 11, 2013 · Vol. 5, No. 2 · pp. 338-350

Keywords: YK-4-279, EWS-FLI1, Ewing Sarcoma, rat xenograft, pharmacokinetic modeling

Enrichment of human osteosarcoma stem cells based on hTERT transcriptional activity Research Paper

Ling Yu, Shiqing Liu, Chun Zhang, Bo Zhang, Bruno M. Simoes, Rachel Eyre, Yi Liang, Huichao Yan, Zheng Wu, Weichun Guo, Robert B. Clarke

Published Nov 5, 2013 · Vol. 4, No. 12 · pp. 2326-2338

Keywords: osteosarcoma, stem cells, sarcospheres, telomerase

FOXD3 is a novel tumor suppressor that affects growth, invasion, metastasis and angiogenesis of neuroblastoma Research Paper

Dan Li, Hong Mei, Meng Qi, Dehua Yang, Xiang Zhao, Xuan Xiang, Jiarui Pu, Kai Huang, Liduan Zheng, Qiangsong Tong

Published Nov 5, 2013 · Vol. 4, No. 11 · pp. 2021-2044

Indoleamine 2,3-dioxygenase 1 (IDO1) activity in leukemia blasts correlates with poor outcome in childhood acute myeloid leukemia Research Paper

Valentina Folgiero, Bianca M. Goffredo, Perla Filippini, Riccardo Masetti, Giuseppina Bonanno, Roberta Caruso, Valentina Bertaina, Angela Mastronuzzi, Stefania Gaspari, Marco Zecca, Giovanni F Torelli, Anna M Testi, Andrea Pession, Franco Locatelli, Sergio Rutella

Published Oct 30, 2013 · Vol. 5, No. 8 · pp. 2052-2064

Keywords: Acute myeloid leukemia, IDO1, immune escape, regulatory T cells

BET bromodomain protein inhibition is a therapeutic option for medulloblastoma Research Paper

Anton George Henssen, Theresa Thor, Andrea Odersky, Lukas Heukamp, Nicolai El-Hindy, Anneleen Beckers, Frank Slpeleman, Kristina Althoff, Simon SchÃ¤fers, Alexander Schramm, Ulrich Sure, Gudrun Fleischhack, Angelika Eggert, Johannes Hubertus Schulte

Published Oct 27, 2013 · Vol. 4, No. 11 · pp. 2080-2095

Keywords: BET bromodomains, BRD4, MYC, JQ1, pediatric brain tumors, targeted therapy

Ribosomes: the future of targeted therapies? Editorial Materials

Virginie Marcel, FrÃ©dÃ©ric Catez, Jean-Jacques Diaz

Published Oct 17, 2013 · Vol. 4, No. 10 · pp. 1554-1555

Keywords: Ribosome, RNA methylation, oncotargets

Identification of anaplastic lymphoma kinase as a potential therapeutic target in Basal Cell Carcinoma Research Paper

Hanna Ning, Hiroshi Mitsui, Claire Q.F. Wang, Mayte SuÃ¡rez-FariÃ±as, Juana Gonzalez, Kejal R. Shah, Jie Chen, Israel Coats, Diane Felsen, John A. Carucci, James G. Krueger

Published Oct 2, 2013 · Vol. 4, No. 12 · pp. 2237-2248

Keywords: oncotarget, basal cell carcinoma, anaplastic lymphoma kinase, laser capture microdissection

The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth Research Paper

Elena Kurenova, Jianqun Liao, Di-Hua He, Darrell Hunt, Michael Yemma, Wiam Bshara, Mukund Seshadri, William G Cance

Published Sep 30, 2013 · Vol. 4, No. 10 · pp. 1632-1646

Keywords: FAK Scaffold Inhibitor, pancreatic cancer, FAK-VEGFR-3 interaction, protein-protein interaction

Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX Research Paper

Marissa V Powers, Melanie Valenti, Susana Mirander, Alison Maloney, Suzanne A Eccles, George Thomas, Paul A Clarke, Paul Workman

Published Sep 29, 2013 · Vol. 4, No. 11 · pp. 1963-1975

Keywords: 17-AAG, HSP90, BAX, Apoptosis, Colon cancer

Identification of novel small molecule inhibitors of centrosome clustering in cancer cells Research Paper

