The Oncosearch | Oncotarget

Pirfenidone anti-fibrotic effects are partially mediated by the inhibition of MUC1 bioactivation Research Paper

Beatriz Ballester, Javier Milara, Julio Cortijo

Published Apr 14, 2020 · Vol. 11, No. 15 · pp. 1306-1320

Keywords: pirfenidone, idiopathic pulmonary fibrosis, MUC1, transforming growth factor beta-1, fibroblasts

Roscovitine enhances all-trans retinoic acid (ATRA)-induced nuclear enrichment of an ensemble of activated signaling molecules and augments ATRA-induced myeloid cell differentiation Research Paper

Asif Rashid, Xin Duan, Feng Gao, Mengsu Yang, Andrew Yen

Published Mar 24, 2020 · Vol. 11, No. 12 · pp. 1017-1036

Keywords: ATRA, roscovitine, APL, HL-60, Lyn

Combined inhibition of PIM and CDK4/6 suppresses both mTOR signaling and Rb phosphorylation and potentiates PI3K inhibition in cancer cells Priority Research Paper

Lacey M. Litchfield, Karsten Boehnke, Manisha Brahmachary, Cecilia Mur, Chen Bi, Jennifer R. Stephens, J. Michael Sauder, Sonia M. Gutiérrez, Ann M. McNulty, Xiang S. Ye, Wenjuan Wu, María José Lallena, Xueqian Gong, Farhana F. Merzoug, Valerie M. Jansen, Sean G. Buchanan

Published Mar 23, 2020 · Vol. 11, No. 17 · pp. 1478-1492

Keywords: abemaciclib, CDK4/6, PIM, mTOR, S6

Both BRCA1-wild type and -mutant triple-negative breast cancers show sensitivity to the NAE inhibitor MLN4924 which is enhanced upon MLN4924 and cisplatin combination treatment Research Paper

Shrilekha Misra, Xiaoli Zhang, Nissar Ahmad Wani, Steven Sizemore, Alo Ray

Published Feb 25, 2020 · Vol. 11, No. 8 · pp. 784-800

Keywords: triple-negative breast cancer, MLN4924, cisplatin, cell cycle, DNA damage

DNA dependent protein kinase (DNA-PK) enhances HIV transcription by promoting RNA polymerase II activity and recruitment of transcription machinery at HIV LTR Research Paper

Sonia Zicari, Adhikarimayum Lakhikumar Sharma, Geetaram Sahu, Larisa Dubrovsky, Lin Sun, Han Yue, Tejaswi Jada, Alex Ochem, Gary Simon, Michael Bukrinsky, Mudit Tyagi

Published Feb 18, 2020 · Vol. 11, No. 7 · pp. 699-726

Keywords: HIV, DNA-PK, transcription, replication, DNA-PK inhibitors

Human insulin modulates α-synuclein aggregation via DAF-2/DAF-16 signalling pathway by antagonising DAF-2 receptor in C. elegans model of Parkinson’s disease Research Paper

Rizwanul Haque, Shamsuzzama, Lalit Kumar, Tanuj Sharma, Soobiya Fatima, Pooja Jadiya, Mohammad I. Siddiqi, Aamir Nazir

Published Feb 11, 2020 · Vol. 11, No. 6 · pp. 634-649

Keywords: Parkinson’s, human insulin, aggregation, Daf-2, Caenorhabditis elegans (C. elegans)

Clostridium perfringens enterotoxin induces claudin-4 to activate YAP in oral squamous cell carcinomas Research Paper

Chie Nakashima, Kazuhiko Yamamoto, Shingo Kishi, Takamitsu Sasaki, Hitoshi Ohmori, Rina Fujiwara-Tani, Shiori Mori, Isao Kawahara, Yukiko Nishiguchi, Takuya Mori, Masuo Kondoh, Yi Luo, Tadaaki Kirita, Hiroki Kuniyasu

Published Jan 28, 2020 · Vol. 11, No. 4 · pp. 309-321

Keywords: clostridium perfringens enterotoxin, claudin-4, YAP, Hippo signal, oral squamous cell carcinoma, Pathology

Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR Research Paper

Hengyu Lu, Chen Liu, Hung Huynh, Thi Bich Uyen Le, Matthew J. LaMarche, Morvarid Mohseni, Jeffrey A. Engelman, Peter S. Hammerman, Giordano Caponigro, Huai-Xiang Hao

Published Jan 21, 2020 · Vol. 11, No. 3 · pp. 265-281

Keywords: SHP2, FGFR, resistance, feedback activation

Novel functional anti-HER3 monoclonal antibodies with potent anti-cancer effects on various human epithelial cancers Research Paper

Kouki Okita, Shogo Okazaki, Shinya Uejima, Erina Yamada, Hiroki Kaminaka, Misa Kondo, Shiho Ueda, Ryo Tokiwa, Nami Iwata, Akitaka Yamasaki, Natsumi Hayashi, Dai Ogura, Kenji Hirotani, Toshiaki Yoshioka, Masahiro Inoue, Kazue Masuko, Takashi Masuko

