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Apoptosis inducers in chronic lymphocytic leukemia Review

Christian Billard

Published Nov 19, 2013 · Vol. 5, No. 2 · pp. 309-325

Keywords: CLL, impaired cell death program, apoptosis-targeted therapies, apoptosis inducers, Bcl-2 family proteins

Computational methods for detecting copy number variations in cancer genome using next generation sequencing: principles and challenges Review

Biao Liu, Carl D. Morrison, Candace S. Johnson, Donald L. Trump, Maochun Qin, Jeffrey C. Conroy, Jianmin Wang, Song Liu

Published Nov 16, 2013 · Vol. 4, No. 11 · pp. 1868-1881

Keywords: copy number variation, next generation sequencing, cancer genome analysis, somatic mutations

Pharmacokinetic modeling optimizes inhibition of the â€˜undruggableâ€™ EWS-FLI1 transcription factor in Ewing Sarcoma Research Paper

Sung-Hyeok Hong, Sarah E. Youbi, S. Peter Hong, Bhaskar Kallakury, Phillip Monroe, Hayriye V. Erkizan, Julie S. Barber-Rotenberg, Peter Houghton, Aykut Ãœren, Jeffrey A. Toretsky

Published Nov 11, 2013 · Vol. 5, No. 2 · pp. 338-350

Keywords: YK-4-279, EWS-FLI1, Ewing Sarcoma, rat xenograft, pharmacokinetic modeling

KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation Research Paper

Changcun Guo, Lee H. Chen, Yafen Huang, Chun-Chi Chang, Ping Wang, Christopher J. Pirozzi, Xiaoxia Qin, Xuhui Bao, Paula K. Greer, Roger E. McLendon, Hai Yan, Stephen T. Keir, Darell D. Bigner, Yiping He

Published Nov 3, 2013 · Vol. 4, No. 11 · pp. 2144-2153

Keywords: MLL2, isogenic cell line, gene knockout, enhancer

6p22.3 amplification as a biomarker and potential therapeutic target of advanced stage bladder cancer Research Paper

He Shen, Carl D. Morrison, Jianmin Zhang, Willie Underwood III, Nuo Yang, Costa Frangou, Kevin Eng, Karen Head, Roni J. Bollag, Sravan K. Kavuri, Amyn M. Rojiani, Yingwei Li, Li Yan, Annette Hill, Anna Woloszynska-Read, Jianmin Wang, Song Liu, Donald L. Trump, Candace S. Johnson

Published Oct 29, 2013 · Vol. 4, No. 11 · pp. 2124-2134

Keywords: bladder cancer, chromosome 6p22, FISH, outcome, survival

Upregulation of adenylate cyclase 3 (ADCY3) increases the tumorigenic potential of cells by activating the CREB pathway Research Paper

Seung-Hyun Hong, Sung-Ho Goh, Sang-Jin Lee, Jung-Ah Hwang, Jieun Lee, Il-Ju Choi, Hyehyun Seo, Jong-Hoon Park, Hiromu Suzuki, Eiichiro Yamamoto, In-Hoo Kim, Jin Sook Jeong, Mi Ha Ju, Dong-Hee Lee, Yeon-Su Lee

Published Sep 30, 2013 · Vol. 4, No. 10 · pp. 1791-1803

Keywords: gastric cancer, adenylate cyclase, tumorigenesis, cAMP/PKA/CREB pathway, promoter methylation

The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth Research Paper

Elena Kurenova, Jianqun Liao, Di-Hua He, Darrell Hunt, Michael Yemma, Wiam Bshara, Mukund Seshadri, William G Cance

Published Sep 30, 2013 · Vol. 4, No. 10 · pp. 1632-1646

Keywords: FAK Scaffold Inhibitor, pancreatic cancer, FAK-VEGFR-3 interaction, protein-protein interaction

Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX Research Paper

Marissa V Powers, Melanie Valenti, Susana Mirander, Alison Maloney, Suzanne A Eccles, George Thomas, Paul A Clarke, Paul Workman

Published Sep 29, 2013 · Vol. 4, No. 11 · pp. 1963-1975

Keywords: 17-AAG, HSP90, BAX, Apoptosis, Colon cancer

Combinatorial antitumor effect of HDACs and the PI3K-Akt-mTOR pathway inhibition in a Pten deficient model of prostate cancer Research Paper

Leigh Ellis, ShengYu Ku, Swathi Ramakrishnan, Elena Lasorsa, Gizzou Azabdaftari, Alejandro Godoy, Roberto Pili

Published Sep 27, 2013 · Vol. 4, No. 12 · pp. 2225-2236

Keywords: prostate cancer, BEZ235, panobinostat, DNA damage, ATM, therapy

Immunological targeting of tumor cells undergoing an epithelial-mesenchymal transition via a recombinant brachyury-yeast vaccine Research Paper

Duane H. Hamilton, Mary T. Litzinger, Alessandra Jales, Bruce Huang, Romaine I. Fernando, James W. Hodge, Andressa Ardiani, David Apelian, Jeffrey Schlom, Claudia Palena

