The Oncosearch | Oncotarget

Nerofe+ldDox releases c-Jun from nuclear ST2 to reprogram the immune microenvironment in mtKRAS tumors Research Paper

Joel Ohana, Uziel Sandler, Benjamin A. Weinberg, Stephen Liu, Yoram Devary

Published Dec 19, 2025 · Vol. 16, No. 1 · pp. 848-857

Keywords: mutant KRAS, Nerofe, ST2 Receptor, tumor immune microenvironment, nuclear immunomodulation

In vivo manipulation of the protein homeostasis network in rhabdomyosarcoma Research Paper

Kristen Kwong, Yue Pan, Jacqueline Morales, Matthew Watson, David V. Allegakoen, Alex G. Lee, Trever G. Bivona, Peter Wipf, Christopher J. Guerriero, Jeffrey L. Brodsky, Amit J. Sabnis

Published Aug 23, 2025 · Vol. 16, No. 1 · pp. 681-696

Keywords: protein homeostasis, rhabdomyosarcoma, unfolded protein response, preclinical therapeutics, p97

The SCD1 inhibitor aramchol interacts with regorafenib to kill GI tumor cells in vitro and in vivo Research Paper

Laurence Booth, Michael R. Booth, Jane L. Roberts, Yang Yue, Emily Kinsey, Andrew Poklepovic, David Boone, L. Ashley Cowhart, Allen Baharaff, Paul Dent

Published Aug 14, 2025 · Vol. 16, No. 1 · pp. 662-678

Keywords: macroautophagy, flux, ER stress, aramchol, regorafenib

PCAIs stimulate MAPK, PI3K/AKT pathways and ROS-Mediated apoptosis in aromatase inhibitor-resistant breast cancer cells while disrupting actin filaments and focal adhesion Research Paper

Jassy Mary S. Lazarte, Kweku Ofosu-Asante, Syreeta L. Tilghman, Nazarius S. Lamango

Published Jul 22, 2025 · Vol. 16, No. 1 · pp. 621-641

Keywords: PCAIs, ROS, MAPK, PI3K/AKT, LTLT-Ca cells

A novel anti-human CD25 mAb with preferential reactivity to activated T regulatory cells depletes them from the tumor microenvironment Research Paper

Maja Buszko, Madalyn Jones, Sruthi Chempati, Lyra Morina, Kirstin Ward, Habtom Habte, Michael Dziegielewski, Ethan M. Shevach

Published Jun 30, 2025 · Vol. 16, No. 1 · pp. 545-558

Keywords: T_reg, CD25, TME, mAb, GVHD

Correction: Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2 Correction

Yan Luo, Lei Liu, Yang Wu, Karnika Singh, Bing Su, Nan Zhang, Xiaowei Liu, Yangmei Shen, Shile Huang

Published Jun 10, 2025 · Vol. 16, No. 1 · pp. 425-426

Retraction: Androgen receptor promotes gastric cancer cell migration and invasion via AKT-phosphorylation dependent upregulation of matrix metalloproteinase 9 Retraction

Bao-gui Zhang, Tao Du, Ming-de Zang, Qing Chang, Zhi-yuan Fan, Jian-fang Li, Bei-qin Yu, Li-ping Su, Chen Li, Chao Yan, Qin-long Gu, Zheng-gang Zhu, Min Yan, Bingya Liu

Published May 29, 2025 · Vol. 16, No. 1 · pp. 410-410

Correction: Small molecule inhibition of Axl receptor tyrosine kinase potently suppresses multiple malignant properties of glioma cells Correction

Mikaella Vouri, Qian An, Matthew Birt, Geoffrey J. Pilkington, Sassan Hafizi

Published Apr 4, 2025 · Vol. 16, No. 1 · pp. 260-261

Imipridones ONC201/ONC206 + RT/TMZ triple (IRT) therapy reduces intracranial tumor burden, prolongs survival in orthotopic IDH-WT GBM mouse model, and suppresses MGMT Research Paper

Lanlan Zhou, Leiqing Zhang, Jun Zhang, Laura Jinxuan Wu, Shengliang Zhang, Andrew George, Marina Hahn, Howard P. Safran, Clark C. Chen, Attila A. Seyhan, Eric T. Wong, Wafik S. El-Deiry

Published Mar 20, 2025 · Vol. 16, No. 1 · pp. 230-248

Keywords: glioblastoma multiforme, IDH, ONC201, ONC206, MGMT, temozolomide, radiotherapy

FGR Src family kinase causes signaling and phenotypic shift mimicking retinoic acid-induced differentiation of leukemic cells Research Paper

Noor Kazim, Wang Peng, Jianbo Yue, Andrew Yen

Published Mar 14, 2025 · Vol. 16, No. 1 · pp. 202-218

Keywords: cancer biology and cell cycle regulation, retinoic acid(RA), FGR Src-family-kinase, cancer differentiation-therapy, leukemia

