The Oncosearch | Oncotarget

A lovastatin-elicited genetic program inhibits M2 macrophage polarization and enhances T cell infiltration into spontaneous mouse mammary tumors Research Paper

Emilia Mira, Lorena Carmona-RodrÃguez, Manuel TardÃ¡guila, IÃ±igo Azcoitia, Alicia GonzÃ¡lez-MartÃn, Luis Almonacid, Josefina Casas, Gemma FabriÃ¡s, Santos MaÃ±es

Published Oct 26, 2013 · Vol. 4, No. 12 · pp. 2288-2301

Keywords: Placental growth factor, statins, immunity, macrophage polarization, inflammation

Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine. Research Paper

Sevin Turcan, Armida WM Fabius, Alexandra Borodovsky, Alicia Pedraza, Cameron Brennan, Jason Huse, Agnes Viale, Gregory J Riggins, Timothy A Chan

Published Sep 16, 2013 · Vol. 4, No. 10 · pp. 1729-1736

Keywords: IDH, glioma, decitabine, DNMT

The AKT Inhibitor MK-2206 is Cytotoxic in Hepatocarcinoma Cells Displaying Hyperphosphorylated AKT-1 and Synergizes with Conventional Chemotherapy Research Paper

Carolina Simioni, Alberto M. Martelli, Alice Cani, Rengul Cetin-Atalay, James A. McCubrey, Silvano Capitani, Luca M. Neri

Published Aug 24, 2013 · Vol. 4, No. 9 · pp. 1496-1506

Keywords: Hepatocellular carcinoma, MK-2206, Akt-1, targeted therapy, apoptosis, autophagy

Notch3 inhibition enhances sorafenib cytotoxic efficacy by promoting GSK3Î² phosphorylation and p21 down-regulation in hepatocellular carcinoma Research Paper

Catia Giovannini, Michele Baglioni, Marco Baron Toaldo, Cristiano Ventrucci, Stefania D'Adamo, Mario Cipone, Pasquale Chieco, Laura Gramantieri, Luigi Bolondi

Published Aug 24, 2013 · Vol. 4, No. 10 · pp. 1618-1631

Keywords: ERK, drug resistance, angiogenesis, cell proliferation, Notch3

Coordinated Targeting of the EGFR Signaling Axis by MicroRNA-27a* Research Paper

Xiaoli Wu, Mihir K. Bhayani, Cristina T. Dodge, Milena S. Nicoloso, Yunyun Chen, Xiaofeng Yan, Makoto Adachi, Ligy Thomas, Chad E. Galer, Tilahun Jiffar, Curtis R. Pickering, Michael E. Kupferman, Jeffrey N. Myers, George A. Calin, Stephen Y. Lai

Published Aug 6, 2013 · Vol. 4, No. 9 · pp. 1388-1398

Keywords: miRNA EGFR AKT1 mTOR miRNA-27a* miRNA-27a-5p

Powerful Inhibition of Experimental Human Pancreatic Cancers by Receptor Targeted Cytotoxic LH-RH analog AEZS-108 Research Paper

Karoly Szepeshazi, Andrew V. Schally, Norman L. Block, Gabor Halmos, Mehrdad Nadji, Luca Szalontay, Irving Vidaurre, Andrew Abi-Chaker, Ferenc G. Rick

Published Jun 3, 2013 · Vol. 4, No. 5 · pp. 751-760

Keywords: pancreatic carcinoma, targeted therapy, LH-RH receptor, cytotoxic LHRH analog, GnRH, doxorubicin, peptide therapy

Cell death sensitization of leukemia cells by opioid receptor activation Research Paper

Claudia Friesen, Mareike Roscher, Inis Hormann, Iduna Fichtner, Andreas Alt, Ralf Hilger, Klaus-Michael Debatin, Erich Miltner

Published Apr 16, 2013 · Vol. 4, No. 5 · pp. 677-690

Keywords: opioids, methadone, doxorubicin, cAMP, apoptosis, acute lymphoblastic leukemia

A conceptually new treatment approach for relapsed glioblastoma: Coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care. Review