Published Jan 7, 2020 · Vol. 11, No. 1 · pp. 31-45

Keywords: CDR, HER3, internalization, mAb, NRG1

Toxoplasma gondii GRA8-derived peptide immunotherapy improves tumor targeting of colorectal cancer Research Paper

Jae-Sung Kim, Daeun Lee, Donggyu Kim, Seok-Jun Mun, Euni Cho, Wooic Son, Chul-Su Yang

Published Jan 7, 2020 · Vol. 11, No. 1 · pp. 62-73

Keywords: Toxoplasma gondii GRA8 peptide, mitochondria, tumor-targeting, metabolism

A novel function of AAA-ATPase p97/VCP in the regulation of cell motility Research Paper

Zi-Jia Khong, Soak-Kuan Lai, Cheng-Gee Koh, Susana Geifman-Shochat, Hoi-Yeung Li

Published Jan 7, 2020 · Vol. 11, No. 1 · pp. 74-85

Keywords: p97/VCP, AAA-ATPase, ROCK, RhoA, cell motility

Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR Research Paper

Hengyu Lu, Chen Liu, Hung Huynh, Thi Bich Uyen Le, Matthew LaMarche, Morvarid Mohseni, Jeffrey A. Engelman, Peter S. Hammerman, Giordano Caponigro, Huai-Xiang Hao

Published Jan 6, 2020

Keywords: SHP2, FGFR, resistance, feedback activation

Inhibitory effects of SEL201 in acute myeloid leukemia Research Paper

Ewa M. Kosciuczuk, Aroop K. Kar, Gavin T. Blyth, Mariafausta Fischietti, Sameem Abedin, Alain A. Mina, Rebekah Siliezar, Tomasz Rzymski, Krzysztof Brzozka, Elizabeth A. Eklund, Elspeth M. Beauchamp, Frank Eckerdt, Diana Saleiro, Leonidas C. Platanias

Published Dec 24, 2019 · Vol. 10, No. 67 · pp. 7112-7121

Keywords: acute myeloid leukemia, MNK, eIF4E, kinase inhibitor, SEL201

HSP90 overexpression potentiates the B-cell receptor and fibroblast growth factor receptor survival signals in chronic lymphocytic leukemia cells Research Paper

Hasan Mahmud, Mariana Mendez, Bedabrata Mukhopadhyay, Jennifer Holter-Chakrabarty, Asish K. Ghosh

Published Dec 23, 2019 · Vol. 11, No. 22 · pp. 2037-2046

Keywords: CLL, HSP90, BCR, CD79a, PTPN22

Correction: Characterization of CDK(5) inhibitor, 20-223 (aka CP668863) for colorectal cancer therapy Correction

Caroline M. Robb, Smit Kour, Jacob I. Contreras, Ekta Agarwal, Carter J. Barger, Sandeep Rana, Yogesh Sonawane, Beth K. Neilsen, Margaret Taylor, Smitha Kizhake, Rhishikesh N. Thakare, Sanjib Chowdhury, Jing Wang, Jennifer D. Black, Michael A. Hollingsworth, Michael G. Brattain, Amarnath Natarajan

Published Dec 18, 2019 · Vol. 11, No. 25 · pp. 2462-2463

Modulation of proliferation factors in lung adenocarcinoma with an analysis of the transcriptional consequences of genomic EGFR activation Research Paper

Melanie Haas Kucherlapati

Published Dec 10, 2019 · Vol. 10, No. 65 · pp. 6913-6933

Keywords: proliferation, mutation, transcription, EGFR, lung adenocarcinoma

Analog-sensitive cell line identifies cellular substrates of CDK9 Research Paper

Tim-Michael Decker, Ignasi Forné, Tobias Straub, Hesham Elsaman, Guoli Ma, Nilay Shah, Axel Imhof, Dirk Eick

Published Dec 10, 2019 · Vol. 10, No. 65 · pp. 6934-6943

Keywords: CDK9, protein kinase, transcription, RNA splicing, phosphoproteomics

p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis Research Paper

Boxiao Ding, Alexander Haidurov, Ayesha Chawla, Anita Parmigiani, Gerarda van de Kamp, Alexandra Dalina, Fang Yuan, Jun Hee Lee, Peter M. Chumakov, Steven R. Grossman, Andrei V. Budanov

Published Dec 10, 2019 · Vol. 10, No. 65 · pp. 6997-7009

Keywords: SESTRINs, lung cancer, mouse model, mTORC1/2, tumor suppression

PTPRS drives adaptive resistance to MEK/ERK inhibitors through SRC Priority Research Paper

Thomas B. Davis, Mingli Yang, Heiman Wang, Changgong Lee, Timothy J. Yeatman, W. Jack Pledger

Published Nov 26, 2019 · Vol. 10, No. 63 · pp. 6768-6780

Keywords: colorectal cancer, PTPRS, ERK, SRC, adaptive resistance

Correction: AMF/PGI-mediated tumorigenesis through MAPK-ERK signaling in endometrial carcinoma Correction

