|
| Oncobiguanides: Paracelsus’ law and nonconventional routes for administering diabetobiguanides for cancer treatment |
|
https://doi.org/10.18632/oncotarget.1965
Javier A. Menendez, Rosa Quirantes-Piné, Esther RodrÃguez-Gallego, SÃlvia CufÃ, Bruna Corominas-Faja, Elisabet Cuyà s, Joaquim Bosch-Barrera, Begoña Martin-Castillo, Antonio Segura-Carretero, and Jorge Joven
|
| 2344-2348 |
|
| Unique molecular signatures as a hallmark of patients with metastatic breast cancer: Implications for current treatment paradigms |
|
https://doi.org/10.18632/oncotarget.1946
Jennifer J. Wheler, Barbara A. Parker, Jack J. Lee, Johnique T. Atkins, Filip Janku, Apostolia M. Tsimberidou, Ralph Zinner, Vivek Subbiah, Siqing Fu, Richard Schwab, Stacy Moulder, Vicente Valero, Maria Schwaederle, Roman Yelensky, Vincent A. Miller, M Philip J. Stephens, Funda Meric-Bernstam, and Razelle Kurzrock
|
| 2349-2354 |
|
| Inhibition of BRD4 attenuates tumor cell selfrenewal and suppresses stem cell signaling in MYC driven medulloblastoma |
|
https://doi.org/10.18632/oncotarget.1659
Sujatha Venataraman, Irina Alimova, Peter Harris, Diane K Birks, Illango Balakrishnan, Marc Remke, Michael D Taylor, Michael Handler, Nicholas K Foreman, and Rajeev Vibhakar
|
| 2355-2371 |
|
| Antitumor activity of the combination of an HSP90 inhibitor and a PI3K/mTOR dual inhibitor against cholangiocarcinoma |
|
https://doi.org/10.18632/oncotarget.1706
Ming-Huang Chen, Kun-Chun Chiang, Chi-Tung Cheng, Shih-Chiang Huang, Yeng-Yang Chen, Tsung-Wen Chen, Ta-Sen Yeh, Yi-Yin Jan, Hsi-Ming Wang, Jiang-Jie Weng, Peter Mu-Hsin Chang, Chun-Yu Liu, Chung-Pin Li, Yee Chao, Ming-Han Chen, Chi-Ying F. Huang, and Chun-Nan Yeh
|
| 2372-2389 |
|
| The KLK5 protease suppresses breast cancer by repressing the mevalonate pathway |
|
https://doi.org/10.18632/oncotarget.1235
Georgios Pampalakis, Osahon Obasuyi, Olga Papadodima, Aristotelis Chatziioannou, Vassileios Zoumpourlis, and Georgia Sotiropoulou
|
| 2390-2403 |
|
| Alternative splicing of FBPinteracting repressor coordinates cMyc P27Kip1/cyclinE and Ku86/XRCC5 expression as a molecular sensor for bleomycininduced DNA damage pathway |
|
https://doi.org/10.18632/oncotarget.1650
Bahityar Rahmutulla, Kazuyuki Matsushita, Mamoru Satoh, Masanori Seimiya, Sachio Tsuchida, Shuji Kubo, Hideaki Shimada, Masayuki Ohtsuka, Masaru Miyazaki, and Fumio Nomura
|
| 2404-2417 |
|
| SERPINB3 protects from oxidative damage by chemotherapeutics through inhibition of mitochondrial respiratory complex I |
|
https://doi.org/10.18632/oncotarget.1411
Francesco Ciscato, Marco Sciacovelli, Gianmarco Villano, Cristian Turato, Paolo Bernardi, Andrea Rasola, and Patrizia Pontisso
|
| 2418-2427 |
|
| Bak and Mcl1 are essential for Temozolomide induced cell death in human glioma |
|
https://doi.org/10.18632/oncotarget.1642
Catherine Gratas, Quentin Séry, Marion Rabé, Lisa Oliver, and François M. Vallette
|
| 2428-2435 |
|
| WT1 regulates angiogenesis in Ewing Sarcoma |
|
https://doi.org/10.18632/oncotarget.1610
Varalakshimi Katuri, Stephanie Gerber, Xiaofei Qiu, Gregory McCarty, Seth D. Goldstein, Hans Hammers, Elizabeth Montgomery, Allen R. Chen, and David M. Loeb
|
| 2436-2449 |
|
| Enrichment of circulating melanoma cells CMCs using negative selection from patients with metastatic melanoma |
|
https://doi.org/10.18632/oncotarget.1683
Powrnima Joshi, Barbara Jacobs, Adeeb Derakhshan, Lee R. Moore, Paul Elson, Pierre L. Triozzi, Ernest Borden, and Maciej Zborowski
|
| 2450-2461 |
|
