The Oncosearch | Oncotarget

MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma Priority Research Paper

David King, Xiao Dun Li, Gilberto S. Almeida, Colin Kwok, Polly Gravells, Daniel Harrison, Saoirse Burke, Albert Hallsworth, Yann Jamin, Sally George, Simon P. Robinson, Christopher J. Lord, Evon Poon, Daniel Yeomanson, Louis Chesler, Helen E. Bryant

Published Nov 6, 2019 · Vol. 11, No. 23 · pp. 2141-2159

Keywords: PARP inhibitor, neuroblastoma, MYCN, replication stress, replication fork stalling

Correction: Frequent amplification of AIB1, a critical oncogene modulating major signaling pathways, is associated with poor survival in gastric cancer Correction

Jing Shi1, Wei Liu, Fang Sui, Rong Lu, Qingyuan He, Qi Yang, Lv Hongjun, Shi Bingyin, Hou Peng

Published Nov 5, 2019

Secretome of pleural effusions associated with non-small cell lung cancer (NSCLC) and malignant mesothelioma: therapeutic implications Research Paper

Albert D. Donnenberg, James D. Luketich, Vera S. Donnenberg

Published Nov 5, 2019 · Vol. 10, No. 60 · pp. 6456-6465

Keywords: pleural effusion, non-small cell lung cancer, malignant mesothelioma, cytokines, IL-6

Efficacy and safety of buparlisib, a PI3K inhibitor, in patients with malignancies harboring a PI3K pathway activation: a phase 2, open-label, single-arm study Research Paper

Sarina A. Piha-Paul, Matthew H. Taylor, Daniel Spitz, Lee Schwartzberg, J. Thaddeus Beck, Todd M. Bauer, Funda Meric-Bernstam, Das Purkayastha, Linda Karpiak, Sebastian Szpakowski, Fadi Braiteh

Published Nov 5, 2019 · Vol. 10, No. 60 · pp. 6526-6535

Keywords: phosphatidylinositol 3-kinase pathway, buparlisib, advanced malignancies, molecular selection, tissue agnostic

Molecular profiling of radical prostatectomy tissue from patients with no sign of progression identifies ERG as the strongest independent predictor of recurrence Research Paper

Wusheng Yan, Muhammad Jamal, Shyh-Han Tan, Yingjie Song, Denise Young, Yongmei Chen, Shilpa Katta, Kai Ying, Lakshmi Ravindranath, Tarah Woodle, Indu Kohaar, Jennifer Cullen, Jacob Kagan, Sudhir Srivastava, Albert Dobi, David G. McLeod, Inger L. Rosner, Isabell A. Sesterhenn, Alagarsamy Srinivasan, Shiv Srivastava, Gyorgy Petrovics

Published Nov 5, 2019 · Vol. 10, No. 60 · pp. 6466-6483

Keywords: prostate cancer, NanoString, prognostic biomarker, biochemical recurrence, ERG

Pre-surgical connectome features predict IDH status in diffuse gliomas Research Paper

Shelli R. Kesler, Rebecca A. Harrison, Melissa L. Petersen, Vikram Rao, Hannah Dyson, Kristin Alfaro-Munoz, Shiao-Pei Weathers, John de Groot

Published Nov 5, 2019 · Vol. 10, No. 60 · pp. 6484-6493

Keywords: MRI, IDH, glioma, machine learning, connectomics

SNiPER: a novel hypermethylation biomarker panel for liquid biopsy based early breast cancer detection Research Paper

Jolein Mijnes, Janina Tiedemann, Julian Eschenbruch, Janina Gasthaus, Sarah Bringezu, Dirk Bauerschlag, Nicolai Maass, Norbert Arnold, Jörg Weimer, Tobias Anzeneder, Peter A. Fasching, Matthias Rübner, Benjamin Bruno, Uwe Heindrichs, Jennifer Freres, Hanna Schulz, Ralf-Dieter Hilgers, Nadina Ortiz-Brüchle, Sonja von Serenyi, Ruth Knüchel, Vera Kloten, Edgar Dahl

