The Oncosearch | Oncotarget

Avoidance of apoptotic death via a hyperploid salvage survival pathway after platinum treatment in high grade serous carcinoma cell line models Research Paper

Tony Yeung, Oliver Fung, Mikhail Bashkurov, Arian Khandani, Omar Subedar, Alexandra Wudwud, Patricia Shaw, Blaise Clarke, John Bartlett, Robert Rottapel, Andras Kapus

Published Nov 19, 2019 · Vol. 10, No. 62 · pp. 6691-6712

Keywords: hyperploid genome, apoptosis, platinum chemotherapy, cell cycle checkpoint, ovarian cancer

Correction: Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity Correction

Adrienne L. Watson, Bryant J. Keller, Kyle A. Williams, Namrata N. Damle, Samuel J. Finnerty, Leah K. Anderson, Andrew D. Greeley, Vincent W. Keng, Eric P. Rahrmann, Amanda L. Halfond, Natasha M. Powell, Margaret H. Collins, Tilat Rizvi, Christopher L. Moertel, Nancy Ratner, David A. Largaespada

Published Nov 15, 2019 · Vol. 11, No. 39 · pp. 3618-3620

High expression of apoptosis protein (Api-5) in chemoresistant triple-negative breast cancers: an innovative target Research Paper

Guilhem Bousquet, Jean-Paul Feugeas, Yuchen Gu, Christophe Leboeuf, Morad El Bouchtaoui, He Lu, Marc Espié, Anne Janin, Melanie Di Benedetto

Published Nov 12, 2019 · Vol. 10, No. 61 · pp. 6577-6588

Keywords: triple-negative breast cancer, chemotherapy resistance, apoptosis-inhibitor-5, peptide, anti-angiogenic therapy

miR-151a enhances Slug dependent angiogenesis Priority Research Paper

Douglas Jury, Iben Daugaard, Katie J. Sanders, Lise Lotte Hansen, Dritan Agalliu, Irene Munk Pedersen

Published Nov 7, 2019 · Vol. 11, No. 23 · pp. 2160-2171

Keywords: angiogenesis, miR-151a, Slug, tumor microenvironment, endothelial cell

Efficacy and safety of buparlisib, a PI3K inhibitor, in patients with malignancies harboring a PI3K pathway activation: a phase 2, open-label, single-arm study Research Paper

Sarina A. Piha-Paul, Matthew H. Taylor, Daniel Spitz, Lee Schwartzberg, J. Thaddeus Beck, Todd M. Bauer, Funda Meric-Bernstam, Das Purkayastha, Linda Karpiak, Sebastian Szpakowski, Fadi Braiteh

Published Nov 5, 2019 · Vol. 10, No. 60 · pp. 6526-6535

Keywords: phosphatidylinositol 3-kinase pathway, buparlisib, advanced malignancies, molecular selection, tissue agnostic

Importance of activated leukocyte cell adhesion molecule (ALCAM) in prostate cancer progression and metastatic dissemination Research Paper

Andrew J. Sanders, Sioned Owen, Liam D. Morgan, Fiona Ruge, Ross J. Collins, Lin Ye, Malcolm D. Mason, Wen G. Jiang

Published Oct 29, 2019 · Vol. 10, No. 59 · pp. 6362-6377

Keywords: ALCAM, prostate cancer, bone, metastasis, serum biomarker

Effect of Fms-like tyrosine kinase 3 (FLT3) ligand (FL) on antitumor activity of gilteritinib, a FLT3 inhibitor, in mice xenografted with FL-overexpressing cells Research Paper

Tatsuya Kawase, Taisuke Nakazawa, Tomohiro Eguchi, Hirofumi Tsuzuki, Yoko Ueno, Yasushi Amano, Tomoyuki Suzuki, Masamichi Mori, Taku Yoshida

Published Oct 22, 2019 · Vol. 10, No. 58 · pp. 6111-6123

Keywords: FLT3, FL, FLT3 inhibitor, gilteritinib, antitumor activity

Preferential targeting of MCL-1 by a hydrocarbon-stapled BIM BH3 peptide Research Paper

Abbas Hadji, Greta K. Schmitt, Mathew R. Schnorenberg, Lauren Roach, Connie M. Hickey, Logan B. Leak, Matthew V. Tirrell, James L. LaBelle

Published Oct 22, 2019 · Vol. 10, No. 58 · pp. 6219-6233

Keywords: MCL-1, BIM, BH3 mimetic, stapled peptides, apoptosis

ERO1α promotes hypoxic tumor progression and is associated with poor prognosis in pancreatic cancer Research Paper

Nikhil Gupta, Jung Eun Park, Wilford Tse, Jee Keem Low, Oi Lian Kon, Neil McCarthy, Siu Kwan Sze

Published Oct 15, 2019 · Vol. 10, No. 57 · pp. 5970-5982

Keywords: pancreatic cancer, hypoxia tumor, ERO1α, SILAC, proteomics

Importance of activated leukocyte cell adhesion molecule (ALCAM) in prostate cancer progression and metastatic dissemination Research Paper

