The Oncosearch | Oncotarget

A phase II study of axalimogene filolisbac for patients with previously treated, unresectable, persistent/recurrent loco-regional or metastatic anal cancer Research Paper

Cathy Eng, Marwan Fakih, Manik Amin, Van Morris, Howard S. Hochster, Patrick M. Boland, Hope Uronis

Published Apr 14, 2020 · Vol. 11, No. 15 · pp. 1334-1343

Keywords: anal neoplasms, immunotherapy, Listeria monocytogenes, papillomaviridae, phase II clinical trial

Molecular imaging reveals biodistribution of P-cadherin LP-DART bispecific and trafficking of adoptively transferred T cells in mouse xenograft model Research Paper

Vijay R. Gupta, Adam Root, Timothy Fisher, Rand Norberg, John David, Tracey Clark, Justin Cohen, Chad May, Anand Giddabasappa

Published Apr 14, 2020 · Vol. 11, No. 15 · pp. 1344-1357

Keywords: bispecific antibody, tumor targeting, biodistribution, T cells, molecular imaging

Pirfenidone anti-fibrotic effects are partially mediated by the inhibition of MUC1 bioactivation Research Paper

Beatriz Ballester, Javier Milara, Julio Cortijo

Published Apr 14, 2020 · Vol. 11, No. 15 · pp. 1306-1320

Keywords: pirfenidone, idiopathic pulmonary fibrosis, MUC1, transforming growth factor beta-1, fibroblasts

Association of germline genetic variants with TMPRSS2-ERG fusion status in prostate cancer Research Paper

Indu Kohaar, Qiyuan Li, Yongmei Chen, Lakshmi Ravindranath, Denise Young, Amina Ali, Isabell A. Sesterhenn, Inger L. Rosner, Jennifer Cullen, Shiv Srivastava, Matthew Freedman, Gyorgy Petrovics

Published Apr 14, 2020 · Vol. 11, No. 15 · pp. 1321-1333

Keywords: prostate cancer, TMPRSS2-ERG, molecular subtype, ERG fusion, SNP

Proteomic analysis of combined IGF1 receptor targeted therapy and chemotherapy identifies signatures associated with survival in breast cancer patients Research Paper

Tali Sinai-Livne, Metsada Pasmanik-Chor, Zoya Cohen, Ilan Tsarfaty, Haim Werner, Raanan Berger

Published Apr 13, 2020 · Vol. 11, No. 17 · pp. 1515-1530

Keywords: insulin-like growth factor-1 (IGF1), IGF1 receptor (IGF1R), targeted therapy, breast cancer, proteomic analysis

First-in-human study of anticancer immunotherapy drug candidate mobilan: safety, pharmacokinetics and pharmacodynamics in prostate cancer patients Research Paper

Natalia V. Eremina, Vasily I. Kazey, Sergey V. Mishugin, Roman V. Leonenkov, Dmitry Y. Pushkar, Vadim L. Mett, Andrei V. Gudkov

Published Apr 7, 2020 · Vol. 11, No. 14 · pp. 1273-1288

Keywords: prostate cancer, immunotherapy, mobilan, adenoviral vector, intratumor injection

A mutation-specific, single-arm, phase 2 study of dovitinib in patients with advanced malignancies Research Paper

Matthew H. Taylor, Ajjai S. Alva, Timothy Larson, Sebastian Szpakowski, Das Purkaystha, Alpesh Amin, Linda Karpiak, Sarina A. Piha-Paul

Published Apr 7, 2020 · Vol. 11, No. 14 · pp. 1235-1243

Keywords: advanced malignancies, basket trial, dovitinib, histology-agnostic, mutation-specific

Synergistic cytotoxic activity of cannabinoids from cannabis sativa against cutaneous T-cell lymphoma (CTCL) in-vitro and ex-vivo Research Paper

