The Oncosearch | Oncotarget

Oncogenic KRAS sensitizes premalignant, but not malignant cells, to Noxa-dependent apoptosis through the activation of the MEK/ERK pathway Research Paper

Annalisa Conti, Maria Teresa Majorini, Richard Elliott, Alan Ashworth, Christopher J. Lord, Carlotta Cancelliere, Alberto Bardelli, Pierfausto Seneci, Henning Walczak, Domenico Delia, Daniele Lecis

Published Mar 12, 2015 · Vol. 6, No. 13 · pp. 10994-11008

Computational design, chemical synthesis, and biological evaluation of a novel ERK inhibitor (BL-EI001) with apoptosis-inducing mechanisms in breast cancer Research Paper

Bo Liu, Leilei Fu, Cui Zhang, Lan Zhang, Yonghui Zhang, Liang Ouyang, Gu He, Jian Huang

Published Jan 27, 2015 · Vol. 6, No. 9 · pp. 6762-6775

Hypoxia/HIF1α induces lapatinib resistance in ERBB2-positive breast cancer cells via regulation of DUSP2 Research Paper

Sergey V. Karakashev, Mauricio J. Reginato

Published Jan 24, 2015 · Vol. 6, No. 4 · pp. 1967-1980

Group I Paks as therapeutic targets in NF2-deficient meningioma Research Paper

Hoi-Yee Chow, Biao Dong, Sergio G. Duron, David A. Campbell, Christy C. Ong, Klaus P. Hoeflich, Long-Sheng Chang, D. Bradley Welling, Zeng-jie Yang, Jonathan Chernoff

Published Jan 24, 2015 · Vol. 6, No. 4 · pp. 1981-1994

Inhibition of EP2/EP4 signaling abrogates IGF-1R-mediated cancer cell growth: Involvement of protein kinase C-Î¸ activation Research Paper

Tetsuyuki Takahashi, Hisanori Uehara, Hirohisa Ogawa, Hitomi Umemoto, Yoshimi Bando, Keisuke Izumi

Published Dec 31, 2014 · Vol. 6, No. 7 · pp. 4829-4844

Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion Research Paper

Olga V. Leontieva, Mikhail V. Blagosklonny

Published Dec 29, 2014 · Vol. 5, No. 24 · pp. 12715-12727

Disrupting LIN28 in atypical teratoid rhabdoid tumors reveals the importance of the mitogen activated protein kinase pathway as a therapeutic target Research Paper

Melanie F. Weingart, Jacquelyn J. Roth, Marianne Hutt-Cabezas, Tracy M. Busse, Harpreet Kaur, Antoinette Price, Rachael Maynard, Jeffrey Rubens, Isabella Taylor, Xing-gang Mao, Jingying Xu, Yasumichi Kuwahara, Sariah J. Allen, Anat Erdreich-Epstein, Bernard E. Weissman, Brent A. Orr, Charles G. Eberhart, Jaclyn A. Biegel, Eric H. Raabe

Published Dec 26, 2014 · Vol. 6, No. 5 · pp. 3165-3177

Prostate cancer stem cells: deciphering the origins and pathways involved in prostate tumorigenesis and aggression Review

Adrian P. Rybak, Robert G. Bristow, Anil Kapoor

Published Dec 10, 2014 · Vol. 6, No. 4 · pp. 1900-1919

MIG-7 and phosphorylated prohibitin coordinately regulate lung cancer invasion/metastasis Research Paper

Ming-Yi Ho, Chi-Ming Liang, Shu-Mei Liang

Published Nov 16, 2014 · Vol. 6, No. 1 · pp. 381-393

Truncated RAF kinases drive resistance to MET inhibition in MET-addicted cancer cells Research Paper

Consalvo Petti, Gabriele Picco, Maria Luisa Martelli, Elena Trisolini, Enrico Bucci, Timothy Perera, Claudio Isella, Enzo Medico

Published Nov 15, 2014 · Vol. 6, No. 1 · pp. 221-233

Overcoming resistance to BRAF inhibition in BRAF-mutated metastatic melanoma Review

Francesco Spagnolo, Paola Ghiorzo, Paola Queirolo

Published Nov 15, 2014 · Vol. 5, No. 21 · pp. 10206-10221

Noxa upregulation by oncogenic activation of MEK/ERK through CREB promotes autophagy in human melanoma cells Research Paper

Yi Lun Liu, Fritz Lai, James S. Wilmott, Xu Guang Yan, Xiao Ying Liu, Qi Luan, Su Tang Guo, Chen Chen Jiang, Hsin-Yi Tseng, Richard A. Scolyer, Lei Jin, Xu Dong Zhang

