The Oncosearch | Oncotarget

Advances in targeted therapies and new promising targets in esophageal cancer Review

Abbes Belkhiri, Wael El-Rifai

Published Dec 30, 2014 · Vol. 6, No. 3 · pp. 1348-1358

Keywords: adenocarcinoma, esophageal, gastric, cancer, targeted therapy

Folate-mediated mitochondrial targeting with doxorubicin-polyrotaxane nanoparticles overcomes multidrug resistance Research Paper

He Wang, Henghui Yin, Fengjiao Yan, Mingna Sun, Lingran Du, Wei Peng, Qiuli Li, Yinghong Feng, Yi Zhou

Published Dec 30, 2014 · Vol. 6, No. 5 · pp. 2827-2842

Adhesion glycoprotein CD44 functions as an upstream regulator of a network connecting ERK, AKT and Hippo-YAP pathways in cancer progression Research Paper

Shiyi Yu, Xiuxiu Cai, Chenxi Wu, Lele Wu, Yuzhi Wang, Yan Liu, Zhenghong Yu, Sheng Qin, Fei Ma, Jean Paul Thiery, Liming Chen

Published Dec 30, 2014 · Vol. 6, No. 5 · pp. 2951-2965

Targeting the tumor microenvironment to enhance antitumor immune responses Review

Kevin Van der Jeught, Lukasz Bialkowski, Lidia Daszkiewicz, Katrijn Broos, Cleo Goyvaerts, Dries Renmans, Sandra Van Lint, Carlo Heirman, Kris Thielemans, Karine Breckpot

Published Dec 26, 2014 · Vol. 6, No. 3 · pp. 1359-1381

Cyclin E1 and RTK/RAS signaling drive CDK inhibitor resistance via activation of E2F and ETS Research Paper

Barbie Taylor-Harding, Paul-Joseph Aspuria, Hasmik Agadjanian, Dong-Joo Cheon, Takako Mizuno, Danielle Greenberg, Jenieke R. Allen, Lindsay Spurka, Vincent Funari, Elizabeth Spiteri, Qiang Wang, Sandra Orsulic, Christine Walsh, Beth Y. Karlan, Ruprecht W. Wiedemeyer

Published Dec 22, 2014 · Vol. 6, No. 2 · pp. 696-714

Keywords: Cyclin-dependent kinase inhibitors, palbociclib, dinaciclib, Cyclin E1, ovarian cancer

Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells Research Paper

Antonella Cusimano, Roberto Puleio, Natale D'Alessandro, Guido R. Loria, James A. McCubrey, Giuseppe Montalto, Melchiorre Cervello

Published Dec 19, 2014 · Vol. 6, No. 3 · pp. 1707-1722

Keywords: HCC, AKT, mTOR, SC66, anoikis.

Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype Priority Research Paper

Lisha Xiang, Daniele M. Gilkes, Hongxia Hu, Naoharu Takano, Weibo Luo, Haiquan Lu, John W. Bullen, Debangshu Samanta, Houjie Liang, Gregg L. Semenza

Published Dec 18, 2014 · Vol. 5, No. 24 · pp. 12509-12527

Cyclin alterations in diverse cancers: Outcome and co-amplification network Research Paper

Maria Schwaederle, Gregory A. Daniels, David E. Piccioni, Paul T. Fanta, Richard B. Schwab, Kelly A. Shimabukuro, Barbara A. Parker, Razelle Kurzrock

Published Dec 18, 2014 · Vol. 6, No. 5 · pp. 3033-3042

Targeting VEGFR1- and VEGFR2-expressing non-tumor cells is essential for esophageal cancer therapy Research Paper

Wen Wen Xu, Bin Li, Alfred KY Lam, Sai Wah Tsao, Simon YK Law, Kwok Wah Chan, Qiu Ju Yuan, Annie LM Cheung

Published Dec 17, 2014 · Vol. 6, No. 3 · pp. 1790-1805

Keywords: Tumor angiogenesis, Bone marrow-derived cells, Tumor microenvironment, VEGF receptors, Antibody therapy

A role for BMP-induced homeobox gene MIXL1 in acute myelogenous leukemia and identification of type I BMP receptor as a potential target for therapy Research Paper

Aaron Raymond, Bin Liu, Hong Liang, Ciamaio Wei, Michele Guindani, Yue Lu, Shoudan Liang, Lisa S. St. John, Jeff Molldrem, Lalitha Nagarajan

Published Dec 17, 2014 · Vol. 5, No. 24 · pp. 12675-12693

DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma Research Paper

Nathaniel Weygant, Dongfeng Qu, Randal May, Ryan M. Tierney, William L. Berry, Lichao Zhao, Shweta Agarwal, Parthasarathy Chandrakesan, Harisha R. Chinthalapally, Nicholas T. Murphy, James D. Li, Sripathi M. Sureban, Michael J. Schlosser, James J. Tomasek, Courtney W. Houchen