Moran Mazuz, Amir Tiroler, Lilach Moyal, Emmilia Hodak, Stalin Nadarajan, Ajjampura C. Vinayaka, Batia Gorovitz-Haris, Ido Lubin, Avi Drori, Guy Drori, Owen Van Cauwenberghe, Adi Faigenboim, Dvora Namdar, Iris Amitay-Laish, Hinanit Koltai

Published Mar 31, 2020 · Vol. 11, No. 13 · pp. 1141-1156

Keywords: cutaneous T-cell lymphoma, cannabis, cannabinoids, peripheral blood lymphocytes, CTCL cell lines

Entinostat augments NK cell functions via epigenetic upregulation of IFIT1-STING-STAT4 pathway Research Paper

John M. Idso, Shunhua Lao, Nathan J. Schloemer, Jeffrey Knipstein, Robert Burns, Monica S. Thakar, Subramaniam Malarkannan

Published Mar 25, 2020 · Vol. 11, No. 20 · pp. 1799-1815

Keywords: NK cells, histone deacetylase inhibitor, Ewing sarcoma, rhabdomyosarcoma, immunotherapy

Characterization of iPS87, a prostate cancer stem cell-like cell line Research Paper

Erika N. Assoun, April N. Meyer, Maggie Y. Jiang, Stephen M. Baird, Martin Haas, Daniel J. Donoghue

Published Mar 24, 2020 · Vol. 11, No. 12 · pp. 1075-1084

Keywords: prostate cancer, stem cells, androgen independent, androgen deprivation therapy, castration resistant prostate cancer

Combined inhibition of PIM and CDK4/6 suppresses both mTOR signaling and Rb phosphorylation and potentiates PI3K inhibition in cancer cells Priority Research Paper

Lacey M. Litchfield, Karsten Boehnke, Manisha Brahmachary, Cecilia Mur, Chen Bi, Jennifer R. Stephens, J. Michael Sauder, Sonia M. Gutiérrez, Ann M. McNulty, Xiang S. Ye, Wenjuan Wu, María José Lallena, Xueqian Gong, Farhana F. Merzoug, Valerie M. Jansen, Sean G. Buchanan

Published Mar 23, 2020 · Vol. 11, No. 17 · pp. 1478-1492

Keywords: abemaciclib, CDK4/6, PIM, mTOR, S6

Targeting PI3Kβ alone and in combination with chemotherapy or immunotherapy in tumors with PTEN loss Research Paper

Nicci Owusu-Brackett, Ming Zhao, Argun Akcakanat, Kurt W. Evans, Erkan Yuca, Ecaterina Ileana Dumbrava, Filip Janku, Funda Meric-Bernstam

Published Mar 17, 2020 · Vol. 11, No. 11 · pp. 969-981

Keywords: PI3Kβ, PTEN loss, AZD8186, chemotherapy, immunotherapy

The anti-tumor activity of pralatrexate (PDX) correlates with the expression of RFC and DHFR mRNA in preclinical models of multiple myeloma Research Paper

Cristina Kinahan, Michael A. Mangone, Luigi Scotto, Michele Visentin, Enrica Marchi, Hearn Jay Cho, Owen A. O’Connor

Published Feb 26, 2020 · Vol. 11, No. 18 · pp. 1576-1589

Keywords: antifolate, multiple myeloma, pralatrexate, biomarker, reduced folate carrier (RFC)

The anti-tumor activity of pralatrexate (PDX) correlates with the expression of RFC and DHFR mRNA in preclinical models of multiple myeloma Research Paper

Cristina Kinahan, Michael A. Mangone, Luigi Scotto, Michele Visentin, Enrica Marchi, Hearn Jay Cho, Owen A. O’Connor

Published Feb 26, 2020

Keywords: antifolate, multiple myeloma, pralatrexate, biomarker, reduced folate carrier (RFC)

The anti-tumor activity of pralatrexate (PDX) correlates with the expression of RFC and DHFR mRNA in preclinical models of multiple myeloma Research Paper

Cristina Kinahan, Michael A. Mangone, Luigi Scotto, Michele Visentin, Enrica Marchi, Hearn Jay Cho, Owen A. O’Connor

