The Oncosearch | Oncotarget

Tumor suppressor genes and allele-specific expression: mechanisms and significance Research Paper

Evan A. Clayton, Shareef Khalid, Dongjo Ban, Lu Wang, I. King Jordan, John F. McDonald

Published Jan 28, 2020 · Vol. 11, No. 4 · pp. 462-479

Keywords: allele-specific expression, alternative splicing, antisense RNA, cancer, tumor-suppressor genes

FOXL2 homozygous genotype and chromosome instability are associated with recurrence in adult granulosa cell tumors of the ovary Research Paper

Francois Kraus, Julie Dremaux, Wajd Altakfi, Magalie Goux, Léa Pontois, Henri Sevestre, Stéphanie Trudel

Published Jan 28, 2020 · Vol. 11, No. 4 · pp. 419-428

Keywords: granulosa cell tumor, recurrence, FOXL2, array comparative genomic hybridization, chromosome instability

Cetuximab is efficient and safe in patients with advanced cutaneous squamous cell carcinoma: a retrospective, multicentre study Research Paper

Henri Montaudié, Julien Viotti, Patrick Combemale, Caroline Dutriaux, Nicolas Dupin, Caroline Robert, Laurent Mortier, Régis Kaphan, Anne-Bénédicte Duval-Modeste, Stéphane Dalle, Julie De Quatrebarbes, Andrea Stefan, Florence Brunet-Possenti, Maria Kogay, Alexandra Picard-Gauci, Gilles Poissonnet, Frédéric Peyrade

Published Jan 28, 2020 · Vol. 11, No. 4 · pp. 378-385

Keywords: cutaneous squamous cell carcinoma, cetuximab, epidermal growth factor receptor

Sequence conservation of mitochondrial (mt)DNA during expansion of clonal mammary epithelial populations suggests a common mtDNA template in CzechII mice Research Paper

Jabril R. Johnson, Justin B. Lack, Corinne A. Boulanger, Lauren E. Ragle, Gilbert H. Smith

Published Jan 14, 2020 · Vol. 11, No. 2 · pp. 161-174

Keywords: mitochondrial DNA, next-generation sequencing, clonal expansion, mammary cancer

The synergistic inhibitory effect of combining therapies targeting EGFR and mitochondria in sarcomas Research Paper

Xiaochun Wang, Reichelle X. Yeo, Philip J. Hogg, David Goldstein, Philip Crowe, Pierre J. Dilda, Jia-Lin Yang

Published Jan 7, 2020 · Vol. 11, No. 1 · pp. 46-61

Keywords: EGFR-targeted therapy, mitochondria inhibitor, tumour metabolism inhibition, sarcomas, combination therapy

Head and neck squamous cancer progression is marked by CLIC4 attenuation in tumor epithelium and reciprocal stromal upregulation of miR-142-3p, a novel post-transcriptional regulator of CLIC4 Research Paper

Brandi L. Carofino, Kayla M. Dinshaw, Pui Yan Ho, Christophe Cataisson, Aleksandra M. Michalowski, Andrew Ryscavage, Addie Alkhas, Nathan W. Wong, Vishal Koparde, Stuart H. Yuspa

Published Dec 31, 2019 · Vol. 10, No. 68 · pp. 7251-7275

Keywords: in situ hybridization, single-cell RNA-sequencing, stroma, miRNA, immune infiltration

Targeting the non-canonical roles of PCNA modifies and increases the response to targeted anti-cancer therapy Research Paper

Caroline K. Søgaard, Anala Nepal, Voin Petrovic, Animesh Sharma, Nina-Beate Liabakk, Tonje S. Steigedal, Marit Otterlei

Published Dec 31, 2019 · Vol. 10, No. 68 · pp. 7185-7197

Keywords: APIM, multi-targeting therapy, signaling pathways, autophagy, cancer

Low-dose metronomic cyclophosphamide complements the actions of an intratumoral C-class CpG TLR9 agonist to potentiate innate immunity and drive potent T cell-mediated anti-tumor responses Research Paper