Andrew J. Sanders, Sioned Owen, Liam Morgan, Fiona Ruge, Ross Collins, Lin Ye, Malcolm Mason, Wenguo Jiang

Published Oct 14, 2019

Keywords: ALCAM, prostate cancer, bone, metastasis, serum biomarker

Overcoming heterogenity in imatinib-resistant gastrointestinal stromal tumor Editorial

César Serrano, Jonathan A. Fletcher

Published Oct 14, 2019 · Vol. 10, No. 59 · pp. 6286-6287

Keywords: GIST, imatinib, sunitinib, regorafenib, therapeutic combination

PTEN deletion drives acute myeloid leukemia resistance to MEK inhibitors Research Paper

Amanda M. Smith, Christine R.C. Zhang, Alexandre S. Cristino, John P. Grady, J. Lynn Fink, Andrew S. Moore

Published Oct 8, 2019 · Vol. 10, No. 56 · pp. 5755-5767

Keywords: myeloid leukemia, therapy, drug resistance, hematological malignancies, gene mutation

Mechanisms by which PE21, an extract from the white willow Salix alba, delays chronological aging in budding yeast Research Paper

Younes Medkour, Karamat Mohammad, Anthony Arlia-Ciommo, Veronika Svistkova, Pamela Dakik, Darya Mitrofanova, Monica Enith Lozano Rodriguez, Jennifer Anne Baratang Junio, Tarek Taifour, Paola Escudero, Fani-Fay Goltsios, Sahar Soodbakhsh, Hana Maalaoui, Éric Simard, Vladimir I. Titorenko

Published Oct 8, 2019 · Vol. 10, No. 56 · pp. 5780-5816

Keywords: cellular aging, geroprotectors, lipid metabolism, necrotic cell death, mitochondria

Tumor necrosis factor related apoptosis inducing ligand (TRAIL) regulates deubiquitinase USP5 in tumor cells Research Paper

Harish Potu, Malathi Kandarpa, Luke F. Peterson, Nicholas J. Donato, Moshe Talpaz

Published Oct 8, 2019 · Vol. 10, No. 56 · pp. 5745-5754

Keywords: USP5, ubiquitin, TRAIL, DUB inhibitor, G9

Ezrin, more than a metastatic detERMinant? Editorial

Victoria Hoskin, Abdi Ghaffari, Bruce E. Elliott

Published Sep 25, 2019 · Vol. 10, No. 63 · pp. 6755-6757

Keywords: ezrin, metastasis, breast cancer, therapeutic target

Dual-Targeting AKT2 and ERK in cancer stem-like cells in neuroblastoma Research Paper

Kwang Woon Kim, Julia Y. Kim, Jingbo Qiao, Rachael A. Clark, Camille M. Powers, Hernan Correa, Dai H. Chung

Published Sep 24, 2019 · Vol. 10, No. 54 · pp. 5645-5659

Keywords: chemotherapy, radiotherapy, resistance, AKT2, MAPK

Excision repair cross-complementing group-1 (ERCC1) induction kinetics and polymorphism are markers of inferior outcome in patients with colorectal cancer treated with oxaliplatin Research Paper

Devika Rao, Atrayee Basu Mallick, Titto Augustine, Cecilia Daroqui, Jeeshan Jiffry, Amartej Merla, Imran Chaudhary, Raviraja Seetharam, Arjun Sood, Srikanth Gajavelli, Santiago Aparo, Lakshmi Rajdev, Andreas Kaubisch, Jennifer Chuy, Abdissa Negassa, John M. Mariadason, Radhashree Maitra, Sanjay Goel

Published Sep 17, 2019 · Vol. 10, No. 53 · pp. 5510-5522

Keywords: oxaliplatin, colorectal cancer, ERCC1, FOLFOX, resistance

Therapeutic inhibition of Mcl-1 blocks cell survival in estrogen receptor-positive breast cancers Research Paper

Michelle M. Williams, David L. Elion, Bushra Rahman, Donna J. Hicks, Violeta Sanchez, Rebecca S. Cook

Published Sep 10, 2019 · Vol. 10, No. 52 · pp. 5389-5402

Keywords: Mcl-1, ABT-263 resistance, mTORC1 signaling, luminal breast cancers

Dual-Targeting AKT2 and ERK in cancer stem-like cells in neuroblastoma Research Paper

Kwang Woon Kim, Julia Y. Kim, Jingbo Qiao, Rachael A. Clark, Camille M. Powers, Hernan Correa, Dai H. Chung

Published Sep 5, 2019

Keywords: chemotherapy, radiotherapy, resistance, AKT2, MAPK

Mechanisms by which PE21, an extract from the white willow Salix alba, delays chronological aging in budding yeast Research Paper