| YB1 expression promotes epithelialtomesenchymal transition in prostate cancer that is inhibited by a small molecule fisetin |
|
https://doi.org/10.18632/oncotarget.1790
Mohammad Imran Khan, Vaqar Mustafa Adhami, Rahul Kumar Lall, Mario Sechi, Dinesh C. Joshi, Omar M. Haidar, Deeba Nadeem Syed, Imtiaz Ahmad Siddiqui, Shing-Yan Chiu, and Hasan Mukhtar
|
| 2462-2474 |
|
| FAAH inhibition enhances anandamide mediated antitumorigenic effects in nonsmall cell lung cancer by downregulating the EGF/EGFR pathway |
|
https://doi.org/10.18632/oncotarget.1723
Janani Ravi, Amita Sneh, Konstantin Shilo, Mohd W. Nasser, and Ramesh K. Ganju
|
| 2475-2486 |
|
| A DNA repair pathway score predicts survival in human multiple myeloma: the potential for therapeutic strategy |
|
https://doi.org/10.18632/oncotarget.1740
Alboukadel Kassambara, Claire Gourzones-Dmitriev, Surinder Sahota, Thierry Rème, Jérôme Moreaux, Hartmut Goldschmidt, Angelos Constantinou, Phillipe Pasero, Dirk Hose, and Bernard Klein
|
| 2487-2498 |
|
| A highcontent morphological screen identifies novel microRNAs that regulate neuroblastoma cell differentiation |
|
https://doi.org/10.18632/oncotarget.1703
Zhenze Zhao, Xiuye Ma, Tzu-Hung Hsiao, Gregory Lin, Adam Kosti, Xiaojie Yu, Uthra Suresh, Yidong Chen, Gail E. Tomlinson, Alexander Pertsemlidis, and Liqin Du
|
| 2499-2512 |
|
| miR199a3p displays tumor suppressor functions in papillary thyroid carcinoma |
|
https://doi.org/10.18632/oncotarget.1830
Emanuela Minna, Paola Romeo, Loris De Cecco, Matteo Dugo, Giuliana Cassinelli, Silvana Pilotti, Debora Degl’Innocenti, Cinzia Lanzi, Patrizia Casalini, Marco A. Pierotti, Angela Greco, and Maria Grazia Borrello
|
| 2513-2528 |
|
| STAT3 down regulates LC3 to inhibit autophagy and pancreatic cancer cell growth |
|
https://doi.org/10.18632/oncotarget.1810
Jingjing Gong, Amanda R. Muñoz, Daniel Chan, Rita Ghosh, and Addanki P. Kumar
|
| 2529-2541 |
|
| Hyperactivation of Akt/mTOR and deficiency in tuberin increased the oxidative DNA damage in kidney cancer patients with diabetes |
|
https://doi.org/10.18632/oncotarget.1833
Samy L. Habib, and Sitai Liang
|
| 2542-2550 |
|
| ATRX mRNA expression combined with IDH1/2 mutational status and Ki67 expression refines the molecular classification of astrocytic tumors: evidence from the whole transcriptome sequencing of 169 samples |
|
https://doi.org/10.18632/oncotarget.1838
Jinquan Cai, Pei Yang, Chuanbao Zhang, Wei Zhang, Yanwei Liu, Zhaoshi Bao, Xing Liu, Wenzhong Du, Hongjun Wang, Tao Jiang, and Chuanlu Jiang
|
| 2551-2561 |
|
| IGF1R a target of let7b mediates crosstalk between IRS2/Akt and MAPK pathways to promote proliferation of oral squamous cell carcinoma |
|
https://doi.org/10.18632/oncotarget.1812
Ling Gao, Xiaolong Wang, Xiaofei Wang, Linmei Zhang, Cui Qiang, Su’e Chang, Wenhao Ren, Shaoming Li, Yang Yang, Dongdong Tong, Cheng Chen, Zongfang Li, Tusheng Song, Keqian Zhi, and Chen Huang
|
| 2562-2574 |
|
| Epigenetic silencing of EYA2 in pancreatic adenocarcinomas promotes tumor growth |
|
https://doi.org/10.18632/oncotarget.1842
Audrey Vincent, Seung-Mo Hong, Chaoxin Hu, Noriyuki Omura, Angela Young, Haeryoung Kim, Jun Yu, Spencer Knight, Michael Ayars, Margaret Griffith, Isabelle Van Seuningen, Anirban Maitra, and Michael Goggins
|
| 2575-2587 |
|
| Biomarkers of reactive resistance and early disease progression during chemotherapy plus bevacizumab treatment for colorectal carcinoma |
|
https://doi.org/10.18632/oncotarget.1811
