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2,396 results found
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Thioaptamer Conjugated Liposomes for Tumor Vasculature Targeting Research Paper
Keywords: drug delivery, aptamer, E-selectin
Enhancing proteotoxic stress as an anticancer strategy Commentary
A stressful life (or death): Combinatorial proteotoxic approaches to cancer-selective therapeutic vulnerability Commentary
Potential Therapeutic Strategies to Overcome Acquired Resistance to BRAF or MEK Inhibitors in BRAF Mutant Cancers Research Perspective
Keywords: BRAF, MEK, acquired resistance, melanoma, colorectal cancer, NRAS, IGF1R, PDGFR
The beating heart of melanomas: a minor subset of cancer cells sustains tumor growth Research Perspective
Keywords: melanoma, cancer stem cell, adoptive cell therapy
Proteotoxic stress targeted therapy (PSTT): induction of protein misfolding enhances the antitumor effect of the proteasome inhibitor bortezomib Research Paper
Keywords: bortezomib, puromycin, hyperthermia, heat shock, apoptosis, cancer treatment, translation, ubiquitination, protein degradation, protein denaturing
Personalizing Therapy with Targeted Agents in Non-Small Cell Lung Cancer Review
Keywords: ALK, EGFR, KRAS, lung cancer, targeted therapy
Mcl-1 Ubiquitination and Destruction Research Perspective
Keywords: Ubiquitination, SCF, Fbw7, GSK3, Mcl-1, Apoptosis, Tumor Suppressor, Phosphorylation, Cell Cycle
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health Review
Keywords: Targeted Therapy, Combination Therapy, Drug Resistance, Cancer Stem Cells, Aging, Senescence, Raf, Akt, PI3K, mTOR