Weng In Leong, Rachel Y. Ames, Jessica M. Haverkamp, Laura Torres, Janine Kline, Ashil Bans, Lauren Rocha, Marilena Gallotta, Cristiana Guiducci, Robert L. Coffman, Mary J. Janatpour

Published Dec 31, 2019 · Vol. 10, No. 68 · pp. 7220-7237

Keywords: TLR9, SD-101, cyclophosphamide, immune therapy, innate immunity

ISG15 induction is required during L1-mediated colon cancer progression and metastasis Research Paper

Sanith Cheriyamundath, Sayon Basu, Gal Haase, Harry Doernberg, Nancy Gavert, Thomas Brabletz, Avri Ben-Ze’ev

Published Dec 24, 2019 · Vol. 10, No. 67 · pp. 7122-7131

Keywords: ISG15, L1, colorectal cancer, metastasis

Single cell correlation analysis of liquid and solid biopsies in metastatic colorectal cancer Research Paper

Anna S. Gerdtsson, Jana-Aletta Thiele, Stephanie N. Shishido, Serena Zheng, Randolph Schaffer, Kelly Bethel, Steven Curley, Heinz-Josef Lenz, Diana L. Hanna, Jorge Nieva, Anand Kolatkar, Carmen Ruiz, Mariam Rodriguez-Lee, Gerard J. Oakley III, Jerry S.H. Lee, James Hicks, Peter Kuhn

Published Dec 17, 2019 · Vol. 10, No. 66 · pp. 7016-7030

Keywords: single cell analysis, liquid biopsy, metastatic colorectal cancer, circulating tumor cells, cytomorphology

Gas6/MerTK signaling is negatively regulated by NF-κB and supports lung carcinogenesis Research Paper

Sergey V. Novitskiy, Rinat Zaynagetdinov, Georgii Vasiukov, Sergey Gutor, Wei Han, Ana Serezani, Anton Matafonov, Linda A. Gleaves, Taylor P. Sherrill, Vasiliy V. Polosukhin, Timothy S. Blackwell

Published Dec 17, 2019 · Vol. 10, No. 66 · pp. 7031-7042

Keywords: lung cancer, NF-κB, Mer-TK, macrophage, Kras

Crizotinib and PARP inhibitors act synergistically by triggering apoptosis in high-grade serous ovarian cancer Research Paper

Irem Durmaz Sahin, Jenny-Maria Jönsson, Ingrid Hedenfalk

Published Dec 10, 2019 · Vol. 10, No. 65 · pp. 6981-6996

Keywords: HGSOC, c-Met, PARP inhibitor, apoptosis

An innovative diagnostic strategy for the detection of rare molecular targets to select cancer patients for tumor-agnostic treatments Research Paper

Antonio Marchetti, Alessia Di Lorito, Lara Felicioni, Fiamma Buttitta

Published Dec 10, 2019 · Vol. 10, No. 65 · pp. 6957-6968

Keywords: tumor-agnostic treatments, microsatellite instability (MSI), neurotrophic receptor tyrosine kinase (NRTK), tissue microarrays (TMAs), tissue slice arrays (TSAs)

BRAF^V600E-mutated ovarian serous borderline tumors are at relatively low risk for progression to serous carcinoma Research Paper

M. Herman Chui, Susanne K. Kjaer, Kirsten Frederiksen, Charlotte G. Hannibal, Tian-Li Wang, Russell Vang, Ie-Ming Shih

Published Dec 3, 2019 · Vol. 10, No. 64 · pp. 6870-6878

Keywords: ovarian serous borderline tumor, mutation, genotyping, risk prediction, serous carcinoma

A mouse model of prostate cancer bone metastasis in a syngeneic immunocompetent host Research Paper

Brian W. Simons, Vishal Kothari, Benjamin Benzon, Kamyar Ghabili, Robert Hughes, Jelani C. Zarif, Ashley E. Ross, Paula J. Hurley, Edward M. Schaeffer