Hidetoshi Hayashi, Tokuzo Arao, Kazuko Matsumoto, Hideharu Kimura Kimura, Yosuke Togashi, Yoshinori Hirashima, Yosuke Horita, Satoru Iwasa, Natsuko Tsuda Okita, Yoshitaka Honma, Atsuo Takashima, Ken Kato, Tetsuya Hamaguchi, Yasuhiro Shimada, Kazuhiko Nakagawa, Kazuto Nishio, and Yasuhide Yamada
|
| 2588-2595 |
|
| HOXC8 promotes breast tumorigenesis by transcriptionally facilitating cadherin11 expression |
|
https://doi.org/10.18632/oncotarget.1841
Yong Li, Fengmei Chao, Bei Huang, Dahai Liu, Jaejik Kim, and Shuang Huang
|
| 2596-2607 |
|
| YAP1 acts as oncogenic target of 11q22 amplification in multiple cancer subtypes |
|
https://doi.org/10.18632/oncotarget.1844
Erica Lorenzetto, Monica Brenca, Mattia Boeri, Carla Verri, Elena Piccinin, Patrizia Gasparini, Federica Facchinetti, Sabrina Rossi, Giuliana Salvatore, Maura Massimino, Gabriella Sozzi, Roberta Maestro, and Piergiorgio Modena
|
| 2608-2621 |
|
| Targeting the MUC1C oncoprotein inhibits selfrenewal capacity of breast cancer cells |
|
https://doi.org/10.18632/oncotarget.1848
Maroof Alam, Hasan Rajabi, Rehan Ahmad, Caining Jin, and Donald Kufe
|
| 2622-2634 |
|
| Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma |
|
https://doi.org/10.18632/oncotarget.1862
Juan Liu, Cen Zhang, Meihua Lin, Wei Zhu, Yingjian Liang, Xuehui Hong, Yuhan Zhao, Ken H. Young, Wenwei Hu, and Zhaohui Feng
|
| 2635-2647 |
|
| Heat shock protein 27 regulates human prostate cancer cell motility and metastatic progression |
|
https://doi.org/10.18632/oncotarget.1917
Eric A. Voll, Irene M. Ogden, Janet M. Pavese, XiaoKe Huang, Li Xu, Borko D. Jovanovic, and Raymond C. Bergan
|
| 2648-2663 |
|
| Isorhapontigenin ISO inhibited cell transformation by inducing G0/G1 phase arrest via increasing MKP1 mRNA stability |
|
https://doi.org/10.18632/oncotarget.1872
Guangxun Gao, Liang Chen, Jingxia Li, Dongyun Zhang, Yong Fang, Haishan Huang, Xiequn Chen, and Chuanshu Huang
|
| 2664-2677 |
|
| Sublethal concentrations of 17AAG suppress homologous recombination DNA repair and enhance sensitivity to carboplatin and olaparib in HR proficient ovarian cancer cells |
|
https://doi.org/10.18632/oncotarget.1929
Young Eun Choi, Chiara Battelli, Jacqueline Watson, Joyce Liu, Jennifer Curtis, Alexander N. Morse, Ursula A. Matulonis, Dipanjan Chowdhury, and Panagiotis A. Konstantinopoulos
|
| 2678-2687 |
|
| Activated Alk triggers prolonged neurogenesis and Ret upregulation providing a therapeutic target in ALKmutated neuroblastoma |
|
https://doi.org/10.18632/oncotarget.1883
Alex Cazes, Lucille Lopez-Delisle, Konstantina Tsarovina, Cécile Pierre-Eugène, Katleen De Preter, Michel Peuchmaur, André Nicolas, Claire Provost, Caroline Louis-Brennetot, Romain Daveau, Candy Kumps, Ilaria Cascone, Gudrun Schleiermacher, Aurélie Prignon, Frank Speleman, Hermann Rohrer, Olivier Delattre, and Isabelle Janoueix-Lerosey
|
| 2688-2702 |
|
| Hyperactivation of Alk induces neonatal lethality in knockin AlkF1178L mice |
|
https://doi.org/10.18632/oncotarget.1882
Lucille Lopez-Delisle, Cécile Pierre-Eugène, Evelyne Bloch-Gallego, Marie-Christine Birling, Jean-Loup Duband, Estelle Durand, Thomas Bourgeois, Boris Matrot, Tania Sorg, Michel Huerre, Hamid Meziane, Michel J. Roux, Marie-France Champy, Jorge Gallego, Olivier Delattre, and Isabelle Janoueix-Lerosey
|
| 2703-2713 |
|
| The antiapoptotic form of tyrosine kinase Lyn that is generated by proteolysis is degraded by the Nend rule pathway |
|
https://doi.org/10.18632/oncotarget.1931
Mohamed A. Eldeeb, and Richard P. Fahlman
|
| 2714-2722 |
|
| Oncogenic functions of IGF1R and INSR in prostate cancer include enhanced tumor growth cell migration and angiogenesis |
