The Oncosearch | Oncotarget

Novel role for the Golgi membrane protein TMEM165 in control of migration and invasion for breast carcinoma Research Paper

Pavitra Murali, Blake P. Johnson, Zhongpeng Lu, Leslie Climer, Danielle A. Scott, Francois Foulquier, Gabriela Oprea-Ilies, Vladimir Lupashin, Richard R. Drake, Karen L. Abbott

Published Jun 27, 2020 · Vol. 11, No. 28 · pp. 2747-2762

Keywords: TMEM165, migration, invasion, breast cancer, glycosylation

Fibrillin-1, induced by Aurora-A but inhibited by BRCA2, promotes ovarian cancer metastasis Correction

Ziliang Wang, Yang Liu, Lili Lu, Lina Yang, Sheng Yin, Yan Wang, Zihao Qi, Jiao Meng, Rongyu Zang, Gong Yang

Published Jun 22, 2020

Development and comprehensive characterization of porcine hepatocellular carcinoma for translational liver cancer investigation Research Paper

Ron C. Gaba, Lobna Elkhadragy, F. Edward Boas, Sulalita Chaki, Hanna H. Chen, Mohammed El-Kebir, Kelly D. Garcia, Eileena F. Giurini, Grace Guzman, Francesca V. LoBianco, Mario F. Neto, Jordan L. Newson, Aisha Qazi, Maureen Regan, Lauretta A. Rund, Regina M. Schwind, Matthew C. Stewart, Faith M. Thomas, Herbert E. Whiteley, Jiaqi Wu, Lawrence B. Schook, Kyle M. Schachtschneider

Published Jun 10, 2020 · Vol. 11, No. 28 · pp. 2686-2701

Keywords: liver cancer, transgenic pigs, large animal model, interventional radiology, personalized medicine

SUSD2 expression correlates with decreased metastasis and increased survival in a high-grade serous ovarian cancer xenograft murine model Research Paper

Jordan N. Sheets, Mitch E. Patrick, Kristi A. Egland

Published May 25, 2020 · Vol. 11, No. 24 · pp. 2290-2301

Keywords: high-grade serous ovarian cancer, SUSD2, xenograft, metastasis

Development and characterization of the novel human osteosarcoma cell line COS-33 with sustained activation of the mTOR pathway Research Paper

Ashley VanCleave, Mykayla Palmer, Fang Fang, Haydee Torres, Tania Rodezno, Qilin Li, Kirby Fuglsby, Claire Evans, Yohannes Afeworki, Alan Ross, Pulivarthi Rao, Patricia Leiferman, Siyuan Zheng, Peter Houghton, Jianning Tao

Published May 18, 2020 · Vol. 11, No. 27 · pp. 2597-2610

Keywords: osteosarcoma, COS-33, mTOR, osteogenic differentiation, TP53

TAK1 regulates the tumor microenvironment through inflammatory, angiogenetic and apoptotic signaling cascades Research Paper

Scott A. Scarneo, Kelly W. Yang, Jose R. Roques, Alanna Dai, Liesl S. Eibschutz, Philip Hughes, Timothy A.J. Haystead

Published May 8, 2020 · Vol. 11, No. 21 · pp. 1961-1970

Keywords: TAK1, breast cancer, therapeutic, inflammation

Efficacy of osimertinib against EGFRvIII+ glioblastoma Research Paper

Gustavo Chagoya, Shawn G. Kwatra, Cory W. Nanni, Callie M. Roberts, Samantha M. Phillips, Sarah Nullmeyergh, Samuel P. Gilmore, Ivan Spasojevic, David L. Corcoran, Christopher C. Young, Karla V. Ballman, Rohan Ramakrishna, Darren A. Cross, James M. Markert, Michael Lim, Mark R. Gilbert, Glenn J. Lesser, Madan M. Kwatra

Published May 5, 2020 · Vol. 11, No. 22 · pp. 2074-2082

Keywords: EGFRvIII, tyrosine kinase, glioblastoma stem cells, osimertinib, xenografts

Inhibition of HAS2 and hyaluronic acid production by 1,25-Dihydroxyvitamin D₃ in breast cancer Research Paper

