The Oncosearch | Oncotarget

The response to PAK1 inhibitor IPA3 distinguishes between cancer cells with mutations in BRAF and Ras oncogenes Research Paper

Ruchi Singhal, Eugene S. Kandel

Published Jul 31, 2012 · Vol. 3, No. 7 · pp. 700-708

Keywords: IPA3, PAK1, BRAF, NRAS, KRAS, melanoma, colon cancer, GDC-0879, AZD6244

Receptor-targeted therapy of human experimental urinary bladder cancers with cytotoxic LH-RH analog AN-152 (AEZS-108) Research Paper

Karoly Szepeshazi, Andrew V Schally, Gunhild Keller, Norman L Block, Daniel Benten, Gabor Halmos, Luca Szalontay, Irving Vidaurre, Miklos Jaszberenyi, Ferenc G Rick

Published Jul 22, 2012 · Vol. 3, No. 7 · pp. 686-699

Keywords: urinary bladder, urothelial cancer, targeted therapy, LH-RH receptor, cytotoxic, doxorubicin

A thymidylate synthase ternary complex-specific antibody, FTS, permits functional monitoring of fluoropyrimidines dosing Research Paper

Kalpesh Patel, Sashidhar R. Yerram, Nilofer A. Azad, Scott E. Kern

Published Jul 22, 2012 · Vol. 3, No. 7 · pp. 678-685

Keywords: ternary complex, thymidylate synthase, drug adduct, drug adduct-specific antibody, ternary complex-specific antibody, FTS

A composite polymer nanoparticle overcomes multidrug resistance and ameliorates doxorubicin-associated cardiomyopathy Research Paper

Dipankar Pramanik, Nathaniel R Campbell, Samarjit Das, Sonal Gupta, Venugopal Chenna, Savita Bisht, Polina Sysa-shah, Djahida Bedja, Collins Karikari, Charles Steenbergen, Kathleen L. Gabrielson, Amarnath Maitra, Anirban Maitra

Published Jul 10, 2012 · Vol. 3, No. 6 · pp. 640-650

A novel co-operative mechanism linking TGFÎ² and Lyn kinase activation to imatinib resistance in chronic myeloid leukaemia cells Brief Reports

Andrew Chantry, Paul G Smith, Hideo Tanaka

Published May 24, 2012 · Vol. 3, No. 5 · pp. 518-524

Keywords: Transforming growth factor-Î², Smads, ubiquitin, c-cbl, Lyn, leukaemia

The Hsp90 inhibitor NVP-AUY922-AG inhibits NF-ÎºB signaling, overcomes microenvironmental cytoprotection and is highly synergistic with fludarabine in primary CLL cells Research Paper

Elisabeth J. Walsby, Laurence Pearce, Alan K. Burnett, Chris Fegan, Chris Pepper

Published May 19, 2012 · Vol. 3, No. 5 · pp. 525-534

Keywords: Hsp90, CLL, apoptosis, synergy, NF-ÎºB

BCL2L10 is a predictive factor for resistance to Azacitidine in MDS and AML patients Research Paper

Thomas Cluzeau, Guillaume Robert, Nicolas Mounier, Jean Michel Karsenti, Maeva Dufies, Alexandre Puissant, Arnaud Jacquel, Aline Renneville, Claude Preudhomme, Jill Patrice Cassuto, Sophie Raynaud, Frederic Luciano, Patrick Auberger

Published May 9, 2012 · Vol. 3, No. 4 · pp. 490-501

Keywords: MDS, Azacitidine, resistance, BCL2L10, prognosis

Metformin-induced preferential killing of breast cancer initiating CD44+CD24-/low cells is sufficient to overcome primary resistance to trastuzumab in HER2+ human breast cancer xenografts Brief Reports

SÃlvia CufÃ, Bruna Corominas-Faja, Alejandro Vazquez-Martin, Cristina Oliveras-Ferraros, Joan Dorca, Joaquim Bosch-Barrera, BegoÃ±a Martin-Castillo, Javier A Menendez

Published May 4, 2012 · Vol. 3, No. 4 · pp. 395-398

Keywords: metformin, trastuzumab, HER2, cancer stem cells, breast cancer

Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment Review

Alberto M. Martelli, Francesca Chiarini, Camilla Evangelisti, Alessandra Cappellini, Francesca Buontempo, Daniela Bressanin, Milena Fini, James A. McCubrey

Published May 4, 2012 · Vol. 3, No. 4 · pp. 371-394

Keywords: apoptosis, leukemia initiating cells, mRNA translation, PI3K/Akt/mTOR, targeted therapy

Over-expression of Thioredoxin-1 mediates growth, survival, and chemoresistance and is a druggable target in diffuse large B-cell lymphoma Research Paper

Changping Li, Michael A. Thompson, Archito T. Tamayo, Zhuang Zuo, John Lee, Francisco Vega, Richard J. Ford, Lan V. Pham

