The Oncosearch | Oncotarget

Circulating tumor DNA analysis in the era of precision oncology Review

Rabih Said, Nicolas Guibert, Geoffrey R. Oxnard, Apostolia M. Tsimberidou

Published Jan 14, 2020 · Vol. 11, No. 2 · pp. 188-211

Keywords: circulating tumor DNA analysis, clinical trials, targeted therapy, genomic profiling

Deregulation of cancer-stem-cell-associated miRNAs in tissues and sera of colorectal cancer patients Research Paper

Cristiano Farace, Andrea Pisano, Carmen Griñan-Lison, Giuliana Solinas, Gema Jiménez, Marina Serra, Esmeralda Carrillo, Fabrizio Scognamillo, Federico Attene, Andrea Montella, Juan Antonio Marchal, Roberto Madeddu

Published Jan 14, 2020 · Vol. 11, No. 2 · pp. 116-130

Keywords: colorectal cancer, metastasis, cancer stem cell, microRNA, biomarker

Isolation and characterization of a CD34⁺ sub-clone in B-cell lymphoma Research Paper

Ayad M. Al-Katib, Abdul Shukkur Ebrahim, Mustapha Kandouz, Feras Zaiem, Ali Raufi, Salah Ebrahim, Anwar Mohamed, Nada Emara, Ali M. Gabali

Published Jan 14, 2020 · Vol. 11, No. 2 · pp. 148-160

Keywords: CD34, B-cell non-Hodgkin’s lymphoma, minimal residual disease, lymphoma stem cell

Identification of signature genes associated with therapeutic resistance to anti-VEGF therapy Research Paper

Pharavee Jaiprasart, Samrita Dogra, Deepika Neelakantan, Bharat Devapatla, Sukyung Woo

Published Jan 7, 2020 · Vol. 11, No. 1 · pp. 99-114

Keywords: anti-VEGF resistance, angiogenesis, bevacizumab, next-generation sequencing (NGS), apelin

Novel functional anti-HER3 monoclonal antibodies with potent anti-cancer effects on various human epithelial cancers Research Paper

Kouki Okita, Shogo Okazaki, Shinya Uejima, Erina Yamada, Hiroki Kaminaka, Misa Kondo, Shiho Ueda, Ryo Tokiwa, Nami Iwata, Akitaka Yamasaki, Natsumi Hayashi, Dai Ogura, Kenji Hirotani, Toshiaki Yoshioka, Masahiro Inoue, Kazue Masuko, Takashi Masuko

Published Jan 7, 2020 · Vol. 11, No. 1 · pp. 31-45

Keywords: CDR, HER3, internalization, mAb, NRG1

Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR Research Paper

Hengyu Lu, Chen Liu, Hung Huynh, Thi Bich Uyen Le, Matthew LaMarche, Morvarid Mohseni, Jeffrey A. Engelman, Peter S. Hammerman, Giordano Caponigro, Huai-Xiang Hao

Published Jan 6, 2020

Keywords: SHP2, FGFR, resistance, feedback activation

Thymoquinone induces apoptosis and DNA damage in 5-Fluorouracil-resistant colorectal cancer stem/progenitor cells Research Paper

Farah Ballout, Alissar Monzer, Maamoun Fatfat, Hala El Ouweini, Miran A. Jaffa, Rana Abdel-Samad, Nadine Darwiche, Wassim Abou-Kheir, Hala Gali-Muhtasib

Published Jan 3, 2020 · Vol. 11, No. 31 · pp. 2959-2972

Keywords: thymoquinone, colorectal cancer stem cells, 5-Fluorouracil resistance, colonospheres, apoptosis

Erratum: PTEN deletion drives acute myeloid leukemia resistance to MEK inhibitors Errata

Amanda M. Smith, Christine R.C. Zhang, Alexandre S. Cristino, John P. Grady, J. Lynn Fink, Andrew S. Moore

Published Dec 18, 2019 · Vol. 11, No. 3 · pp. 305-305

CRISPR/Cas9 genome-wide screening identifies KEAP1 as a sorafenib, lenvatinib, and regorafenib sensitivity gene in hepatocellular carcinoma Research Paper

Adi Zheng, Nadja Chevalier, Margot Calderoni, Gilles Dubuis, Olivier Dormond, Panos G. Ziros, Gerasimos P. Sykiotis, Christian Widmann

Published Dec 17, 2019 · Vol. 10, No. 66 · pp. 7058-7070

Keywords: KEAP1, sorafenib, hepatocellular carcinoma, lenvatinib, Regorafenib

Gas6/MerTK signaling is negatively regulated by NF-κB and supports lung carcinogenesis Research Paper

