The Oncosearch | Oncotarget

DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma Research Paper

Nathaniel Weygant, Dongfeng Qu, Randal May, Ryan M. Tierney, William L. Berry, Lichao Zhao, Shweta Agarwal, Parthasarathy Chandrakesan, Harisha R. Chinthalapally, Nicholas T. Murphy, James D. Li, Sripathi M. Sureban, Michael J. Schlosser, James J. Tomasek, Courtney W. Houchen

Published Dec 11, 2014 · Vol. 6, No. 4 · pp. 2193-2205

Multiple receptor tyrosine kinase activation attenuates therapeutic efficacy of the fibroblast growth factor receptor 2 inhibitor AZD4547 in FGFR2 amplified gastric cancer Research Paper

Jinjia Chang, Shanshan Wang, Zhe Zhang, Xinyang Liu, Zheng Wu, Ruixuan Geng, Xiaoxiao Ge, Congqi Dai, Rujiao Liu, Qunling Zhang, Wenhua Li, Jin Li

Published Dec 10, 2014 · Vol. 6, No. 4 · pp. 2009-2022

MicroRNAs in B-cells: from normal differentiation to treatment of malignancies Review

Sara Correia Marques, Maria Bach Laursen, Julie StÃ¸ve BÃ¸dker, Malene Krag Kjeldsen, Steffen Falgreen, Alexander Schmitz, Martin BÃ¸gsted, Hans Erik Johnsen, Karen Dybkaer

Published Dec 10, 2014 · Vol. 6, No. 1 · pp. 7-25

Î²III-Tubulin: A novel mediator of chemoresistance and metastases in pancreatic cancer Research Paper

Joshua A. McCarroll, George Sharbeen, Jie Liu, Janet Youkhana, David Goldstein, Nigel McCarthy, Lydia F. Limbri, Dominic Dischl, GÃ¼ralp O. Ceyhan, Mert Erkan, Amber L. Johns, Andrew V. Biankin, Maria Kavallaris, Phoebe A. Phillips

Published Dec 10, 2014 · Vol. 6, No. 4 · pp. 2235-2249

Inhibition of HIF-1Î± by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma Research Paper

Tiansuo Zhao, He Ren, Li Jia, Jing Chen, Wen Xin, Fan Yan, Jing Li, Xiuchao Wang, Song Gao, Dong Qian, Chongbiao Huang, Jihui Hao

Published Dec 10, 2014 · Vol. 6, No. 4 · pp. 2250-2262

Novel receptor tyrosine kinase targeted combination therapies for imatinib-resistant gastrointestinal stromal tumors (GIST) Research Paper

Daruka Mahadevan, Noah Theiss, Carla Morales, Amy E. Stejskal, Laurence S. Cooke, Min Zhu, Drew Kurtzman, Rachel Swart, Evan Ong, Wenqing Qi

Published Dec 10, 2014 · Vol. 6, No. 4 · pp. 1954-1966

Targeting a ribonucleoprotein complex containing the caprin-1 protein and the c-Myc mRNA suppresses tumor growth in mice: an identification of a novel oncotarget Research Paper

Ya-Qi Qiu, Cheng-Wei Yang, Yue-Zhi Lee, Ruey-Bing Yang, Chih-Hao Lee, Hsing-Yu Hsu, Chien-Chung Chang, Shiow-Ju Lee

Published Dec 10, 2014 · Vol. 6, No. 4 · pp. 2148-2163

NEK2 mediates ALDH1A1-dependent drug resistance in multiple myeloma Research Paper

Ye Yang, Wen Zhou, Jiliang Xia, Zhimin Gu, Erik Wendlandt, Xin Zhan, Siegfried Janz, Guido Tricot, Fenghuang Zhan

Published Dec 9, 2014 · Vol. 5, No. 23 · pp. 11986-11997

Down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation Research Paper

Jie Zhang, Pengxing He, Yong Xi, Meiyu Geng, Yi Chen, Jian Ding

Published Dec 9, 2014 · Vol. 6, No. 5 · pp. 2917-2927

Keywords: colorectal cancer, G9a, epigenetics, DNA damage response (DDR), SN38/CPT, synergistic effect

A subgroup of pancreatic adenocarcinoma is sensitive to the 5-aza-dC DNA methyltransferase inhibitor Research Paper

Odile Gayet, Celine Loncle, Pauline Duconseil, Marine Gilabert, Maria Belen Lopez, Vincent Moutardier, Olivier Turrini, Ezequiel Calvo, Jacques Ewald, Marc Giovannini, Mohamed Gasmi, Erwan Bories, Marc Barthet, Mehdi Ouaissi, Anthony Goncalves, Flora Poizat, Jean Luc Raoul, Veronique Secq, Stephane Garcia, Patrice Viens, Nelson Dusetti, Juan Iovanna

