The Oncosearch | Oncotarget

Multi-modal effects of 1B3, a novel synthetic miR-193a-3p mimic, support strong potential for therapeutic intervention in oncology Research Paper

Bryony J. Telford, Sanaz Yahyanejad, Thijs de Gunst, Harm C. den Boer, Rogier M. Vos, Marieke Stegink, Marion T.J. van den Bosch, Mir Farshid Alemdehy, Laurens A.H. van Pinxteren, Roel Q.J. Schaapveld, Michel Janicot

Published Feb 7, 2021 · Vol. 12, No. 5 · pp. 422-439

Keywords: miR-193a-3p, microRNA mimic, microRNA delivery in vivo, pleiotropic mechanism of microRNA,

Phase 1 study of Z-endoxifen in patients with advanced gynecologic, desmoid, and hormone receptor-positive solid tumors Research Paper

Naoko Takebe, Geraldine O'Sullivan Coyne, Shivaani Kummar, Jerry Collins, Joel M. Reid, Richard Piekarz, Nancy Moore, Lamin Juwara, Barry C. Johnson, Rachel Bishop, Frank I. Lin, Esther Mena, Peter L. Choyke, M. Liza Lindenberg, Larry V. Rubinstein, Cecilia Monge Bonilla, Matthew P. Goetz, Matthew M. Ames, Renee M. McGovern, Howard Streicher, Joseph M. Covey, James H. Doroshow, Alice P. Chen

Published Feb 1, 2021 · Vol. 12, No. 4 · pp. 268-277

Keywords: Z-endoxifen, phase 1, tamoxifen, pharmacokinetics

Downregulation of SOX2 by inhibition of Usp9X induces apoptosis in melanoma Research Paper

Harish Potu, Malathi Kandarpa, Luke F. Peterson, Alison Durham, Nicholas J. Donato, Moshe Talpaz

Published Jan 12, 2021 · Vol. 12, No. 3 · pp. 160-172

Keywords: melanoma, deubiquitinase (DUB) enzyme, transcription factors, USP9X, DUB inhibitor

Drug resistant cells with very large proliferative potential grow exponentially in metastatic prostate cancer Research Paper

Krastan B. Blagoev, Roumen Iordanov, Mengxi Zhou, Tito Fojo, Susan E. Bates

Published Dec 19, 2020 · Vol. 12, No. 1 · pp. 15-21

Keywords: drug resistance, metastatic prostate cancer, exponential growth, tumor kinetics, cancer stem cells

MicroRNA-4287 is a novel tumor suppressor microRNA controlling epithelial-to mesenchymal transition in prostate cancer Research Paper

Divya Bhagirath, Thao Ly Yang, Theresa Akoto, Nikhil Patel, Laura Z. Tabatabai, Sharanjot Saini

Published Dec 15, 2020 · Vol. 11, No. 51 · pp. 4681-4692

Keywords: miR-4287, prostate cancer, chromosome 8p, EMT, SLUG

Amalgamation of PI3K and EZH2 blockade synergistically regulates invasion and angiogenesis: combination therapy for glioblastoma multiforme Research Paper

Vishnu S. Mishra, Naveen Kumar, Masoom Raza, Seema Sehrawat

Published Dec 2, 2020 · Vol. 11, No. 51 · pp. 4754-4769

Keywords: precision neuroOncology, combination therapy, glioblastoma multiforme, pharmacological intervention, cytokine based proteomics

miR-708-5p enhances erlotinib/paclitaxel efficacy and overcomes chemoresistance in lung cancer cells Research Paper

Nicholas J. Monteleone, Carol S. Lutz

Published Dec 1, 2020 · Vol. 11, No. 51 · pp. 4699-4721

Keywords: miR-708-5p, miR-708, erlotinib, paclitaxel, chemoresistance

Alphastatin-C a new inhibitor of endothelial cell activation is a pro-arteriogenic agent in vivo and retards B16-F10 melanoma growth in a preclinical model Research Paper

