The Oncosearch | Oncotarget

Deconstructing the role of MALAT1 in MAPK-signaling in melanoma: insights from antisense oligonucleotide treatment Research Paper

Valentin Feichtenschlager, Yixuan James Zheng, Wilson Ho, Linan Chen, Ciara Callanan, Christopher Chen, Albert Lee, Jose Ortiz, Klemens Rappersberger, Susana Ortiz-Urda

Published May 19, 2023 · Vol. 14, No. 1 · pp. 543-560

Keywords: MALAT1, MAPK-pathway, BRAF, melanoma, antisense oligonucleotides

Decoding the mechanism behind MCL-1 inhibitors: A pathway to understanding MCL-1 protein stability Editorial

Shady I. Tantawy, Natalia Timofeeva, Ana Hernandez, Aloke Sarkar, Varsha Gandhi

Published May 13, 2023 · Vol. 14, No. 1 · pp. 653-655

Keywords: AMG-176, AZD5991, B-cell leukemia, MCL-1 inhibitor, MCL-1 protein

Role of creatine shuttle in colorectal cancer cells Research Paper

Mayu Kita, Rina Fujiwara-Tani, Shingo Kishi, Shiori Mori, Hitoshi Ohmori, Chie Nakashima, Kei Goto, Takamitsu Sasaki, Kiyomu Fujii, Isao Kawahara, Ujjal Kumar Bhawal, Yi Luo, Hiroki Kuniyasu

Published May 12, 2023 · Vol. 14, No. 1 · pp. 485-501

Keywords: creatine kinase B, mitochondrial creatine kinase, ATP metabolism, phosphorylation signal, stemness

G-protein-coupled receptor 141 mediates breast cancer proliferation and metastasis by regulating oncogenic mediators and the p-mTOR/p53 axis Research Paper

Monalisa Parija, Amit K. Adhya, Sandip K. Mishra

Published May 11, 2023 · Vol. 14, No. 1 · pp. 466-480

Keywords: G-protein-coupled receptor 141, cell migration, metastasis, p-mTOR, p53

Differential silencing of STAT3 isoforms leads to changes in STAT3 activation Research Paper

Inbal Shamir, Ilan Tsarfaty, Gidi Paret, Yael Nevo-Caspi

Published Apr 17, 2023 · Vol. 14, No. 1 · pp. 366-376

Keywords: STAT3, STAT3 isoforms, breast cancer, cancer diagnosis, cancer therapy

Impact of SHP2 tyrosine phosphorylation on the development of acquired resistance to allosteric SHP2 inhibitors Editorial

Giulia Franciosa, Jesper V. Olsen

Published Mar 21, 2023 · Vol. 14, No. 1 · pp. 281-283

Keywords: SHP2, PTPN11, tyrosine, phosphorylation

AGO2 in T-prolymphocytic leukemia: its canonical and non-canonical deregulation and function Editorial

Till Braun, Hanna Klepzig, Marco Herling

Published Feb 28, 2023 · Vol. 14, No. 1 · pp. 395-397

Keywords: T-PLL, AGO2, microRNA

The “extreme phenotype approach” applied to male breast cancer allows the identification of rare variants of ATR as potential breast cancer susceptibility alleles Research Paper

Martin Chevarin, Diana Alcantara, Juliette Albuisson, Marie-Agnès Collonge-Rame, Céline Populaire, Zohair Selmani, Amandine Baurand, Caroline Sawka, Geoffrey Bertolone, Patrick Callier, Yannis Duffourd, Philippe Jonveaux, Yves-Jean Bignon, Isabelle Coupier, François Cornelis, Christophe Cordier, Monique Mozelle-Nivoix, Jean-Baptiste Rivière, Paul Kuentz, Christel Thauvin, Romain Boidot, François Ghiringhelli, Marc O'Driscoll, Laurence Faivre, Sophie Nambot

Published Feb 1, 2023 · Vol. 14, No. 1 · pp. 111-125

Keywords: male breast cancer, genetic predisposition to cancer, exome sequencing, ATR, extreme phenotype

Everolimus downregulates STAT3/HIF-1α/VEGF pathway to inhibit angiogenesis and lymphangiogenesis in TP53 mutant head and neck squamous cell carcinoma (HNSCC) Research Paper

Md Maksudul Alam, Janmaris Marin Fermin, Mark Knackstedt, Mackenzie J. Noonan, Taylor Powell, Landon Goodreau, Emily K. Daniel, Xiaohua Rong, Tara Moore-Medlin, Alok R. Khandelwal, Cherie-Ann O. Nathan

Published Jan 27, 2023 · Vol. 14, No. 1 · pp. 85-95

Keywords: TP53 mutant, HNSCC, angiogenesis, everolimus, mTOR

Candidate drugs associated with sensitivity of cancer cell lines with DLST amplification or high mRNA levels Research Paper

Christina Kuhn, Myriam Boeschen, Manuel Philip, Torsten Schöneberg, Doreen Thor, Susanne Horn

