The Oncosearch | Oncotarget

Caveolin-1 Y14 phosphorylation suppresses tumor growth while promoting invasion Research Paper

Bharat Joshi, Judy Pawling, Jay Shankar, Karina Pacholczyk, Yohan Kim, Wynn Tran, Fanrui Meng, Anas M. Abdel Rahman, Leonard J. Foster, Hon S. Leong, James W. Dennis, Ivan R. Nabi

Published Nov 19, 2019 · Vol. 10, No. 62 · pp. 6668-6677

Keywords: caveolin-1, TP53, tumor suppressor, tumor cell metabolism, invadopodia

MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma Priority Research Paper

David King, Xiao Dun Li, Gilberto S. Almeida, Colin Kwok, Polly Gravells, Daniel Harrison, Saoirse Burke, Albert Hallsworth, Yann Jamin, Sally George, Simon P. Robinson, Christopher J. Lord, Evon Poon, Daniel Yeomanson, Louis Chesler, Helen E. Bryant

Published Nov 6, 2019 · Vol. 11, No. 23 · pp. 2141-2159

Keywords: PARP inhibitor, neuroblastoma, MYCN, replication stress, replication fork stalling

Volasertib preclinical activity in high-risk hepatoblastoma Research Paper

Dina Kats, Cora A. Ricker, Noah E. Berlow, Bénédicte Noblet, Delphine Nicolle, Katell Mevel, Sophie Branchereau, Jean-Gabriel Judde, Cody D. Stiverson, Christina L. Stiverson, Matthew N. Svalina, Teagan Settelmeyer, Kevin Matlock, Melvin Lathara, Charlotte Mussini, James I. Geller, Christopher Noakes, Ido Sloma, Narendra Bharathy, Stefano Cairo, Charles Keller

Published Nov 5, 2019 · Vol. 10, No. 60 · pp. 6403-6417

Keywords: hepatoblastoma, PLK1, volasertib, liver, cell cycle

Efficacy and safety of buparlisib, a PI3K inhibitor, in patients with malignancies harboring a PI3K pathway activation: a phase 2, open-label, single-arm study Research Paper

Sarina A. Piha-Paul, Matthew H. Taylor, Daniel Spitz, Lee Schwartzberg, J. Thaddeus Beck, Todd M. Bauer, Funda Meric-Bernstam, Das Purkayastha, Linda Karpiak, Sebastian Szpakowski, Fadi Braiteh

Published Nov 5, 2019 · Vol. 10, No. 60 · pp. 6526-6535

Keywords: phosphatidylinositol 3-kinase pathway, buparlisib, advanced malignancies, molecular selection, tissue agnostic

Randomized phase 3 open label study of quality of life of patients on Pemetrexed versus Erlotinib as maintenance therapy for advanced non squamous non EGFR mutated non small cell lung cancer Research Paper

Vijay Patil, Amit Joshi, Vanita Noronha, Vivek Agarwala, Anuradha Chougule, Sadhana Kanan, Atanu Bhattacharjee, Arun Chandrasekharan, Nikhil Pande, Vijai Simha, Supriya Goud, Sucheta More, Rajiv Kumar, Abhishek Mahajan, Amit Janu, Nilendu Purandare, Kumar Prabhash

Published Oct 29, 2019 · Vol. 10, No. 59 · pp. 6297-6307

Keywords: maintenance, pemetrexed, erlotinib, NSCLC

Central nervous system-specific efficacy of CDK4/6 inhibitors in randomized controlled trials for metastatic breast cancer Research Paper

Long V. Nguyen, Karlee Searle, Katarzyna J. Jerzak

Published Oct 29, 2019 · Vol. 10, No. 59 · pp. 6317-6322

Keywords: breast neoplasms, blood-brain barrier, palbociclib, ribociclib, abemaciclib

Correction: SETD2 loss sensitizes cells to PI3Kβ and AKT inhibition Correction

Esteban A. Terzo, Aaron R. Lim, Anna Chytil, Yun Chen Chiang, Leah Farmer, Kathryn H. Gessner, Cheryl Lyn Walker, Valerie M. Jansen, W. Kimryn Rathmell

Published Oct 22, 2019 · Vol. 10, No. 59 · pp. 6391-6392

The phenanthrene derivative PJ34 exclusively eradicates human pancreatic cancer cells in xenografts Research Paper

