The Oncosearch | Oncotarget

DNA dependent protein kinase (DNA-PK) enhances HIV transcription by promoting RNA polymerase II activity and recruitment of transcription machinery at HIV LTR Research Paper

Sonia Zicari, Adhikarimayum Lakhikumar Sharma, Geetaram Sahu, Larisa Dubrovsky, Lin Sun, Han Yue, Tejaswi Jada, Alex Ochem, Gary Simon, Michael Bukrinsky, Mudit Tyagi

Published Feb 18, 2020 · Vol. 11, No. 7 · pp. 699-726

Keywords: HIV, DNA-PK, transcription, replication, DNA-PK inhibitors

Identification of biomarkers of immune checkpoint blockade efficacy in recurrent or refractory solid tumor malignancies Research Paper

Richard K. Yang, Yun Qing, Fatima Zahra Jelloul, Mark J. Routbort, Peng Wang, Kenna Shaw, Jiexin Zhang, Jack Lee, L. Jeffrey Medeiros, Scott Kopetz, Michael T. Tetzlaff, Russell R. Broaddus

Published Feb 11, 2020 · Vol. 11, No. 6 · pp. 600-618

Keywords: biomarkers, immunotherapy, mutations, TMB, histology

In vitro studies on CNGRC-CPG2 fusion proteins for ligand-directed enzyme prodrug therapy for targeted cancer therapy Research Paper

Layla Al-mansoori, Sara S. Bashraheel, Alanod D. Al Qahtani, C. David O’Connor, Philip Elsinga, Sayed K. Goda

Published Feb 11, 2020 · Vol. 11, No. 6 · pp. 619-633

Keywords: targeted cancer therapy, carboxypeptidase G2, glucarpidase, ligand directed enzyme prodrug therapy, antibody directed enzyme prodrug therapy

Calcitriol and non-calcemic vitamin D analogue, 22-oxacalcitriol, attenuate developmental and pathological choroidal vasculature angiogenesis ex vivo and in vivo Research Paper

Stephanie L. Merrigan, Bomina Park, Zaheer Ali, Lasse D. Jensen, Timothy W. Corson, Breandán N. Kennedy

Published Feb 4, 2020 · Vol. 11, No. 5 · pp. 493-509

Keywords: developmental angiogenesis, pathological angiogenesis, ocular angiogenesis, calcitriol, 22-oxacalcitriol

Overall survival in patients with lung adenocarcinoma harboring “niche” mutations: an observational study Research Paper

Beatrice Aramini, Federico Banchelli, Stefania Bettelli, Samantha Manfredini, Roberto D’Amico, Valentina Masciale, Massimo Pinelli, Margherita Moretti, Alessandro Stefani, Federica Bertolini, Massimo Dominici, Uliano Morandi, Antonino Maiorana

Published Feb 4, 2020 · Vol. 11, No. 5 · pp. 550-559

Keywords: somatic mutations, non-small cell lung cancer (NSCLC), lung cancer treatment, overall survival, target therapy

Tumor secreted ANGPTL2 facilitates recruitment of neutrophils to the lung to promote lung pre-metastatic niche formation and targeting ANGPTL2 signaling affects metastatic disease Research Paper

Manish Charan, Piyush Dravid, Maren Cam, Bhuvana Setty, Ryan D. Roberts, Peter J. Houghton, Hakan Cam

Published Feb 4, 2020 · Vol. 11, No. 5 · pp. 510-522

Keywords: pre-metastatic niche formation, osteosarcoma, ANGPTL2, tumor microenvironment, neutrophils

Inherited DNA-repair gene mutations in African American men with prostate cancer Research Paper

Oliver Sartor, Shan Yang, Elisa Ledet, Marcus Moses, Piper Nicolosi

Published Jan 28, 2020 · Vol. 11, No. 4 · pp. 440-442

Keywords: prostate cancer, DNA repair, BRCA, African American, ethnicity

Clostridium perfringens enterotoxin induces claudin-4 to activate YAP in oral squamous cell carcinomas Research Paper