Eiko Kawamura, Andrew B. Fielding, Nagarajan Kannan, Aruna Balgi, Connie J. Eaves, Michel Roberge, Shoukat Dedhar

Published Sep 25, 2013 · Vol. 4, No. 10 · pp. 1763-1776

Keywords: centrosome clustering, multipolar mitosis, small molecule, cancer specific, spindle

Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine. Research Paper

Sevin Turcan, Armida WM Fabius, Alexandra Borodovsky, Alicia Pedraza, Cameron Brennan, Jason Huse, Agnes Viale, Gregory J Riggins, Timothy A Chan

Published Sep 16, 2013 · Vol. 4, No. 10 · pp. 1729-1736

Keywords: IDH, glioma, decitabine, DNMT

Lung cancer tumorigenicity and drug resistance are maintained through ALDH^hi CD44^hi tumor initiating cells Research Paper

Jing Liu, Zhijie Xiao, Sunny Kit-Man Wong, Vicky Pui-Chi Tin, Ka-Yan Ho, Junwen Wang, Mai-Har Sham, Maria Pik Wong

Published Aug 30, 2013 · Vol. 4, No. 10 · pp. 1698-1711

Keywords: lung cancer, tumor initiating cell, aldehyde dehydrogenase, CD44, drug resistance

Regulation of histone H2A.Z expression is mediated by sirtuin 1 in prostate cancer Research Paper

Tiago Baptista, InÃªs GraÃ§a, Elsa J Sousa, Ana I Oliveira, NatÃ¡lia R Costa, Pedro Costa-Pinheiro, Francisco Amado, Rui Henrique, Carmen Jeronimo

Published Aug 29, 2013 · Vol. 4, No. 10 · pp. 1673-1685

Keywords: Prostate cancer, H2A.Z, sirtuin 1, epigenetic drugs

The AKT Inhibitor MK-2206 is Cytotoxic in Hepatocarcinoma Cells Displaying Hyperphosphorylated AKT-1 and Synergizes with Conventional Chemotherapy Research Paper

Carolina Simioni, Alberto M. Martelli, Alice Cani, Rengul Cetin-Atalay, James A. McCubrey, Silvano Capitani, Luca M. Neri

Published Aug 24, 2013 · Vol. 4, No. 9 · pp. 1496-1506

Keywords: Hepatocellular carcinoma, MK-2206, Akt-1, targeted therapy, apoptosis, autophagy

Dietary restriction-resistant human tumors harboring the PIK3CA-activating mutation H1047R are sensitive to metformin Research Paper

Silvia Cufi, Bruna Corominas-Faja, Eugeni Lopez-Bonet, Rosa Bonavia, Sonia Pernas, Isabel Alvarez Lopez, Joan Dorca, Susana Martinez, Norberto Batista Lopez, Severina Dominguez Martinez, Elisabet Cuyas, Joana Visa, Esther Rodriguez-Gallego, Rosa Quirantes-Pine, Antonio Segura-Carretero, Jorge Joven, Begona Martin-Castillo, Javier A Menendez

Published Aug 21, 2013 · Vol. 4, No. 9 · pp. 1484-1495

Keywords: Metformin, cancer, PI3K, PIK3CA mutations, dietary restriction, calorie restriction, rapamycin

Improving apoptotic responses to targeted therapy Editorial Materials

Rizwan Haq, David E. Fisher

Published Aug 6, 2013 · Vol. 4, No. 9 · pp. 1331

Identification of pregnancy-associated plasma protein A as a migration-promoting gene in malignant pleural mesothelioma cells: a potential therapeutic target Research Paper

Jun Huang, Sho Tabata, Soji Kakiuchi, Trung The Van, Hisatsugu Goto, Masaki Hanibuchi, Yasuhiko Nishioka

Published Jul 8, 2013 · Vol. 4, No. 8 · pp. 1172-1184

Keywords: malignant pleural mesothelioma, pregnancy-associated plasma protein A, migration, orthotopic xenograft mouse model

Targeting mixed lineage kinases in ER-positive breast cancer cells leads to G2/M cell cycle arrest and apoptosis. Research Paper

Limin Wang, Kathleen A Gallo, Susan E Conrad

Published Jul 7, 2013 · Vol. 4, No. 8 · pp. 1158-1171

Keywords: breast cancer, kinase inhibitors, cell cycle, apoptosis

Publication Alerts

European Cancer and Oncology Congress

Post-Publication Promotion

Search Oncotarget

A novel immunomodulatory and molecularly targeted strategy for refractory Hodgkinâ€™s lymphoma Brief Reports