Published Dec 11, 2014 · Vol. 6, No. 4 · pp. 2193-2205

Multiple receptor tyrosine kinase activation attenuates therapeutic efficacy of the fibroblast growth factor receptor 2 inhibitor AZD4547 in FGFR2 amplified gastric cancer Research Paper

Jinjia Chang, Shanshan Wang, Zhe Zhang, Xinyang Liu, Zheng Wu, Ruixuan Geng, Xiaoxiao Ge, Congqi Dai, Rujiao Liu, Qunling Zhang, Wenhua Li, Jin Li

Published Dec 10, 2014 · Vol. 6, No. 4 · pp. 2009-2022

Novel receptor tyrosine kinase targeted combination therapies for imatinib-resistant gastrointestinal stromal tumors (GIST) Research Paper

Daruka Mahadevan, Noah Theiss, Carla Morales, Amy E. Stejskal, Laurence S. Cooke, Min Zhu, Drew Kurtzman, Rachel Swart, Evan Ong, Wenqing Qi

Published Dec 10, 2014 · Vol. 6, No. 4 · pp. 1954-1966

Clinically relevant genes and regulatory pathways associated with NRAS^Q61 mutations in melanoma through an integrative genomics approach Research Paper

Wei Jiang, Peilin Jia, Katherine E. Hutchinson, Douglas B. Johnson, Jeffrey A. Sosman, Zhongming Zhao

Published Dec 10, 2014 · Vol. 6, No. 4 · pp. 2496-2508

Targeting a ribonucleoprotein complex containing the caprin-1 protein and the c-Myc mRNA suppresses tumor growth in mice: an identification of a novel oncotarget Research Paper

Ya-Qi Qiu, Cheng-Wei Yang, Yue-Zhi Lee, Ruey-Bing Yang, Chih-Hao Lee, Hsing-Yu Hsu, Chien-Chung Chang, Shiow-Ju Lee

Published Dec 10, 2014 · Vol. 6, No. 4 · pp. 2148-2163

The PI3K inhibitor GDC-0941 displays promising in vitro and in vivo efficacy for targeted medulloblastoma therapy Research Paper

Michael Ehrhardt, Rogerio B. Craveiro, Martin I. Holst, Torsten Pietsch, Dagmar Dilloo

Published Dec 6, 2014 · Vol. 6, No. 2 · pp. 802-813

Keywords: medulloblastoma, GDC-0941, PI3K inhibitor, targeted therapy, c-myc

Targeting of mutant p53-induced FoxM1 with thiostrepton induces cytotoxicity and enhances carboplatin sensitivity in cancer cells Research Paper

Xuan Zhang, Lihua Cheng, Kay Minn, Rashna Madan, Andrew K. Godwin, Viji Shridhar, Jeremy Chien

Published Dec 4, 2014 · Vol. 5, No. 22 · pp. 11365-11380

PKM2 promotes metastasis by recruiting myeloid-derived suppressor cells and indicates poor prognosis for hepatocellular carcinoma Research Paper

Wei-Ren Liu, Meng-Xin Tian, Liu-Xiao Yang, Yu-Li Lin, Lei Jin, Zhen-Bin Ding, Ying-Hao Shen, Yuan-Fei Peng, Dong-Mei Gao, Jian Zhou, Shuang-Jian Qiu, Zhi Dai, Rui He, Jia Fan, Ying-Hong Shi

Published Dec 2, 2014 · Vol. 6, No. 2 · pp. 846-861

Keywords: PKM2, Myeloid-derived Suppressor Cells, Prognosis, Hepatocellular Carcinoma, Metastasis

Targeting of hyperactivated mTOR signaling in high-risk acute lymphoblastic leukemia in a pre-clinical model Priority Research Paper

Md. Nabiul Hasan, Manon Queudeville, Luca Trentin, Sarah Mirjam Eckhoff, Ilaria Bronzini, Chiara Palmi, Thomas Barth, Giovanni Cazzaniga, Geertruy te Kronnie, Klaus-Michael Debatin, LÃ¼der Hinrich Meyer

Published Dec 2, 2014 · Vol. 6, No. 3 · pp. 1382-1395

Targeted Hsp70 expression combined with CIK-activated immune reconstruction synergistically exerts antitumor efficacy in patient-derived hepatocellular carcinoma xenograft mouse models Research Paper

Huanzhang Hu, Yinghe Qiu, Minggao Guo, Yao Huang, Lin Fang, Zhangxiao Peng, Weidan Ji, Yang Xu, Shuwen Shen, Yan Yan, Xuandong Huang, Junnian Zheng, Changqing Su

Published Nov 26, 2014 · Vol. 6, No. 2 · pp. 1079-1089

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Advances in targeted therapies and new promising targets in esophageal cancer Review

