The Oncosearch | Oncotarget

The use of a uPAR-targeted probe for photothermal cancer therapy prolongs survival in a xenograft mouse model of glioblastoma Research Paper

Marina Simón, Jesper Tranekjær Jørgensen, Karina Juhl, Andreas Kjaer

Published Jun 22, 2021 · Vol. 12, No. 14 · pp. 1366-1376

Keywords: photothermal therapy (PTT), indocyanine green (ICG), urokinase plasminogen activator receptor (uPAR), cancer, hyperthermia

Next-generation multimodality of nutrigenomic cancer therapy: sulforaphane in combination with acetazolamide actively target bronchial carcinoid cancer in disabling the PI3K/Akt/mTOR survival pathway and inducing apoptosis Research Paper

Reza Bayat Mokhtari, Bessi Qorri, Narges Baluch, Angelo Sparaneo, Federico Pio Fabrizio, Lucia Anna Muscarella, Albina Tyker, Sushil Kumar, Hai-Ling Margaret Cheng, Myron R. Szewczuk, Bikul Das, Herman Yeger

Published Jun 22, 2021 · Vol. 12, No. 15 · pp. 1470-1489

Keywords: sulforaphane, acetazolamide, bronchial carcinoid tumors, serotonin, carbonic anhydrase

Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells Research Paper

Andrew E. Greenstein, Hazel J. Hunt

Published Jun 9, 2021 · Vol. 12, No. 13 · pp. 1243-1255

Keywords: glucocorticoid, tumors, apoptosis, chemotherapy, drug resistance

A Dynamic Energy Budget (DEB) based modeling framework to describe tumor-in-host growth inhibition and cachexia onset during anticancer treatment in in vivo xenograft studies Research Perspective

Elena Maria Tosca, Maurizio Rocchetti, Paolo Magni

Published May 6, 2021 · Vol. 12, No. 14 · pp. 1434-1441

Keywords: PK-PD modeling, tumor-growth-inhibition model, dynamic energy budget theory, cancer cachexia, xenograft model

Targeting super-enhancers reprograms glioblastoma central carbon metabolism Research Perspective

Trang T.T. Nguyen, Mike-Andrew Westhoff, Georg Karpel-Massler, Markus D. Siegelin

Published Mar 30, 2021 · Vol. 12, No. 13 · pp. 1309-1313

Keywords: glioblastoma, metabolism, HDAC-inhibitor, c-Myc, fatty acid oxidation

High in vitro and in vivo synergistic activity between mTORC1 and PLK1 inhibition in adenocarcinoma NSCLC Research Paper

Elodie Montaudon, Rania El Botty, Sophie Vacher, Olivier Déas, Adnan Naguez, Sophie Chateau-Joubert, Damien Treguer, Ludmilla de Plater, Leïla Zemoura, Fariba Némati, André Nicolas, Alain Chapelier, Alain Livartowski, Stefano Cairo, Catherine Daniel, Marie Brevet, Elisabetta Marangoni, Didier Meseure, Sergio Roman-Roman, Ivan Bieche, Nicolas Girard, Didier Decaudin

Published Mar 26, 2021 · Vol. 12, No. 8 · pp. 859-872

Keywords: NSCLC, Pi3K signalling pathway, mTORC1, RAD001 (everolimus), PLK1

Development of a ghrelin receptor inverse agonist for positron emission tomography Research Paper

Ralf Bergmann, Constance Chollet, Sylvia Els-Heindl, Martin Ullrich, Nicole Berndt, Jens Pietzsch, Domokos Máthé, Michael Bachmann, Annette G. Beck-Sickinger

Published Feb 7, 2021 · Vol. 12, No. 5 · pp. 450-474

Keywords: cancer, prostate cancer, growth hormone secretagogue receptor (GHS-R), small animal imaging, copper-64

The noradrenergic profile of plasma metanephrine in neuroblastoma patients is reproduced in xenograft mice models and arise from PNMT downregulation Research Paper

