The Oncosearch | Oncotarget

Radiotherapy combined with TLR7/8 activation induces strong immune responses against gastrointestinal tumors Research Paper

Sebastian SchÃ¶lch, Conrad Rauber, Alexandra Tietz, Nuh N. Rahbari, Ulrich Bork, Thomas Schmidt, Christoph Kahlert, Uwe Haberkorn, Mark A. Tomai, Kenneth E. Lipson, Rafael Carretero, JÃ¼rgen Weitz, Moritz Koch, Peter E. Huber

Published Dec 31, 2014 · Vol. 6, No. 7 · pp. 4663-4676

Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance Research Paper

Benny Zhitomirsky, Yehuda G. Assaraf

Published Dec 31, 2014 · Vol. 6, No. 2 · pp. 1143-1156

Keywords: Cancer, Chemotherapeutics, Multidrug resistance, Lysosomes, Drug sequestration, Lysosomal biogenesis

HDAC1,2 inhibition impairs EZH2- and BBAP- mediated DNA repair to overcome chemoresistance in EZH2 gain-of-function mutant diffuse large B-cell lymphoma Research Paper

Danielle P. Johnson, Gabriella S. Spitz, Shweta Tharkar, Steven N. Quayle, Jeffrey R. Shearstone, Simon Jones, Maria E. McDowell, Hannah Wellman, Jessica K. Tyler, Bradley R. Cairns, Mahesh B. Chandrasekharan, Srividya Bhaskara

Published Dec 31, 2014 · Vol. 6, No. 7 · pp. 4863-4887

Prognostic and predictive value of PDL1 expression in breast cancer Clinical Research Papers

Renaud Sabatier, Pascal Finetti, Emilie Mamessier, JosÃ© Adelaide, Max Chaffanet, Hamid Raza Ali, Patrice Viens, Carlos Caldas, Daniel Birnbaum, FranÃ§ois Bertucci

Published Dec 31, 2014 · Vol. 6, No. 7 · pp. 5449-5464

Folate-mediated mitochondrial targeting with doxorubicin-polyrotaxane nanoparticles overcomes multidrug resistance Research Paper

He Wang, Henghui Yin, Fengjiao Yan, Mingna Sun, Lingran Du, Wei Peng, Qiuli Li, Yinghong Feng, Yi Zhou

Published Dec 30, 2014 · Vol. 6, No. 5 · pp. 2827-2842

Novel HDAC inhibitors exhibit pre-clinical efficacy in lymphoma models and point to the importance of CDKN1A expression levels in mediating their anti-tumor response Research Paper

Afua Adjeiwaa Mensah, Ivo Kwee, Eugenio Gaudio, Andrea Rinaldi, Maurilio Ponzoni, Luciano Cascione, Gianluca Fossati, Anastasios Stathis, Emanuele Zucca, Gianluca Caprini, Francesco Bertoni

Published Dec 30, 2014 · Vol. 6, No. 7 · pp. 5059-5071

Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells Research Paper

Antonella Cusimano, Roberto Puleio, Natale D'Alessandro, Guido R. Loria, James A. McCubrey, Giuseppe Montalto, Melchiorre Cervello

Published Dec 19, 2014 · Vol. 6, No. 3 · pp. 1707-1722

Keywords: HCC, AKT, mTOR, SC66, anoikis.

Genistein suppresses FLT4 and inhibits human colorectal cancer metastasis Research Paper

Xiao Xiao, Zhiguo Liu, Rui Wang, Jiayin Wang, Song Zhang, Xiqiang Cai, Kaichun Wu, Raymond C. Bergan, Li Xu, Daiming Fan

Published Dec 18, 2014 · Vol. 6, No. 5 · pp. 3225-3239

mTOR kinase inhibitors synergize with histone deacetylase inhibitors to kill B-cell acute lymphoblastic leukemia cells Research Paper

Brandon R. Beagle, Duc M. Nguyen, Sharmila Mallya, Sarah S. Tang, Mengrou Lu, Zhihong Zeng, Marina Konopleva, Thanh-Trang Vo, David A. Fruman

Published Dec 12, 2014 · Vol. 6, No. 4 · pp. 2088-2100

Active secretion of CXCL10 and CCL5 from colorectal cancer microenvironments associates with GranzymeB+ CD8+ T-cell infiltration Research Paper

Timothy J. Zumwalt, Mildred Arnold, Ajay Goel, C. Richard Boland

Published Dec 11, 2014 · Vol. 6, No. 5 · pp. 2981-2991

DNA damage induces GDNF secretion in the tumor microenvironment with paracrine effects promoting prostate cancer treatment resistance Research Paper