Adilson Kleber Ferreira, Brunella Cristofaro, Milene Cristina Menezes, Ana Karina de Oliveira, Alexandre Keiji Tashima, Robson Lopes de Melo, Cristiane Castilho Fernandes Silva, Miryam Guillermina Palomino Rodriguez, Daniela Cajado de Oliveira Souza Carvalho, Ricardo Alexandre de Azevedo, Paulo Luiz de Sá Junior, Lisley Inata Mambelli, Fernanda Vieira Portaro, Luc Pardanaud, Anne Eichmann, Osvaldo Augusto Sant’Anna, Mxarcella Faria

Published Nov 30, 2020 · Vol. 11, No. 51 · pp. 4770-4787

Keywords: alphastatin-C, angiogenesis, peptides, melanoma, angiostatic

Immune-stimulatory (TK/Flt3L) gene therapy opens the door to a promising new treatment strategy against brainstem gliomas Research Perspective

Syed M. Faisal, Flor M. Mendez, Fernando Nunez, Maria G. Castro, Pedro R. Lowenstein

Published Nov 27, 2020 · Vol. 11, No. 50 · pp. 4607-4612

Keywords: immunotherapy, gene therapy, thymidine kinase, Flt3L, DIPG

Auto-antibodies against apolipoprotein A-1 block cancer cells proliferation and induce apoptosis Research Paper

Nathalie Satta, Rémy Weppe, Sabrina Pagano, Miguel Frias, Catherine Juillard, Nicolas Vuilleumier

Published Nov 7, 2020 · Vol. 11, No. 46 · pp. 4266-4280

Keywords: anti-apoA-1 antibodies, apoptose, cell proliferation, oxidative stress

A case series of advanced renal cell carcinoma patients treated with neoadjuvant cabozantinib prior to cytoreductive nephrectomy within the phase 2 CABOPRE trial Case Report

Guillermo de Velasco, Lucia Carril-Ajuria, Felix Guerrero-Ramos, Teresa Alonso-Gordoa, Juan F. Rodríguez-Moreno, Alberto Carretero, Maricruz Martin-Soberon, Federico de la Rosa-Kehrmann, Daniel Castellano

Published Nov 4, 2020 · Vol. 11, No. 47 · pp. 4457-4462

Keywords: kidney cancer, renal cell carcinoma, neoadjuvant treatment, cabozantinib, trial

Phase I dose escalation study of 12b80 (hydroxybisphosphonate linked doxorubicin) in naturally occurring osteosarcoma Research Paper

Pierre Boyé, Emmanuelle David, François Serres, Quentin Pascal, Franck Floch, Kévyn Geeraert, Virginie Coste, Laurent Marescaux, Sébastien Cagnol, Jean-Yves Goujon, Maxim Egorov, Ronan Le Bot, Dominique Tierny

Published Nov 3, 2020 · Vol. 11, No. 46 · pp. 4281-4292

Keywords: bisphosphonate, bone targeting, canine, doxorubicin, osteosarcoma

T-cell redirecting bispecific antibodies targeting BCMA for the treatment of multiple myeloma Research Perspective

Christie P.M. Verkleij, Kristine A. Frerichs, Marloes Broekmans, Saida Absalah, Patricia W.C. Maas-Bosman, Sandy Kruyswijk, Inger S. Nijhof, Tuna Mutis, Sonja Zweegman, Niels W.C.J. van de Donk

Published Oct 24, 2020 · Vol. 11, No. 45 · pp. 4076-4081

Keywords: multiple myeloma, bispecific antibody, immunotherapy, BCMA, CD38

Phase I trial of TRC102 (methoxyamine HCl) in combination with temozolomide in patients with relapsed solid tumors and lymphomas Research Paper

Geraldine O'Sullivan Coyne, Shivaani Kummar, Robert S. Meehan, Khanh Do, Jerry M. Collins, Larry Anderson, Kazusa Ishii, Naoko Takebe, Jennifer Zlott, Lamin Juwara, Richard Piekarz, Howard Streicher, Elad Sharon, Larry Rubinstein, Andrea Regier Voth, Jay Lozier, Angie B. Dull, Deborah Wilsker, Toshinori Hinoue, Peter W. Laird, Katherine V. Ferry-Galow, Robert J. Kinders, Ralph E. Parchment, James H. Doroshow, Alice P. Chen