Richard E. Kast, John A. Boockvar, Ansgar BrÃ¼ning, Francesco Cappello, Wen-Wei Chang, Boris Cvek, Q Ping Dou, Alfonso Duenas-Gonzalez, Thomas Efferth, Daniele Focosi, Seyed H. Ghaffari, Georg Karpel-Massler, Kirsi Ketola, Alireza Khoshnevisan, Daniel Keizman, Nicolas MagnÃ©, Christine Marosi, Kerrie McDonald, Miguel MuÃ±oz, Nathan David Sassoon, Mohammad H. Pourgholami, Iacopo Sardi, Avishay Sella, Kalkunte S. Srivenugopal, Marco Tuccori, Weiguang Wang, Christian R. Wirtz, Marc-Eric Halatsch

Published Apr 13, 2013 · Vol. 4, No. 4 · pp. 502-530

Keywords: angiotensin, aprepitant, artesunate, auranofin, captopril, cytokines, disulfiram, glioblastoma, ketoconazole, nelfinavir, neurokinin, sertraline, temozolomide

Combinatorial drug screening identifies compensatory pathway interactions and adaptive resistance mechanisms Research Paper

Mark J Axelrod, Vicki Gordon, Mark Conaway, Adel Tarcsafalvi, Daniel J Neitzke, Daniel Gioeli, Michael J Weber

Published Apr 10, 2013 · Vol. 4, No. 4 · pp. 622-635

Keywords: Targeted therapies, Compensatory signaling, Pathway interactions, Crosstalk, Feedback inhibition

Inhibition of U-87 MG glioblastoma by AN-152 (AEZS-108), a targeted cytotoxic analog of luteinizing hormone-releasing hormone Research Paper

Miklos Jaszberenyi, Andrew V Schally, Norman L Block, Mehrdad Nadji, Irving Vidaurre, Luca Szalontay, Ferenc G Rick

Published Mar 7, 2013 · Vol. 4, No. 3 · pp. 422-432

Keywords: glioblastoma multiforme, U-87 MG, cytotoxic, LHRHor GnRH receptors, AN-152, AEZS-108, nude mice, targeted therapy

Mesenchymal stem cells deliver synthetic microRNA mimics to glioma cells and glioma stem cells and inhibit their cell migration and self-renewal Research Paper

Hae-Kyung Lee, Susan Finniss, Simona Cazacu, Efrat Bucris, Amotz Ziv-Av, Cunli Xiang, Kevin Bobbitt, Sandra Rempel, Laura Hasselbach, Tom Mikkelsen, Shimon Slavin, Chaya Brodie

Published Feb 28, 2013 · Vol. 4, No. 2 · pp. 346-361

Keywords: miRNA delivery, mesenchymal stem cells, glioma, exosomes

Quantification of Mesenchymal Stem Cells (MSCs) at Sites of Human Prostate Cancer Research Paper

W. Nathaniel Brennen, Shuangling Chen, Samuel R. Denmeade, John T. Isaacs

Published Jan 13, 2013 · Vol. 4, No. 1 · pp. 106-117

Keywords: Mesenchymal Stem Cells, MSC, Inflammation, Prostate Cancer, Drug Delivery, CAF

Intraductal Delivery of Adenoviruses Targets Pancreatic Tumors in Transgenic Ela-myc Mice and Orthotopic Xenografts Research Paper

Anabel JosÃ©, Luciano Sobrevals, Juan Miguel Camacho-SÃ¡nchez, Meritxell Huch, NÃºria Andreu, Eduard Ayuso, Pilar Navarro, Ramon Alemany, Cristina Fillat

Published Jan 12, 2013 · Vol. 4, No. 1 · pp. 94-105

Keywords: Pancreatic cancer, adenovirus, orthotopic xenografts, transgenic mice, thymidine kinase

Simalikalactone E (SkE), a new weapon in the armamentarium of drugs targeting cancers that exhibit constitutive activation of the ERK pathway Research Paper

Guillaume Robert, ValÃ©rie Jullian, Arnaud Jacquel, ClÃ©mence Ginet, Maeva Dufies, Stephanie Torino, AnaÃ¯s Pottier, Frederic Peyrade, Sophie Tartare-Deckert, GeneviÃ¨ve Bourdy, Eric Deharo, Patrick Auberger

Published Dec 30, 2012 · Vol. 3, No. 12 · pp. 1688-1699

Keywords: Simalikalactone E, B-Raf inhibitor, CML, Melanoma, Hairy Cell Leukemia, ERK pathway