Leonid Visochek, Dikla Atias, Itay Spektor, Asher Castiel, Talia Golan, Malka Cohen-Armon

Published Oct 22, 2019 · Vol. 10, No. 58 · pp. 6269-6282

Keywords: PJ34, pancreas cancer, stroma, PANC1 cancer xenografts

Mechanisms by which PE21, an extract from the white willow Salix alba, delays chronological aging in budding yeast Research Paper

Younes Medkour, Karamat Mohammad, Anthony Arlia-Ciommo, Veronika Svistkova, Pamela Dakik, Darya Mitrofanova, Monica Enith Lozano Rodriguez, Jennifer Anne Baratang Junio, Tarek Taifour, Paola Escudero, Fani-Fay Goltsios, Sahar Soodbakhsh, Hana Maalaoui, Éric Simard, Vladimir I. Titorenko

Published Oct 8, 2019 · Vol. 10, No. 56 · pp. 5780-5816

Keywords: cellular aging, geroprotectors, lipid metabolism, necrotic cell death, mitochondria

GCN5 HAT inhibition reduces human Burkitt lymphoma cell survival through reduction of MYC target gene expression and impeding BCR signaling pathways Research Paper

Aimee T. Farria, Lisa Maria Mustachio, Zeynep H. Coban Akdemir, Sharon Y.R. Dent

Published Oct 8, 2019 · Vol. 10, No. 56 · pp. 5847-5858

Keywords: GCN5, MYC, lymphoma, BCR

Encyclopedic tumor analysis for guiding treatment of advanced, broadly refractory cancers: results from the RESILIENT trial Research Paper

Rajnish Nagarkar, Darshana Patil, Timothy Crook, Vineet Datta, Sagar Bhalerao, Sonal Dhande, Vijay Palwe, Shirsendu Roy, Prakash Pandit, Ashwini Ghaisas, Raymond Page, Harjeetsingh Kathuria, Ajay Srinivasan, Dadasaheb Akolkar

Published Sep 24, 2019 · Vol. 10, No. 54 · pp. 5605-5621

Keywords: precision oncology, encyclopedic tumor analysis, personalized cancer treatment, objective response rate, progression free survival

Anti-VEGFR2 therapy delays growth of preclinical pediatric tumor models and enhances anti-tumor activity of chemotherapy Research Paper

Caitlin D. Lowery, Wayne Blosser, Michele Dowless, Matthew Renschler, Lisa V. Perez, Jennifer Stephens, Bronislaw Pytowski, Heather Wasserstrom, Louis F. Stancato, Beverly Falcon

Published Sep 17, 2019 · Vol. 10, No. 53 · pp. 5523-5533

Keywords: angiogenesis, pediatric cancer, VEGFR2, ramucirumab, DC101

The effects of focal adhesion kinase and platelet-derived growth factor receptor beta inhibition in a patient-derived xenograft model of primary and metastatic Wilms tumor Research Paper

Jamie M. Aye, Laura L. Stafman, Adele P. Williams, Evan F. Garner, Jerry E. Stewart, Joshua C. Anderson, Smitha Mruthyunjayappa, Mary G. Waldrop, Caroline D. Goolsby, Hooper R. Markert, Colin Quinn, Raoud Marayati, Elizabeth Mroczek-Musulman, Christopher D. Willey, Karina J. Yoon, Kimberly F. Whelan, Elizabeth A. Beierle

Published Sep 17, 2019 · Vol. 10, No. 53 · pp. 5534-5548

Keywords: kinase inhibition, Wilms tumor

Mechanisms by which PE21, an extract from the white willow Salix alba, delays chronological aging in budding yeast Research Paper

Younes Medkour, Karamat Mohammad, Anthony Arlia-Ciommo, Veronika Svistkova, Pamela Dakik, Darya Mitrofanova, Monica Enith Lozano Rodriguez, Jennifer Anne Baratang Junio, Tarek Taifour, Paola Escudero, Fani-Fay Goltsios, Sahar Soodbakhsh, Hana Maalaoui, Éric Simard, Vladimir I. Titorenko

Published Sep 5, 2019

Keywords: cellular aging, geroprotectors, lipid metabolism, necrotic cell death, mitochondria