|
https://doi.org/10.18632/oncotarget.1884
Isabel Heidegger, Johann Kern, Philipp Ofer, Helmut Klocker, and Petra Massoner
|
| 2723-2735 |
|
| Tumor cellproduced matrix metalloproteinase 9 MMP9 drives malignant progression and metastasis of basallike triple negative breast cancer |
|
https://doi.org/10.18632/oncotarget.1932
Christine Mehner, Alexandra Hockla, Erin Miller, Sophia Ran, Derek C. Radisky, and Evette S. Radisky
|
| 2736-2749 |
|
| The characterization of a novel monoclonal antibody against CD93 unveils a new antiangiogenic target |
|
https://doi.org/10.18632/oncotarget.1887
Maurizio Orlandini, Federico Galvagni, Monia Bardelli, Marina Rocchigiani, Claudia Lentucci, Francesca Anselmi, Alessio Zippo, Luca Bini, and Salvatore Oliviero
|
| 2750-2760 |
|
| Direct endothelial junction restoration results in significant tumor vascular normalization and metastasis inhibition in mice |
|
https://doi.org/10.18632/oncotarget.1942
Vijayendra Agrawal, Sony Maharjan, Kyeojin Kim, Nam-Jung Kim, Jimin Son, Keunho Lee, Hyun-Jung Choi Choi, Seung-Sik Rho, Sunjoo Ahn, Moo-Ho Won, Sang-Jun Ha, Gou Young Koh, Young-Myeong Kim, Young-Ger Suh, and Young-Guen Kwon
|
| 2761-2777 |
|
| Indoleamine 23dioxygenase mediates immuneindependent human tumor cell resistance to olaparib gamma radiation and cisplatin |
|
https://doi.org/10.18632/oncotarget.1916
Saman Maleki Vareki, Mateusz Rytelewski, Rene Figueredo, Di Chen, Peter J. Ferguson, Mark Vincent, Weiping Min, Xiufen Zheng, and James Koropatnick
|
| 2778-2791 |
|
| microRNA148a dysregulation discriminates poor prognosis of hepatocellular carcinoma in association with USP4 overexpression |
|
https://doi.org/10.18632/oncotarget.1920
Mi Jeong Heo, Young Mi Kim, Ja Hyun Koo, Yoon Mee Yang, Jihyun An, Sook-Kyung Lee, Seung Jin Lee, Kang Mo Kim, Joong-Won Park, and Sang Geon Kim
|
| 2792-2806 |
|
| Oncolytic reovirus preferentially induces apoptosis in KRAS mutant colorectal cancer cells and synergizes with irinotecan |
|
https://doi.org/10.18632/oncotarget.1921
Radhashree Maitra, Raviraja Seetharam, Lydia Tesfa, Titto A. Augustine, Lidija Klampfer, Matthew C. Coffey, John M. Mariadason, and Sanjay Goel
|
| 2807-2819 |
|
| RNA binding protein RBM14 promotes radioresistance in glioblastoma by regulating DNA repair and cell differentiation |
|
https://doi.org/10.18632/oncotarget.1924
Ming Yuan, Charles G. Eberhart, and Mihoko Kai
|
| 2820-2826 |
|
| ROSinduced epithelialmesenchymal transition in mammary epithelial cells is mediated by NFκBdependent activation of Snail |
|
https://doi.org/10.18632/oncotarget.1940
Magdalena A. Cichon, and Derek C. Radisky
|
| 2827-2838 |
|
| Multigene mutational profiling of cholangiocarcinomas identifies actionable molecular subgroups |
|
https://doi.org/10.18632/oncotarget.1943
Michele Simbolo, Matteo Fassan, Andrea Ruzzenente, Andrea Mafficini, Laura D. Wood, Vincenzo Corbo, Davide Melisi, Giuseppe Malleo, Caterina Vicentini, Giorgio Malpeli, Davide Antonello, Nicola Sperandio, Paola Capelli, Anna Tomezzoli, Calogero Iacono, Rita T. Lawlor, Claudio Bassi, Ralph H. Hruban, Alfredo Guglielmi, Giampaolo Tortora, Filippo de Braud, and Aldo Scarpa
|
| 2839-2852 |
|
| Strategy to enhance the therapeutic effect of doxorubicin in human hepatocellular carcinoma by selenocystine a synergistic agent that regulates the ROSmediated signaling |
|
https://doi.org/10.18632/oncotarget.1854
Cundong Fan, Wenjie Zheng, Xiaoyan Fu, Xiaoling Li, Yum-Shing Wong, and Tianfeng Chen
|
| 2853-2863 |