Published Mar 23, 2012 · Vol. 3, No. 3 · pp. 314-326

Keywords: Trx-1, chemoresistance, DLBCL, cellular redox

Polo Like Kinase 2 Tumour Suppressor and cancer biomarker: new perspectives on drug sensitivity/resistance in cancer Research Perspective

Helen M. Coley, Eleftheria Hatzmichael, Sarah P. Blagden, Iain A. McNeish, Alastair Thompson, Tim Crook, Nelofer Syed

Published Jan 28, 2012 · Vol. 3, No. 1 · pp. 78-83

Keywords: PLK2, drug resistance, ovarian cancer

A combination of a ribonucleotide reductase inhibitor and histone deacetylase inhibitors downregulates EGFR and triggers BIM-dependent apoptosis in head and neck cancer Research Paper

Roland H. Stauber, Shirley K. Knauer, Negusse Habtemichael, Carolin Bier, Britta Unruhe, Simona Weisheit, Stephanie Spange, Frank Nonnenmacher, Verena Fetz, Torsten Ginter, Sigrid Reichardt, Claus Liebmann, GÃ¼nter Schneider, Oliver H. KrÃ¤mer

Published Jan 28, 2012 · Vol. 3, No. 1 · pp. 31-43

Keywords: apoptosis, BH3-only protein, chemotherapy, hydroxyurea, oral cancer, therapy resistance, tumor xenograft, valproic acid

Resistance to EGFR inhibitors: Molecular determinants and the enigma of head and neck cancer Editorial Comments

Luc G.T. Morris, Timothy A. Chan

Published Dec 31, 2011 · Vol. 2, No. 12 · pp. 894-895

Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target Review

Mourad Sanhaji, Claire T Friel, Linda Wordeman, Frank Louwen, Juping Yuan

Published Dec 31, 2011 · Vol. 2, No. 12 · pp. 935-947

Keywords: MCAK, mitotic kinases, chromosome instability, drug resistance, invasiveness

AMPK in BCR-ABL expressing leukemias. Regulatory effects and therapeutic implications. Research Perspective

Leonidas Platanias, Eliza Vakana

Published Dec 31, 2011 · Vol. 2, No. 12 · pp. 1322-1328

Keywords: AMPK, mTOR, leukemia, BCR-ABL

AHI-1: a novel signaling protein and potential therapeutic target in human leukemia and brain disorders Review

Sharmin Esmailzadeh, Xiaoyan Jiang

Published Dec 30, 2011 · Vol. 2, No. 12 · pp. 918-934

Keywords: AHI-1, oncogene, CML, CTCL, AHI-1-BCR-ABL-JAK2 interaction complex, tyrosine kinase inhibitors, leukemic stem cells, TKI resistance

Pooled shRNA screen for sensitizers to inhibition of the mitotic regulator polo-like kinase (PLK1) Research Paper

Nancy Liu-Sullivan, Jianping Zhang, Amy Bakleh, John Marchica, Jinyu Li, Despina Siolas, Sylvie Laquerre, Yan Y. Degenhardt, Richard Wooster, Kenneth Chang, Gregory J. Hannon, Scott Powers

Published Dec 30, 2011 · Vol. 2, No. 12 · pp. 1254-1264

Keywords: Polo-like kinase 1, shRNA library screening, retinoids, combination therapy strategies

Genome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementation Research Paper

Michal Sheffer, Amos J. Simon, Jasmine Jacob-Hirsch, Gideon Rechavi, Eytan Domany, David Givol, Gabriella D'Orazi

Published Dec 24, 2011 · Vol. 2, No. 12 · pp. 1191-1202

Keywords: hypoxia, cobalt, pathway analysis, Principal Component Analysis (PCA), cDNA microarray, colon cancer

Thyrocyte-specific inactivation of p53 and Pten results in anaplastic thyroid carcinomas faithfully recapitulating human tumors Research Paper

Valeria G. Antico Arciuch, Marika A. Russo, Mariavittoria Dima, Kristy S. Kang, Florence Dasrath, Xiao-Hui Liao, Samuel Refetoff, Cristina Montagna, Antonio Di Cristofano

Published Dec 20, 2011 · Vol. 2, No. 12 · pp. 1109-1126

Keywords: thyroid cancer, mouse model, anaplastic, glycolysis, PI3K, Pten, p53

Geminin overexpression induces mammary tumors via suppressing cytokinesis. Research Paper

Zannel Blanchard, Rohit Malik, Nicole Mullins, Christine Maric, Hugh Luk, David Horio, Brenda Hernandez, Jeffrey Killeen, Wael M. ElShamy

Published Dec 17, 2011 · Vol. 2, No. 12 · pp. 1011-1027

Keywords: Geminin, breast cancer, aneuploidy, Aurora B kinase, xenograft and orthotopic mouse tumors.