Published Sep 26, 2013 · Vol. 4, No. 10 · pp. 1777-1790

Keywords: epithelial-mesenchymal transition, brachyury, T-box transcription factor, cancer vaccine, T-cell immunotherapy

CCAT2, a novel long non-coding RNA in breast cancer: expression study and clinical correlations Research Paper

Roxana S Redis, Anieta M Siewerts, Maxime P Look, Oana Tudoran, Cristina Ivan, Riccardo Spizzo, Xinna Zhang, Vanja de Weerd, Masayoshi Shimizu, Hui Ling, Rares Buiga, Victor Pop, Alexandru Irimie, Riccardo Fodde, Isabella Bedrosian, John WM Martens, John A Foekens, Ioana Berindan-Neagoe, George A Calin

Published Sep 18, 2013 · Vol. 4, No. 10 · pp. 1748-1762

Keywords: non coding RNA, CCAT2, breast cancer, prognosis, real-time PCR

TAp63 regulates oncogenic miR-155 to mediate migration and tumour growth Research Paper

Sam Mattiske, Kristen Ho, Jacqueline E. Noll, Paul M. Neilsen, David F. Callen, Rachel J. Suetani

Published Aug 31, 2013 · Vol. 4, No. 11 · pp. 1894-1903

Keywords: miR-155, TAp63, Î”Np63, cancer, tumorigenesis, migration

The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design Research Paper

Sylvain Couty, Isaac M. Westwood, Andrew Kalusa, Celine Cano, Jon Travers, Kathy Boxall, Chiau Ling Chow, Sam Burns, Jessica Schmitt, Lisa Pickard, Caterina Barillari, P. Craig McAndrew, Paul A. Clarke, Spiros Linardopoulos, Roger J. Griffin, G. Wynne Aherne, Florence I. Raynaud, Paul Workman, Keith Jones, Rob L.M. van Montfort

Published Aug 25, 2013 · Vol. 4, No. 10 · pp. 1647-1661

Keywords: S6 kinase, P70S6K, cancer, inhibitor, structure-based drug design

Isolation and genome-wide expression and methylation characterization of CD31+ cells from normal and malignant human prostate tissue Research Paper

Wei Luo, Hu Qiang, Dan Wang, Kristin K Deeb, Yingyu Ma, Carl D Morrison, Song Liu, Candace S Johnson, Donald L Trump

Published Aug 21, 2013 · Vol. 4, No. 9 · pp. 1472-1483

Keywords: Endothelial cell, Gene expression, DNA methylation, Prostate cancer

The combination of HDAC and aminopeptidase inhibitors is highly synergistic in myeloma and leads to disruption of the NFÎºB signalling pathway Research Paper

Emma M. Smith, Lei Zhang, Brian A. Walker, Emma L. Davenport, Lauren I. Aronson, David Krige, Leon Hooftman, Alan H. Drummond, Gareth J. Morgan, Faith E. Davies

Published Aug 12, 2013 · Vol. 6, No. 19 · pp. 17314-17327

Keywords: Myeloma, HDAC inhibitor, aminopeptidase inhibitor, NFÎºB

Coordinated Targeting of the EGFR Signaling Axis by MicroRNA-27a* Research Paper

Xiaoli Wu, Mihir K. Bhayani, Cristina T. Dodge, Milena S. Nicoloso, Yunyun Chen, Xiaofeng Yan, Makoto Adachi, Ligy Thomas, Chad E. Galer, Tilahun Jiffar, Curtis R. Pickering, Michael E. Kupferman, Jeffrey N. Myers, George A. Calin, Stephen Y. Lai

Published Aug 6, 2013 · Vol. 4, No. 9 · pp. 1388-1398

Keywords: miRNA EGFR AKT1 mTOR miRNA-27a* miRNA-27a-5p

Loss of PDCD4 contributes to enhanced chemoresistance in Glioblastoma Multiforme through de-repression of Bcl-xL translation Research Paper

Urszula Liwak, Lindsay E Jordan, Sally Davidson Von-Holt, Poonam Singh, Jennifer E. L. Hanson, Ian A Lorimer, Federico Roncaroli, Martin Holcik

Published Jul 28, 2013 · Vol. 4, No. 9 · pp. 1365-1372

Keywords: Glioblastoma multiforme, Bcl-xL, PDCD4, ABT-737, translation initiation

PTEN loss represses glioblastoma tumor initiating cell differentiation via inactivation of Lgl1 Research Paper

Alexander Gont, Jennifer E. L. Hanson, Sylvie J. Lavictoire, Doris A. E. Parolin, Manijeh Daneshmand, Ian J. restall, Mathieu Soucie, Garth Nicholas, John Woulfe, Amin Kassam, Vasco F. Da Silva, Ian A. J. Lorimer

Published Jul 21, 2013 · Vol. 4, No. 8 · pp. 1266-1279

Keywords: glioblastoma, glioma, PTEN, atypical PKC, Lgl, tumor initiating cell

Combining TRAIL with PI3 kinase or HSP90 inhibitors enhances apoptosis in colorectal cancer cells via suppression of survival signaling Research Paper