Carmen J. Narvaez, Erika LaPorta, Samantha Robilotto, Jennifer Liang, JoEllen Welsh

Published Apr 25, 2020 · Vol. 11, No. 30 · pp. 2889-2905

Keywords: vitamin D, hyaluronic acid, hyaluronan synthase, HAS2, breast cancer

Immunotherapy of ovarian cancer with a monoclonal antibody specific for the extracellular domain of anti-Müllerian hormone receptor II Research Paper

Suparna Mazumder, Valerie Swank, Anton A. Komar, Justin M. Johnson, Vincent K. Tuohy

Published Apr 22, 2020 · Vol. 11, No. 20 · pp. 1894-1910

Keywords: monoclonal antibody, anti-Müllerian hormone receptor type II, immunotherapy, ovarian cancer, 4D12G1

Characterization of GRK5 as a novel regulator of rhabdomyosarcoma tumor cell growth and self-renewal Research Paper

Thao Pham, Kristin Robinson, Terra Vleeshouwer-Neumann, James E. Annis, Eleanor Y. Chen

Published Apr 21, 2020 · Vol. 11, No. 16 · pp. 1448-1461

Keywords: rhabdomyosarcoma, self-renewal, GRK5, kinase, cell cycle

Synergistic combinations of paclitaxel and withaferin A against human non-small cell lung cancer cells Research Paper

Al Hassan Kyakulaga, Farrukh Aqil, Radha Munagala, Ramesh C. Gupta

Published Apr 21, 2020 · Vol. 11, No. 16 · pp. 1399-1416

Keywords: non-small cell lung cancer, withaferin A, synergistic, combination index, paclitaxel

Expression of receptor activator of NFkB (RANK) drives stemness and resistance to therapy in ER+HER2- breast cancer Research Paper

Inês Gomes, Bernardo P. de Almeida, Sara Dâmaso, André Mansinho, Inês Correia, Sara Henriques, Raquel Cruz-Duarte, Guilherme Vilhais, Pedro Félix, Patrícia Alves, Patrícia Corredeira, Nuno L. Barbosa-Morais, Luis Costa, Sandra Casimiro

Published Apr 18, 2020 · Vol. 11, No. 19 · pp. 1714-1728

Keywords: RANKL-RANK pathway, ER+ breast cancer, resistance to chemo and hormone therapy, stemness, metastization

Knock-down of the TIM/TIPIN complex promotes apoptosis in melanoma cells Research Paper

Abhijit Chakraborty, Faisal Aziz, Eunmiri Roh, Le Thi My Le, Raja Dey, Tianshun Zhang, Moeez G. Rathore, Aalekhya Sharma Biswas, Ann M. Bode, Zigang Dong

Published Apr 17, 2020 · Vol. 11, No. 20 · pp. 1846-1861

Keywords: TIMELESS, TIPIN, apoptosis, xenograft, Cryo-EM

Protein phosphatase 1 regulatory subunit 1A regulates cell cycle progression in Ewing sarcoma Research Paper

Wen Luo, Changxin Xu, Sarah Phillips, Aliza Gardenswartz, Jeremy M. Rosenblum, Janet Ayello, Stephen L. Lessnick, Huai-Xiang Hao, Mitchell S. Cairo

Published Apr 16, 2020 · Vol. 11, No. 19 · pp. 1691-1704

Keywords: PPP1R1A, cell cycle control, IGF-1R, metastasis, Ewing sarcoma

Molecular imaging reveals biodistribution of P-cadherin LP-DART bispecific and trafficking of adoptively transferred T cells in mouse xenograft model Research Paper

Vijay R. Gupta, Adam Root, Timothy Fisher, Rand Norberg, John David, Tracey Clark, Justin Cohen, Chad May, Anand Giddabasappa

Published Apr 14, 2020 · Vol. 11, No. 15 · pp. 1344-1357

Keywords: bispecific antibody, tumor targeting, biodistribution, T cells, molecular imaging

Targeted alpha therapy using astatine (²¹¹At)-labeled phenylalanine: A preclinical study in glioma bearing mice Research Paper