Yiran Li, Yuanhui Jia, Qi Che, Qian Zhou, Kai Wang, Xiao-Ping Wan

Published Nov 19, 2019 · Vol. 11, No. 7 · pp. 755-757

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Pirfenidone anti-fibrotic effects are partially mediated by the inhibition of MUC1 bioactivation Research Paper

Roscovitine enhances all-trans retinoic acid (ATRA)-induced nuclear enrichment of an ensemble of activated signaling molecules and augments ATRA-induced myeloid cell differentiation Research Paper

Combined inhibition of PIM and CDK4/6 suppresses both mTOR signaling and Rb phosphorylation and potentiates PI3K inhibition in cancer cells Priority Research Paper

Both BRCA1-wild type and -mutant triple-negative breast cancers show sensitivity to the NAE inhibitor MLN4924 which is enhanced upon MLN4924 and cisplatin combination treatment Research Paper

DNA dependent protein kinase (DNA-PK) enhances HIV transcription by promoting RNA polymerase II activity and recruitment of transcription machinery at HIV LTR Research Paper

Human insulin modulates α-synuclein aggregation via DAF-2/DAF-16 signalling pathway by antagonising DAF-2 receptor in C. elegans model of Parkinson’s disease Research Paper

Clostridium perfringens enterotoxin induces claudin-4 to activate YAP in oral squamous cell carcinomas Research Paper

Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR Research Paper

Novel functional anti-HER3 monoclonal antibodies with potent anti-cancer effects on various human epithelial cancers Research Paper

Toxoplasma gondii GRA8-derived peptide immunotherapy improves tumor targeting of colorectal cancer Research Paper

A novel function of AAA-ATPase p97/VCP in the regulation of cell motility Research Paper

Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR Research Paper

Inhibitory effects of SEL201 in acute myeloid leukemia Research Paper

HSP90 overexpression potentiates the B-cell receptor and fibroblast growth factor receptor survival signals in chronic lymphocytic leukemia cells Research Paper

Correction: Characterization of CDK(5) inhibitor, 20-223 (aka CP668863) for colorectal cancer therapy Correction

Modulation of proliferation factors in lung adenocarcinoma with an analysis of the transcriptional consequences of genomic EGFR activation Research Paper

Analog-sensitive cell line identifies cellular substrates of CDK9 Research Paper

p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis Research Paper

PTPRS drives adaptive resistance to MEK/ERK inhibitors through SRC Priority Research Paper

Correction: AMF/PGI-mediated tumorigenesis through MAPK-ERK signaling in endometrial carcinoma Correction

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Pirfenidone anti-fibrotic effects are partially mediated by the inhibition of MUC1 bioactivation Research Paper

Roscovitine enhances all-trans retinoic acid (ATRA)-induced nuclear enrichment of an ensemble of activated signaling molecules and augments ATRA-induced myeloid cell differentiation Research Paper

Combined inhibition of PIM and CDK4/6 suppresses both mTOR signaling and Rb phosphorylation and potentiates PI3K inhibition in cancer cells Priority Research Paper

Both BRCA1-wild type and -mutant triple-negative breast cancers show sensitivity to the NAE inhibitor MLN4924 which is enhanced upon MLN4924 and cisplatin combination treatment Research Paper

DNA dependent protein kinase (DNA-PK) enhances HIV transcription by promoting RNA polymerase II activity and recruitment of transcription machinery at HIV LTR Research Paper

Human insulin modulates α-synuclein aggregation via DAF-2/DAF-16 signalling pathway by antagonising DAF-2 receptor in C. elegans model of Parkinson’s disease Research Paper

Clostridium perfringens enterotoxin induces claudin-4 to activate YAP in oral squamous cell carcinomas Research Paper

Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR Research Paper

Novel functional anti-HER3 monoclonal antibodies with potent anti-cancer effects on various human epithelial cancers Research Paper

Toxoplasma gondii GRA8-derived peptide immunotherapy improves tumor targeting of colorectal cancer Research Paper

A novel function of AAA-ATPase p97/VCP in the regulation of cell motility Research Paper

Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR Research Paper

Inhibitory effects of SEL201 in acute myeloid leukemia Research Paper

HSP90 overexpression potentiates the B-cell receptor and fibroblast growth factor receptor survival signals in chronic lymphocytic leukemia cells Research Paper

Correction: Characterization of CDK(5) inhibitor, 20-223 (aka CP668863) for colorectal cancer therapy Correction

Modulation of proliferation factors in lung adenocarcinoma with an analysis of the transcriptional consequences of genomic EGFR activation Research Paper

Analog-sensitive cell line identifies cellular substrates of CDK9 Research Paper

p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis Research Paper

PTPRS drives adaptive resistance to MEK/ERK inhibitors through SRC Priority Research Paper

Correction: AMF/PGI-mediated tumorigenesis through MAPK-ERK signaling in endometrial carcinoma Correction