Published Nov 5, 2019 · Vol. 10, No. 60 · pp. 6494-6508

Keywords: liquid biopsy, breast cancer, early detection, hypermethylation, discriminative CpG dinucleotides

The anti-cancer effects of phenformin in thyroid cancer cell lines and in normal thyrocytes Research Paper

Francesca Coperchini, Laura Croce, Marco Denegri, Oriana Awwad, Samuel Tata Ngnitejeu, Flavia Magri, Luca Chiovato, Mario Rotondi

Published Nov 5, 2019 · Vol. 10, No. 60 · pp. 6432-6443

Keywords: phenformin, tumor-microenvironment, thyroid cancer, CXCL8

Dynamic transition of the blood-brain barrier in the development of non-small cell lung cancer brain metastases Research Paper

Gozde Uzunalli, Alexandra M. Dieterly, Chinyere M. Kemet, Hsin-Yi Weng, Arvin H. Soepriatna, Craig J. Goergen, Aparna B. Shinde, Michael K. Wendt, L. Tiffany Lyle

Published Oct 29, 2019 · Vol. 10, No. 59 · pp. 6334-6348

Keywords: blood-brain barrier, blood-tumor barrier, non-small cell lung cancer, brain metastasis, aquaporin-4

Randomized phase 3 open label study of quality of life of patients on Pemetrexed versus Erlotinib as maintenance therapy for advanced non squamous non EGFR mutated non small cell lung cancer Research Paper

Vijay Patil, Amit Joshi, Vanita Noronha, Vivek Agarwala, Anuradha Chougule, Sadhana Kanan, Atanu Bhattacharjee, Arun Chandrasekharan, Nikhil Pande, Vijai Simha, Supriya Goud, Sucheta More, Rajiv Kumar, Abhishek Mahajan, Amit Janu, Nilendu Purandare, Kumar Prabhash

Published Oct 29, 2019 · Vol. 10, No. 59 · pp. 6297-6307

Keywords: maintenance, pemetrexed, erlotinib, NSCLC

Investigating the duality of Inpp4b function in the cellular transformation of mouse fibroblasts Research Paper

Emily Marie Mangialardi, Keyue Chen, Brittany Salmon, Jean Vacher, Leonardo Salmena

Published Oct 29, 2019 · Vol. 10, No. 59 · pp. 6378-6390

Keywords: Inpp4b, MEF, RAS, E1A, SV40-T-Large

Correction: A novel therapeutic approach to colorectal cancer in diabetes: role of metformin and rapamycin Correction

Alice Gerges Geagea, Manfredi Rizzo, Abdo Jurjus, Francesco Cappello, Angelo Leone, Giovanni Tomasello, Céline Gracia, Sahar Al Kattar, Liliane Massaad-Massade, Assaad Eid

Published Oct 23, 2019 · Vol. 10, No. 60 · pp. 6538-6539

Correction: MicroRNA-34a expression levels in serum and intratumoral tissue can predict bone metastasis in patients with hepatocellular carcinoma Correction

Zuo-Lin Xiang, Xiao-Mei Zhao, Li Zhang, Ping Yang, Jia Fan, Zhao-You Tang, Zhao-Chong Zeng

Published Oct 23, 2019 · Vol. 10, No. 59 · pp. 6398-6399

Integrated copy number and miRNA expression analysis in triple negative breast cancer of Latin American patients Research Paper

Bruna M. Sugita, Silma R. Pereira, Rodrigo C. de Almeida, Mandeep Gill, Akanksha Mahajan, Anju Duttargi, Saurabh Kirolikar, Paolo Fadda, Rubens S. de Lima, Cicero A. Urban, Kepher Makambi, Subha Madhavan, Simina M. Boca, Yuriy Gusev, Iglenir J. Cavalli, Enilze M.S.F. Ribeiro, Luciane R. Cavalli

Published Oct 22, 2019 · Vol. 10, No. 58 · pp. 6184-6203

Keywords: microRNA, triple-negative breast cancer, copy number, latinas, disparities