Karim Abid, Maja Beck Popovic, Katia Balmas Bourloud, Jacqueline Schoumans, Joana Grand-Guillaume, Eric Grouzmann, Annick Mühlethaler-Mottet

Published Dec 23, 2020 · Vol. 12, No. 1 · pp. 49-60

Keywords: neuroblastoma, metanephrine, patient-derived xenograft, mouse model, Phenylethanolamine N-Methyltransferase

Correction: Paradoxical role of CBX8 in proliferation and metastasis of colorectal cancer Correction

Jianjun Tang, Gang Wang, Meifang Zhang, Feng-yan Li, Yi Sang, Boqing Wang, Kaishun Hu, Yuanzhong Wu, Rongzhen Luo, Dan Liao, Jingying Cao, Xin Wang, Li Wang, Ruhua Zhang, Xiaoshi Zhang, Wu-Guo Deng, Dan Xie, Rui-hua Xu, Tiebang Kang

Published Nov 7, 2020 · pp. 1026-1028

Phase I trial of TRC102 (methoxyamine HCl) in combination with temozolomide in patients with relapsed solid tumors and lymphomas Research Paper

Geraldine O'Sullivan Coyne, Shivaani Kummar, Robert S. Meehan, Khanh Do, Jerry M. Collins, Larry Anderson, Kazusa Ishii, Naoko Takebe, Jennifer Zlott, Lamin Juwara, Richard Piekarz, Howard Streicher, Elad Sharon, Larry Rubinstein, Andrea Regier Voth, Jay Lozier, Angie B. Dull, Deborah Wilsker, Toshinori Hinoue, Peter W. Laird, Katherine V. Ferry-Galow, Robert J. Kinders, Ralph E. Parchment, James H. Doroshow, Alice P. Chen

Published Oct 12, 2020 · Vol. 11, No. 44 · pp. 3959-3971

Keywords: DNA damage repair, base excision repair, MGMT, rational combination therapy, molecular pharmacodynamics

TRAIL receptor agonists convert the response of breast cancer cells to ONC201 from anti-proliferative to apoptotic Priority Research Paper

Marie D. Ralff, Aakash Jhaveri, Jocelyn E. Ray, Lanlan Zhou, Avital Lev, Kerry S. Campbell, David T. Dicker, Eric A. Ross, Wafik S. El-Deiry

Published Oct 6, 2020 · Vol. 11, No. 42 · pp. 3753-3769

Keywords: ONC201, TRAIL, breast cancer, death receptors, apoptosis

Combination of copanlisib with cetuximab improves tumor response in cetuximab-resistant patient-derived xenografts of head and neck cancer Research Paper

Konrad Klinghammer, Oliver Politz, Theresa Eder, Raik Otto, Jan-Dirk Raguse, Andreas Albers, Andreas Kaufmann, Ingeborg Tinhofer, Jens Hoffmann, Ulrich Keller, Ulrich Keilholz

Published Oct 1, 2020 · Vol. 11, No. 41 · pp. 3688-3697

Keywords: cetuximab, copanlisib, head and neck squamous cell carcinoma, HPV, patient-derived xenograft model

Correction: Preclinical evaluation of biomarkers associated with antitumor activity of MELK inhibitor Correction

Suyoun Chung, Kyoko Kijima, Aiko Kudo, Yoshiko Fujisawa, Yosuke Harada, Akiko Taira, Naofumi Takamatsu, Takashi Miyamoto, Yo Matsuo, Yusuke Nakamura

Published Sep 12, 2020 · Vol. 11, No. 41 · pp. 3749-3750

ATM inhibition overcomes resistance to histone deacetylase inhibitor due to p21 induction and cell cycle arrest Research Paper

Luigi Scotto, Xavier J. Serrano, Kelly Zullo, Cristina Kinahan, Changchun Deng, Ahmed Sawas, Susan Bates, Owen A. O’Connor