Tadashi Watabe, Kazuko Kaneda-Nakashima, Yoshifumi Shirakami, Yuwei Liu, Kazuhiro Ooe, Takahiro Teramoto, Atsushi Toyoshima, Eku Shimosegawa, Takashi Nakano, Yoshikatsu Kanai, Atsushi Shinohara, Jun Hatazawa

Published Apr 14, 2020 · Vol. 11, No. 15 · pp. 1388-1398

Keywords: alpha therapy, astatine, glioma, LAT1, phenylalanine

Combined inhibition of PIM and CDK4/6 suppresses both mTOR signaling and Rb phosphorylation and potentiates PI3K inhibition in cancer cells Priority Research Paper

Lacey M. Litchfield, Karsten Boehnke, Manisha Brahmachary, Cecilia Mur, Chen Bi, Jennifer R. Stephens, J. Michael Sauder, Sonia M. Gutiérrez, Ann M. McNulty, Xiang S. Ye, Wenjuan Wu, María José Lallena, Xueqian Gong, Farhana F. Merzoug, Valerie M. Jansen, Sean G. Buchanan

Published Mar 23, 2020 · Vol. 11, No. 17 · pp. 1478-1492

Keywords: abemaciclib, CDK4/6, PIM, mTOR, S6

Quizartinib, a selective FLT3 inhibitor, maintains antileukemic activity in preclinical models of RAS-mediated midostaurin-resistant acute myeloid leukemia cells Research Paper

Tomoya Aikawa, Noriko Togashi, Koichi Iwanaga, Hiroyuki Okada, Yumi Nishiya, Shinichi Inoue, Mark J. Levis, Takeshi Isoyama

Published Mar 17, 2020 · Vol. 11, No. 11 · pp. 943-955

Keywords: relapsed/refractory AML, FLT3 inhibitors, quizartinib, AC886, midostaurin resistance

DOT1L inhibition is lethal for multiple myeloma due to perturbation of the endoplasmic reticulum stress pathway Research Paper

Caroline Dafflon, Swann Gaulis, Louise Barys, Karen Kapur, Vanessa Cornacchione, Lina Schukur, Sebastian Bergling, Elisabetta Traggiai, Selina Jansky, Leon Hellmann, Barbara Schacher Engstler, Grainne Kerr, Antoine de Weck, David A. Ruddy, Ulrike Naumann, Frédéric Stauffer, Christoph Gaul, Ying Lin, Eric Billy, Andreas Weiss, Francesco Hofmann, Moriko Ito, Ralph Tiedt

Published Mar 17, 2020 · Vol. 11, No. 11 · pp. 956-968

Keywords: DOT1L, multiple myeloma, epigenetics, histone methylation, unfolded protein response

Targeting PI3Kβ alone and in combination with chemotherapy or immunotherapy in tumors with PTEN loss Research Paper

Nicci Owusu-Brackett, Ming Zhao, Argun Akcakanat, Kurt W. Evans, Erkan Yuca, Ecaterina Ileana Dumbrava, Filip Janku, Funda Meric-Bernstam

Published Mar 17, 2020 · Vol. 11, No. 11 · pp. 969-981

Keywords: PI3Kβ, PTEN loss, AZD8186, chemotherapy, immunotherapy

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Novel role for the Golgi membrane protein TMEM165 in control of migration and invasion for breast carcinoma Research Paper

Fibrillin-1, induced by Aurora-A but inhibited by BRCA2, promotes ovarian cancer metastasis Correction

Development and comprehensive characterization of porcine hepatocellular carcinoma for translational liver cancer investigation Research Paper

SUSD2 expression correlates with decreased metastasis and increased survival in a high-grade serous ovarian cancer xenograft murine model Research Paper

Development and characterization of the novel human osteosarcoma cell line COS-33 with sustained activation of the mTOR pathway Research Paper

TAK1 regulates the tumor microenvironment through inflammatory, angiogenetic and apoptotic signaling cascades Research Paper

Efficacy of osimertinib against EGFRvIII+ glioblastoma Research Paper

Inhibition of HAS2 and hyaluronic acid production by 1,25-Dihydroxyvitamin D₃ in breast cancer Research Paper

Immunotherapy of ovarian cancer with a monoclonal antibody specific for the extracellular domain of anti-Müllerian hormone receptor II Research Paper