Chie Nakashima, Kazuhiko Yamamoto, Shingo Kishi, Takamitsu Sasaki, Hitoshi Ohmori, Rina Fujiwara-Tani, Shiori Mori, Isao Kawahara, Yukiko Nishiguchi, Takuya Mori, Masuo Kondoh, Yi Luo, Tadaaki Kirita, Hiroki Kuniyasu

Published Jan 28, 2020 · Vol. 11, No. 4 · pp. 309-321

Keywords: clostridium perfringens enterotoxin, claudin-4, YAP, Hippo signal, oral squamous cell carcinoma, Pathology

Sexual dimorphism in atrophic effects of topical glucocorticoids is driven by differential regulation of atrophogene REDD1 in male and female skin Research Paper

Gleb Baida, Shivani Agarwal, Ben Readhead, Joel T. Dudley, Irina Budunova

Published Jan 28, 2020 · Vol. 11, No. 4 · pp. 409-418

Keywords: glucocorticoid, skin atrophy, REDD1, mTOR, sexual dimorphism

FOXL2 homozygous genotype and chromosome instability are associated with recurrence in adult granulosa cell tumors of the ovary Research Paper

Francois Kraus, Julie Dremaux, Wajd Altakfi, Magalie Goux, Léa Pontois, Henri Sevestre, Stéphanie Trudel

Published Jan 28, 2020 · Vol. 11, No. 4 · pp. 419-428

Keywords: granulosa cell tumor, recurrence, FOXL2, array comparative genomic hybridization, chromosome instability

Tumor suppressor genes and allele-specific expression: mechanisms and significance Research Paper

Evan A. Clayton, Shareef Khalid, Dongjo Ban, Lu Wang, I. King Jordan, John F. McDonald

Published Jan 28, 2020 · Vol. 11, No. 4 · pp. 462-479

Keywords: allele-specific expression, alternative splicing, antisense RNA, cancer, tumor-suppressor genes

Characterization of unique PMEPA1 gene splice variants (isoforms d and e) from RNA Seq profiling provides novel insights into prognostic evaluation of prostate cancer Research Paper

Shashwat Sharad, Allissa Amanda Dillman, Zsófia M. Sztupinszki, Zoltan Szallasi, Inger Rosner, Jennifer Cullen, Shiv Srivastava, Alagarsamy Srinivasan, Hua Li

Published Jan 28, 2020 · Vol. 11, No. 4 · pp. 362-377

Keywords: prostate cancer, PMEPA1, gene isoform, splice variant, TGF-β

Correction: Minimal contribution of ERK1/2-MAPK signalling towards the maintenance of oncogenic GNAQ^Q209P-driven uveal melanomas in zebrafish Correction

Mai Abdel Mouti, Christopher Dee, Sarah E. Coupland, Adam F.L. Hurlstone

Published Jan 26, 2020

TP53 co-mutations in EGFR mutated patients in NSCLC stage IV: A strong predictive factor of ORR, PFS and OS in EGFR mt+ NSCLC Research Paper

Julia Roeper, Markus Falk, Athena Chalaris-Rißmann, Anne C. Lueers, Hayat Ramdani, Katrin Wedeken, Ursula Stropiep, Linda Diehl, Markus Tiemann, Lukas C. Heukamp, Fabian Otto-Sobotka, Frank Griesinger

Published Jan 21, 2020 · Vol. 11, No. 3 · pp. 250-264

Keywords: NSCLC, EGFR, TP53 mutation, TKI

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Wayne D. Blosser, Jack A. Dempsey, Ann M. McNulty, Xi Rao, Philip J. Ebert, Caitlin D. Lowery, Philip W. Iversen, Yue Wang Webster, Gregory P. Donoho, Xueqian Gong, Farhana F. Merzoug, Sean Buchanan, Karsten Boehnke, Chunping Yu, Xin Tian You, Richard P. Beckmann, Wenjuan Wu, Samuel C. McNeely, Aimee Bence Lin, Ricardo Martinez