Published Dec 3, 2019 · Vol. 10, No. 64 · pp. 6845-6854

Keywords: prostate cancer, bone metastasis, murine model

Mesangiogenic progenitor cells are forced toward the angiogenic fate, in multiple myeloma Research Paper

Simone Pacini, Marina Montali, Francesco Mazziotta, Claudia P. Schifone, Lucia Macchia, Vittoria Carnicelli, Francesca M. Panvini, Serena Barachini, Laura Notarfranchi, Giovanni Battista Previti, Gabriele Buda, Mario Petrini

Published Nov 26, 2019 · Vol. 10, No. 63 · pp. 6781-6790

Keywords: multiple myeloma, bone marrow microenvironment, angiogenesis, osteogenesis, mesangiogenic progenitor cells

Correction: FGFR1β is a driver isoform of FGFR1 alternative splicing in breast cancer cells Correction

Ming Zhao, Ming-Lei Zhuo, Xiaofeng Zheng, Xiaoping Su, Funda Meric-Bernstam

Published Nov 16, 2019 · Vol. 10, No. 65 · pp. 7014-7015

MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma Priority Research Paper

David King, Xiao Dun Li, Gilberto S. Almeida, Colin Kwok, Polly Gravells, Daniel Harrison, Saoirse Burke, Albert Hallsworth, Yann Jamin, Sally George, Simon P. Robinson, Christopher J. Lord, Evon Poon, Daniel Yeomanson, Louis Chesler, Helen E. Bryant

Published Nov 6, 2019 · Vol. 11, No. 23 · pp. 2141-2159

Keywords: PARP inhibitor, neuroblastoma, MYCN, replication stress, replication fork stalling

Efficacy and safety of buparlisib, a PI3K inhibitor, in patients with malignancies harboring a PI3K pathway activation: a phase 2, open-label, single-arm study Research Paper

Sarina A. Piha-Paul, Matthew H. Taylor, Daniel Spitz, Lee Schwartzberg, J. Thaddeus Beck, Todd M. Bauer, Funda Meric-Bernstam, Das Purkayastha, Linda Karpiak, Sebastian Szpakowski, Fadi Braiteh

Published Nov 5, 2019 · Vol. 10, No. 60 · pp. 6526-6535

Keywords: phosphatidylinositol 3-kinase pathway, buparlisib, advanced malignancies, molecular selection, tissue agnostic

SNiPER: a novel hypermethylation biomarker panel for liquid biopsy based early breast cancer detection Research Paper

Jolein Mijnes, Janina Tiedemann, Julian Eschenbruch, Janina Gasthaus, Sarah Bringezu, Dirk Bauerschlag, Nicolai Maass, Norbert Arnold, Jörg Weimer, Tobias Anzeneder, Peter A. Fasching, Matthias Rübner, Benjamin Bruno, Uwe Heindrichs, Jennifer Freres, Hanna Schulz, Ralf-Dieter Hilgers, Nadina Ortiz-Brüchle, Sonja von Serenyi, Ruth Knüchel, Vera Kloten, Edgar Dahl

Published Nov 5, 2019 · Vol. 10, No. 60 · pp. 6494-6508

Keywords: liquid biopsy, breast cancer, early detection, hypermethylation, discriminative CpG dinucleotides

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Tumor suppressor genes and allele-specific expression: mechanisms and significance Research Paper

FOXL2 homozygous genotype and chromosome instability are associated with recurrence in adult granulosa cell tumors of the ovary Research Paper

Cetuximab is efficient and safe in patients with advanced cutaneous squamous cell carcinoma: a retrospective, multicentre study Research Paper

Sequence conservation of mitochondrial (mt)DNA during expansion of clonal mammary epithelial populations suggests a common mtDNA template in CzechII mice Research Paper

The synergistic inhibitory effect of combining therapies targeting EGFR and mitochondria in sarcomas Research Paper

Head and neck squamous cancer progression is marked by CLIC4 attenuation in tumor epithelium and reciprocal stromal upregulation of miR-142-3p, a novel post-transcriptional regulator of CLIC4 Research Paper

Targeting the non-canonical roles of PCNA modifies and increases the response to targeted anti-cancer therapy Research Paper

