The Oncosearch | Oncotarget

Unique molecular signatures as a hallmark of patients with metastatic breast cancer: Implications for current treatment paradigms Research Perspective

Jennifer J. Wheler, Barbara A. Parker, Jack J. Lee, Johnique T. Atkins, Filip Janku, Apostolia M. Tsimberidou, Ralph Zinner, Vivek Subbiah, Siqing Fu, Richard Schwab, Stacy Moulder, Vicente Valero, Maria Schwaederle, Roman Yelensky, Vincent A. Miller, M Philip J. Stephens, Funda Meric-Bernstam, Razelle Kurzrock

Published May 2, 2014 · Vol. 5, No. 9 · pp. 2349-2354

MDM2 antagonists synergize broadly and robustly with compounds targeting fundamental oncogenic signaling pathways Priority Research Paper

Anne Y. Saiki, Sean Caenepeel, Dongyin Yu, Julie A. Lofgren, Tao Osgood, Rebecca Robertson, Jude Canon, Cheng Su, Adrie Jones, Xiaoning Zhao, Chetan Deshpande, Marc Payton, Jebediah Ledell, Paul E. Hughes, Jonathan D. Oliner

Published Apr 23, 2014 · Vol. 5, No. 8 · pp. 2030-2043

Nuclear retention of Fbw7 by specific inhibitors of nuclear export leads to Notch1 degradation in pancreatic cancer Research Paper

Jiankun Gao, Asfar S. Azmi, Amro Aboukameel, Michael Kauffman, Sharon Shacham, Abdul-Badi Abou-Samra, Ramzi M. Mohammad

Published Mar 21, 2014 · Vol. 5, No. 11 · pp. 3444-3454

Advanced gynecologic malignancies treated with a combination of the VEGF inhibitor bevacizumab and the mTOR inhibitor temsirolimus Research Paper

Sarina A. Piha-Paul, Jennifer J. Wheler, Siqing Fu, Charles Levenback, Karen Lu, Gerald S. Falchook, Aung Naing, David S. Hong, Apostolia M. Tsimberidou, Razelle Kurzrock

Published Mar 20, 2014 · Vol. 5, No. 7 · pp. 1846-1855

MET aberrations and c-MET inhibitors in patients with gastric and esophageal cancers in a phase I unit Research Paper

Denis L. Fontes Jardim, Debora de Melo Gagliato, Gerald S. Falchook, Filip Janku, Ralph Zinner, Jennifer J. Wheler, Vivek Subbiah, Sarina A. Piha-Paul, Siqing Fu, Mariela Blum Murphy, Jaffer Ajani, Chad Tang, Kenneth Hess, Stanley R. Hamilton, Sinchita Roy-Chowdhuri, Razelle Kurzrock, Funda Meric-Bernstam, David S. Hong

Published Mar 16, 2014 · Vol. 5, No. 7 · pp. 1837-1845

Anastrozole and everolimus in advanced gynecologic and breast malignancies: activity and molecular alterations in the PI3K/AKT/mTOR pathway Research Paper

Jennifer J. Wheler, Stacy L. Moulder, Aung Naing, Filip Janku, Sarina A. Piha-Paul, Gerald S. Falchook, Ralph Zinner, Apostolia M. Tsimberidou, Siqing Fu, David S. Hong, Johnique T. Atkins, Roman Yelensky, Philip J. Stephens, Razelle Kurzrock

Published Mar 14, 2014 · Vol. 5, No. 10 · pp. 3029-3038

Contact inhibition modulates intracellular levels of miR-223 in a p27kip1-dependent manner Priority Research Paper

Joshua Armenia, Linda Fabris, Francesca Lovat, Stefania Berton, Ilenia Segatto, Sara Dâ€™Andrea, Cristina Ivan, Luciano Cascione, George A. Calin, Carlo M. Croce, Alfonso Colombatti, Andrea Vecchione, Barbara Belletti, Gustavo Baldassarre

Published Mar 4, 2014 · Vol. 5, No. 5 · pp. 1185-1197

Targeting Src-mediated Tyr216 phosphorylation and activation of GSK-3 in prostate cancer cells inhibit prostate cancer progression in vitro and in vivo Research Paper

Anna Goc, Belal Al-Husein Al-Husein, Katerina Katsanevas, Alison Steinbach, Uvette Lou, Harika Sabbineni, David L. DeRemer, Payaningal R. Somanath

Published Feb 15, 2014 · Vol. 5, No. 3 · pp. 775-787

Serum microRNA expression patterns that predict early treatment failure in prostate cancer patients Research Paper

Prashant K. Singh, Leah Preus, Qiang Hu, Li Yan, Mark D. Long, Carl D. Morrison, Mary Nesline, Candace S. Johnson, Shahriar Koochekpour, Manish Kohli, Song Liu, Donald L. Trump, Lara E. Sucheston-Campbell, Moray J. Campbell