Published Jan 21, 2020 · Vol. 11, No. 3 · pp. 216-236

Keywords: CHK1, prexasertib, replication stress, replication fork, innate immunity

The virome of HPV-positive tonsil squamous cell carcinoma and neck metastasis Research Paper

Ryan M. Carey, Karthik Rajasekaran, Tyler Seckar, Xiang Lin, Zhi Wei, Charles C.L. Tong, Viran J. Ranasinghe, Jason G. Newman, Bert W. O'Malley Jr., Gregory S. Weinstein, Michael D. Feldman, Erle S. Robertson

Published Jan 21, 2020 · Vol. 11, No. 3 · pp. 282-293

Keywords: HPV, cancer, virus, virome, oropharyngeal squamous cell carcinoma

Carcinogenetic initiation contributed by EpCAM+ cancer cells in orthotopic HCC models of immunocompetent and athymic mice Research Paper

Harshul Pandit, Yan Li, Qianqian Zheng, Wei Guo, Youxi Yu, Suping Li, Robert C.G. Martin

Published Jan 17, 2020 · Vol. 11, No. 22 · pp. 2047-2060

Keywords: hepatocellular carcinoma, Wnt/β-catenin signaling, cancer stem cells, epithelial cell adhesion molecule (EpCAM), tumor-initiating cells

Correction: Prevention of irradiation-induced salivary hypofunction by rapamycin in swine parotid glands Correction

Zhao Zhu, Baoxing Pang, Ramiro Iglesias-Bartolome, Xiaoshan Wu, Lei Hu, Chunmei Zhang, Jinsong Wang, J. Silvio Gutkind, Songlin Wang

Published Jan 16, 2020

Isolation and characterization of a CD34⁺ sub-clone in B-cell lymphoma Research Paper

Ayad M. Al-Katib, Abdul Shukkur Ebrahim, Mustapha Kandouz, Feras Zaiem, Ali Raufi, Salah Ebrahim, Anwar Mohamed, Nada Emara, Ali M. Gabali

Published Jan 14, 2020 · Vol. 11, No. 2 · pp. 148-160

Keywords: CD34, B-cell non-Hodgkin’s lymphoma, minimal residual disease, lymphoma stem cell

Circulating tumor DNA analysis in the era of precision oncology Review

Rabih Said, Nicolas Guibert, Geoffrey R. Oxnard, Apostolia M. Tsimberidou

Published Jan 14, 2020 · Vol. 11, No. 2 · pp. 188-211

Keywords: circulating tumor DNA analysis, clinical trials, targeted therapy, genomic profiling

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DNA dependent protein kinase (DNA-PK) enhances HIV transcription by promoting RNA polymerase II activity and recruitment of transcription machinery at HIV LTR Research Paper

Identification of biomarkers of immune checkpoint blockade efficacy in recurrent or refractory solid tumor malignancies Research Paper

In vitro studies on CNGRC-CPG2 fusion proteins for ligand-directed enzyme prodrug therapy for targeted cancer therapy Research Paper

Calcitriol and non-calcemic vitamin D analogue, 22-oxacalcitriol, attenuate developmental and pathological choroidal vasculature angiogenesis ex vivo and in vivo Research Paper

Overall survival in patients with lung adenocarcinoma harboring “niche” mutations: an observational study Research Paper

Tumor secreted ANGPTL2 facilitates recruitment of neutrophils to the lung to promote lung pre-metastatic niche formation and targeting ANGPTL2 signaling affects metastatic disease Research Paper

Inherited DNA-repair gene mutations in African American men with prostate cancer Research Paper

Clostridium perfringens enterotoxin induces claudin-4 to activate YAP in oral squamous cell carcinomas Research Paper

Sexual dimorphism in atrophic effects of topical glucocorticoids is driven by differential regulation of atrophogene REDD1 in male and female skin Research Paper