Published Dec 3, 2014 · Vol. 6, No. 2 · pp. 746-754

The cytotoxic effects of regorafenib in combination with protein kinase D inhibition in human colorectal cancer cells Research Paper

Ning Wei, Edward Chu, Shao-yu Wu, Peter Wipf, John C. Schmitz

Published Dec 3, 2014 · Vol. 6, No. 7 · pp. 4745-4756

Co-culture of primary CLL cells with bone marrow mesenchymal cells, CD40 ligand and CpG ODN promotes proliferation of chemoresistant CLL cells phenotypically comparable to those proliferating in vivo Research Paper

Noelia Purroy, Pau Abrisqueta, JÃºlia Carabia, Cecilia Carpio, Carles Palacio, Francesc Bosch, Marta Crespo

Published Dec 3, 2014 · Vol. 6, No. 10 · pp. 7632-7643

Altered radiation responses of breast cancer cells resistant to hormonal therapy Research Paper

Lidiya Luzhna, Anne E. Lykkesfeldt, Olga Kovalchuk

Published Dec 2, 2014 · Vol. 6, No. 3 · pp. 1678-1694

P62 regulates resveratrol-mediated Fas/Cav-1 complex formation and transition from autophagy to apoptosis Research Paper

Jun Zhang, Ke Ma, Tingting Qi, Xiaoning Wei, Qing Zhang, Guanwu Li, Jen-Fu Chiu

Published Nov 29, 2014 · Vol. 6, No. 2 · pp. 789-801

Keywords: apoptosis, autophagy, cell death, resveratrol, Fas/Cav-1 complex, P62

MicroRNA-34a regulates WNT/TCF7 signaling and inhibits bone metastasis in Ras-activated prostate cancer Research Paper

Wei-Yu Chen, Shih-Yang Liu, Yung-Sheng Chang, Juan Juan Yin, Hsiu-lien Yeh, Tarek H. Mouhieddine, Ola Hadadeh, Wassim Abou-Kheir, Yen-Nien Liu

Published Nov 25, 2014 · Vol. 6, No. 1 · pp. 441-457

Dichloroacetate, a selective mitochondria-targeting drug for oral squamous cell carcinoma: a metabolic perspective of treatment Research Paper

Vitalba Ruggieri, Francesca Agriesti, Rosella Scrima, Ilaria Laurenzana, Donatella Perrone, Tiziana Tataranni, Carmela Mazzoccoli, Lorenzo Lo Muzio, Nazzareno Capitanio, Claudia Piccoli

Published Nov 25, 2014 · Vol. 6, No. 2 · pp. 1217-1230

Keywords: oral squamous cell carcinoma, dichloroacetate, oxidative metabolism, mitochondria, reactive oxygen species

Pre-clinical study of drug combinations that reduce breast cancer burden due to aberrant mTOR and metabolism promoted by LKB1 loss Research Paper

Rafaela Andrade-Vieira, Donna Goguen, Heidi A. Bentley, Chris V. Bowen, Paola A. Marignani

Published Nov 25, 2014 · Vol. 5, No. 24 · pp. 12738-12752

Intrinsic TGF-Î²2-triggered SDF-1-CXCR4 signaling axis is crucial for drug resistance and a slow-cycling state in bone marrow-disseminated tumor cells Research Paper

Takuya Nakamura, Satoru Shinriki, Hirofumi Jono, Jianying Guo, Mitsuharu Ueda, Mitsuhiro Hayashi, Satoshi Yamashita, Andries Zijlstra, Hideki Nakayama, Akimitsu Hiraki, Masanori Shinohara, Yukio Ando

Published Nov 25, 2014 · Vol. 6, No. 2 · pp. 1008-1019

HDAC2 deregulation in tumorigenesis is causally connected to repression of immune modulation and defense escape Research Paper

Mariarosaria Conte, Carmela Dellâ€™Aversana, Rosaria Benedetti, Francesca Petraglia, Annamaria Carissimo, Valeria Belsito Petrizzi, Alfonso Maria Dâ€™Arco, Ciro Abbondanza, Angela Nebbioso, Lucia Altucci

Published Nov 25, 2014 · Vol. 6, No. 2 · pp. 886-901

Afatinib circumvents multidrug resistance via dually inhibiting ATP binding cassette subfamily G member 2 in vitro and in vivo Research Paper

Xiao-kun Wang, Kenneth Kin Wah To, Li-yan Huang, Jing-hong Xu, Ke Yang, Fang Wang, Zhen-cong Huang, Sheng Ye, Li-wu Fu

Published Nov 24, 2014 · Vol. 5, No. 23 · pp. 11971-11985

Publication Alerts

European Cancer and Oncology Congress

Post-Publication Promotion

Search Oncotarget

DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma Research Paper

Multiple receptor tyrosine kinase activation attenuates therapeutic efficacy of the fibroblast growth factor receptor 2 inhibitor AZD4547 in FGFR2 amplified gastric cancer Research Paper

