The Oncosearch | Oncotarget

Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: Treating cancer like an infectious disease Priority Research Paper

Rebecca Lamb, Bela Ozsvari, Camilla L. Lisanti, Herbert B. Tanowitz, Anthony Howell, Ubaldo E. Martinez-Outschoorn, Federica Sotgia, Michael P. Lisanti

Published Jan 22, 2015 · Vol. 6, No. 7 · pp. 4569-4584

Initiation of esophageal squamous cell carcinoma (ESCC) in a murine 4-nitroquinoline-1-oxide and alcohol carcinogenesis model Research Paper

Kwame Osei-Sarfo, Alison M. Urvalek, Xiao-Han Tang, Theresa Scognamiglio, Lorraine J. Gudas

Published Jan 21, 2015 · Vol. 6, No. 8 · pp. 6040-6052

Flubendazole, FDA-approved anthelmintic, targets breast cancer stem-like cells Research Paper

Zhi-Jie Hou, Xi Luo, Wei Zhang, Fei Peng, Bai Cui, Si-Jin Wu, Fei-Meng Zheng, Jie Xu, Ling-Zhi Xu, Zi-Jie Long, Xue-Ting Wang, Guo-Hui Li, Xian-Yao Wan, Yong-Liang Yang, Quentin Liu

Published Jan 21, 2015 · Vol. 6, No. 8 · pp. 6326-6340

Inhibition of hedgehog signaling improves the anti-carcinogenic effects of docetaxel in prostate cancer Research Paper

Murielle Mimeault, Satyanarayana Rachagani, Sakthivel Muniyan, Parthasarathy Seshacharyulu, Sonny L. Johansson, Kaustubh Datta, Ming-Fong Lin, Surinder K. Batra

Published Jan 21, 2015 · Vol. 6, No. 6 · pp. 3887-3903

Combining lapatinib and pertuzumab to overcome lapatinib resistance due to NRG1-mediated signalling in HER2-amplified breast cancer Research Paper

Wing-yin Leung, Ioannis Roxanis, Helen Sheldon, Francesca M. Buffa, Ji-Liang Li, Adrian L. Harris, Anthony Kong

Published Jan 21, 2015 · Vol. 6, No. 8 · pp. 5678-5694

Carboxyl-terminal domain of MUC16 imparts tumorigenic and metastatic functions through nuclear translocation of JAK2 to pancreatic cancer cells Research Paper

Srustidhar Das, Satyanarayana Rachagani, Maria P. Torres-Gonzalez, Imayavaramban Lakshmanan, Prabin D. Majhi, Lynette M. Smith, Kay-Uwe Wagner, Surinder K. Batra

Published Jan 21, 2015 · Vol. 6, No. 8 · pp. 5772-5787

MBL-II-141, a chromone derivative, enhances irinotecan (CPT-11) anticancer efficiency in ABCG2-positive xenografts Research Paper

MylÃ¨ne Honorat, JÃ©rÃ´me Guitton, Charlotte Gauthier, Charlotte Bouard, Florine Lecerf-Schmidt, Basile Peres, RaphaÃ«l Terreux, HÃ©loÃ¯se Gervot, Catherine Rioufol, AhcÃ¨ne Boumendjel, Alain Puisieux, Attilio Di Pietro, LÃ©a Payen

Published Jan 20, 2015 · Vol. 5, No. 23 · pp. 11957-11970

Gab1 is essential for membrane translocation, activity and integrity of mTORCs after EGF stimulation in urothelial cell carcinoma Research Paper

Chi-Hao Chang, Po-Chao Chan, Jian-Ri Li, Chun-Jung Chen, Jeng-Jer Shieh, Yun-Ching Fu, Hong-Chen Chen, Ming-Ju Wu

Published Jan 20, 2015 · Vol. 6, No. 3 · pp. 1478-1489

Keywords: mTORCs, Gab1, EGF, urothelial carcinoma

NF-kB signaling mediates acquired resistance after PARP inhibition Research Paper

Yuko Nakagawa, Anna S Sedukhina, Naoki Okamoto, Satoi Nagasawa, Nao Suzuki, Tomohiko Ohta, Hiroyoshi Hattori, Marta Roche-Molina, Ana J NarvÃ¡ez, Anand D Jeyasekharan, Juan A Bernal, Ko Sato

Published Jan 12, 2015 · Vol. 6, No. 6 · pp. 3825-3839

Asparaginase induces apoptosis and cytoprotective autophagy in chronic myeloid leukemia cells Research Paper

Ping Song, Li Ye, Jiajun Fan, Yubin Li, Xian Zeng, Ziyu Wang, Shaofei Wang, Guoping Zhang, Ping Yang, Zhonglian Cao, Dianwen Ju