Published Feb 26, 2020

Keywords: antifolate, multiple myeloma, pralatrexate, biomarker, reduced folate carrier (RFC)

SLC25A32 sustains cancer cell proliferation by regulating flavin adenine nucleotide (FAD) metabolism Research Paper

Valeria Santoro, Ilya Kovalenko, Kim Vriens, Stefan Christen, Andreas Bernthaler, Andrea Haegebarth, Sarah-Maria Fendt, Sven Christian

Published Feb 25, 2020 · Vol. 11, No. 8 · pp. 801-812

Keywords: transporter, mitochondria, metabolism, ROS, FAD

CrkL is required for donor T cell migration to GvHD target organs Research Paper

Nathan H. Roy, Mahinbanu Mammadli, Janis K. Burkhardt, Mobin Karimi

Published Feb 24, 2020 · Vol. 11, No. 17 · pp. 1505-1514

Keywords: graft-versus-host disease, CrkL, T cell, migration, inflammation

Checkpoint blockade inhibitors enhances the effectiveness of a Listeria monocytogenes-based melanoma vaccine Research Paper

Ryan P. Gilley, Peter H. Dube

Published Feb 18, 2020 · Vol. 11, No. 7 · pp. 740-754

Keywords: cancer immunotherapy, cancer vaccination, checkpoint blockade, melanoma, listeria

In vitro studies on CNGRC-CPG2 fusion proteins for ligand-directed enzyme prodrug therapy for targeted cancer therapy Research Paper

Layla Al-mansoori, Sara S. Bashraheel, Alanod D. Al Qahtani, C. David O’Connor, Philip Elsinga, Sayed K. Goda

Published Feb 11, 2020 · Vol. 11, No. 6 · pp. 619-633

Keywords: targeted cancer therapy, carboxypeptidase G2, glucarpidase, ligand directed enzyme prodrug therapy, antibody directed enzyme prodrug therapy

Human insulin modulates α-synuclein aggregation via DAF-2/DAF-16 signalling pathway by antagonising DAF-2 receptor in C. elegans model of Parkinson’s disease Research Paper

Rizwanul Haque, Shamsuzzama, Lalit Kumar, Tanuj Sharma, Soobiya Fatima, Pooja Jadiya, Mohammad I. Siddiqi, Aamir Nazir

Published Feb 11, 2020 · Vol. 11, No. 6 · pp. 634-649

Keywords: Parkinson’s, human insulin, aggregation, Daf-2, Caenorhabditis elegans (C. elegans)

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A phase II study of axalimogene filolisbac for patients with previously treated, unresectable, persistent/recurrent loco-regional or metastatic anal cancer Research Paper

Molecular imaging reveals biodistribution of P-cadherin LP-DART bispecific and trafficking of adoptively transferred T cells in mouse xenograft model Research Paper

Pirfenidone anti-fibrotic effects are partially mediated by the inhibition of MUC1 bioactivation Research Paper

Association of germline genetic variants with TMPRSS2-ERG fusion status in prostate cancer Research Paper

Proteomic analysis of combined IGF1 receptor targeted therapy and chemotherapy identifies signatures associated with survival in breast cancer patients Research Paper

First-in-human study of anticancer immunotherapy drug candidate mobilan: safety, pharmacokinetics and pharmacodynamics in prostate cancer patients Research Paper

A mutation-specific, single-arm, phase 2 study of dovitinib in patients with advanced malignancies Research Paper

Synergistic cytotoxic activity of cannabinoids from cannabis sativa against cutaneous T-cell lymphoma (CTCL) in-vitro and ex-vivo Research Paper

Entinostat augments NK cell functions via epigenetic upregulation of IFIT1-STING-STAT4 pathway Research Paper

Characterization of iPS87, a prostate cancer stem cell-like cell line Research Paper

Combined inhibition of PIM and CDK4/6 suppresses both mTOR signaling and Rb phosphorylation and potentiates PI3K inhibition in cancer cells Priority Research Paper