Genome-wide miRNA profiling and pivotal roles of miRs 125a-5p and 17-92 cluster in human neutrophil maturation and differentiation of acute myeloid leukemia cells Research Paper

El-Habib Dakir, Faustino Mollinedo

Published Sep 3, 2019 · Vol. 10, No. 51 · pp. 5313-5331

Keywords: miRNA, miR-125a-5p, miR-17-92, neutrophil differentiation, human

Deep insights into the response of human cervical carcinoma cells to a new cyano enone-bearing triterpenoid soloxolone methyl: a transcriptome analysis Research Paper

Andrey V. Markov, Alexander E. Kel, Oksana V. Salomatina, Nariman F. Salakhutdinov, Marina A. Zenkova, Evgeniya B. Logashenko

Published Sep 3, 2019 · Vol. 10, No. 51 · pp. 5267-5297

Keywords: soloxolone methyl, cervical carcinoma, CDDO-Me, cytoscape, mechanism of action

TAK228 enhances antitumor activity of eribulin in triple negative breast cancer Research Paper

Nicci Owusu-Brackett, Kurt W. Evans, Argun Akcakanat, Erkan Yuca, Coya Tapia, Yasmeen Qamar Rizvi, Ecaterina Ileana Dumbrava, Filip Janku, Funda Meric-Bernstam

Published Aug 20, 2019 · Vol. 10, No. 49 · pp. 5011-5019

Keywords: breast cancer, TAK228, PI3K, PTEN, TNBC

Combinatorial drug screening of mammary cells with induced mesenchymal transformation to identify drug combinations for triple-negative breast cancer Research Paper

Sierra A. Colavito, James T. Platt, Matthew A. Held, Zongzhi Liu, Ryan Sokup, David F. Stern

Published Aug 6, 2019 · Vol. 10, No. 47 · pp. 4822-4839

Keywords: epithelial-mesenchymal transition, triple-negative breast cancer, targeted drug combination screen, claudin-low breast cancer, CHK1

Folic acid supplementation acts as a chemopreventive factor in tumorigenesis of hepatocellular carcinoma by inducing H3K9Me2-dependent transcriptional repression of LCN2 Research Paper

Yin-Ling Zhang, Geng Xue, Hui Miao, Chuan-Chuan Zhou, Shu-Han Sun, Yi Zhang

Published Jul 29, 2019 · Vol. 12, No. 4 · pp. 366-378

Keywords: folic acid, hepatocarcinogenesis, chemoprevention, LCN2, H3K9Me2

Targeting cyclin-dependent kinase 9 by a novel inhibitor enhances radiosensitization and identifies Axl as a novel downstream target in esophageal adenocarcinoma Research Paper

Omkara Lakshmi Veeranki, Zhimin Tong, Rashmi Dokey, Alicia Mejia, Jianhu Zhang, Yawei Qiao, Pankaj Kumar Singh, Riham Katkhuda, Barbara Mino, Ramesh Tailor, Jaime Rodriguez Canales, Roland Bassett, Jaffer Ajani, Ji Yuan Wu, Scott Kopetz, Mariela Blum, Wayne Hofstetter, Michael Tetzlaff, Sunil Krishnan, Steven H. Lin, Dipen Maru

Published Jul 23, 2019 · Vol. 10, No. 45 · pp. 4703-4718

Keywords: CDK 9 Inhibitor, esophageal adenocarcinoma, radiation, Axl

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Caveolin-1 Y14 phosphorylation suppresses tumor growth while promoting invasion Research Paper

MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma Priority Research Paper

Volasertib preclinical activity in high-risk hepatoblastoma Research Paper

Efficacy and safety of buparlisib, a PI3K inhibitor, in patients with malignancies harboring a PI3K pathway activation: a phase 2, open-label, single-arm study Research Paper

Randomized phase 3 open label study of quality of life of patients on Pemetrexed versus Erlotinib as maintenance therapy for advanced non squamous non EGFR mutated non small cell lung cancer Research Paper

Central nervous system-specific efficacy of CDK4/6 inhibitors in randomized controlled trials for metastatic breast cancer Research Paper

Correction: SETD2 loss sensitizes cells to PI3Kβ and AKT inhibition Correction

The phenanthrene derivative PJ34 exclusively eradicates human pancreatic cancer cells in xenografts Research Paper

Mechanisms by which PE21, an extract from the white willow Salix alba, delays chronological aging in budding yeast Research Paper