Low-dose metronomic cyclophosphamide complements the actions of an intratumoral C-class CpG TLR9 agonist to potentiate innate immunity and drive potent T cell-mediated anti-tumor responses Research Paper

ISG15 induction is required during L1-mediated colon cancer progression and metastasis Research Paper

Single cell correlation analysis of liquid and solid biopsies in metastatic colorectal cancer Research Paper

Gas6/MerTK signaling is negatively regulated by NF-κB and supports lung carcinogenesis Research Paper

Crizotinib and PARP inhibitors act synergistically by triggering apoptosis in high-grade serous ovarian cancer Research Paper

An innovative diagnostic strategy for the detection of rare molecular targets to select cancer patients for tumor-agnostic treatments Research Paper

BRAF^V600E-mutated ovarian serous borderline tumors are at relatively low risk for progression to serous carcinoma Research Paper

A mouse model of prostate cancer bone metastasis in a syngeneic immunocompetent host Research Paper

Mesangiogenic progenitor cells are forced toward the angiogenic fate, in multiple myeloma Research Paper

Correction: FGFR1β is a driver isoform of FGFR1 alternative splicing in breast cancer cells Correction

MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma Priority Research Paper

Efficacy and safety of buparlisib, a PI3K inhibitor, in patients with malignancies harboring a PI3K pathway activation: a phase 2, open-label, single-arm study Research Paper

SNiPER: a novel hypermethylation biomarker panel for liquid biopsy based early breast cancer detection Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Tumor suppressor genes and allele-specific expression: mechanisms and significance Research Paper

FOXL2 homozygous genotype and chromosome instability are associated with recurrence in adult granulosa cell tumors of the ovary Research Paper

Cetuximab is efficient and safe in patients with advanced cutaneous squamous cell carcinoma: a retrospective, multicentre study Research Paper

Sequence conservation of mitochondrial (mt)DNA during expansion of clonal mammary epithelial populations suggests a common mtDNA template in CzechII mice Research Paper

The synergistic inhibitory effect of combining therapies targeting EGFR and mitochondria in sarcomas Research Paper

Head and neck squamous cancer progression is marked by CLIC4 attenuation in tumor epithelium and reciprocal stromal upregulation of miR-142-3p, a novel post-transcriptional regulator of CLIC4 Research Paper

Targeting the non-canonical roles of PCNA modifies and increases the response to targeted anti-cancer therapy Research Paper

Low-dose metronomic cyclophosphamide complements the actions of an intratumoral C-class CpG TLR9 agonist to potentiate innate immunity and drive potent T cell-mediated anti-tumor responses Research Paper

ISG15 induction is required during L1-mediated colon cancer progression and metastasis Research Paper

Single cell correlation analysis of liquid and solid biopsies in metastatic colorectal cancer Research Paper

Gas6/MerTK signaling is negatively regulated by NF-κB and supports lung carcinogenesis Research Paper

Crizotinib and PARP inhibitors act synergistically by triggering apoptosis in high-grade serous ovarian cancer Research Paper

An innovative diagnostic strategy for the detection of rare molecular targets to select cancer patients for tumor-agnostic treatments Research Paper

BRAFV600E-mutated ovarian serous borderline tumors are at relatively low risk for progression to serous carcinoma Research Paper

A mouse model of prostate cancer bone metastasis in a syngeneic immunocompetent host Research Paper

Mesangiogenic progenitor cells are forced toward the angiogenic fate, in multiple myeloma Research Paper

Correction: FGFR1β is a driver isoform of FGFR1 alternative splicing in breast cancer cells Correction

MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma Priority Research Paper

Efficacy and safety of buparlisib, a PI3K inhibitor, in patients with malignancies harboring a PI3K pathway activation: a phase 2, open-label, single-arm study Research Paper

SNiPER: a novel hypermethylation biomarker panel for liquid biopsy based early breast cancer detection Research Paper

BRAF^V600E-mutated ovarian serous borderline tumors are at relatively low risk for progression to serous carcinoma Research Paper