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A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Wayne D. Blosser, Jack A. Dempsey, Ann M. Mc Nulty, Xi Rao, Philip J. Ebert, Caitlin D. Lowery, Philip W. Iversen, Yue Wang Webster, Gregory P. Donoho, Xueqian Gong, Farhana F. Merzoug, Sean Buchanan, Karsten Boehnke, Chunping Yu, Xin Tian You, Richard P. Beckmann, Wenjuan Wu, Samuel C. McNeely, Aimee Bence Lin, Ricardo Martinez

Published Dec 16, 2019

Keywords: CHK1, prexasertib, replication stress, replication fork, innate immunity

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Wayne D. Blosser, Jack A. Dempsey, Ann M. Mc Nulty, Xi Rao, Philip J. Ebert, Caitlin D. Lowery, Philip W. Iversen, Yue Wang Webster, Gregory P. Donoho, Xueqian Gong, Farhana F. Merzoug, Sean Buchanan, Karsten Boehnke, Chunping Yu, Xin Tian You, Richard P. Beckmann, Wenjuan Wu, Samuel C. McNeely, Aimee Bence Lin, Ricardo Martinez

Published Dec 16, 2019

Keywords: CHK1, prexasertib, replication stress, replication fork, innate immunity

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Wayne D. Blosser, Jack A. Dempsey, Ann M. Mc Nulty, Xi Rao, Philip J. Ebert, Caitlin D. Lowery, Philip W. Iversen, Yue Wang Webster, Gregory P. Donoho, Xueqian Gong, Farhana F. Merzoug, Sean Buchanan, Karsten Boehnke, Chunping Yu, Xin Tian You, Richard P. Beckmann, Wenjuan Wu, Samuel C. McNeely, Aimee Bence Lin, Ricardo Martinez

Published Dec 16, 2019

Keywords: CHK1, prexasertib, replication stress, replication fork, innate immunity

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Wayne D. Blosser, Jack A. Dempsey, Ann M. Mc Nulty, Xi Rao, Philip J. Ebert, Caitlin D. Lowery, Philip W. Iversen, Yue Wang Webster, Gregory P. Donoho, Xueqian Gong, Farhana F. Merzoug, Sean Buchanan, Karsten Boehnke, Chunping Yu, Xin Tian You, Richard P. Beckmann, Wenjuan Wu, Samuel C. McNeely, Aimee Bence Lin, Ricardo Martinez

Published Dec 16, 2019

Keywords: CHK1, prexasertib, replication stress, replication fork, innate immunity

Systemic oncolytic adenovirus delivered in mesenchymal carrier cells modulate tumor infiltrating immune cells and tumor microenvironment in mice with neuroblastoma Research Paper

Lidia Franco-Luzón, África González-Murillo, Cristina Alcántara-Sánchez, Lorena García-García, Maryam Tabasi, Ana Luis Huertas, Louis Chesler, Manuel Ramírez

Published Dec 12, 2019

Keywords: oncolytic virotherapy, neuroblastoma, mesenchymal stem cells, tumor microenvironment, immune response

Correction: High expression of CTHRC1 promotes EMT of epithelial ovarian cancer (EOC) and is associated with poor prognosis Correction

Minzhi Hou, Zhiqiang Cheng, Hongwei Shen, Shanyang He, Yang Li, Yunping Pan, Chongjin Feng, Xinlin Chen, Yang Zhang, Millicent Lin, Liantang Wang, Zunfu Ke

Published Nov 26, 2019 · Vol. 11, No. 8 · pp. 825-826

Correction: Lactate promotes PGE2 synthesis and gluconeogenesis in monocytes to benefit the growth of inflammation-associated colorectal tumor Correction

Libin Wei, Yuxin Zhou, Jing Yao, Chen Qiao, Ting Ni, Ruichen Guo, Qinglong Guo, Na Lu

Published Nov 20, 2019

Correction: BM microenvironmental protection of CML cells from imatinib through Stat5/NF-κB signaling and reversal by Wogonin Correction

Xuefen Xu, Xiaobo Zhang, Yicheng Liu, Lin Yang, Shaoliang Huang, Lu Lu, Shuhao Wang, Qinglong Guo, Li Zhao

Published Nov 19, 2019

A squalamine derivative, NV669, as a novel PTP1B inhibitor: in vitro and in vivo effects on pancreatic and hepatic tumor growth Research Paper

Sylvie Carmona, Jean-Michel Brunel, Rénaté Bonier, Véronique Sbarra, Stéphane Robert, Patrick Borentain, Dominique Lombardo, Eric Mas, René Gerolami

Published Nov 19, 2019 · Vol. 10, No. 62 · pp. 6651-6667

Keywords: aminosterol, pancreas, liver, PTP1B, cancer

The growth of a xenograft breast cancer tumor model with engineered hyaluronan-accumulating stroma is dependent on hyaluronan and independent of CD44 Research Paper

Chunmei Zhao, Benjamin J. Thompson, Kelly Chen, Feng Gao, Barbara Blouw, Mathieu Marella, Susan Zimmerman, Trevor Kimbler, Sheryl Garrovillo, Jesse Bahn, Lei Huang, Zhongdong Huang, H. Michael Shepard, Sanna Rosengren, Christopher D. Thanos, Daniel C. Maneval

