The Oncosearch | Oncotarget

Mechanisms of AXL overexpression and function in Imatinib-resistant chronic myeloid leukemia cells Research Paper

Maeva Dufies, Arnaud Jacquel, Nathalie Belhacene, Guillaume Robert, Thomas Cluzeau, FrÃ©deric Luciano, Jill Patrice Cassuto, Sophie Raynaud, Patrick Auberger

Published Nov 30, 2011 · Vol. 2, No. 11 · pp. 874-885

Keywords: CML, Imatinib resistance, AXL, ERK1/2, PKC

Chronic myeloid leukemia stem cells in the era of targeted therapies: resistance, persistence and long-term dormancy Research Perspective

Jean-Claude Chomel, Ali G. Turhan

Published Sep 22, 2011 · Vol. 2, No. 9 · pp. 713-727

Keywords: CML, tyrosine kinase inhibitors, leukemic stem cells, persistency, quiescence, undetectable molecular disease

Protection of acute myeloid leukaemia cells from apoptosis induced by front-line chemotherapeutics is mediated by haem oxygenase-1 Research Paper

Sally-Anne Heasman, Lyubov Zaitseva, Kristian M. Bowles, Stuart A. Rushworth, David J. MacEwan

Published Sep 9, 2011 · Vol. 2, No. 9 · pp. 658-668

Keywords: drug-resistance, antioxidant, transcription factor, apoptosis, chemotherapy

Assessment of EGFR/HER2 dimerization by FRET-FLIM utilizing Alexa-conjugated secondary antibodies in relation to targeted therapies in cancers Methodological Reports

Benjamin R. Waterhouse, Merel Gijsen, Paul R. Barber, Iain D.C. Tullis, Borivoj Vojnovic, Anthony Kong

Published Sep 8, 2011 · Vol. 2, No. 9 · pp. 728-736

Keywords: HER (ErbB) receptors, EGFR, HER2 (ErbB2), dimerization, FRET, FLIM

Cooperative Effects of Akt-1 and Raf-1 on the Induction of Cellular Senescence in Doxorubicin or Tamoxifen Treated Breast Cancer Cells Research Paper

Jackson R. Taylor, Brian D. Lehmann, William H. Chappell, Stephen L. Abrams, Linda S. Steelman, James A. McCubrey

Published Aug 30, 2011 · Vol. 2, No. 8 · pp. 610-626

Keywords: Akt, ERK, mTOR, Senescence, Drug Resistance, Tamoxifen

Aurora Kinase Inhibition Overcomes Cetuximab Resistance in Squamous Cell Cancer of the Head and Neck Research Paper

Alexander Hoellein, Anja Pickhard, Fabienne von Keitz, Stephanie Schoeffmann, Guido Piontek, Martina Rudelius, Anja Baumgart, Stefan Wagenpfeil, Christian Peschel, Tobias Dechow, Henning Bier, Ulrich Keller

Published Aug 23, 2011 · Vol. 2, No. 8 · pp. 599-609

Keywords: Squamous cell cancer of the head and neck, Aurora kinase, EGFR

Involvement of Akt-1 and mTOR in Sensitivity of Breast Cancer to Targeted Therapy Research Paper

Melissa L. Sokolosky, Kristin M. Stadelman, William H. Chappell, Stephen L. Abrams, Alberto M. Martelli, Franca Stivala, Massimo Libra, Ferdinando Nicoletti, Lyudmyla B. Drobot, Richard A. Franklin, Linda S. Steelman, James A. McCubrey

Published Jul 1, 2011 · Vol. 2, No. 7 · pp. 538-550

Keywords: Akt, mTOR, Targeted Therapy, Drug Resistance

Phosphorylation of AKT: a Mutational Analysis. Research Paper

Jonathan R. Hart, Peter K. Vogt

Published Jun 10, 2011 · Vol. 2, No. 6 · pp. 467-476

Keywords: Oncogenic transformation, signaling, myristylation, phosphomimetic

Class III Î²-Tubulin Counteracts the Ability of Paclitaxel to Inhibit Cell Migration Research Paper

Anutosh Ganguly, Hailing Yang, Fernando Cabral

Published May 16, 2011 · Vol. 2, No. 5 · pp. 368-377

Keywords: tubulin isotypes, microtubules, dynamic instability, motility, drug resistance

Netrin-1 overexpression is predictive of ovarian malignancies Research Paper

Anastasios D. Papanastasiou, Georgios Pampalakis, Dionyssios Katsaros, Georgia Sotiropoulou