Correction: The anti-HER3 (ErbB3) therapeutic antibody 9F7-F11 induces HER3 ubiquitination and degradation in tumors through JNK1/2- dependent ITCH/AIP4 activation Correction

Christophe Le Clorennec, Yassamine Lazrek, Olivier Dubreuil, Christel Larbouret, Marie-Alix Poul, Philippe Mondon, Gerry Melino, André Pèlegrin, Thierry Chardès

Published Oct 11, 2024 · Vol. 15, No. 1 · pp. 748-749

Correction: Cyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimetics Correction

Gaurav S. Choudhary, Trinh T. Tat, Saurav Misra, Brian T. Hill, Mitchell R. Smith, Alexandru Almasan, Suparna Mazumder

Published Jun 11, 2024 · Vol. 15, No. 1 · pp. 468-469

Synergistic cytotoxicity of histone deacetylase and poly-ADP ribose polymerase inhibitors and decitabine in pancreatic cancer cells: Implications for novel therapy Research Paper

Benigno C. Valdez, Apostolia M. Tsimberidou, Bin Yuan, Yago Nieto, Mehmet A. Baysal, Abhijit Chakraborty, Clark R. Andersen, Borje S. Andersson

Published May 25, 2024 · Vol. 15, No. 1 · pp. 361-373

Keywords: decitabine, HDAC inhibitors, pancreatic cancer, PARP inhibitors, synergistic cytotoxicity

GZ17-6.02 interacts with proteasome inhibitors to kill multiple myeloma cells Research Paper

Laurence Booth, Jane L. Roberts, Cameron West, Paul Dent

Published Jan 29, 2024 · Vol. 15, No. 1 · pp. 159-174

Keywords: autophagy, ER stress, GZ17-6.02, bortezomib, proteasome inhibitor

GZ17-6.02 interacts with bexarotene to kill mycosis fungoides cells Research Paper

Michael R. Booth, Laurence Booth, Jane L. Roberts, Cameron West, Paul Dent

Published Jan 29, 2024 · Vol. 15, No. 1 · pp. 124-133

Keywords: autophagy, ER stress, GZ17-6.02, bexarotene, vorinostat

Differential expression of Mad2 gene is consequential to the patterns of histone H3 post-translational modifications in its promoter region in human esophageal cancer samples Research Paper

Chongtham Sovachandra Singh, Nabamita Boruah, Atanu Banerjee, Sillarine Kurkalang, Pooja Swargiary, Hughbert Dakhar, Anupam Chatterjee

Published Jan 11, 2024 · Vol. 15, No. 1 · pp. 76-89

Keywords: Mad2 gene, histone methylation, histone acetylation, Rb-phosphorylation, esophageal cancer

Osteopontin induces mitochondrial biogenesis in deadherent cancer cells Research Paper

Gulimirerouzi Fnu, Georg F. Weber

Published Nov 24, 2023 · Vol. 14, No. 1 · pp. 957-969

Keywords: metastasis, metabolism, anchorage independence, mitochondrial mass, peroxide

Utilizing metformin to prevent metabolic syndrome due to androgen deprivation therapy (ADT): a randomized phase II study of metformin in non-diabetic men initiating ADT for advanced prostate cancer Research Paper

Devalingam Mahalingam, Salih Hanni, Anthony V. Serritella, Christos Fountzilas, Joel Michalek, Brian Hernandez, John Sarantopoulos, Paromitta Datta, Ofelia Romero, Sureshkumar Mulampurath Achutan Pillai, John Kuhn, Michael Pollak, Ian M. Thompson

Published Jun 8, 2023 · Vol. 14, No. 1 · pp. 622-636

Keywords: prostate cancer, metformin, metastatic, androgen deprivation therapy, clinical trial

Deciphering the mechanisms of action of progesterone in breast cancer Research Perspective

Gaurav Chakravorty, Suhail Ahmad, Mukul S. Godbole, Sudeep Gupta, Rajendra A. Badwe, Amit Dutt

Published Jun 5, 2023 · Vol. 14, No. 1 · pp. 660-667

Keywords: breast cancer, progesterone, DSCAM-AS1, endocrine therapy

LP-284, a small molecule acylfulvene, exerts potent antitumor activity in preclinical non-Hodgkin's lymphoma models and in cells deficient in DNA damage repair Research Paper

Jianli Zhou, Drew Sturtevant, Cassie Love, Aditya Kulkarni, Neha Biyani, Umesh Kathad, Elizabeth Thacker, Sandeep Dave, Kishor Bhatia

Published Jun 5, 2023 · Vol. 14, No. 1 · pp. 597-611

Keywords: non-Hodgkin's lymphoma, DNA damage, homologous recombination repair, transcription-coupled nucleotide excision repair, ATM

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Nerofe+ldDox releases c-Jun from nuclear ST2 to reprogram the immune microenvironment in mtKRAS tumors Research Paper

In vivo manipulation of the protein homeostasis network in rhabdomyosarcoma Research Paper

The SCD1 inhibitor aramchol interacts with regorafenib to kill GI tumor cells in vitro and in vivo Research Paper