Published Aug 18, 2020 · Vol. 11, No. 37 · pp. 3432-3442

Keywords: lymphoma, HDAC inhibitor, ATM inhibitor, p21, cell cycle

Delivering a RAS protease halts tumor growth Editorial

Vania Vidimar, Roman A. Melnyk, Karla J.F. Satchell

Published Aug 13, 2020 · Vol. 11, No. 35 · pp. 3265-3266

Keywords: RAS, RRSP, chimeric toxins, cancer, xenografts

Therapeutic applications of the selective high affinity ligand drug SH7139 extend beyond non-Hodgkin’s lymphoma to many other types of solid cancers Research Paper

Rod Balhorn, Monique Cosman Balhorn

Published Aug 5, 2020 · Vol. 11, No. 35 · pp. 3315-3349

Keywords: HLA-DR, selective high affinity ligand, SH7139, SH7129, solid cancers

GATA3 and APOBEC3B are prognostic markers in adrenocortical carcinoma and APOBEC3B is directly transcriptionally regulated by GATA3 Research Paper

Sudheer Kumar Gara, Monica Varun Tyagi, Dhaval Thakkur Patel, Kelli Gaskins, Justin Lack, Yi Liu, Electron Kebebew

Published Jul 30, 2020 · Vol. 11, No. 36 · pp. 3354-3370

Keywords: adrenocortical carcinoma, APOBEC3B, GATA3, prognosis, DNA damage

Targeting 14-3-3ε-CDC25A interactions to trigger apoptotic cell death in skin cancer Research Paper

Thomas R. Holmes, Jenan Al-Matouq, Matti Holmes, Lauren Nicola, Justin C. Rudd, Sándor Lovas, Laura A. Hansen

Published Jul 30, 2020 · Vol. 11, No. 35 · pp. 3267-3278

Keywords: skin cancer, squamous cell carcinoma, CDC25A, 14-3-3ε, apoptosis

The bromodomain inhibitor IBET-151 attenuates vismodegib-resistant esophageal adenocarcinoma growth through reduction of GLI signaling Research Paper

Annamil Alvarez-Trotta, Zhiqiang Wang, Elena Shersher, Bin Li, Jun Long, Ines Lohse, Claes Wahlestedt, Wael El-Rifai, David J. Robbins, Anthony J. Capobianco

Published Jul 28, 2020 · Vol. 11, No. 33 · pp. 3174-3187

Keywords: IBET-151, esophageal adenocarcinoma, GDC-0449 resistance, patient-derived xenografts, Hedgehog/GLI signaling pathway

Obinutuzumab (GA101) vs. rituximab significantly enhances cell death, antibody-dependent cytotoxicity and improves overall survival against CD20+ primary mediastinal B-cell lymphoma (PMBL) in a xenograft NOD-scid IL2Rgnull (NSG) mouse model: a potential targeted agent in the treatment of PMBL Research Paper

Yaya Chu, Aradhana Awasthi, Sanghoon Lee, Dina Edani, Changhong Yin, Jessica Hochberg, Tishi Shah, Tae-Hoon Chung, Janet Ayello, Carmella van de Ven, Christian Klein, Dean Lee, Mitchell S. Cairo

Published Jul 21, 2020 · Vol. 11, No. 32 · pp. 3035-3047

Keywords: Obinutuzumab, rituximab, survival, primary mediastinal large B-cell lymphoma, antibody-dependent cellular cytotoxicity

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The use of a uPAR-targeted probe for photothermal cancer therapy prolongs survival in a xenograft mouse model of glioblastoma Research Paper

Next-generation multimodality of nutrigenomic cancer therapy: sulforaphane in combination with acetazolamide actively target bronchial carcinoid cancer in disabling the PI3K/Akt/mTOR survival pathway and inducing apoptosis Research Paper

Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells Research Paper

A Dynamic Energy Budget (DEB) based modeling framework to describe tumor-in-host growth inhibition and cachexia onset during anticancer treatment in in vivo xenograft studies Research Perspective

Targeting super-enhancers reprograms glioblastoma central carbon metabolism Research Perspective

High in vitro and in vivo synergistic activity between mTORC1 and PLK1 inhibition in adenocarcinoma NSCLC Research Paper