Published Oct 12, 2020 · Vol. 11, No. 44 · pp. 3959-3971

Keywords: DNA damage repair, base excision repair, MGMT, rational combination therapy, molecular pharmacodynamics

Regulation of breast cancer oncogenesis by the cell of origin’s differentiation state Research Paper

Sarah C. Petrova, Ihsaan Ahmad, Christine Nguyen, Stuart D. Ferrell Jr, Sabrina R. Wilhelm, Yin Ye, Sanford H. Barsky

Published Oct 10, 2020 · Vol. 11, No. 43 · pp. 3832-3848

Keywords: transgenic mice, induced pluripotent stem cells (iPSCs), breast oncogenesis, differentiation

Evidence for functional and regulatory cross-talk between Wnt/β-catenin signalling and Mre11–Rad50–Nbs1 complex in the repair of cisplatin-induced DNA cross-links Research Paper

Sanjeev Pasadi, Kalappa Muniyappa

Published Oct 7, 2020 · Vol. 11, No. 44 · pp. 4028-4044

Keywords: cancer, cisplatin resistance, cisplatin-induced DNA crosslinks, Wnt/β-catenin signalling, Mre11–Rad50–Nbs1 complex

Targeting an engineered cytokine with interleukin-2 and interleukin-15 activity to the neovasculature of solid tumors Research Paper

Michael R. Mortensen, Jacqueline Mock, Marco Bertolini, Marco Stringhini, Marco Catalano, Dario Neri

Published Oct 6, 2020 · Vol. 11, No. 44 · pp. 3972-3983

Keywords: immunotherapy, immunocytokines, EDB of fibronectin, antibody-cytokine fusion proteins, engineered cytokine

Laser speckle flowgraphy in juxtapapillary retinal capillary hemangioblastoma: a case report on natural course and therapeutic effect Case Report

Mizuho Mitamura, Satoru Kase, Kiriko Hirooka, Susumu Ishida

Published Oct 6, 2020 · Vol. 11, No. 42 · pp. 3800-3804

Keywords: juxtapapillary retinal capillary hemangioblastoma, laser photocoagulation, laser speckle flowgraphy, fluorescein angiography, von Hippel-Lindau disease

Simvastatin is a potential candidate drug in ovarian clear cell carcinomas Research Paper

Nicolai Skovbjerg Arildsen, Ingrid Hedenfalk

Published Sep 8, 2020 · Vol. 11, No. 40 · pp. 3660-3674

Keywords: ovarian clear cell cancer, simvastatin, CID-1067700, Rho GTPase, actin

Novel combination therapy for melanoma induces apoptosis via a gap junction positive feedback mechanism Research Paper

Archis Bagati, Timothy C. Hutcherson, Zethan Koch, Joseph Pechette, Hossein Dianat, Cory Higley, Lisa Chiu, Yesul Song, Jay Shah, Elana Chazen, Andrew Nicolais, Peter Casey, Kyle Thompson, Kevin Burke, Mikhail A. Nikiforov, Jennifer Zirnheld, Shoshanna N. Zucker

Published Aug 27, 2020 · Vol. 11, No. 37 · pp. 3443-3458

Keywords: non-thermal plasma, gap junction, tirapazamine, melanoma, intercellular communication

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Multi-modal effects of 1B3, a novel synthetic miR-193a-3p mimic, support strong potential for therapeutic intervention in oncology Research Paper

Phase 1 study of Z-endoxifen in patients with advanced gynecologic, desmoid, and hormone receptor-positive solid tumors Research Paper

Downregulation of SOX2 by inhibition of Usp9X induces apoptosis in melanoma Research Paper

Drug resistant cells with very large proliferative potential grow exponentially in metastatic prostate cancer Research Paper

MicroRNA-4287 is a novel tumor suppressor microRNA controlling epithelial-to mesenchymal transition in prostate cancer Research Paper

Amalgamation of PI3K and EZH2 blockade synergistically regulates invasion and angiogenesis: combination therapy for glioblastoma multiforme Research Paper

miR-708-5p enhances erlotinib/paclitaxel efficacy and overcomes chemoresistance in lung cancer cells Research Paper

Alphastatin-C a new inhibitor of endothelial cell activation is a pro-arteriogenic agent in vivo and retards B16-F10 melanoma growth in a preclinical model Research Paper