MicroRNAs in B-cells: from normal differentiation to treatment of malignancies Review

Î²III-Tubulin: A novel mediator of chemoresistance and metastases in pancreatic cancer Research Paper

Inhibition of HIF-1Î± by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma Research Paper

Novel receptor tyrosine kinase targeted combination therapies for imatinib-resistant gastrointestinal stromal tumors (GIST) Research Paper

Targeting a ribonucleoprotein complex containing the caprin-1 protein and the c-Myc mRNA suppresses tumor growth in mice: an identification of a novel oncotarget Research Paper

NEK2 mediates ALDH1A1-dependent drug resistance in multiple myeloma Research Paper

Down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation Research Paper

A subgroup of pancreatic adenocarcinoma is sensitive to the 5-aza-dC DNA methyltransferase inhibitor Research Paper

The cytotoxic effects of regorafenib in combination with protein kinase D inhibition in human colorectal cancer cells Research Paper

Co-culture of primary CLL cells with bone marrow mesenchymal cells, CD40 ligand and CpG ODN promotes proliferation of chemoresistant CLL cells phenotypically comparable to those proliferating in vivo Research Paper

Altered radiation responses of breast cancer cells resistant to hormonal therapy Research Paper

P62 regulates resveratrol-mediated Fas/Cav-1 complex formation and transition from autophagy to apoptosis Research Paper

MicroRNA-34a regulates WNT/TCF7 signaling and inhibits bone metastasis in Ras-activated prostate cancer Research Paper

Dichloroacetate, a selective mitochondria-targeting drug for oral squamous cell carcinoma: a metabolic perspective of treatment Research Paper

Pre-clinical study of drug combinations that reduce breast cancer burden due to aberrant mTOR and metabolism promoted by LKB1 loss Research Paper

Intrinsic TGF-Î²2-triggered SDF-1-CXCR4 signaling axis is crucial for drug resistance and a slow-cycling state in bone marrow-disseminated tumor cells Research Paper

HDAC2 deregulation in tumorigenesis is causally connected to repression of immune modulation and defense escape Research Paper

Afatinib circumvents multidrug resistance via dually inhibiting ATP binding cassette subfamily G member 2 in vitro and in vivo Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma Research Paper

Multiple receptor tyrosine kinase activation attenuates therapeutic efficacy of the fibroblast growth factor receptor 2 inhibitor AZD4547 in FGFR2 amplified gastric cancer Research Paper

MicroRNAs in B-cells: from normal differentiation to treatment of malignancies Review

Î²III-Tubulin: A novel mediator of chemoresistance and metastases in pancreatic cancer Research Paper

Inhibition of HIF-1Î± by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma Research Paper

Novel receptor tyrosine kinase targeted combination therapies for imatinib-resistant gastrointestinal stromal tumors (GIST) Research Paper

Targeting a ribonucleoprotein complex containing the caprin-1 protein and the c-Myc mRNA suppresses tumor growth in mice: an identification of a novel oncotarget Research Paper

NEK2 mediates ALDH1A1-dependent drug resistance in multiple myeloma Research Paper

Down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation Research Paper

A subgroup of pancreatic adenocarcinoma is sensitive to the 5-aza-dC DNA methyltransferase inhibitor Research Paper

The cytotoxic effects of regorafenib in combination with protein kinase D inhibition in human colorectal cancer cells Research Paper

Co-culture of primary CLL cells with bone marrow mesenchymal cells, CD40 ligand and CpG ODN promotes proliferation of chemoresistant CLL cells phenotypically comparable to those proliferating in vivo Research Paper

Altered radiation responses of breast cancer cells resistant to hormonal therapy Research Paper

P62 regulates resveratrol-mediated Fas/Cav-1 complex formation and transition from autophagy to apoptosis Research Paper

MicroRNA-34a regulates WNT/TCF7 signaling and inhibits bone metastasis in Ras-activated prostate cancer Research Paper

Dichloroacetate, a selective mitochondria-targeting drug for oral squamous cell carcinoma: a metabolic perspective of treatment Research Paper

Pre-clinical study of drug combinations that reduce breast cancer burden due to aberrant mTOR and metabolism promoted by LKB1 loss Research Paper

Intrinsic TGF-Î²2-triggered SDF-1-CXCR4 signaling axis is crucial for drug resistance and a slow-cycling state in bone marrow-disseminated tumor cells Research Paper

HDAC2 deregulation in tumorigenesis is causally connected to repression of immune modulation and defense escape Research Paper

Afatinib circumvents multidrug resistance via dually inhibiting ATP binding cassette subfamily G member 2 in vitro and in vivo Research Paper