Younes Medkour, Karamat Mohammad, Anthony Arlia-Ciommo, Veronika Svistkova, Pamela Dakik, Darya Mitrofanova, Monica Enith Lozano Rodriguez, Jennifer Anne Baratang Junio, Tarek Taifour, Paola Escudero, Fani-Fay Goltsios, Sahar Soodbakhsh, Hana Maalaoui, Éric Simard, Vladimir I. Titorenko

Published Sep 5, 2019

Keywords: cellular aging, geroprotectors, lipid metabolism, necrotic cell death, mitochondria

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Avoidance of apoptotic death via a hyperploid salvage survival pathway after platinum treatment in high grade serous carcinoma cell line models Research Paper

Correction: Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity Correction

High expression of apoptosis protein (Api-5) in chemoresistant triple-negative breast cancers: an innovative target Research Paper

miR-151a enhances Slug dependent angiogenesis Priority Research Paper

Efficacy and safety of buparlisib, a PI3K inhibitor, in patients with malignancies harboring a PI3K pathway activation: a phase 2, open-label, single-arm study Research Paper

Importance of activated leukocyte cell adhesion molecule (ALCAM) in prostate cancer progression and metastatic dissemination Research Paper

Effect of Fms-like tyrosine kinase 3 (FLT3) ligand (FL) on antitumor activity of gilteritinib, a FLT3 inhibitor, in mice xenografted with FL-overexpressing cells Research Paper

Preferential targeting of MCL-1 by a hydrocarbon-stapled BIM BH3 peptide Research Paper

ERO1α promotes hypoxic tumor progression and is associated with poor prognosis in pancreatic cancer Research Paper

Importance of activated leukocyte cell adhesion molecule (ALCAM) in prostate cancer progression and metastatic dissemination Research Paper

Overcoming heterogenity in imatinib-resistant gastrointestinal stromal tumor Editorial

PTEN deletion drives acute myeloid leukemia resistance to MEK inhibitors Research Paper

Mechanisms by which PE21, an extract from the white willow Salix alba, delays chronological aging in budding yeast Research Paper

Tumor necrosis factor related apoptosis inducing ligand (TRAIL) regulates deubiquitinase USP5 in tumor cells Research Paper

Ezrin, more than a metastatic detERMinant? Editorial

Dual-Targeting AKT2 and ERK in cancer stem-like cells in neuroblastoma Research Paper

Excision repair cross-complementing group-1 (ERCC1) induction kinetics and polymorphism are markers of inferior outcome in patients with colorectal cancer treated with oxaliplatin Research Paper

Therapeutic inhibition of Mcl-1 blocks cell survival in estrogen receptor-positive breast cancers Research Paper

Dual-Targeting AKT2 and ERK in cancer stem-like cells in neuroblastoma Research Paper

Mechanisms by which PE21, an extract from the white willow Salix alba, delays chronological aging in budding yeast Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Avoidance of apoptotic death via a hyperploid salvage survival pathway after platinum treatment in high grade serous carcinoma cell line models Research Paper

Correction: Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity Correction

High expression of apoptosis protein (Api-5) in chemoresistant triple-negative breast cancers: an innovative target Research Paper

miR-151a enhances Slug dependent angiogenesis Priority Research Paper

Efficacy and safety of buparlisib, a PI3K inhibitor, in patients with malignancies harboring a PI3K pathway activation: a phase 2, open-label, single-arm study Research Paper

Importance of activated leukocyte cell adhesion molecule (ALCAM) in prostate cancer progression and metastatic dissemination Research Paper

Effect of Fms-like tyrosine kinase 3 (FLT3) ligand (FL) on antitumor activity of gilteritinib, a FLT3 inhibitor, in mice xenografted with FL-overexpressing cells Research Paper

Preferential targeting of MCL-1 by a hydrocarbon-stapled BIM BH3 peptide Research Paper

ERO1α promotes hypoxic tumor progression and is associated with poor prognosis in pancreatic cancer Research Paper

Importance of activated leukocyte cell adhesion molecule (ALCAM) in prostate cancer progression and metastatic dissemination Research Paper

Overcoming heterogenity in imatinib-resistant gastrointestinal stromal tumor Editorial

PTEN deletion drives acute myeloid leukemia resistance to MEK inhibitors Research Paper

Mechanisms by which PE21, an extract from the white willow Salix alba, delays chronological aging in budding yeast Research Paper

Tumor necrosis factor related apoptosis inducing ligand (TRAIL) regulates deubiquitinase USP5 in tumor cells Research Paper

Ezrin, more than a metastatic detERMinant? Editorial

Dual-Targeting AKT2 and ERK in cancer stem-like cells in neuroblastoma Research Paper

Excision repair cross-complementing group-1 (ERCC1) induction kinetics and polymorphism are markers of inferior outcome in patients with colorectal cancer treated with oxaliplatin Research Paper

Therapeutic inhibition of Mcl-1 blocks cell survival in estrogen receptor-positive breast cancers Research Paper

Dual-Targeting AKT2 and ERK in cancer stem-like cells in neuroblastoma Research Paper

Mechanisms by which PE21, an extract from the white willow Salix alba, delays chronological aging in budding yeast Research Paper