Published Jan 8, 2015 · Vol. 6, No. 6 · pp. 3861-3873

Keywords: asparaginase, autophagy, apoptosis, chronic myeloid leukemia

LCK over-expression drives STAT5 oncogenic signaling in PAX5 translocated BCP-ALL patients Research Paper

Valeria Cazzaniga, Cristina Bugarin, Michela Bardini, Marco Giordan, Geertruy te Kronnie, Giuseppe Basso, Andrea Biondi, Grazia Fazio, Giovanni Cazzaniga

Published Jan 8, 2015 · Vol. 6, No. 3 · pp. 1569-1581

ERp57 modulates STAT3 activity in radioresistant laryngeal cancer cells and serves as a prognostic marker for laryngeal cancer Research Paper

Min Ho Choe, Joong Won Min, Hong Bae Jeon, Dong-Hyung Cho, Jeong Su Oh, Hyun Gyu Lee, Sang-Gu Hwang, Sungkwan An, Young-Hoon Han, Jae-Sung Kim

Published Jan 8, 2015 · Vol. 6, No. 5 · pp. 2654-2666

Mislocalization of p27 to the cytoplasm of breast cancer cells confers resistance to anti-HER2 targeted therapy Research Paper

Hui Zhao, Claire M. Faltermeier, Lori Mendelsohn, Peggy L. Porter, Bruce E. Clurman, James M. Roberts

Published Jan 3, 2015 · Vol. 5, No. 24 · pp. 12704-12714

Keywords: p27Kip1 (p27), cell proliferation, cytoplasmic localization, Her2+ breast cancer cells, lapatinib, drug sensitivity

Novel oral histone deacetylase inhibitor, MPT0E028, displays potent growth-inhibitory activity against human B-cell lymphoma in vitro and in vivo Research Paper

Han-Li Huang, Chieh-Yu Peng, Mei-Jung Lai, Chun-Han Chen, Hsueh-Yun Lee, Jing-Chi Wang, Jing-Ping Liou, Shiow-Lin Pan, Che-Ming Teng

Published Dec 31, 2014 · Vol. 6, No. 7 · pp. 4976-4991

Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance Research Paper

Benny Zhitomirsky, Yehuda G. Assaraf

Published Dec 31, 2014 · Vol. 6, No. 2 · pp. 1143-1156

Keywords: Cancer, Chemotherapeutics, Multidrug resistance, Lysosomes, Drug sequestration, Lysosomal biogenesis

Zoledronic acid overcomes chemoresistance and immunosuppression of malignant mesothelioma Research Paper

Iris Chiara Salaroglio, Ivana Campia, Joanna Kopecka, Elena Gazzano, Sara Orecchia, Dario Ghigo, Chiara Riganti

Published Dec 31, 2014 · Vol. 6, No. 2 · pp. 1128-1142

Keywords: malignant mesothelioma, chemoresistance, P-glycoprotein, immunosuppression, indoleamine 1, 2 dioxygenase, zoledronic acid

Activating enhancer-binding protein-2Î± induces cyclooxygenase-2 expression and promotes nasopharyngeal carcinoma growth Research Paper

Dingbo Shi, Xiangsheng Xiao, Yun Tian, Lijun Qin, Fangyun Xie, Rui Sun, Jingshu Wang, Wenbin Li, Tianze Liu, Yao Xiao, Wendan Yu, Wei Guo, Yuqing Xiong, Huijuan Qiu, Tiebang Kang, Wenlin Huang, Chong Zhao, Wuguo Deng

Published Dec 31, 2014 · Vol. 6, No. 7 · pp. 5005-5021

Activation of RAS family members confers resistance to ROS1 targeting drugs Research Paper

Marilisa Cargnelutti, Simona Corso, Margherita Pergolizzi, Laurence MÃ©vellec, Dara L. Aisner, Rafal Dziadziuszko, Marileila Varella-Garcia, Paolo M. Comoglio, Robert C. Doebele, Jorge Vialard, Silvia Giordano

Published Dec 31, 2014 · Vol. 6, No. 7 · pp. 5182-5194

Down-regulation of miR-223 reverses epithelial-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells Research Paper

Jia Ma, Binbin Fang, Fanpeng Zeng, Cong Ma, Haijie Pang, Long Cheng, Ying Shi, Hui Wang, Bin Yin, Jun Xia, Zhiwei Wang

Published Dec 31, 2014 · Vol. 6, No. 3 · pp. 1740-1749

Keywords: Gemcitabine, miR-223, EMT, invasion, pancreatic cancer.