GCN5 HAT inhibition reduces human Burkitt lymphoma cell survival through reduction of MYC target gene expression and impeding BCR signaling pathways Research Paper

Encyclopedic tumor analysis for guiding treatment of advanced, broadly refractory cancers: results from the RESILIENT trial Research Paper

Anti-VEGFR2 therapy delays growth of preclinical pediatric tumor models and enhances anti-tumor activity of chemotherapy Research Paper

The effects of focal adhesion kinase and platelet-derived growth factor receptor beta inhibition in a patient-derived xenograft model of primary and metastatic Wilms tumor Research Paper

Mechanisms by which PE21, an extract from the white willow Salix alba, delays chronological aging in budding yeast Research Paper

Genome-wide miRNA profiling and pivotal roles of miRs 125a-5p and 17-92 cluster in human neutrophil maturation and differentiation of acute myeloid leukemia cells Research Paper

Deep insights into the response of human cervical carcinoma cells to a new cyano enone-bearing triterpenoid soloxolone methyl: a transcriptome analysis Research Paper

TAK228 enhances antitumor activity of eribulin in triple negative breast cancer Research Paper

Combinatorial drug screening of mammary cells with induced mesenchymal transformation to identify drug combinations for triple-negative breast cancer Research Paper

Folic acid supplementation acts as a chemopreventive factor in tumorigenesis of hepatocellular carcinoma by inducing H3K9Me2-dependent transcriptional repression of LCN2 Research Paper

Targeting cyclin-dependent kinase 9 by a novel inhibitor enhances radiosensitization and identifies Axl as a novel downstream target in esophageal adenocarcinoma Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Caveolin-1 Y14 phosphorylation suppresses tumor growth while promoting invasion Research Paper

MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma Priority Research Paper

Volasertib preclinical activity in high-risk hepatoblastoma Research Paper

Efficacy and safety of buparlisib, a PI3K inhibitor, in patients with malignancies harboring a PI3K pathway activation: a phase 2, open-label, single-arm study Research Paper

Randomized phase 3 open label study of quality of life of patients on Pemetrexed versus Erlotinib as maintenance therapy for advanced non squamous non EGFR mutated non small cell lung cancer Research Paper

Central nervous system-specific efficacy of CDK4/6 inhibitors in randomized controlled trials for metastatic breast cancer Research Paper

Correction: SETD2 loss sensitizes cells to PI3Kβ and AKT inhibition Correction

The phenanthrene derivative PJ34 exclusively eradicates human pancreatic cancer cells in xenografts Research Paper

Mechanisms by which PE21, an extract from the white willow Salix alba, delays chronological aging in budding yeast Research Paper

GCN5 HAT inhibition reduces human Burkitt lymphoma cell survival through reduction of MYC target gene expression and impeding BCR signaling pathways Research Paper

Encyclopedic tumor analysis for guiding treatment of advanced, broadly refractory cancers: results from the RESILIENT trial Research Paper

Anti-VEGFR2 therapy delays growth of preclinical pediatric tumor models and enhances anti-tumor activity of chemotherapy Research Paper

The effects of focal adhesion kinase and platelet-derived growth factor receptor beta inhibition in a patient-derived xenograft model of primary and metastatic Wilms tumor Research Paper

Mechanisms by which PE21, an extract from the white willow Salix alba, delays chronological aging in budding yeast Research Paper

Genome-wide miRNA profiling and pivotal roles of miRs 125a-5p and 17-92 cluster in human neutrophil maturation and differentiation of acute myeloid leukemia cells Research Paper

Deep insights into the response of human cervical carcinoma cells to a new cyano enone-bearing triterpenoid soloxolone methyl: a transcriptome analysis Research Paper

TAK228 enhances antitumor activity of eribulin in triple negative breast cancer Research Paper

Combinatorial drug screening of mammary cells with induced mesenchymal transformation to identify drug combinations for triple-negative breast cancer Research Paper

Folic acid supplementation acts as a chemopreventive factor in tumorigenesis of hepatocellular carcinoma by inducing H3K9Me2-dependent transcriptional repression of LCN2 Research Paper

Targeting cyclin-dependent kinase 9 by a novel inhibitor enhances radiosensitization and identifies Axl as a novel downstream target in esophageal adenocarcinoma Research Paper