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The response to PAK1 inhibitor IPA3 distinguishes between cancer cells with mutations in BRAF and Ras oncogenes Research Paper

Receptor-targeted therapy of human experimental urinary bladder cancers with cytotoxic LH-RH analog AN-152 (AEZS-108) Research Paper

A thymidylate synthase ternary complex-specific antibody, FTS, permits functional monitoring of fluoropyrimidines dosing Research Paper

A composite polymer nanoparticle overcomes multidrug resistance and ameliorates doxorubicin-associated cardiomyopathy Research Paper

A novel co-operative mechanism linking TGFÎ² and Lyn kinase activation to imatinib resistance in chronic myeloid leukaemia cells Brief Reports

The Hsp90 inhibitor NVP-AUY922-AG inhibits NF-ÎºB signaling, overcomes microenvironmental cytoprotection and is highly synergistic with fludarabine in primary CLL cells Research Paper

BCL2L10 is a predictive factor for resistance to Azacitidine in MDS and AML patients Research Paper

Metformin-induced preferential killing of breast cancer initiating CD44+CD24-/low cells is sufficient to overcome primary resistance to trastuzumab in HER2+ human breast cancer xenografts Brief Reports

Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment Review

Over-expression of Thioredoxin-1 mediates growth, survival, and chemoresistance and is a druggable target in diffuse large B-cell lymphoma Research Paper

Polo Like Kinase 2 Tumour Suppressor and cancer biomarker: new perspectives on drug sensitivity/resistance in cancer Research Perspective

A combination of a ribonucleotide reductase inhibitor and histone deacetylase inhibitors downregulates EGFR and triggers BIM-dependent apoptosis in head and neck cancer Research Paper

Resistance to EGFR inhibitors: Molecular determinants and the enigma of head and neck cancer Editorial Comments

Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target Review

AMPK in BCR-ABL expressing leukemias. Regulatory effects and therapeutic implications. Research Perspective

AHI-1: a novel signaling protein and potential therapeutic target in human leukemia and brain disorders Review

Pooled shRNA screen for sensitizers to inhibition of the mitotic regulator polo-like kinase (PLK1) Research Paper

Genome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementation Research Paper

Thyrocyte-specific inactivation of p53 and Pten results in anaplastic thyroid carcinomas faithfully recapitulating human tumors Research Paper

Geminin overexpression induces mammary tumors via suppressing cytokinesis. Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

The response to PAK1 inhibitor IPA3 distinguishes between cancer cells with mutations in BRAF and Ras oncogenes Research Paper

Receptor-targeted therapy of human experimental urinary bladder cancers with cytotoxic LH-RH analog AN-152 (AEZS-108) Research Paper

A thymidylate synthase ternary complex-specific antibody, FTS, permits functional monitoring of fluoropyrimidines dosing Research Paper

A composite polymer nanoparticle overcomes multidrug resistance and ameliorates doxorubicin-associated cardiomyopathy Research Paper

A novel co-operative mechanism linking TGFÎ² and Lyn kinase activation to imatinib resistance in chronic myeloid leukaemia cells Brief Reports

The Hsp90 inhibitor NVP-AUY922-AG inhibits NF-ÎºB signaling, overcomes microenvironmental cytoprotection and is highly synergistic with fludarabine in primary CLL cells Research Paper

BCL2L10 is a predictive factor for resistance to Azacitidine in MDS and AML patients Research Paper

Metformin-induced preferential killing of breast cancer initiating CD44+CD24-/low cells is sufficient to overcome primary resistance to trastuzumab in HER2+ human breast cancer xenografts Brief Reports

Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment Review

Over-expression of Thioredoxin-1 mediates growth, survival, and chemoresistance and is a druggable target in diffuse large B-cell lymphoma Research Paper

Polo Like Kinase 2 Tumour Suppressor and cancer biomarker: new perspectives on drug sensitivity/resistance in cancer Research Perspective

A combination of a ribonucleotide reductase inhibitor and histone deacetylase inhibitors downregulates EGFR and triggers BIM-dependent apoptosis in head and neck cancer Research Paper

Resistance to EGFR inhibitors: Molecular determinants and the enigma of head and neck cancer Editorial Comments

Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target Review

AMPK in BCR-ABL expressing leukemias. Regulatory effects and therapeutic implications. Research Perspective

AHI-1: a novel signaling protein and potential therapeutic target in human leukemia and brain disorders Review

Pooled shRNA screen for sensitizers to inhibition of the mitotic regulator polo-like kinase (PLK1) Research Paper

Genome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementation Research Paper

Thyrocyte-specific inactivation of p53 and Pten results in anaplastic thyroid carcinomas faithfully recapitulating human tumors Research Paper

Geminin overexpression induces mammary tumors via suppressing cytokinesis. Research Paper