Differential gene expression analysis of HNSCC tumors deciphered tobacco dependent and independent molecular signatures Research Paper

Inayatullah Shaikh, Afzal Ansari, Garima Ayachit, Monika Gandhi, Priyanka Sharma, Shivarudrappa Bhairappanavar, Chaitanya G. Joshi, Jayashankar Das

Published Oct 22, 2019 · Vol. 10, No. 58 · pp. 6168-6183

Keywords: tobacco, head and neck squamous cell carcinoma (HNSCC), differentially expressed genes, hub gene, miRNA

Kallikrein 6 protease advances colon tumorigenesis via induction of the high mobility group A2 protein Research Paper

Hwudaurw Chen, Earlphia Sells, Ritu Pandey, Edward R. Abril, Chiu-Hsieh Hsu, Robert S. Krouse, Raymond B. Nagle, Georgios Pampalakis, Georgia Sotiropoulou, Natalia A. Ignatenko

Published Oct 22, 2019 · Vol. 10, No. 58 · pp. 6062-6078

Keywords: colorectal cancer, kallikrein-related peptidase 6 or KLK6, SMAD2/3, epithelial-mesenchymal transition, HMGA2

Preclinical analysis of human mesenchymal stem cells: tumor tropism and therapeutic efficiency of local HSV-TK suicide gene therapy in glioblastoma Research Paper

Lasse Dührsen, Sophie Hartfuß, Daniela Hirsch, Sabine Geiger, Cecile L. Maire, Jan Sedlacik, Christine Guenther, Manfred Westphal, Katrin Lamszus, Felix G. Hermann, Nils Ole Schmidt

Published Oct 22, 2019 · Vol. 10, No. 58 · pp. 6049-6061

Keywords: glioblastoma, brain tumor, stem cells, gene therapy, migration

Hyperpolarized in vivo pH imaging reveals grade-dependent acidification in prostate cancer Research Paper

David E. Korenchan, Robert Bok, Renuka Sriram, Kristina Liu, Romelyn Delos Santos, Hecong Qin, Iryna Lobach, Natalie Korn, David M. Wilson, John Kurhanewicz, Robert R. Flavell

Published Oct 22, 2019 · Vol. 10, No. 58 · pp. 6096-6110

Keywords: prostate cancer, extracellular pH, hyperpolarization, MRI, metabolism

Mutational profile and genotype/phenotype correlation of non-familial pheochromocytoma and paraganglioma Research Paper

Shatha Albattal, Meshael Alswailem, Yosra Moria, Hindi Al-Hindi, Majed Dasouki, Mohamed Abouelhoda, Hala Aba Alkhail, Entissar Alsuhaibani, Ali S. Alzahrani

Published Oct 15, 2019 · Vol. 10, No. 57 · pp. 5919-5931

Keywords: pheochromocytoma, paraganglioma, mutations, NGS, SDHB

Splicing regulatory factors in breast cancer hallmarks and disease progression Review

Esmee Koedoot, Liesanne Wolters, Bob van de Water, Sylvia E. Le Dévédec

Published Oct 15, 2019 · Vol. 10, No. 57 · pp. 6021-6037

Keywords: hallmarks of cancer, breast cancer, alternative splicing, splice factors, RNA sequencing

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MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma Priority Research Paper

Correction: Frequent amplification of AIB1, a critical oncogene modulating major signaling pathways, is associated with poor survival in gastric cancer Correction

Secretome of pleural effusions associated with non-small cell lung cancer (NSCLC) and malignant mesothelioma: therapeutic implications Research Paper

Efficacy and safety of buparlisib, a PI3K inhibitor, in patients with malignancies harboring a PI3K pathway activation: a phase 2, open-label, single-arm study Research Paper

Molecular profiling of radical prostatectomy tissue from patients with no sign of progression identifies ERG as the strongest independent predictor of recurrence Research Paper

Pre-surgical connectome features predict IDH status in diffuse gliomas Research Paper