A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia Research Paper

Francesca Chiarini, Annalisa Lonetti, Gabriella Teti, Ester Orsini, Daniela Bressanin, Alessandra Cappellini, Francesca Ricci, Pier Luigi Tazzari, Andrea Ognibene, Mirella Falconi, Pasqualepaolo Pagliaro, Ilaria Iacobucci, Giovanni Martinelli, Sergio Amadori, James A McCubrey, Alberto M Martelli

Published Dec 18, 2012 · Vol. 3, No. 12 · pp. 1615-1628

Keywords: AML, PI3K/Akt/mTOR signaling, apoptosis, autophagy combination therapy, leukemia initiating cells

Autophagy-related gene 12 (ATG12) is a novel determinant of primary resistance to HER2-targeted therapies: Utility of transcriptome analysis of the autophagy interactome to guide breast cancer treatment Research Paper

SÃlvia CufÃ, Alejandro Vazquez-Martin, Ceistina Oliveras-Ferraros, Bruna Corominas-Faja, Ander Urruticoechea, BegoÃ±a Martin-Castillo, Javier A Menendez

Published Nov 17, 2012 · Vol. 3, No. 12 · pp. 1600-1614

Keywords: Autophagy, ATG genes, HER2, trastuzumab, lapatinib

Harnessing the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia: Eliminating activity by targeting at different levels Research Paper

Daniela Bressanin, Camilla Evangelisti, Francesca Ricci, Giovanna Tabellini, Francesca Chiarini, Pier Luigi Tazzari, Fraia Melchionda, Francesca Buontempo, Pasqualepaolo Pagliaro, Andrea Pession, James A McCubrey, Alberto M. Martelli

Published Aug 9, 2012 · Vol. 3, No. 8 · pp. 811-823

Keywords: acute leukemia, targeted therapy, signal transduction modulators, PI3K/PDK1, vertical inhibition

Receptor-targeted therapy of human experimental urinary bladder cancers with cytotoxic LH-RH analog AN-152 (AEZS-108) Research Paper

Karoly Szepeshazi, Andrew V Schally, Gunhild Keller, Norman L Block, Daniel Benten, Gabor Halmos, Luca Szalontay, Irving Vidaurre, Miklos Jaszberenyi, Ferenc G Rick

Published Jul 22, 2012 · Vol. 3, No. 7 · pp. 686-699

Keywords: urinary bladder, urothelial cancer, targeted therapy, LH-RH receptor, cytotoxic, doxorubicin

The Hsp90 inhibitor NVP-AUY922-AG inhibits NF-ÎºB signaling, overcomes microenvironmental cytoprotection and is highly synergistic with fludarabine in primary CLL cells Research Paper

Elisabeth J. Walsby, Laurence Pearce, Alan K. Burnett, Chris Fegan, Chris Pepper

Published May 19, 2012 · Vol. 3, No. 5 · pp. 525-534

Keywords: Hsp90, CLL, apoptosis, synergy, NF-ÎºB

Ras inhibition by FTS attenuates brain tumor growth in mice directly and by enhancing reactivity of cytotoxic lymphocytes Research Paper

Elizabeta Aizman, Adi Mor, Ayelet Levy, Jacob George, Yoel Kloog

Published Feb 7, 2012 · Vol. 3, No. 2 · pp. 144-157

Keywords: Ras, Glioblastoma, CTL, FTS, Salirasib

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A lovastatin-elicited genetic program inhibits M2 macrophage polarization and enhances T cell infiltration into spontaneous mouse mammary tumors Research Paper

Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine. Research Paper

The AKT Inhibitor MK-2206 is Cytotoxic in Hepatocarcinoma Cells Displaying Hyperphosphorylated AKT-1 and Synergizes with Conventional Chemotherapy Research Paper

Notch3 inhibition enhances sorafenib cytotoxic efficacy by promoting GSK3Î² phosphorylation and p21 down-regulation in hepatocellular carcinoma Research Paper

Coordinated Targeting of the EGFR Signaling Axis by MicroRNA-27a* Research Paper

Powerful Inhibition of Experimental Human Pancreatic Cancers by Receptor Targeted Cytotoxic LH-RH analog AEZS-108 Research Paper

Cell death sensitization of leukemia cells by opioid receptor activation Research Paper