Published Nov 12, 2019 · Vol. 10, No. 61 · pp. 6561-6576

Keywords: hyaluronan, breast cancer, xenograft, tumor microenvironment, CD44

High expression of apoptosis protein (Api-5) in chemoresistant triple-negative breast cancers: an innovative target Research Paper

Guilhem Bousquet, Jean-Paul Feugeas, Yuchen Gu, Christophe Leboeuf, Morad El Bouchtaoui, He Lu, Marc Espié, Anne Janin, Melanie Di Benedetto

Published Nov 12, 2019 · Vol. 10, No. 61 · pp. 6577-6588

Keywords: triple-negative breast cancer, chemotherapy resistance, apoptosis-inhibitor-5, peptide, anti-angiogenic therapy

Volasertib preclinical activity in high-risk hepatoblastoma Research Paper

Dina Kats, Cora A. Ricker, Noah E. Berlow, Bénédicte Noblet, Delphine Nicolle, Katell Mevel, Sophie Branchereau, Jean-Gabriel Judde, Cody D. Stiverson, Christina L. Stiverson, Matthew N. Svalina, Teagan Settelmeyer, Kevin Matlock, Melvin Lathara, Charlotte Mussini, James I. Geller, Christopher Noakes, Ido Sloma, Narendra Bharathy, Stefano Cairo, Charles Keller

Published Nov 5, 2019 · Vol. 10, No. 60 · pp. 6403-6417

Keywords: hepatoblastoma, PLK1, volasertib, liver, cell cycle

Improved surgical resection of metastatic pancreatic cancer using uPAR targeted in vivo fluorescent guidance: comparison with traditional white light surgery Research Paper

Karina Juhl, Anders Christensen, Niclas Rubek, Kirstine Kim Schmidt Karnov, Christian von Buchwald, Andreas Kjaer

Published Oct 29, 2019 · Vol. 10, No. 59 · pp. 6308-6316

Keywords: optical imaging, near-infrared imaging (NIR), NIR-I, urokinase plasminogen activator receptor (uPAR), cancer

The multikinase inhibitor RXDX-105 is effective against neuroblastoma in vitro and in vivo Research Paper

Sean M. Flynn, Jacqueline Lesperance, Andrew Macias, Nikki Phanhthilath, Megan Rose Paul, Jong Wook Kim, Pablo Tamayo, Peter E. Zage

Published Oct 29, 2019 · Vol. 10, No. 59 · pp. 6323-6333

Keywords: neuroblastoma, RXDX-105, CEP-32496, RET, BRAF

The phenanthrene derivative PJ34 exclusively eradicates human pancreatic cancer cells in xenografts Research Paper

Leonid Visochek, Dikla Atias, Itay Spektor, Asher Castiel, Talia Golan, Malka Cohen-Armon

Published Oct 22, 2019 · Vol. 10, No. 58 · pp. 6269-6282

Keywords: PJ34, pancreas cancer, stroma, PANC1 cancer xenografts

Effect of Fms-like tyrosine kinase 3 (FLT3) ligand (FL) on antitumor activity of gilteritinib, a FLT3 inhibitor, in mice xenografted with FL-overexpressing cells Research Paper

Tatsuya Kawase, Taisuke Nakazawa, Tomohiro Eguchi, Hirofumi Tsuzuki, Yoko Ueno, Yasushi Amano, Tomoyuki Suzuki, Masamichi Mori, Taku Yoshida

Published Oct 22, 2019 · Vol. 10, No. 58 · pp. 6111-6123

Keywords: FLT3, FL, FLT3 inhibitor, gilteritinib, antitumor activity

Preclinical analysis of human mesenchymal stem cells: tumor tropism and therapeutic efficiency of local HSV-TK suicide gene therapy in glioblastoma Research Paper

Lasse Dührsen, Sophie Hartfuß, Daniela Hirsch, Sabine Geiger, Cecile L. Maire, Jan Sedlacik, Christine Guenther, Manfred Westphal, Katrin Lamszus, Felix G. Hermann, Nils Ole Schmidt

Published Oct 22, 2019 · Vol. 10, No. 58 · pp. 6049-6061

Keywords: glioblastoma, brain tumor, stem cells, gene therapy, migration

The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-β/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer Research Paper

Shiho Fukui, Kazunori Nagasaka, Yuko Miyagawa, Ryoko Kikuchi-Koike, Yoshiko Kawata, Ranka Kanda, Takayuki Ichinose, Takeru Sugihara, Haruko Hiraike, Osamu Wada-Hiraike, Yuko Sasajima, Takuya Ayabe

Published Oct 15, 2019 · Vol. 10, No. 57 · pp. 5932-5948

Keywords: ovarian cancer, bAP15, TGF-β/Smad signaling, UCHL5, apoptosis

ERO1α promotes hypoxic tumor progression and is associated with poor prognosis in pancreatic cancer Research Paper