Targeting PI3Kβ alone and in combination with chemotherapy or immunotherapy in tumors with PTEN loss Research Paper

The anti-tumor activity of pralatrexate (PDX) correlates with the expression of RFC and DHFR mRNA in preclinical models of multiple myeloma Research Paper

The anti-tumor activity of pralatrexate (PDX) correlates with the expression of RFC and DHFR mRNA in preclinical models of multiple myeloma Research Paper

The anti-tumor activity of pralatrexate (PDX) correlates with the expression of RFC and DHFR mRNA in preclinical models of multiple myeloma Research Paper

SLC25A32 sustains cancer cell proliferation by regulating flavin adenine nucleotide (FAD) metabolism Research Paper

CrkL is required for donor T cell migration to GvHD target organs Research Paper

Checkpoint blockade inhibitors enhances the effectiveness of a Listeria monocytogenes-based melanoma vaccine Research Paper

In vitro studies on CNGRC-CPG2 fusion proteins for ligand-directed enzyme prodrug therapy for targeted cancer therapy Research Paper

Human insulin modulates α-synuclein aggregation via DAF-2/DAF-16 signalling pathway by antagonising DAF-2 receptor in C. elegans model of Parkinson’s disease Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

A phase II study of axalimogene filolisbac for patients with previously treated, unresectable, persistent/recurrent loco-regional or metastatic anal cancer Research Paper

Molecular imaging reveals biodistribution of P-cadherin LP-DART bispecific and trafficking of adoptively transferred T cells in mouse xenograft model Research Paper

Pirfenidone anti-fibrotic effects are partially mediated by the inhibition of MUC1 bioactivation Research Paper

Association of germline genetic variants with TMPRSS2-ERG fusion status in prostate cancer Research Paper

Proteomic analysis of combined IGF1 receptor targeted therapy and chemotherapy identifies signatures associated with survival in breast cancer patients Research Paper

First-in-human study of anticancer immunotherapy drug candidate mobilan: safety, pharmacokinetics and pharmacodynamics in prostate cancer patients Research Paper

A mutation-specific, single-arm, phase 2 study of dovitinib in patients with advanced malignancies Research Paper

Synergistic cytotoxic activity of cannabinoids from cannabis sativa against cutaneous T-cell lymphoma (CTCL) in-vitro and ex-vivo Research Paper

Entinostat augments NK cell functions via epigenetic upregulation of IFIT1-STING-STAT4 pathway Research Paper

Characterization of iPS87, a prostate cancer stem cell-like cell line Research Paper

Combined inhibition of PIM and CDK4/6 suppresses both mTOR signaling and Rb phosphorylation and potentiates PI3K inhibition in cancer cells Priority Research Paper

Targeting PI3Kβ alone and in combination with chemotherapy or immunotherapy in tumors with PTEN loss Research Paper

The anti-tumor activity of pralatrexate (PDX) correlates with the expression of RFC and DHFR mRNA in preclinical models of multiple myeloma Research Paper

The anti-tumor activity of pralatrexate (PDX) correlates with the expression of RFC and DHFR mRNA in preclinical models of multiple myeloma Research Paper

The anti-tumor activity of pralatrexate (PDX) correlates with the expression of RFC and DHFR mRNA in preclinical models of multiple myeloma Research Paper

SLC25A32 sustains cancer cell proliferation by regulating flavin adenine nucleotide (FAD) metabolism Research Paper

CrkL is required for donor T cell migration to GvHD target organs Research Paper

Checkpoint blockade inhibitors enhances the effectiveness of a Listeria monocytogenes-based melanoma vaccine Research Paper

In vitro studies on CNGRC-CPG2 fusion proteins for ligand-directed enzyme prodrug therapy for targeted cancer therapy Research Paper

Human insulin modulates α-synuclein aggregation via DAF-2/DAF-16 signalling pathway by antagonising DAF-2 receptor in C. elegans model of Parkinson’s disease Research Paper