Folate-mediated mitochondrial targeting with doxorubicin-polyrotaxane nanoparticles overcomes multidrug resistance Research Paper

Adhesion glycoprotein CD44 functions as an upstream regulator of a network connecting ERK, AKT and Hippo-YAP pathways in cancer progression Research Paper

Targeting the tumor microenvironment to enhance antitumor immune responses Review

Cyclin E1 and RTK/RAS signaling drive CDK inhibitor resistance via activation of E2F and ETS Research Paper

Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells Research Paper

Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype Priority Research Paper

Cyclin alterations in diverse cancers: Outcome and co-amplification network Research Paper

Targeting VEGFR1- and VEGFR2-expressing non-tumor cells is essential for esophageal cancer therapy Research Paper

A role for BMP-induced homeobox gene MIXL1 in acute myelogenous leukemia and identification of type I BMP receptor as a potential target for therapy Research Paper

DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma Research Paper

Multiple receptor tyrosine kinase activation attenuates therapeutic efficacy of the fibroblast growth factor receptor 2 inhibitor AZD4547 in FGFR2 amplified gastric cancer Research Paper

Novel receptor tyrosine kinase targeted combination therapies for imatinib-resistant gastrointestinal stromal tumors (GIST) Research Paper

Clinically relevant genes and regulatory pathways associated with NRAS^Q61 mutations in melanoma through an integrative genomics approach Research Paper

Targeting a ribonucleoprotein complex containing the caprin-1 protein and the c-Myc mRNA suppresses tumor growth in mice: an identification of a novel oncotarget Research Paper

The PI3K inhibitor GDC-0941 displays promising in vitro and in vivo efficacy for targeted medulloblastoma therapy Research Paper

Targeting of mutant p53-induced FoxM1 with thiostrepton induces cytotoxicity and enhances carboplatin sensitivity in cancer cells Research Paper

PKM2 promotes metastasis by recruiting myeloid-derived suppressor cells and indicates poor prognosis for hepatocellular carcinoma Research Paper

Targeting of hyperactivated mTOR signaling in high-risk acute lymphoblastic leukemia in a pre-clinical model Priority Research Paper

Targeted Hsp70 expression combined with CIK-activated immune reconstruction synergistically exerts antitumor efficacy in patient-derived hepatocellular carcinoma xenograft mouse models Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Advances in targeted therapies and new promising targets in esophageal cancer Review

Folate-mediated mitochondrial targeting with doxorubicin-polyrotaxane nanoparticles overcomes multidrug resistance Research Paper

Adhesion glycoprotein CD44 functions as an upstream regulator of a network connecting ERK, AKT and Hippo-YAP pathways in cancer progression Research Paper

Targeting the tumor microenvironment to enhance antitumor immune responses Review

Cyclin E1 and RTK/RAS signaling drive CDK inhibitor resistance via activation of E2F and ETS Research Paper

Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells Research Paper

Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype Priority Research Paper

Cyclin alterations in diverse cancers: Outcome and co-amplification network Research Paper

Targeting VEGFR1- and VEGFR2-expressing non-tumor cells is essential for esophageal cancer therapy Research Paper

A role for BMP-induced homeobox gene MIXL1 in acute myelogenous leukemia and identification of type I BMP receptor as a potential target for therapy Research Paper

DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma Research Paper

Multiple receptor tyrosine kinase activation attenuates therapeutic efficacy of the fibroblast growth factor receptor 2 inhibitor AZD4547 in FGFR2 amplified gastric cancer Research Paper

Novel receptor tyrosine kinase targeted combination therapies for imatinib-resistant gastrointestinal stromal tumors (GIST) Research Paper

Clinically relevant genes and regulatory pathways associated with NRASQ61 mutations in melanoma through an integrative genomics approach Research Paper

Targeting a ribonucleoprotein complex containing the caprin-1 protein and the c-Myc mRNA suppresses tumor growth in mice: an identification of a novel oncotarget Research Paper

The PI3K inhibitor GDC-0941 displays promising in vitro and in vivo efficacy for targeted medulloblastoma therapy Research Paper

Targeting of mutant p53-induced FoxM1 with thiostrepton induces cytotoxicity and enhances carboplatin sensitivity in cancer cells Research Paper

PKM2 promotes metastasis by recruiting myeloid-derived suppressor cells and indicates poor prognosis for hepatocellular carcinoma Research Paper

Targeting of hyperactivated mTOR signaling in high-risk acute lymphoblastic leukemia in a pre-clinical model Priority Research Paper

Targeted Hsp70 expression combined with CIK-activated immune reconstruction synergistically exerts antitumor efficacy in patient-derived hepatocellular carcinoma xenograft mouse models Research Paper

Clinically relevant genes and regulatory pathways associated with NRAS^Q61 mutations in melanoma through an integrative genomics approach Research Paper