Sergey V. Novitskiy, Rinat Zaynagetdinov, Georgii Vasiukov, Sergey Gutor, Wei Han, Ana Serezani, Anton Matafonov, Linda A. Gleaves, Taylor P. Sherrill, Vasiliy V. Polosukhin, Timothy S. Blackwell

Published Dec 17, 2019 · Vol. 10, No. 66 · pp. 7031-7042

Keywords: lung cancer, NF-κB, Mer-TK, macrophage, Kras

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Wayne D. Blosser, Jack A. Dempsey, Ann M. Mc Nulty, Xi Rao, Philip J. Ebert, Caitlin D. Lowery, Philip W. Iversen, Yue Wang Webster, Gregory P. Donoho, Xueqian Gong, Farhana F. Merzoug, Sean Buchanan, Karsten Boehnke, Chunping Yu, Xin Tian You, Richard P. Beckmann, Wenjuan Wu, Samuel C. McNeely, Aimee Bence Lin, Ricardo Martinez

Published Dec 16, 2019

Keywords: CHK1, prexasertib, replication stress, replication fork, innate immunity

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Wayne D. Blosser, Jack A. Dempsey, Ann M. Mc Nulty, Xi Rao, Philip J. Ebert, Caitlin D. Lowery, Philip W. Iversen, Yue Wang Webster, Gregory P. Donoho, Xueqian Gong, Farhana F. Merzoug, Sean Buchanan, Karsten Boehnke, Chunping Yu, Xin Tian You, Richard P. Beckmann, Wenjuan Wu, Samuel C. McNeely, Aimee Bence Lin, Ricardo Martinez

Published Dec 16, 2019

Keywords: CHK1, prexasertib, replication stress, replication fork, innate immunity

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Wayne D. Blosser, Jack A. Dempsey, Ann M. Mc Nulty, Xi Rao, Philip J. Ebert, Caitlin D. Lowery, Philip W. Iversen, Yue Wang Webster, Gregory P. Donoho, Xueqian Gong, Farhana F. Merzoug, Sean Buchanan, Karsten Boehnke, Chunping Yu, Xin Tian You, Richard P. Beckmann, Wenjuan Wu, Samuel C. McNeely, Aimee Bence Lin, Ricardo Martinez

Published Dec 16, 2019

Keywords: CHK1, prexasertib, replication stress, replication fork, innate immunity

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Wayne D. Blosser, Jack A. Dempsey, Ann M. Mc Nulty, Xi Rao, Philip J. Ebert, Caitlin D. Lowery, Philip W. Iversen, Yue Wang Webster, Gregory P. Donoho, Xueqian Gong, Farhana F. Merzoug, Sean Buchanan, Karsten Boehnke, Chunping Yu, Xin Tian You, Richard P. Beckmann, Wenjuan Wu, Samuel C. McNeely, Aimee Bence Lin, Ricardo Martinez

Published Dec 16, 2019

Keywords: CHK1, prexasertib, replication stress, replication fork, innate immunity

Flow cytometric significance of cellular alkaline phosphatase activity in acute myeloid leukemia Research Paper

Laura G. Rico, Jordi Juncà, Michael D. Ward, Jolene A. Bradford, Jordi Petriz

Published Dec 10, 2019 · Vol. 10, No. 65 · pp. 6969-6980

Keywords: alkaline phosphatase, acute myeloid leukemia, stem cells, leukemic stem cells, CD34

Crizotinib and PARP inhibitors act synergistically by triggering apoptosis in high-grade serous ovarian cancer Research Paper

Irem Durmaz Sahin, Jenny-Maria Jönsson, Ingrid Hedenfalk

Published Dec 10, 2019 · Vol. 10, No. 65 · pp. 6981-6996

Keywords: HGSOC, c-Met, PARP inhibitor, apoptosis

p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis Research Paper

Boxiao Ding, Alexander Haidurov, Ayesha Chawla, Anita Parmigiani, Gerarda van de Kamp, Alexandra Dalina, Fang Yuan, Jun Hee Lee, Peter M. Chumakov, Steven R. Grossman, Andrei V. Budanov

Published Dec 10, 2019 · Vol. 10, No. 65 · pp. 6997-7009

Keywords: SESTRINs, lung cancer, mouse model, mTORC1/2, tumor suppression

PTPRS drives adaptive resistance to MEK/ERK inhibitors through SRC Priority Research Paper

Thomas B. Davis, Mingli Yang, Heiman Wang, Changgong Lee, Timothy J. Yeatman, W. Jack Pledger