Published Feb 13, 2014 · Vol. 5, No. 3 · pp. 824-840

Identification of a long non-coding RNA as a novel biomarker and potential therapeutic target for metastatic prostate cancer Research Paper

Francesco Crea, Akira Watahiki, Luca Quagliata, Hui Xue, Larissa Pikor, Abhijit Parolia, Yuwei Wang, Dong Lin, Wan L. Lam, William L. Farrar, Takao Isogai, Rudolf Morant, Serenella Castori-Eppenberger, Kim N. Chi, Yuzhuo Wang, Cheryl D. Helgason

Published Feb 6, 2014 · Vol. 5, No. 3 · pp. 764-774

Synergistic anti-tumor activity of acadesine (AICAR) in combination with the anti-CD20 monoclonal antibody rituximab in in vivo and in vitro models of mantle cell lymphoma Research Paper

Arnau Montraveta, Silvia Xargay-Torrent, MÃ³nica LÃ³pez-Guerra, Laia Rosich, Patricia PÃ©rez-GalÃ¡n, Itziar Salaverria, Silvia BeÃ, Susana G. Kalko, MercÃ¨ de Frias, Clara CampÃ s, GaÃ«l RouÃ©, Dolors Colomer

Published Jan 25, 2014 · Vol. 5, No. 3 · pp. 726-739

Keywords: Acadesine, rituximab, mantle cell lymphoma, xenograft mouse model

First Mnks degrading agents block phosphorylation of eIF4E, induce apoptosis, inhibit cell growth, migration and invasion in triple negative and Her2-overexpressing breast cancer cell lines Research Paper

Senthilmurugan Ramalingam, Lalji Gediya, Andrew K. Kwegyir-Afful, Vidya P. Ramamurthy, Puranik Purushottamachar, Hannah Mbatia, Vincent C.O. Njar

Published Jan 25, 2014 · Vol. 5, No. 2 · pp. 530-543

Keywords: Breast cancer, RAMBA retinamides, eukaryotic initiation factor 4E, Mnk1/2

Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor. Research Paper

Paul MÃ©sange, Virginie Poindessous, MichÃ¨le Sabbah, Alexandre E. Escargueil, Aimery de Gramont, Annette K. Larsen

Published Jan 20, 2014 · Vol. 5, No. 13 · pp. 4709-4721

Keywords: resistance, angiogenesis inhibition, vascular endothelial growth factor (VEGF)-signaling, hypoxia, bevacizumab, nintedanib

Heat shock proteins in multiple myeloma Review

Lei Zhang, Jacqueline H.L. Fok, Faith E. Davies

Published Jan 19, 2014 · Vol. 5, No. 5 · pp. 1132-1148

Keywords: heat shock proteins, multiple myeloma, protein folding, ER stress, haematology

Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response Research Paper

Marcella Salzano, Marta VÃ¡zquez-Cedeira, Marta Sanz-GarcÃa, Alberto Valbuena, Sandra Blanco, Isabel F. FernÃ¡ndez, Pedro A. Lazo

Published Jan 17, 2014 · Vol. 5, No. 7 · pp. 1770-1778

Keywords: Breast cancer, VRK1, Radiation, doxorubicin, chemotherapy, DNA damage, 53BP1

GATA2 as a potential metastasis-driving gene in prostate cancer Research Paper

Yan Ting Chiang, Kendric Wang, Ladan Fazli, Robert Z. Qi, Martin E. Gleave, Colin C. Collins, Peter W. Gout, Yuzhuo Wang

Published Jan 12, 2014 · Vol. 5, No. 2 · pp. 451-461

Keywords: GATA2 gene, prostate cancer, metastasis, focal adhesion, master regulatory gene

A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabine Research Paper

Elisabeth Walsby, Guy Pratt, Hao Shao, Abdullah Y. Abbas, Peter M. Fischer, Tracey D. Bradshaw, Paul Brennan, Chris Fegan, Shudong Wang, Chris Pepper

Published Dec 18, 2013 · Vol. 5, No. 2 · pp. 375-385

Keywords: CLL, cdk9, synergy, MCL1

NF2/Merlin in hereditary neurofibromatosis 2 versus cancer: biologic mechanisms and clinical associations Review

Rebecca Dunbar Schroeder, Laura S. Angelo, Razelle Kurzrock

Published Dec 17, 2013 · Vol. 5, No. 1 · pp. 67-77

Keywords: NF2, Nuerofibromatosis 2, Cancer, Mutations

High Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia Research Paper

Ban Xiong Tan, Kian Hoe Khoo, Tit Meng Lim, David Philip Lane

Published Nov 22, 2013 · Vol. 5, No. 4 · pp. 933-943

Keywords: p53, AML, Mdm4

A novel immunomodulatory and molecularly targeted strategy for refractory Hodgkinâ€™s lymphoma Brief Reports