Published Dec 27, 2022 · Vol. 14, No. 1 · pp. 14-20

Keywords: neuroblastoma, drug sensitivity, drug resistance, drug repurposing, DLST

HDAC inhibitors suppress protein poly(ADP-ribosyl)ation and DNA repair protein levels and phosphorylation status in hematologic cancer cells: implications for their use in combination with PARP inhibitors and chemotherapeutic drugs Research Paper

Benigno C. Valdez, Yago Nieto, Bin Yuan, David Murray, Borje S. Andersson

Published Sep 24, 2022 · Vol. 13, No. 1 · pp. 1122-1135

Keywords: poly(ADP-ribosyl)ation, HDAC inhibitors, PARP inhibitors, chemotherapy, hematologic malignancy

Kinase activity profiling in renal cell carcinoma, benign renal tissue and in response to four different tyrosine kinase inhibitors Research Paper

Andliena Tahiri, Katarina Puco, Faris Naji, Vessela N. Kristensen, Glenny Cecilie Alfsen, Lorant Farkas, Frode S. Nilsen, Stig Müller, Jan Oldenburg, Jürgen Geisler

Published Jul 8, 2022 · Vol. 13, No. 1 · pp. 970-981

Keywords: kidney cancer, kinase activity, tyrosine kinase inhibitors, renal cell carcinoma, tyrosine kinase

Continuous treatment with abemaciclib leads to sustained and efficient inhibition of breast cancer cell proliferation Research Paper

Raquel Torres-Guzmán, Maria Patricia Ganado, Cecilia Mur, Carlos Marugan, Carmen Baquero, Yanzhu Yang, Yi Zeng, Huimin Bian, Jian Du, Alfonso de Dios, Oscar Puig, María José Lallena

Published Jun 22, 2022 · Vol. 13, No. 1 · pp. 864-875

Keywords: abemaciclib, breast cancer, cell lines, CDK4/6, continuous dosing

Proteomic analysis reveals dual requirement for Grb2 and PLCγ1 interactions for BCR-FGFR1-Driven 8p11 cell proliferation Research Paper

Malalage N. Peiris, April N. Meyer, Dalida Warda, Alexandre Rosa Campos, Daniel J. Donoghue

Published Apr 27, 2022 · Vol. 13, No. 1 · pp. 659-676

Keywords: oncogenic fusion protein, chromosomal translocation, protein interactome, phosphoproteome, stem cell leukemia/lymphoma

Combined treatment with niclosamide and camptothecin enhances anticancer effect in U87 MG human glioblastoma cells Research Paper

Laura Valdez, Benxu Cheng, Daniela Gonzalez, Reanna Rodriguez, Paola Campano, Andrew Tsin, Xiaoqian Fang

Published Apr 22, 2022 · Vol. 13, No. 1 · pp. 642-658

Keywords: glioblastoma, niclosamide, camptothecin, cancer, chemotherapy

The role of IGF-pathway biomarkers in determining risks, screening, and prognosis in lung cancer Review

Alexander W. Pohlman, Hita Moudgalya, Lia Jordano, Gabriela C. Lobato, David Gerard, Michael J. Liptay, Christopher W. Seder, Jeffrey A. Borgia

Published Feb 15, 2022 · Vol. 13, No. 1 · pp. 393-407

Keywords: IGF, lung cancer, biomarkers, screening, prognostication

Telomere shortening accelerates tumor initiation in the L2-IL1B mouse model of Barrett esophagus and emerges as a possible biomarker Research Paper

Vincenz Sahm, Carlo Maurer, Theresa Baumeister, Akanksha Anand, Julia Strangmann, Roland M. Schmid, Timothy C. Wang, Michael Quante

Published Feb 10, 2022 · Vol. 13, No. 1 · pp. 347-359

Keywords: Barrett's esophagus, telomere shortening, esophageal cancer, risk factor, TERT/TERC

PACER lncRNA regulates COX-2 expression in lung cancer cells Research Paper

Samuel Z. Desind, Joseph R. Iacona, Christina Y. Yu, Antonina Mitrofanova, Carol S. Lutz

Published Jan 29, 2022 · Vol. 13, No. 1 · pp. 291-306

Keywords: PACER, COX-2, PGE₂, lung adenocarcinoma, inflammation

GZ17-6.02 and axitinib interact to kill renal carcinoma cells Research Paper

Laurence Booth, Cameron West, Robert P. Moore, Daniel Von Hoff, Paul Dent

Published Jan 28, 2022 · Vol. 13, No. 1 · pp. 281-290

Keywords: GZ17-6.02, axitinib, renal cell carcinoma, autophagy, HDAC

GZ17-6.02 and palbociclib interact to kill ER+ breast cancer cells Research Paper

Laurence Booth, Cameron West, Robert P. Moore, Daniel Von Hoff, Paul Dent

Published Jan 6, 2022 · Vol. 13, No. 1 · pp. 92-104

Keywords: GZ17-6.02, palbociclib, 5FU, autophagy, breast cancer

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Deconstructing the role of MALAT1 in MAPK-signaling in melanoma: insights from antisense oligonucleotide treatment Research Paper