FOXL2 homozygous genotype and chromosome instability are associated with recurrence in adult granulosa cell tumors of the ovary Research Paper

Tumor suppressor genes and allele-specific expression: mechanisms and significance Research Paper

Characterization of unique PMEPA1 gene splice variants (isoforms d and e) from RNA Seq profiling provides novel insights into prognostic evaluation of prostate cancer Research Paper

Correction: Minimal contribution of ERK1/2-MAPK signalling towards the maintenance of oncogenic GNAQ^Q209P-driven uveal melanomas in zebrafish Correction

TP53 co-mutations in EGFR mutated patients in NSCLC stage IV: A strong predictive factor of ORR, PFS and OS in EGFR mt+ NSCLC Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

The virome of HPV-positive tonsil squamous cell carcinoma and neck metastasis Research Paper

Carcinogenetic initiation contributed by EpCAM+ cancer cells in orthotopic HCC models of immunocompetent and athymic mice Research Paper

Correction: Prevention of irradiation-induced salivary hypofunction by rapamycin in swine parotid glands Correction

Isolation and characterization of a CD34⁺ sub-clone in B-cell lymphoma Research Paper

Circulating tumor DNA analysis in the era of precision oncology Review

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

DNA dependent protein kinase (DNA-PK) enhances HIV transcription by promoting RNA polymerase II activity and recruitment of transcription machinery at HIV LTR Research Paper

Identification of biomarkers of immune checkpoint blockade efficacy in recurrent or refractory solid tumor malignancies Research Paper

In vitro studies on CNGRC-CPG2 fusion proteins for ligand-directed enzyme prodrug therapy for targeted cancer therapy Research Paper

Calcitriol and non-calcemic vitamin D analogue, 22-oxacalcitriol, attenuate developmental and pathological choroidal vasculature angiogenesis ex vivo and in vivo Research Paper

Overall survival in patients with lung adenocarcinoma harboring “niche” mutations: an observational study Research Paper

Tumor secreted ANGPTL2 facilitates recruitment of neutrophils to the lung to promote lung pre-metastatic niche formation and targeting ANGPTL2 signaling affects metastatic disease Research Paper

Inherited DNA-repair gene mutations in African American men with prostate cancer Research Paper

Clostridium perfringens enterotoxin induces claudin-4 to activate YAP in oral squamous cell carcinomas Research Paper

Sexual dimorphism in atrophic effects of topical glucocorticoids is driven by differential regulation of atrophogene REDD1 in male and female skin Research Paper

FOXL2 homozygous genotype and chromosome instability are associated with recurrence in adult granulosa cell tumors of the ovary Research Paper

Tumor suppressor genes and allele-specific expression: mechanisms and significance Research Paper

Characterization of unique PMEPA1 gene splice variants (isoforms d and e) from RNA Seq profiling provides novel insights into prognostic evaluation of prostate cancer Research Paper

Correction: Minimal contribution of ERK1/2-MAPK signalling towards the maintenance of oncogenic GNAQQ209P-driven uveal melanomas in zebrafish Correction

TP53 co-mutations in EGFR mutated patients in NSCLC stage IV: A strong predictive factor of ORR, PFS and OS in EGFR mt+ NSCLC Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

The virome of HPV-positive tonsil squamous cell carcinoma and neck metastasis Research Paper

Carcinogenetic initiation contributed by EpCAM+ cancer cells in orthotopic HCC models of immunocompetent and athymic mice Research Paper

Correction: Prevention of irradiation-induced salivary hypofunction by rapamycin in swine parotid glands Correction

Isolation and characterization of a CD34+ sub-clone in B-cell lymphoma Research Paper

Circulating tumor DNA analysis in the era of precision oncology Review

Correction: Minimal contribution of ERK1/2-MAPK signalling towards the maintenance of oncogenic GNAQ^Q209P-driven uveal melanomas in zebrafish Correction

Isolation and characterization of a CD34⁺ sub-clone in B-cell lymphoma Research Paper