Immune-stimulatory (TK/Flt3L) gene therapy opens the door to a promising new treatment strategy against brainstem gliomas Research Perspective

Auto-antibodies against apolipoprotein A-1 block cancer cells proliferation and induce apoptosis Research Paper

A case series of advanced renal cell carcinoma patients treated with neoadjuvant cabozantinib prior to cytoreductive nephrectomy within the phase 2 CABOPRE trial Case Report

Phase I dose escalation study of 12b80 (hydroxybisphosphonate linked doxorubicin) in naturally occurring osteosarcoma Research Paper

T-cell redirecting bispecific antibodies targeting BCMA for the treatment of multiple myeloma Research Perspective

Phase I trial of TRC102 (methoxyamine HCl) in combination with temozolomide in patients with relapsed solid tumors and lymphomas Research Paper

Regulation of breast cancer oncogenesis by the cell of origin’s differentiation state Research Paper

Evidence for functional and regulatory cross-talk between Wnt/β-catenin signalling and Mre11–Rad50–Nbs1 complex in the repair of cisplatin-induced DNA cross-links Research Paper

Targeting an engineered cytokine with interleukin-2 and interleukin-15 activity to the neovasculature of solid tumors Research Paper

Laser speckle flowgraphy in juxtapapillary retinal capillary hemangioblastoma: a case report on natural course and therapeutic effect Case Report

Simvastatin is a potential candidate drug in ovarian clear cell carcinomas Research Paper

Novel combination therapy for melanoma induces apoptosis via a gap junction positive feedback mechanism Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Multi-modal effects of 1B3, a novel synthetic miR-193a-3p mimic, support strong potential for therapeutic intervention in oncology Research Paper

Phase 1 study of Z-endoxifen in patients with advanced gynecologic, desmoid, and hormone receptor-positive solid tumors Research Paper

Downregulation of SOX2 by inhibition of Usp9X induces apoptosis in melanoma Research Paper

Drug resistant cells with very large proliferative potential grow exponentially in metastatic prostate cancer Research Paper

MicroRNA-4287 is a novel tumor suppressor microRNA controlling epithelial-to mesenchymal transition in prostate cancer Research Paper

Amalgamation of PI3K and EZH2 blockade synergistically regulates invasion and angiogenesis: combination therapy for glioblastoma multiforme Research Paper

miR-708-5p enhances erlotinib/paclitaxel efficacy and overcomes chemoresistance in lung cancer cells Research Paper

Alphastatin-C a new inhibitor of endothelial cell activation is a pro-arteriogenic agent in vivo and retards B16-F10 melanoma growth in a preclinical model Research Paper

Immune-stimulatory (TK/Flt3L) gene therapy opens the door to a promising new treatment strategy against brainstem gliomas Research Perspective

Auto-antibodies against apolipoprotein A-1 block cancer cells proliferation and induce apoptosis Research Paper

A case series of advanced renal cell carcinoma patients treated with neoadjuvant cabozantinib prior to cytoreductive nephrectomy within the phase 2 CABOPRE trial Case Report

Phase I dose escalation study of 12b80 (hydroxybisphosphonate linked doxorubicin) in naturally occurring osteosarcoma Research Paper

T-cell redirecting bispecific antibodies targeting BCMA for the treatment of multiple myeloma Research Perspective

Phase I trial of TRC102 (methoxyamine HCl) in combination with temozolomide in patients with relapsed solid tumors and lymphomas Research Paper

Regulation of breast cancer oncogenesis by the cell of origin’s differentiation state Research Paper

Evidence for functional and regulatory cross-talk between Wnt/β-catenin signalling and Mre11–Rad50–Nbs1 complex in the repair of cisplatin-induced DNA cross-links Research Paper

Targeting an engineered cytokine with interleukin-2 and interleukin-15 activity to the neovasculature of solid tumors Research Paper

Laser speckle flowgraphy in juxtapapillary retinal capillary hemangioblastoma: a case report on natural course and therapeutic effect Case Report

Simvastatin is a potential candidate drug in ovarian clear cell carcinomas Research Paper

Novel combination therapy for melanoma induces apoptosis via a gap junction positive feedback mechanism Research Paper