Advances in targeted therapies and new promising targets in esophageal cancer Review

Abbes Belkhiri, Wael El-Rifai

Published Dec 30, 2014 · Vol. 6, No. 3 · pp. 1348-1358

Keywords: adenocarcinoma, esophageal, gastric, cancer, targeted therapy

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Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: Treating cancer like an infectious disease Priority Research Paper

Initiation of esophageal squamous cell carcinoma (ESCC) in a murine 4-nitroquinoline-1-oxide and alcohol carcinogenesis model Research Paper

Flubendazole, FDA-approved anthelmintic, targets breast cancer stem-like cells Research Paper

Inhibition of hedgehog signaling improves the anti-carcinogenic effects of docetaxel in prostate cancer Research Paper

Combining lapatinib and pertuzumab to overcome lapatinib resistance due to NRG1-mediated signalling in HER2-amplified breast cancer Research Paper

Carboxyl-terminal domain of MUC16 imparts tumorigenic and metastatic functions through nuclear translocation of JAK2 to pancreatic cancer cells Research Paper

MBL-II-141, a chromone derivative, enhances irinotecan (CPT-11) anticancer efficiency in ABCG2-positive xenografts Research Paper

Gab1 is essential for membrane translocation, activity and integrity of mTORCs after EGF stimulation in urothelial cell carcinoma Research Paper

NF-kB signaling mediates acquired resistance after PARP inhibition Research Paper

Asparaginase induces apoptosis and cytoprotective autophagy in chronic myeloid leukemia cells Research Paper

LCK over-expression drives STAT5 oncogenic signaling in PAX5 translocated BCP-ALL patients Research Paper

ERp57 modulates STAT3 activity in radioresistant laryngeal cancer cells and serves as a prognostic marker for laryngeal cancer Research Paper

Mislocalization of p27 to the cytoplasm of breast cancer cells confers resistance to anti-HER2 targeted therapy Research Paper

Novel oral histone deacetylase inhibitor, MPT0E028, displays potent growth-inhibitory activity against human B-cell lymphoma in vitro and in vivo Research Paper

Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance Research Paper

Zoledronic acid overcomes chemoresistance and immunosuppression of malignant mesothelioma Research Paper

Activating enhancer-binding protein-2Î± induces cyclooxygenase-2 expression and promotes nasopharyngeal carcinoma growth Research Paper

Activation of RAS family members confers resistance to ROS1 targeting drugs Research Paper

Down-regulation of miR-223 reverses epithelial-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells Research Paper

Advances in targeted therapies and new promising targets in esophageal cancer Review

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: Treating cancer like an infectious disease Priority Research Paper

Initiation of esophageal squamous cell carcinoma (ESCC) in a murine 4-nitroquinoline-1-oxide and alcohol carcinogenesis model Research Paper

Flubendazole, FDA-approved anthelmintic, targets breast cancer stem-like cells Research Paper

Inhibition of hedgehog signaling improves the anti-carcinogenic effects of docetaxel in prostate cancer Research Paper

Combining lapatinib and pertuzumab to overcome lapatinib resistance due to NRG1-mediated signalling in HER2-amplified breast cancer Research Paper

Carboxyl-terminal domain of MUC16 imparts tumorigenic and metastatic functions through nuclear translocation of JAK2 to pancreatic cancer cells Research Paper

MBL-II-141, a chromone derivative, enhances irinotecan (CPT-11) anticancer efficiency in ABCG2-positive xenografts Research Paper

Gab1 is essential for membrane translocation, activity and integrity of mTORCs after EGF stimulation in urothelial cell carcinoma Research Paper

NF-kB signaling mediates acquired resistance after PARP inhibition Research Paper

Asparaginase induces apoptosis and cytoprotective autophagy in chronic myeloid leukemia cells Research Paper

LCK over-expression drives STAT5 oncogenic signaling in PAX5 translocated BCP-ALL patients Research Paper

ERp57 modulates STAT3 activity in radioresistant laryngeal cancer cells and serves as a prognostic marker for laryngeal cancer Research Paper

Mislocalization of p27 to the cytoplasm of breast cancer cells confers resistance to anti-HER2 targeted therapy Research Paper

Novel oral histone deacetylase inhibitor, MPT0E028, displays potent growth-inhibitory activity against human B-cell lymphoma in vitro and in vivo Research Paper

Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance Research Paper

Zoledronic acid overcomes chemoresistance and immunosuppression of malignant mesothelioma Research Paper

Activating enhancer-binding protein-2Î± induces cyclooxygenase-2 expression and promotes nasopharyngeal carcinoma growth Research Paper

Activation of RAS family members confers resistance to ROS1 targeting drugs Research Paper

Down-regulation of miR-223 reverses epithelial-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells Research Paper

Advances in targeted therapies and new promising targets in esophageal cancer Review