Grazia Saturno, Melanie Valenti, Alexis De Haven Brandon, George V. Thomas, Suzanne Eccles, Paul A. Clarke, Paul Workman

Published Jul 14, 2013 · Vol. 4, No. 8 · pp. 1185-1198

Keywords: TRAIL, PI3 Kinase/mTOR, HSP90, apoptosis, colorectal cancer

Targeting mixed lineage kinases in ER-positive breast cancer cells leads to G2/M cell cycle arrest and apoptosis. Research Paper

Limin Wang, Kathleen A Gallo, Susan E Conrad

Published Jul 7, 2013 · Vol. 4, No. 8 · pp. 1158-1171

Keywords: breast cancer, kinase inhibitors, cell cycle, apoptosis

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Apoptosis inducers in chronic lymphocytic leukemia Review

Computational methods for detecting copy number variations in cancer genome using next generation sequencing: principles and challenges Review

Pharmacokinetic modeling optimizes inhibition of the â€˜undruggableâ€™ EWS-FLI1 transcription factor in Ewing Sarcoma Research Paper

KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation Research Paper

6p22.3 amplification as a biomarker and potential therapeutic target of advanced stage bladder cancer Research Paper

Upregulation of adenylate cyclase 3 (ADCY3) increases the tumorigenic potential of cells by activating the CREB pathway Research Paper

The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth Research Paper

Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX Research Paper

Combinatorial antitumor effect of HDACs and the PI3K-Akt-mTOR pathway inhibition in a Pten deficient model of prostate cancer Research Paper

Immunological targeting of tumor cells undergoing an epithelial-mesenchymal transition via a recombinant brachyury-yeast vaccine Research Paper

CCAT2, a novel long non-coding RNA in breast cancer: expression study and clinical correlations Research Paper

TAp63 regulates oncogenic miR-155 to mediate migration and tumour growth Research Paper

The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design Research Paper

Isolation and genome-wide expression and methylation characterization of CD31+ cells from normal and malignant human prostate tissue Research Paper

The combination of HDAC and aminopeptidase inhibitors is highly synergistic in myeloma and leads to disruption of the NFÎºB signalling pathway Research Paper

Coordinated Targeting of the EGFR Signaling Axis by MicroRNA-27a* Research Paper

Loss of PDCD4 contributes to enhanced chemoresistance in Glioblastoma Multiforme through de-repression of Bcl-xL translation Research Paper

PTEN loss represses glioblastoma tumor initiating cell differentiation via inactivation of Lgl1 Research Paper

Combining TRAIL with PI3 kinase or HSP90 inhibitors enhances apoptosis in colorectal cancer cells via suppression of survival signaling Research Paper

Targeting mixed lineage kinases in ER-positive breast cancer cells leads to G2/M cell cycle arrest and apoptosis. Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Apoptosis inducers in chronic lymphocytic leukemia Review

Computational methods for detecting copy number variations in cancer genome using next generation sequencing: principles and challenges Review

Pharmacokinetic modeling optimizes inhibition of the â€˜undruggableâ€™ EWS-FLI1 transcription factor in Ewing Sarcoma Research Paper

KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation Research Paper

6p22.3 amplification as a biomarker and potential therapeutic target of advanced stage bladder cancer Research Paper

Upregulation of adenylate cyclase 3 (ADCY3) increases the tumorigenic potential of cells by activating the CREB pathway Research Paper

The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth Research Paper

Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX Research Paper

Combinatorial antitumor effect of HDACs and the PI3K-Akt-mTOR pathway inhibition in a Pten deficient model of prostate cancer Research Paper

Immunological targeting of tumor cells undergoing an epithelial-mesenchymal transition via a recombinant brachyury-yeast vaccine Research Paper

CCAT2, a novel long non-coding RNA in breast cancer: expression study and clinical correlations Research Paper

TAp63 regulates oncogenic miR-155 to mediate migration and tumour growth Research Paper

The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design Research Paper

Isolation and genome-wide expression and methylation characterization of CD31+ cells from normal and malignant human prostate tissue Research Paper

The combination of HDAC and aminopeptidase inhibitors is highly synergistic in myeloma and leads to disruption of the NFÎºB signalling pathway Research Paper

Coordinated Targeting of the EGFR Signaling Axis by MicroRNA-27a* Research Paper

Loss of PDCD4 contributes to enhanced chemoresistance in Glioblastoma Multiforme through de-repression of Bcl-xL translation Research Paper

PTEN loss represses glioblastoma tumor initiating cell differentiation via inactivation of Lgl1 Research Paper

Combining TRAIL with PI3 kinase or HSP90 inhibitors enhances apoptosis in colorectal cancer cells via suppression of survival signaling Research Paper

Targeting mixed lineage kinases in ER-positive breast cancer cells leads to G2/M cell cycle arrest and apoptosis. Research Paper