PCAIs stimulate MAPK, PI3K/AKT pathways and ROS-Mediated apoptosis in aromatase inhibitor-resistant breast cancer cells while disrupting actin filaments and focal adhesion Research Paper

A novel anti-human CD25 mAb with preferential reactivity to activated T regulatory cells depletes them from the tumor microenvironment Research Paper

Correction: Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2 Correction

Retraction: Androgen receptor promotes gastric cancer cell migration and invasion via AKT-phosphorylation dependent upregulation of matrix metalloproteinase 9 Retraction

Correction: Small molecule inhibition of Axl receptor tyrosine kinase potently suppresses multiple malignant properties of glioma cells Correction

Imipridones ONC201/ONC206 + RT/TMZ triple (IRT) therapy reduces intracranial tumor burden, prolongs survival in orthotopic IDH-WT GBM mouse model, and suppresses MGMT Research Paper

FGR Src family kinase causes signaling and phenotypic shift mimicking retinoic acid-induced differentiation of leukemic cells Research Paper

Correction: The anti-HER3 (ErbB3) therapeutic antibody 9F7-F11 induces HER3 ubiquitination and degradation in tumors through JNK1/2- dependent ITCH/AIP4 activation Correction

Correction: Cyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimetics Correction

Synergistic cytotoxicity of histone deacetylase and poly-ADP ribose polymerase inhibitors and decitabine in pancreatic cancer cells: Implications for novel therapy Research Paper

GZ17-6.02 interacts with proteasome inhibitors to kill multiple myeloma cells Research Paper

GZ17-6.02 interacts with bexarotene to kill mycosis fungoides cells Research Paper

Differential expression of Mad2 gene is consequential to the patterns of histone H3 post-translational modifications in its promoter region in human esophageal cancer samples Research Paper

Osteopontin induces mitochondrial biogenesis in deadherent cancer cells Research Paper

Utilizing metformin to prevent metabolic syndrome due to androgen deprivation therapy (ADT): a randomized phase II study of metformin in non-diabetic men initiating ADT for advanced prostate cancer Research Paper

Deciphering the mechanisms of action of progesterone in breast cancer Research Perspective

LP-284, a small molecule acylfulvene, exerts potent antitumor activity in preclinical non-Hodgkin's lymphoma models and in cells deficient in DNA damage repair Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Nerofe+ldDox releases c-Jun from nuclear ST2 to reprogram the immune microenvironment in mtKRAS tumors Research Paper

In vivo manipulation of the protein homeostasis network in rhabdomyosarcoma Research Paper

The SCD1 inhibitor aramchol interacts with regorafenib to kill GI tumor cells in vitro and in vivo Research Paper

PCAIs stimulate MAPK, PI3K/AKT pathways and ROS-Mediated apoptosis in aromatase inhibitor-resistant breast cancer cells while disrupting actin filaments and focal adhesion Research Paper

A novel anti-human CD25 mAb with preferential reactivity to activated T regulatory cells depletes them from the tumor microenvironment Research Paper

Correction: Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2 Correction

Retraction: Androgen receptor promotes gastric cancer cell migration and invasion via AKT-phosphorylation dependent upregulation of matrix metalloproteinase 9 Retraction

Correction: Small molecule inhibition of Axl receptor tyrosine kinase potently suppresses multiple malignant properties of glioma cells Correction

Imipridones ONC201/ONC206 + RT/TMZ triple (IRT) therapy reduces intracranial tumor burden, prolongs survival in orthotopic IDH-WT GBM mouse model, and suppresses MGMT Research Paper

FGR Src family kinase causes signaling and phenotypic shift mimicking retinoic acid-induced differentiation of leukemic cells Research Paper

Correction: The anti-HER3 (ErbB3) therapeutic antibody 9F7-F11 induces HER3 ubiquitination and degradation in tumors through JNK1/2- dependent ITCH/AIP4 activation Correction

Correction: Cyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimetics Correction

Synergistic cytotoxicity of histone deacetylase and poly-ADP ribose polymerase inhibitors and decitabine in pancreatic cancer cells: Implications for novel therapy Research Paper

GZ17-6.02 interacts with proteasome inhibitors to kill multiple myeloma cells Research Paper

GZ17-6.02 interacts with bexarotene to kill mycosis fungoides cells Research Paper

Differential expression of Mad2 gene is consequential to the patterns of histone H3 post-translational modifications in its promoter region in human esophageal cancer samples Research Paper

Osteopontin induces mitochondrial biogenesis in deadherent cancer cells Research Paper

Utilizing metformin to prevent metabolic syndrome due to androgen deprivation therapy (ADT): a randomized phase II study of metformin in non-diabetic men initiating ADT for advanced prostate cancer Research Paper

Deciphering the mechanisms of action of progesterone in breast cancer Research Perspective

LP-284, a small molecule acylfulvene, exerts potent antitumor activity in preclinical non-Hodgkin's lymphoma models and in cells deficient in DNA damage repair Research Paper