Published Oct 21, 2014 · Vol. 5, No. 22 · pp. 11237-11251

Melanoma patient-derived xenografts accurately model the disease and develop fast enough to guide treatment decisions Clinical Research Papers

Berglind O. Einarsdottir, Roger Olofsson Bagge, Joydeep Bhadury, Henrik Jespersen, Jan Mattsson, Lisa M. Nilsson, Katarina TruvÃ©, Marcela DÃ¡vila LÃ³pez, Peter Naredi, Ola Nilsson, Ulrika Stierner, Lars Ny, Jonas A. Nilsson

Published Sep 8, 2014 · Vol. 5, No. 20 · pp. 9609-9618

MUC1-C confers EMT and KRAS independence in mutant KRAS lung cancer cells Priority Research Paper

Akriti Kharbanda, Hasan Rajabi, Caining Jin, Maroof Alam, Kwok-Kin Wong, Donald Kufe

Published Aug 22, 2014 · Vol. 5, No. 19 · pp. 8893-8905

Keywords: KRAS, NSCLC, MUC1-C, AKT, ZEB1, EMT, self-renewal

Wogonin induces cell cycle arrest and erythroid differentiation inÂ imatinib-resistant K562 cells and primary CML cells Research Paper

Hao Yang, Hui Hui, Qian Wang, Hui Li, Kai Zhao, Yuxin Zhou, Yu Zhu, Xiaotang Wang, Qidong You, Qinglong Guo, Na Lu

Published Aug 10, 2014 · Vol. 5, No. 18 · pp. 8188-8201

Outcomes of patients with advanced cancer and KRAS mutations in phase I clinical trials Clinical Research Papers

Rabih Said, Yang Ye, Gerald Steven Falchook, Filip Janku, Aung Naing, Ralph Zinner, George R. Blumenschein Jr, Siqing Fu, David S. Hong, Sarina Anne Piha-Paul, Jennifer J. Wheler, Razelle Kurzrock, Gary A. Palmer, Kenneth Aldape, Kenneth . R Hess, Apostolia Maria Tsimberidou

Published Aug 10, 2014 · Vol. 5, No. 19 · pp. 8937-8946

Mutant NRAS^Q61 shares signaling similarities across various cancer types â€“ potential implications for future therapies Research Paper

Igor Vujic, Christian Posch, Martina Sanlorenzo, Adam J. Yen, Aaron Tsumura, Andrew Kwong, Valentin Feichtenschlager, Kevin Lai, Douglas V. Arneson, Klemens Rappersberger, Susana M. Ortiz-Urda

Published Aug 8, 2014 · Vol. 5, No. 17 · pp. 7936-7944

miR-200c overexpression is associated with better efficacy of EGFR-TKIs in non-small cell lung cancer patients with EGFR wild-type Research Paper

Jiayu Li, Xuefei Li, Shengxiang Ren, Xiaoxia Chen, Yishi Zhang, Fei Zhou, Mingchuan Zhao, Chao Zhao, Xiu Chen, Ningning Cheng, Yinmin Zhao, Caicun Zhou, Fred R. Hirsch

Published Aug 8, 2014 · Vol. 5, No. 17 · pp. 7902-7916

CDK4/6 inhibitors have potent activity in combination with pathway selective therapeutic agents in models of pancreatic cancer Research Paper

Jorge Franco, Agnieszka . K. Witkiewicz, Erik S. Knudsen

Published Jul 26, 2014 · Vol. 5, No. 15 · pp. 6512-6525

Epigenetic regulations in the IFNÎ³ signalling pathway: IFNÎ³-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes Research Paper

Veronika VlkovÃ¡, Ivan Å tÄ›pÃ¡nek, Veronika HruÅ¡kovÃ¡, Filip Å enigl, Veronika MayerovÃ¡, Martin Å rÃ¡mek, Jana Å ÃmovÃ¡, Jana BieblovÃ¡, Marie IndrovÃ¡, TomÃ¡Å¡ Hejhal, Nicolas DÃ©rian, David Klatzmann, Adrien Six, Milan ReiniÅ¡

Published Jul 15, 2014 · Vol. 5, No. 16 · pp. 6923-6935

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Oncogenic KRAS sensitizes premalignant, but not malignant cells, to Noxa-dependent apoptosis through the activation of the MEK/ERK pathway Research Paper

Computational design, chemical synthesis, and biological evaluation of a novel ERK inhibitor (BL-EI001) with apoptosis-inducing mechanisms in breast cancer Research Paper