Nikhil Gupta, Jung Eun Park, Wilford Tse, Jee Keem Low, Oi Lian Kon, Neil McCarthy, Siu Kwan Sze

Published Oct 15, 2019 · Vol. 10, No. 57 · pp. 5970-5982

Keywords: pancreatic cancer, hypoxia tumor, ERO1α, SILAC, proteomics

Targeting glutaminase1 and synergizing with clinical drugs achieved more promising antitumor activity on multiple myeloma Research Paper

Qiang Qiu, Mengyuan Li, Linyu Yang, Minghai Tang, Li Zheng, Fang Wang, Huandi Qiu, Cailing Liang, Ning Li, Dongni Yi, Yuyao Yi, Cong Pan, Shengyong Yang, Lijuan Chen, Yiguo Hu

Published Oct 15, 2019 · Vol. 10, No. 57 · pp. 5993-6005

Keywords: glutaminase1, multiple myeloma, BPTES, cMYC/KRAS12V-transduced plasmacytoma, mouse model

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A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Systemic oncolytic adenovirus delivered in mesenchymal carrier cells modulate tumor infiltrating immune cells and tumor microenvironment in mice with neuroblastoma Research Paper

Correction: High expression of CTHRC1 promotes EMT of epithelial ovarian cancer (EOC) and is associated with poor prognosis Correction

Correction: Lactate promotes PGE2 synthesis and gluconeogenesis in monocytes to benefit the growth of inflammation-associated colorectal tumor Correction

Correction: BM microenvironmental protection of CML cells from imatinib through Stat5/NF-κB signaling and reversal by Wogonin Correction

A squalamine derivative, NV669, as a novel PTP1B inhibitor: in vitro and in vivo effects on pancreatic and hepatic tumor growth Research Paper

The growth of a xenograft breast cancer tumor model with engineered hyaluronan-accumulating stroma is dependent on hyaluronan and independent of CD44 Research Paper

High expression of apoptosis protein (Api-5) in chemoresistant triple-negative breast cancers: an innovative target Research Paper

Volasertib preclinical activity in high-risk hepatoblastoma Research Paper

Improved surgical resection of metastatic pancreatic cancer using uPAR targeted in vivo fluorescent guidance: comparison with traditional white light surgery Research Paper

The multikinase inhibitor RXDX-105 is effective against neuroblastoma in vitro and in vivo Research Paper

The phenanthrene derivative PJ34 exclusively eradicates human pancreatic cancer cells in xenografts Research Paper

Effect of Fms-like tyrosine kinase 3 (FLT3) ligand (FL) on antitumor activity of gilteritinib, a FLT3 inhibitor, in mice xenografted with FL-overexpressing cells Research Paper

Preclinical analysis of human mesenchymal stem cells: tumor tropism and therapeutic efficiency of local HSV-TK suicide gene therapy in glioblastoma Research Paper

The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-β/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer Research Paper

ERO1α promotes hypoxic tumor progression and is associated with poor prognosis in pancreatic cancer Research Paper

Targeting glutaminase1 and synergizing with clinical drugs achieved more promising antitumor activity on multiple myeloma Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Systemic oncolytic adenovirus delivered in mesenchymal carrier cells modulate tumor infiltrating immune cells and tumor microenvironment in mice with neuroblastoma Research Paper

Correction: High expression of CTHRC1 promotes EMT of epithelial ovarian cancer (EOC) and is associated with poor prognosis Correction

Correction: Lactate promotes PGE2 synthesis and gluconeogenesis in monocytes to benefit the growth of inflammation-associated colorectal tumor Correction

Correction: BM microenvironmental protection of CML cells from imatinib through Stat5/NF-κB signaling and reversal by Wogonin Correction

A squalamine derivative, NV669, as a novel PTP1B inhibitor: in vitro and in vivo effects on pancreatic and hepatic tumor growth Research Paper

The growth of a xenograft breast cancer tumor model with engineered hyaluronan-accumulating stroma is dependent on hyaluronan and independent of CD44 Research Paper

High expression of apoptosis protein (Api-5) in chemoresistant triple-negative breast cancers: an innovative target Research Paper

Volasertib preclinical activity in high-risk hepatoblastoma Research Paper

Improved surgical resection of metastatic pancreatic cancer using uPAR targeted in vivo fluorescent guidance: comparison with traditional white light surgery Research Paper

The multikinase inhibitor RXDX-105 is effective against neuroblastoma in vitro and in vivo Research Paper

The phenanthrene derivative PJ34 exclusively eradicates human pancreatic cancer cells in xenografts Research Paper

Effect of Fms-like tyrosine kinase 3 (FLT3) ligand (FL) on antitumor activity of gilteritinib, a FLT3 inhibitor, in mice xenografted with FL-overexpressing cells Research Paper

Preclinical analysis of human mesenchymal stem cells: tumor tropism and therapeutic efficiency of local HSV-TK suicide gene therapy in glioblastoma Research Paper

The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-β/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer Research Paper

ERO1α promotes hypoxic tumor progression and is associated with poor prognosis in pancreatic cancer Research Paper

Targeting glutaminase1 and synergizing with clinical drugs achieved more promising antitumor activity on multiple myeloma Research Paper