Characterization of GRK5 as a novel regulator of rhabdomyosarcoma tumor cell growth and self-renewal Research Paper

Synergistic combinations of paclitaxel and withaferin A against human non-small cell lung cancer cells Research Paper

Expression of receptor activator of NFkB (RANK) drives stemness and resistance to therapy in ER+HER2- breast cancer Research Paper

Knock-down of the TIM/TIPIN complex promotes apoptosis in melanoma cells Research Paper

Protein phosphatase 1 regulatory subunit 1A regulates cell cycle progression in Ewing sarcoma Research Paper

Molecular imaging reveals biodistribution of P-cadherin LP-DART bispecific and trafficking of adoptively transferred T cells in mouse xenograft model Research Paper

Targeted alpha therapy using astatine (²¹¹At)-labeled phenylalanine: A preclinical study in glioma bearing mice Research Paper

Combined inhibition of PIM and CDK4/6 suppresses both mTOR signaling and Rb phosphorylation and potentiates PI3K inhibition in cancer cells Priority Research Paper

Quizartinib, a selective FLT3 inhibitor, maintains antileukemic activity in preclinical models of RAS-mediated midostaurin-resistant acute myeloid leukemia cells Research Paper

DOT1L inhibition is lethal for multiple myeloma due to perturbation of the endoplasmic reticulum stress pathway Research Paper

Targeting PI3Kβ alone and in combination with chemotherapy or immunotherapy in tumors with PTEN loss Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Novel role for the Golgi membrane protein TMEM165 in control of migration and invasion for breast carcinoma Research Paper

Fibrillin-1, induced by Aurora-A but inhibited by BRCA2, promotes ovarian cancer metastasis Correction

Development and comprehensive characterization of porcine hepatocellular carcinoma for translational liver cancer investigation Research Paper

SUSD2 expression correlates with decreased metastasis and increased survival in a high-grade serous ovarian cancer xenograft murine model Research Paper

Development and characterization of the novel human osteosarcoma cell line COS-33 with sustained activation of the mTOR pathway Research Paper

TAK1 regulates the tumor microenvironment through inflammatory, angiogenetic and apoptotic signaling cascades Research Paper

Efficacy of osimertinib against EGFRvIII+ glioblastoma Research Paper

Inhibition of HAS2 and hyaluronic acid production by 1,25-Dihydroxyvitamin D3 in breast cancer Research Paper

Immunotherapy of ovarian cancer with a monoclonal antibody specific for the extracellular domain of anti-Müllerian hormone receptor II Research Paper

Characterization of GRK5 as a novel regulator of rhabdomyosarcoma tumor cell growth and self-renewal Research Paper

Synergistic combinations of paclitaxel and withaferin A against human non-small cell lung cancer cells Research Paper

Expression of receptor activator of NFkB (RANK) drives stemness and resistance to therapy in ER+HER2- breast cancer Research Paper

Knock-down of the TIM/TIPIN complex promotes apoptosis in melanoma cells Research Paper

Protein phosphatase 1 regulatory subunit 1A regulates cell cycle progression in Ewing sarcoma Research Paper

Molecular imaging reveals biodistribution of P-cadherin LP-DART bispecific and trafficking of adoptively transferred T cells in mouse xenograft model Research Paper

Targeted alpha therapy using astatine (211At)-labeled phenylalanine: A preclinical study in glioma bearing mice Research Paper

Combined inhibition of PIM and CDK4/6 suppresses both mTOR signaling and Rb phosphorylation and potentiates PI3K inhibition in cancer cells Priority Research Paper

Quizartinib, a selective FLT3 inhibitor, maintains antileukemic activity in preclinical models of RAS-mediated midostaurin-resistant acute myeloid leukemia cells Research Paper

DOT1L inhibition is lethal for multiple myeloma due to perturbation of the endoplasmic reticulum stress pathway Research Paper

Targeting PI3Kβ alone and in combination with chemotherapy or immunotherapy in tumors with PTEN loss Research Paper

Inhibition of HAS2 and hyaluronic acid production by 1,25-Dihydroxyvitamin D₃ in breast cancer Research Paper

Targeted alpha therapy using astatine (²¹¹At)-labeled phenylalanine: A preclinical study in glioma bearing mice Research Paper