Published Nov 26, 2019 · Vol. 10, No. 63 · pp. 6768-6780

Keywords: colorectal cancer, PTPRS, ERK, SRC, adaptive resistance

Correction: BM microenvironmental protection of CML cells from imatinib through Stat5/NF-κB signaling and reversal by Wogonin Correction

Xuefen Xu, Xiaobo Zhang, Yicheng Liu, Lin Yang, Shaoliang Huang, Lu Lu, Shuhao Wang, Qinglong Guo, Li Zhao

Published Nov 19, 2019

Sequential somatic mutations upon secondary anti-HER2 treatment resistance in metastatic ERBB2^S310F mutated extramammary Paget’s disease Research Paper

Thierry M. Nordmann, Olivia Messerli-Odermatt, Larissa Meier, Sara Micaletto, Thomas Coppetti, Mirjam Nägeli, Jivko Kamarachev, Ken Kudura, Sandra N. Freiberger, Tamara Rordorf, Joanna Mangana, Ralph Braun, Reinhard Dummer

Published Nov 19, 2019 · Vol. 10, No. 62 · pp. 6647-6650

Keywords: ERBB2 protein, Paget disease, extramammary, trastuzumab, lapatinib

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Circulating tumor DNA analysis in the era of precision oncology Review

Deregulation of cancer-stem-cell-associated miRNAs in tissues and sera of colorectal cancer patients Research Paper

Isolation and characterization of a CD34⁺ sub-clone in B-cell lymphoma Research Paper

Identification of signature genes associated with therapeutic resistance to anti-VEGF therapy Research Paper

Novel functional anti-HER3 monoclonal antibodies with potent anti-cancer effects on various human epithelial cancers Research Paper

Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR Research Paper

Thymoquinone induces apoptosis and DNA damage in 5-Fluorouracil-resistant colorectal cancer stem/progenitor cells Research Paper

Erratum: PTEN deletion drives acute myeloid leukemia resistance to MEK inhibitors Errata

CRISPR/Cas9 genome-wide screening identifies KEAP1 as a sorafenib, lenvatinib, and regorafenib sensitivity gene in hepatocellular carcinoma Research Paper

Gas6/MerTK signaling is negatively regulated by NF-κB and supports lung carcinogenesis Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Flow cytometric significance of cellular alkaline phosphatase activity in acute myeloid leukemia Research Paper

Crizotinib and PARP inhibitors act synergistically by triggering apoptosis in high-grade serous ovarian cancer Research Paper

p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis Research Paper

PTPRS drives adaptive resistance to MEK/ERK inhibitors through SRC Priority Research Paper

Correction: BM microenvironmental protection of CML cells from imatinib through Stat5/NF-κB signaling and reversal by Wogonin Correction

Sequential somatic mutations upon secondary anti-HER2 treatment resistance in metastatic ERBB2^S310F mutated extramammary Paget’s disease Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Circulating tumor DNA analysis in the era of precision oncology Review

Deregulation of cancer-stem-cell-associated miRNAs in tissues and sera of colorectal cancer patients Research Paper

Isolation and characterization of a CD34+ sub-clone in B-cell lymphoma Research Paper

Identification of signature genes associated with therapeutic resistance to anti-VEGF therapy Research Paper

Novel functional anti-HER3 monoclonal antibodies with potent anti-cancer effects on various human epithelial cancers Research Paper

Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR Research Paper

Thymoquinone induces apoptosis and DNA damage in 5-Fluorouracil-resistant colorectal cancer stem/progenitor cells Research Paper

Erratum: PTEN deletion drives acute myeloid leukemia resistance to MEK inhibitors Errata

CRISPR/Cas9 genome-wide screening identifies KEAP1 as a sorafenib, lenvatinib, and regorafenib sensitivity gene in hepatocellular carcinoma Research Paper

Gas6/MerTK signaling is negatively regulated by NF-κB and supports lung carcinogenesis Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Flow cytometric significance of cellular alkaline phosphatase activity in acute myeloid leukemia Research Paper

Crizotinib and PARP inhibitors act synergistically by triggering apoptosis in high-grade serous ovarian cancer Research Paper

p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis Research Paper

PTPRS drives adaptive resistance to MEK/ERK inhibitors through SRC Priority Research Paper

Correction: BM microenvironmental protection of CML cells from imatinib through Stat5/NF-κB signaling and reversal by Wogonin Correction

Sequential somatic mutations upon secondary anti-HER2 treatment resistance in metastatic ERBB2S310F mutated extramammary Paget’s disease Research Paper

Isolation and characterization of a CD34⁺ sub-clone in B-cell lymphoma Research Paper

Sequential somatic mutations upon secondary anti-HER2 treatment resistance in metastatic ERBB2^S310F mutated extramammary Paget’s disease Research Paper