Development of a ghrelin receptor inverse agonist for positron emission tomography Research Paper

The noradrenergic profile of plasma metanephrine in neuroblastoma patients is reproduced in xenograft mice models and arise from PNMT downregulation Research Paper

Correction: Paradoxical role of CBX8 in proliferation and metastasis of colorectal cancer Correction

Phase I trial of TRC102 (methoxyamine HCl) in combination with temozolomide in patients with relapsed solid tumors and lymphomas Research Paper

TRAIL receptor agonists convert the response of breast cancer cells to ONC201 from anti-proliferative to apoptotic Priority Research Paper

Combination of copanlisib with cetuximab improves tumor response in cetuximab-resistant patient-derived xenografts of head and neck cancer Research Paper

Correction: Preclinical evaluation of biomarkers associated with antitumor activity of MELK inhibitor Correction

ATM inhibition overcomes resistance to histone deacetylase inhibitor due to p21 induction and cell cycle arrest Research Paper

Delivering a RAS protease halts tumor growth Editorial

Therapeutic applications of the selective high affinity ligand drug SH7139 extend beyond non-Hodgkin’s lymphoma to many other types of solid cancers Research Paper

GATA3 and APOBEC3B are prognostic markers in adrenocortical carcinoma and APOBEC3B is directly transcriptionally regulated by GATA3 Research Paper

Targeting 14-3-3ε-CDC25A interactions to trigger apoptotic cell death in skin cancer Research Paper

The bromodomain inhibitor IBET-151 attenuates vismodegib-resistant esophageal adenocarcinoma growth through reduction of GLI signaling Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

The use of a uPAR-targeted probe for photothermal cancer therapy prolongs survival in a xenograft mouse model of glioblastoma Research Paper

Next-generation multimodality of nutrigenomic cancer therapy: sulforaphane in combination with acetazolamide actively target bronchial carcinoid cancer in disabling the PI3K/Akt/mTOR survival pathway and inducing apoptosis Research Paper

Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells Research Paper

A Dynamic Energy Budget (DEB) based modeling framework to describe tumor-in-host growth inhibition and cachexia onset during anticancer treatment in in vivo xenograft studies Research Perspective

Targeting super-enhancers reprograms glioblastoma central carbon metabolism Research Perspective

High in vitro and in vivo synergistic activity between mTORC1 and PLK1 inhibition in adenocarcinoma NSCLC Research Paper

Development of a ghrelin receptor inverse agonist for positron emission tomography Research Paper

The noradrenergic profile of plasma metanephrine in neuroblastoma patients is reproduced in xenograft mice models and arise from PNMT downregulation Research Paper

Correction: Paradoxical role of CBX8 in proliferation and metastasis of colorectal cancer Correction

Phase I trial of TRC102 (methoxyamine HCl) in combination with temozolomide in patients with relapsed solid tumors and lymphomas Research Paper

TRAIL receptor agonists convert the response of breast cancer cells to ONC201 from anti-proliferative to apoptotic Priority Research Paper

Combination of copanlisib with cetuximab improves tumor response in cetuximab-resistant patient-derived xenografts of head and neck cancer Research Paper

Correction: Preclinical evaluation of biomarkers associated with antitumor activity of MELK inhibitor Correction

ATM inhibition overcomes resistance to histone deacetylase inhibitor due to p21 induction and cell cycle arrest Research Paper

Delivering a RAS protease halts tumor growth Editorial

Therapeutic applications of the selective high affinity ligand drug SH7139 extend beyond non-Hodgkin’s lymphoma to many other types of solid cancers Research Paper

GATA3 and APOBEC3B are prognostic markers in adrenocortical carcinoma and APOBEC3B is directly transcriptionally regulated by GATA3 Research Paper

Targeting 14-3-3ε-CDC25A interactions to trigger apoptotic cell death in skin cancer Research Paper

The bromodomain inhibitor IBET-151 attenuates vismodegib-resistant esophageal adenocarcinoma growth through reduction of GLI signaling Research Paper