Roland M. Huber, Jared M. Lucas, Luis A. Gomez-Sarosi, Ilsa Coleman, Song Zhao, Roger Coleman, Peter S. Nelson

Published Dec 10, 2014 · Vol. 6, No. 4 · pp. 2134-2147

Inhibition of HIF-1Î± by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma Research Paper

Tiansuo Zhao, He Ren, Li Jia, Jing Chen, Wen Xin, Fan Yan, Jing Li, Xiuchao Wang, Song Gao, Dong Qian, Chongbiao Huang, Jihui Hao

Published Dec 10, 2014 · Vol. 6, No. 4 · pp. 2250-2262

Targeting the microRNA-21/AP1 axis by 5-fluorouracil and pirarubicin in human hepatocellular carcinoma Research Paper

Xiaodong He, Jingjing Li, Weidong Guo, Wei Liu, Jia Yu, Wei Song, Lei Dong, Fang Wang, Shuangni Yu, Yi Zheng, Songsen Chen, Yan Kong, Changzheng Liu

Published Dec 10, 2014 · Vol. 6, No. 4 · pp. 2302-2314

The cytotoxic effects of regorafenib in combination with protein kinase D inhibition in human colorectal cancer cells Research Paper

Ning Wei, Edward Chu, Shao-yu Wu, Peter Wipf, John C. Schmitz

Published Dec 3, 2014 · Vol. 6, No. 7 · pp. 4745-4756

MUTYH mediates the toxicity of combined DNA 6-thioguanine and UVA radiation Research Paper

Francesca Grasso, Vitalba Ruggieri, Gabriele De Luca, Paola Leopardi, Maria Teresa Mancuso, Ida Casorelli, Pietro Pichierri, Peter Karran, Margherita Bignami

Published Dec 2, 2014 · Vol. 6, No. 10 · pp. 7481-7492

Human rpL3 plays a crucial role in cell response to nucleolar stress induced by 5-FU and L-OHP Research Paper

Davide Esposito, Elvira Crescenzi, Vinay Sagar, Fabrizio Loreni, Annapina Russo, Giulia Russo

Published Nov 28, 2014 · Vol. 5, No. 22 · pp. 11737-11751

Keywords: p21, ribosomal protein, 5-FU, Oxaliplatin, DNA repair

Evaluation of azacitidine and entinostat as sensitization agents to cytotoxic chemotherapy in preclinical models of non-small cell lung cancer Priority Research Paper

Frank P. Vendetti, Michael Topper, Peng Huang, Irina Dobromilskaya, Hariharan Easwaran, John Wrangle, Stephen B. Baylin, J. T. Poirier, Charles M. Rudin

Published Nov 25, 2014 · Vol. 6, No. 1 · pp. 56-70

Keywords: epigenetic, azacitidine, entinostat, priming, chemosensitivity, non-small cell lung cancer (NSCLC)

Comprehensive tumor profiling identifies numerous biomarkers of drug response in cancers of unknown primary site: Analysis of 1806 cases Clinical Research Papers

Zoran Gatalica, Sherri Z. Millis, Semir Vranic, Ryan Bender, Gargi D. Basu, Andreas Voss, Daniel D. Von Hoff

Published Oct 31, 2014 · Vol. 5, No. 23 · pp. 12440-12447

Combined inhibition of Chk1 and Wee1 as a new therapeutic strategy for mantle cell lymphoma Research Paper

Rosaria ChilÃ, Alessandra Basana, Monica Lupi, Federica Guffanti, Eugenio Gaudio, Andrea Rinaldi, Luciano Cascione, Valentina Restelli, Chiara Tarantelli, Francesco Bertoni, Giovanna Damia, Laura Carrassa

Published Oct 25, 2014 · Vol. 6, No. 5 · pp. 3394-3408

Proscillaridin A is cytotoxic for glioblastoma cell lines and controls tumor xenograft growth in vivo Research Paper

Emilie DenicolaÃ¯, Nathalie Baeza-Kallee, AurÃ©lie Tchoghandjian, Manon CarrÃ©, Carole Colin, Carine Jiguet Jiglaire, Sandy Mercurio, Christophe Beclin, Dominique Figarella-Branger

Published Oct 21, 2014 · Vol. 5, No. 21 · pp. 10934-10948

Keywords: Proscillaridin A, glioblastoma, cytotoxicity, tumor growth control, Na+/K+ ATPase Î±1 subunit

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Radiotherapy combined with TLR7/8 activation induces strong immune responses against gastrointestinal tumors Research Paper

Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance Research Paper

HDAC1,2 inhibition impairs EZH2- and BBAP- mediated DNA repair to overcome chemoresistance in EZH2 gain-of-function mutant diffuse large B-cell lymphoma Research Paper

Prognostic and predictive value of PDL1 expression in breast cancer Clinical Research Papers

Folate-mediated mitochondrial targeting with doxorubicin-polyrotaxane nanoparticles overcomes multidrug resistance Research Paper

Novel HDAC inhibitors exhibit pre-clinical efficacy in lymphoma models and point to the importance of CDKN1A expression levels in mediating their anti-tumor response Research Paper

Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells Research Paper

Genistein suppresses FLT4 and inhibits human colorectal cancer metastasis Research Paper

mTOR kinase inhibitors synergize with histone deacetylase inhibitors to kill B-cell acute lymphoblastic leukemia cells Research Paper

Active secretion of CXCL10 and CCL5 from colorectal cancer microenvironments associates with GranzymeB+ CD8+ T-cell infiltration Research Paper

DNA damage induces GDNF secretion in the tumor microenvironment with paracrine effects promoting prostate cancer treatment resistance Research Paper

Inhibition of HIF-1Î± by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma Research Paper

Targeting the microRNA-21/AP1 axis by 5-fluorouracil and pirarubicin in human hepatocellular carcinoma Research Paper

The cytotoxic effects of regorafenib in combination with protein kinase D inhibition in human colorectal cancer cells Research Paper

MUTYH mediates the toxicity of combined DNA 6-thioguanine and UVA radiation Research Paper

Human rpL3 plays a crucial role in cell response to nucleolar stress induced by 5-FU and L-OHP Research Paper

Evaluation of azacitidine and entinostat as sensitization agents to cytotoxic chemotherapy in preclinical models of non-small cell lung cancer Priority Research Paper

Comprehensive tumor profiling identifies numerous biomarkers of drug response in cancers of unknown primary site: Analysis of 1806 cases Clinical Research Papers

Combined inhibition of Chk1 and Wee1 as a new therapeutic strategy for mantle cell lymphoma Research Paper

Proscillaridin A is cytotoxic for glioblastoma cell lines and controls tumor xenograft growth in vivo Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Radiotherapy combined with TLR7/8 activation induces strong immune responses against gastrointestinal tumors Research Paper

Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance Research Paper

HDAC1,2 inhibition impairs EZH2- and BBAP- mediated DNA repair to overcome chemoresistance in EZH2 gain-of-function mutant diffuse large B-cell lymphoma Research Paper

Prognostic and predictive value of PDL1 expression in breast cancer Clinical Research Papers

Folate-mediated mitochondrial targeting with doxorubicin-polyrotaxane nanoparticles overcomes multidrug resistance Research Paper

Novel HDAC inhibitors exhibit pre-clinical efficacy in lymphoma models and point to the importance of CDKN1A expression levels in mediating their anti-tumor response Research Paper

Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells Research Paper

Genistein suppresses FLT4 and inhibits human colorectal cancer metastasis Research Paper

mTOR kinase inhibitors synergize with histone deacetylase inhibitors to kill B-cell acute lymphoblastic leukemia cells Research Paper

Active secretion of CXCL10 and CCL5 from colorectal cancer microenvironments associates with GranzymeB+ CD8+ T-cell infiltration Research Paper

DNA damage induces GDNF secretion in the tumor microenvironment with paracrine effects promoting prostate cancer treatment resistance Research Paper

Inhibition of HIF-1Î± by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma Research Paper

Targeting the microRNA-21/AP1 axis by 5-fluorouracil and pirarubicin in human hepatocellular carcinoma Research Paper

The cytotoxic effects of regorafenib in combination with protein kinase D inhibition in human colorectal cancer cells Research Paper

MUTYH mediates the toxicity of combined DNA 6-thioguanine and UVA radiation Research Paper

Human rpL3 plays a crucial role in cell response to nucleolar stress induced by 5-FU and L-OHP Research Paper

Evaluation of azacitidine and entinostat as sensitization agents to cytotoxic chemotherapy in preclinical models of non-small cell lung cancer Priority Research Paper

Comprehensive tumor profiling identifies numerous biomarkers of drug response in cancers of unknown primary site: Analysis of 1806 cases Clinical Research Papers

Combined inhibition of Chk1 and Wee1 as a new therapeutic strategy for mantle cell lymphoma Research Paper

Proscillaridin A is cytotoxic for glioblastoma cell lines and controls tumor xenograft growth in vivo Research Paper