A conceptually new treatment approach for relapsed glioblastoma: Coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care. Review

Combinatorial drug screening identifies compensatory pathway interactions and adaptive resistance mechanisms Research Paper

Inhibition of U-87 MG glioblastoma by AN-152 (AEZS-108), a targeted cytotoxic analog of luteinizing hormone-releasing hormone Research Paper

Mesenchymal stem cells deliver synthetic microRNA mimics to glioma cells and glioma stem cells and inhibit their cell migration and self-renewal Research Paper

Quantification of Mesenchymal Stem Cells (MSCs) at Sites of Human Prostate Cancer Research Paper

Intraductal Delivery of Adenoviruses Targets Pancreatic Tumors in Transgenic Ela-myc Mice and Orthotopic Xenografts Research Paper

Simalikalactone E (SkE), a new weapon in the armamentarium of drugs targeting cancers that exhibit constitutive activation of the ERK pathway Research Paper

A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia Research Paper

Autophagy-related gene 12 (ATG12) is a novel determinant of primary resistance to HER2-targeted therapies: Utility of transcriptome analysis of the autophagy interactome to guide breast cancer treatment Research Paper

Harnessing the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia: Eliminating activity by targeting at different levels Research Paper

Receptor-targeted therapy of human experimental urinary bladder cancers with cytotoxic LH-RH analog AN-152 (AEZS-108) Research Paper

The Hsp90 inhibitor NVP-AUY922-AG inhibits NF-ÎºB signaling, overcomes microenvironmental cytoprotection and is highly synergistic with fludarabine in primary CLL cells Research Paper

Ras inhibition by FTS attenuates brain tumor growth in mice directly and by enhancing reactivity of cytotoxic lymphocytes Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

A lovastatin-elicited genetic program inhibits M2 macrophage polarization and enhances T cell infiltration into spontaneous mouse mammary tumors Research Paper

Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine. Research Paper

The AKT Inhibitor MK-2206 is Cytotoxic in Hepatocarcinoma Cells Displaying Hyperphosphorylated AKT-1 and Synergizes with Conventional Chemotherapy Research Paper

Notch3 inhibition enhances sorafenib cytotoxic efficacy by promoting GSK3Î² phosphorylation and p21 down-regulation in hepatocellular carcinoma Research Paper

Coordinated Targeting of the EGFR Signaling Axis by MicroRNA-27a* Research Paper

Powerful Inhibition of Experimental Human Pancreatic Cancers by Receptor Targeted Cytotoxic LH-RH analog AEZS-108 Research Paper

Cell death sensitization of leukemia cells by opioid receptor activation Research Paper

A conceptually new treatment approach for relapsed glioblastoma: Coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care. Review

Combinatorial drug screening identifies compensatory pathway interactions and adaptive resistance mechanisms Research Paper

Inhibition of U-87 MG glioblastoma by AN-152 (AEZS-108), a targeted cytotoxic analog of luteinizing hormone-releasing hormone Research Paper

Mesenchymal stem cells deliver synthetic microRNA mimics to glioma cells and glioma stem cells and inhibit their cell migration and self-renewal Research Paper

Quantification of Mesenchymal Stem Cells (MSCs) at Sites of Human Prostate Cancer Research Paper

Intraductal Delivery of Adenoviruses Targets Pancreatic Tumors in Transgenic Ela-myc Mice and Orthotopic Xenografts Research Paper

Simalikalactone E (SkE), a new weapon in the armamentarium of drugs targeting cancers that exhibit constitutive activation of the ERK pathway Research Paper

A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia Research Paper

Autophagy-related gene 12 (ATG12) is a novel determinant of primary resistance to HER2-targeted therapies: Utility of transcriptome analysis of the autophagy interactome to guide breast cancer treatment Research Paper

Harnessing the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia: Eliminating activity by targeting at different levels Research Paper

Receptor-targeted therapy of human experimental urinary bladder cancers with cytotoxic LH-RH analog AN-152 (AEZS-108) Research Paper

The Hsp90 inhibitor NVP-AUY922-AG inhibits NF-ÎºB signaling, overcomes microenvironmental cytoprotection and is highly synergistic with fludarabine in primary CLL cells Research Paper

Ras inhibition by FTS attenuates brain tumor growth in mice directly and by enhancing reactivity of cytotoxic lymphocytes Research Paper