SNiPER: a novel hypermethylation biomarker panel for liquid biopsy based early breast cancer detection Research Paper

The anti-cancer effects of phenformin in thyroid cancer cell lines and in normal thyrocytes Research Paper

Dynamic transition of the blood-brain barrier in the development of non-small cell lung cancer brain metastases Research Paper

Randomized phase 3 open label study of quality of life of patients on Pemetrexed versus Erlotinib as maintenance therapy for advanced non squamous non EGFR mutated non small cell lung cancer Research Paper

Investigating the duality of Inpp4b function in the cellular transformation of mouse fibroblasts Research Paper

Correction: A novel therapeutic approach to colorectal cancer in diabetes: role of metformin and rapamycin Correction

Correction: MicroRNA-34a expression levels in serum and intratumoral tissue can predict bone metastasis in patients with hepatocellular carcinoma Correction

Integrated copy number and miRNA expression analysis in triple negative breast cancer of Latin American patients Research Paper

Differential gene expression analysis of HNSCC tumors deciphered tobacco dependent and independent molecular signatures Research Paper

Kallikrein 6 protease advances colon tumorigenesis via induction of the high mobility group A2 protein Research Paper

Preclinical analysis of human mesenchymal stem cells: tumor tropism and therapeutic efficiency of local HSV-TK suicide gene therapy in glioblastoma Research Paper

Hyperpolarized in vivo pH imaging reveals grade-dependent acidification in prostate cancer Research Paper

Mutational profile and genotype/phenotype correlation of non-familial pheochromocytoma and paraganglioma Research Paper

Splicing regulatory factors in breast cancer hallmarks and disease progression Review

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma Priority Research Paper

Correction: Frequent amplification of AIB1, a critical oncogene modulating major signaling pathways, is associated with poor survival in gastric cancer Correction

Secretome of pleural effusions associated with non-small cell lung cancer (NSCLC) and malignant mesothelioma: therapeutic implications Research Paper

Efficacy and safety of buparlisib, a PI3K inhibitor, in patients with malignancies harboring a PI3K pathway activation: a phase 2, open-label, single-arm study Research Paper

Molecular profiling of radical prostatectomy tissue from patients with no sign of progression identifies ERG as the strongest independent predictor of recurrence Research Paper

Pre-surgical connectome features predict IDH status in diffuse gliomas Research Paper

SNiPER: a novel hypermethylation biomarker panel for liquid biopsy based early breast cancer detection Research Paper

The anti-cancer effects of phenformin in thyroid cancer cell lines and in normal thyrocytes Research Paper

Dynamic transition of the blood-brain barrier in the development of non-small cell lung cancer brain metastases Research Paper

Randomized phase 3 open label study of quality of life of patients on Pemetrexed versus Erlotinib as maintenance therapy for advanced non squamous non EGFR mutated non small cell lung cancer Research Paper

Investigating the duality of Inpp4b function in the cellular transformation of mouse fibroblasts Research Paper

Correction: A novel therapeutic approach to colorectal cancer in diabetes: role of metformin and rapamycin Correction

Correction: MicroRNA-34a expression levels in serum and intratumoral tissue can predict bone metastasis in patients with hepatocellular carcinoma Correction

Integrated copy number and miRNA expression analysis in triple negative breast cancer of Latin American patients Research Paper

Differential gene expression analysis of HNSCC tumors deciphered tobacco dependent and independent molecular signatures Research Paper

Kallikrein 6 protease advances colon tumorigenesis via induction of the high mobility group A2 protein Research Paper

Preclinical analysis of human mesenchymal stem cells: tumor tropism and therapeutic efficiency of local HSV-TK suicide gene therapy in glioblastoma Research Paper

Hyperpolarized in vivo pH imaging reveals grade-dependent acidification in prostate cancer Research Paper

Mutational profile and genotype/phenotype correlation of non-familial pheochromocytoma and paraganglioma Research Paper

Splicing regulatory factors in breast cancer hallmarks and disease progression Review