Decoding the mechanism behind MCL-1 inhibitors: A pathway to understanding MCL-1 protein stability Editorial

Role of creatine shuttle in colorectal cancer cells Research Paper

G-protein-coupled receptor 141 mediates breast cancer proliferation and metastasis by regulating oncogenic mediators and the p-mTOR/p53 axis Research Paper

Differential silencing of STAT3 isoforms leads to changes in STAT3 activation Research Paper

Impact of SHP2 tyrosine phosphorylation on the development of acquired resistance to allosteric SHP2 inhibitors Editorial

AGO2 in T-prolymphocytic leukemia: its canonical and non-canonical deregulation and function Editorial

The “extreme phenotype approach” applied to male breast cancer allows the identification of rare variants of ATR as potential breast cancer susceptibility alleles Research Paper

Everolimus downregulates STAT3/HIF-1α/VEGF pathway to inhibit angiogenesis and lymphangiogenesis in TP53 mutant head and neck squamous cell carcinoma (HNSCC) Research Paper

Candidate drugs associated with sensitivity of cancer cell lines with DLST amplification or high mRNA levels Research Paper

HDAC inhibitors suppress protein poly(ADP-ribosyl)ation and DNA repair protein levels and phosphorylation status in hematologic cancer cells: implications for their use in combination with PARP inhibitors and chemotherapeutic drugs Research Paper

Kinase activity profiling in renal cell carcinoma, benign renal tissue and in response to four different tyrosine kinase inhibitors Research Paper

Continuous treatment with abemaciclib leads to sustained and efficient inhibition of breast cancer cell proliferation Research Paper

Proteomic analysis reveals dual requirement for Grb2 and PLCγ1 interactions for BCR-FGFR1-Driven 8p11 cell proliferation Research Paper

Combined treatment with niclosamide and camptothecin enhances anticancer effect in U87 MG human glioblastoma cells Research Paper

The role of IGF-pathway biomarkers in determining risks, screening, and prognosis in lung cancer Review

Telomere shortening accelerates tumor initiation in the L2-IL1B mouse model of Barrett esophagus and emerges as a possible biomarker Research Paper

PACER lncRNA regulates COX-2 expression in lung cancer cells Research Paper

GZ17-6.02 and axitinib interact to kill renal carcinoma cells Research Paper

GZ17-6.02 and palbociclib interact to kill ER+ breast cancer cells Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Deconstructing the role of MALAT1 in MAPK-signaling in melanoma: insights from antisense oligonucleotide treatment Research Paper

Decoding the mechanism behind MCL-1 inhibitors: A pathway to understanding MCL-1 protein stability Editorial

Role of creatine shuttle in colorectal cancer cells Research Paper

G-protein-coupled receptor 141 mediates breast cancer proliferation and metastasis by regulating oncogenic mediators and the p-mTOR/p53 axis Research Paper

Differential silencing of STAT3 isoforms leads to changes in STAT3 activation Research Paper

Impact of SHP2 tyrosine phosphorylation on the development of acquired resistance to allosteric SHP2 inhibitors Editorial

AGO2 in T-prolymphocytic leukemia: its canonical and non-canonical deregulation and function Editorial

The “extreme phenotype approach” applied to male breast cancer allows the identification of rare variants of ATR as potential breast cancer susceptibility alleles Research Paper

Everolimus downregulates STAT3/HIF-1α/VEGF pathway to inhibit angiogenesis and lymphangiogenesis in TP53 mutant head and neck squamous cell carcinoma (HNSCC) Research Paper

Candidate drugs associated with sensitivity of cancer cell lines with DLST amplification or high mRNA levels Research Paper

HDAC inhibitors suppress protein poly(ADP-ribosyl)ation and DNA repair protein levels and phosphorylation status in hematologic cancer cells: implications for their use in combination with PARP inhibitors and chemotherapeutic drugs Research Paper

Kinase activity profiling in renal cell carcinoma, benign renal tissue and in response to four different tyrosine kinase inhibitors Research Paper

Continuous treatment with abemaciclib leads to sustained and efficient inhibition of breast cancer cell proliferation Research Paper

Proteomic analysis reveals dual requirement for Grb2 and PLCγ1 interactions for BCR-FGFR1-Driven 8p11 cell proliferation Research Paper

Combined treatment with niclosamide and camptothecin enhances anticancer effect in U87 MG human glioblastoma cells Research Paper

The role of IGF-pathway biomarkers in determining risks, screening, and prognosis in lung cancer Review

Telomere shortening accelerates tumor initiation in the L2-IL1B mouse model of Barrett esophagus and emerges as a possible biomarker Research Paper

PACER lncRNA regulates COX-2 expression in lung cancer cells Research Paper

GZ17-6.02 and axitinib interact to kill renal carcinoma cells Research Paper

GZ17-6.02 and palbociclib interact to kill ER+ breast cancer cells Research Paper