Hypoxia/HIF1α induces lapatinib resistance in ERBB2-positive breast cancer cells via regulation of DUSP2 Research Paper

Group I Paks as therapeutic targets in NF2-deficient meningioma Research Paper

Inhibition of EP2/EP4 signaling abrogates IGF-1R-mediated cancer cell growth: Involvement of protein kinase C-Î¸ activation Research Paper

Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion Research Paper

Disrupting LIN28 in atypical teratoid rhabdoid tumors reveals the importance of the mitogen activated protein kinase pathway as a therapeutic target Research Paper

Prostate cancer stem cells: deciphering the origins and pathways involved in prostate tumorigenesis and aggression Review

MIG-7 and phosphorylated prohibitin coordinately regulate lung cancer invasion/metastasis Research Paper

Truncated RAF kinases drive resistance to MET inhibition in MET-addicted cancer cells Research Paper

Overcoming resistance to BRAF inhibition in BRAF-mutated metastatic melanoma Review

Noxa upregulation by oncogenic activation of MEK/ERK through CREB promotes autophagy in human melanoma cells Research Paper

Melanoma patient-derived xenografts accurately model the disease and develop fast enough to guide treatment decisions Clinical Research Papers

MUC1-C confers EMT and KRAS independence in mutant KRAS lung cancer cells Priority Research Paper

Wogonin induces cell cycle arrest and erythroid differentiation inÂ imatinib-resistant K562 cells and primary CML cells Research Paper

Outcomes of patients with advanced cancer and KRAS mutations in phase I clinical trials Clinical Research Papers

Mutant NRAS^Q61 shares signaling similarities across various cancer types â€“ potential implications for future therapies Research Paper

miR-200c overexpression is associated with better efficacy of EGFR-TKIs in non-small cell lung cancer patients with EGFR wild-type Research Paper

CDK4/6 inhibitors have potent activity in combination with pathway selective therapeutic agents in models of pancreatic cancer Research Paper

Epigenetic regulations in the IFNÎ³ signalling pathway: IFNÎ³-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Oncogenic KRAS sensitizes premalignant, but not malignant cells, to Noxa-dependent apoptosis through the activation of the MEK/ERK pathway Research Paper

Computational design, chemical synthesis, and biological evaluation of a novel ERK inhibitor (BL-EI001) with apoptosis-inducing mechanisms in breast cancer Research Paper

Hypoxia/HIF1α induces lapatinib resistance in ERBB2-positive breast cancer cells via regulation of DUSP2 Research Paper

Group I Paks as therapeutic targets in NF2-deficient meningioma Research Paper

Inhibition of EP2/EP4 signaling abrogates IGF-1R-mediated cancer cell growth: Involvement of protein kinase C-Î¸ activation Research Paper

Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion Research Paper

Disrupting LIN28 in atypical teratoid rhabdoid tumors reveals the importance of the mitogen activated protein kinase pathway as a therapeutic target Research Paper

Prostate cancer stem cells: deciphering the origins and pathways involved in prostate tumorigenesis and aggression Review

MIG-7 and phosphorylated prohibitin coordinately regulate lung cancer invasion/metastasis Research Paper

Truncated RAF kinases drive resistance to MET inhibition in MET-addicted cancer cells Research Paper

Overcoming resistance to BRAF inhibition in BRAF-mutated metastatic melanoma Review

Noxa upregulation by oncogenic activation of MEK/ERK through CREB promotes autophagy in human melanoma cells Research Paper

Melanoma patient-derived xenografts accurately model the disease and develop fast enough to guide treatment decisions Clinical Research Papers

MUC1-C confers EMT and KRAS independence in mutant KRAS lung cancer cells Priority Research Paper

Wogonin induces cell cycle arrest and erythroid differentiation inÂ imatinib-resistant K562 cells and primary CML cells Research Paper

Outcomes of patients with advanced cancer and KRAS mutations in phase I clinical trials Clinical Research Papers

Mutant NRASQ61 shares signaling similarities across various cancer types â€“ potential implications for future therapies Research Paper

miR-200c overexpression is associated with better efficacy of EGFR-TKIs in non-small cell lung cancer patients with EGFR wild-type Research Paper

CDK4/6 inhibitors have potent activity in combination with pathway selective therapeutic agents in models of pancreatic cancer Research Paper

Epigenetic regulations in the IFNÎ³ signalling pathway: IFNÎ³-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes Research Paper

Mutant NRAS^Q61 shares signaling similarities across various cancer types â€“ potential implications for future therapies Research Paper