Vivek Subbiah, Robert E. Brown, Mary F. McGuire, Jamie Buryanek, Filip Janku, Anas Younes, David Hong

Published Nov 19, 2013 · Vol. 5, No. 1 · pp. 95-102

Keywords: Hodgkin's lymphoma, mTOR, HDAC, Sirolimus, Vorinostat, Targeted therapy

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Unique molecular signatures as a hallmark of patients with metastatic breast cancer: Implications for current treatment paradigms Research Perspective

MDM2 antagonists synergize broadly and robustly with compounds targeting fundamental oncogenic signaling pathways Priority Research Paper

Nuclear retention of Fbw7 by specific inhibitors of nuclear export leads to Notch1 degradation in pancreatic cancer Research Paper

Advanced gynecologic malignancies treated with a combination of the VEGF inhibitor bevacizumab and the mTOR inhibitor temsirolimus Research Paper

MET aberrations and c-MET inhibitors in patients with gastric and esophageal cancers in a phase I unit Research Paper

Anastrozole and everolimus in advanced gynecologic and breast malignancies: activity and molecular alterations in the PI3K/AKT/mTOR pathway Research Paper

Contact inhibition modulates intracellular levels of miR-223 in a p27kip1-dependent manner Priority Research Paper

Targeting Src-mediated Tyr216 phosphorylation and activation of GSK-3 in prostate cancer cells inhibit prostate cancer progression in vitro and in vivo Research Paper

Serum microRNA expression patterns that predict early treatment failure in prostate cancer patients Research Paper

Identification of a long non-coding RNA as a novel biomarker and potential therapeutic target for metastatic prostate cancer Research Paper

Synergistic anti-tumor activity of acadesine (AICAR) in combination with the anti-CD20 monoclonal antibody rituximab in in vivo and in vitro models of mantle cell lymphoma Research Paper

First Mnks degrading agents block phosphorylation of eIF4E, induce apoptosis, inhibit cell growth, migration and invasion in triple negative and Her2-overexpressing breast cancer cell lines Research Paper

Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor. Research Paper

Heat shock proteins in multiple myeloma Review

Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response Research Paper

GATA2 as a potential metastasis-driving gene in prostate cancer Research Paper

A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabine Research Paper

NF2/Merlin in hereditary neurofibromatosis 2 versus cancer: biologic mechanisms and clinical associations Review

High Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia Research Paper

A novel immunomodulatory and molecularly targeted strategy for refractory Hodgkinâ€™s lymphoma Brief Reports

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Unique molecular signatures as a hallmark of patients with metastatic breast cancer: Implications for current treatment paradigms Research Perspective

MDM2 antagonists synergize broadly and robustly with compounds targeting fundamental oncogenic signaling pathways Priority Research Paper

Nuclear retention of Fbw7 by specific inhibitors of nuclear export leads to Notch1 degradation in pancreatic cancer Research Paper

Advanced gynecologic malignancies treated with a combination of the VEGF inhibitor bevacizumab and the mTOR inhibitor temsirolimus Research Paper

MET aberrations and c-MET inhibitors in patients with gastric and esophageal cancers in a phase I unit Research Paper

Anastrozole and everolimus in advanced gynecologic and breast malignancies: activity and molecular alterations in the PI3K/AKT/mTOR pathway Research Paper

Contact inhibition modulates intracellular levels of miR-223 in a p27kip1-dependent manner Priority Research Paper

Targeting Src-mediated Tyr216 phosphorylation and activation of GSK-3 in prostate cancer cells inhibit prostate cancer progression in vitro and in vivo Research Paper

Serum microRNA expression patterns that predict early treatment failure in prostate cancer patients Research Paper

Identification of a long non-coding RNA as a novel biomarker and potential therapeutic target for metastatic prostate cancer Research Paper

Synergistic anti-tumor activity of acadesine (AICAR) in combination with the anti-CD20 monoclonal antibody rituximab in in vivo and in vitro models of mantle cell lymphoma Research Paper

First Mnks degrading agents block phosphorylation of eIF4E, induce apoptosis, inhibit cell growth, migration and invasion in triple negative and Her2-overexpressing breast cancer cell lines Research Paper

Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor. Research Paper

Heat shock proteins in multiple myeloma Review

Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response Research Paper

GATA2 as a potential metastasis-driving gene in prostate cancer Research Paper

A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabine Research Paper

NF2/Merlin in hereditary neurofibromatosis 2 versus cancer: biologic mechanisms and clinical associations Review

High Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia Research Paper

A novel immunomodulatory and molecularly targeted strategy for refractory Hodgkinâ€™s lymphoma Brief Reports