Apoptosis inducers in chronic lymphocytic leukemia Review

Pharmacokinetic modeling optimizes inhibition of the â€˜undruggableâ€™ EWS-FLI1 transcription factor in Ewing Sarcoma Research Paper

Enrichment of human osteosarcoma stem cells based on hTERT transcriptional activity Research Paper

FOXD3 is a novel tumor suppressor that affects growth, invasion, metastasis and angiogenesis of neuroblastoma Research Paper

Indoleamine 2,3-dioxygenase 1 (IDO1) activity in leukemia blasts correlates with poor outcome in childhood acute myeloid leukemia Research Paper

BET bromodomain protein inhibition is a therapeutic option for medulloblastoma Research Paper

Ribosomes: the future of targeted therapies? Editorial Materials

Identification of anaplastic lymphoma kinase as a potential therapeutic target in Basal Cell Carcinoma Research Paper

The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth Research Paper

Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX Research Paper

Identification of novel small molecule inhibitors of centrosome clustering in cancer cells Research Paper

Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine. Research Paper

Lung cancer tumorigenicity and drug resistance are maintained through ALDH^hi CD44^hi tumor initiating cells Research Paper

Regulation of histone H2A.Z expression is mediated by sirtuin 1 in prostate cancer Research Paper

The AKT Inhibitor MK-2206 is Cytotoxic in Hepatocarcinoma Cells Displaying Hyperphosphorylated AKT-1 and Synergizes with Conventional Chemotherapy Research Paper

Dietary restriction-resistant human tumors harboring the PIK3CA-activating mutation H1047R are sensitive to metformin Research Paper

Improving apoptotic responses to targeted therapy Editorial Materials

Identification of pregnancy-associated plasma protein A as a migration-promoting gene in malignant pleural mesothelioma cells: a potential therapeutic target Research Paper

Targeting mixed lineage kinases in ER-positive breast cancer cells leads to G2/M cell cycle arrest and apoptosis. Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

A novel immunomodulatory and molecularly targeted strategy for refractory Hodgkinâ€™s lymphoma Brief Reports

Apoptosis inducers in chronic lymphocytic leukemia Review

Pharmacokinetic modeling optimizes inhibition of the â€˜undruggableâ€™ EWS-FLI1 transcription factor in Ewing Sarcoma Research Paper

Enrichment of human osteosarcoma stem cells based on hTERT transcriptional activity Research Paper

FOXD3 is a novel tumor suppressor that affects growth, invasion, metastasis and angiogenesis of neuroblastoma Research Paper

Indoleamine 2,3-dioxygenase 1 (IDO1) activity in leukemia blasts correlates with poor outcome in childhood acute myeloid leukemia Research Paper

BET bromodomain protein inhibition is a therapeutic option for medulloblastoma Research Paper

Ribosomes: the future of targeted therapies? Editorial Materials

Identification of anaplastic lymphoma kinase as a potential therapeutic target in Basal Cell Carcinoma Research Paper

The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth Research Paper

Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX Research Paper

Identification of novel small molecule inhibitors of centrosome clustering in cancer cells Research Paper

Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine. Research Paper

Lung cancer tumorigenicity and drug resistance are maintained through ALDHhi CD44hi tumor initiating cells Research Paper

Regulation of histone H2A.Z expression is mediated by sirtuin 1 in prostate cancer Research Paper

The AKT Inhibitor MK-2206 is Cytotoxic in Hepatocarcinoma Cells Displaying Hyperphosphorylated AKT-1 and Synergizes with Conventional Chemotherapy Research Paper

Dietary restriction-resistant human tumors harboring the PIK3CA-activating mutation H1047R are sensitive to metformin Research Paper

Improving apoptotic responses to targeted therapy Editorial Materials

Identification of pregnancy-associated plasma protein A as a migration-promoting gene in malignant pleural mesothelioma cells: a potential therapeutic target Research Paper

Targeting mixed lineage kinases in ER-positive breast cancer cells leads to G2/M cell cycle arrest and apoptosis. Research Paper

Lung cancer tumorigenicity and drug resistance are maintained through ALDH^hi CD44^hi tumor initiating cells Research Paper