Published May 2, 2011 · Vol. 2, No. 5 · pp. 363-367

Keywords: Netrin-1 (NTN1), ovarian cancer, biomarker

Potential Therapeutic Strategies to Overcome Acquired Resistance to BRAF or MEK Inhibitors in BRAF Mutant Cancers Research Perspective

Ryan B. Corcoran, Jeffrey Settleman, Jeffrey A. Engelman

Published Apr 19, 2011 · Vol. 2, No. 4 · pp. 336-346

Keywords: BRAF, MEK, acquired resistance, melanoma, colorectal cancer, NRAS, IGF1R, PDGFR

Using quantitative proteomic analysis to understand genotype specific intrinsic drug resistance in melanoma Research Perspective

John M. Koomen, Keiran S. M. Smalley

Published Apr 15, 2011 · Vol. 2, No. 4 · pp. 329-335

Keywords: Oncogene, cancer, kinase, BRAF V600E, drug resistance, proteomics

Association of Mycoplasma hominis infection with prostate cancer Research Paper

Yulia A. Barykova, Denis Yu. Logunov, Maxim M. Shmarov, Andrei Z. Vinarov, Dmitry N. Fiev, Natalia A. Vinarova, Irina V. Rakovskaya, Patricia Stanhope Baker, Inna Shyshynova, Andrew J. Stephenson, Eric A. Klein, Boris S. Naroditsky, Alexander L. Gintsburg, Andrei V. Gudkov

Published Apr 4, 2011 · Vol. 2, No. 4 · pp. 289-297

Keywords: PCR, diagnostics, prostate biopsies, prostate intraepithelial neoplasia, benign prostate hyperplasia

Caveolin-1 in sarcomas: friend or foe? Research Perspective

Miguel SÃ¡inz-Jaspeado, Juan Martin-Liberal, Laura Lagares-Tena, Silvia Mateo-Lozano, Xavier Garcia del Muro, Oscar M. Tirado

Published Apr 2, 2011 · Vol. 2, No. 4 · pp. 305-312

Keywords: Caveolin-1, Sarcomas, Oncogene, Tumor suppressor

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health Review

William H. Chappell, Linda S. Steelman, Jacquelyn M. Long, Ruth C. Kempf, Stephen L. Abrams, Richard A. Franklin, JÃ¶rg BÃ¤secke, Franca Stivala, Marco Donia, Paolo Fagone, Graziella Malaponte, Maria C. Mazzarino, Ferdinando Nicoletti, Massimo Libra, Danijela Maksimovic-Ivanic, Sanja Mijatovic, Giuseppe Montalto, Melchiorre Cervello, Piotr Laidler, Michele Milella, Agostino Tafuri, Antonio Bonati, Camilla Evangelisti, Lucio Cocco, Alberto M. Martelli, James A. McCubrey

Published Mar 11, 2011 · Vol. 2, No. 3 · pp. 135-164

Keywords: Targeted Therapy, Combination Therapy, Drug Resistance, Cancer Stem Cells, Aging, Senescence, Raf, Akt, PI3K, mTOR

Inhibition of SREBP1 sensitizes cells to death ligands Research Paper

Yanina Eberhard, Marcela Gronda, Rose Hurren, Alessandro Datti, Neil MacLean, Troy Ketela, Jason Moffat, Jeffrey L. Wrana, Aaron D. Schimmer

Published Mar 10, 2011 · Vol. 2, No. 3 · pp. 186-196

Keywords: death receptor pathway of caspase activation, FASL, TRAIL, SREBP1, Orlistat

Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence Research Perspective

Suzan K. Chao, Susan Band Horwitz, Hayley M. McDaid

Published Feb 22, 2011 · Vol. 2, No. 1-2 · pp. 89-98

Keywords: Senescence, 4E-BP1, mTORC1, p53, discodermolide

Targeting tumor angiogenesis with TSP-1-based compounds: rational design of antiangiogenic mimetics of endogenous inhibitors Research Perspective

Giulia Taraboletti, Marco Rusnati, Laura Ragona, Giorgio Colombo

Published Nov 25, 2010 · Vol. 1, No. 7 · pp. 662-673

Refractory chronic lymphocytic leukemia â€“ new therapeutic strategies Review

Andrea Schnaiter, Stephan Stilgenbauer

Published Nov 19, 2010 · Vol. 1, No. 7 · pp. 472-482

EGFR-mutated lung cancer: a paradigm of molecular oncology Review

Zhenfeng Zhang, Amy L. Stiegler, Titus J. Boggon, Susumu Kobayashi, Balazs Halmos

Published Oct 25, 2010 · Vol. 1, No. 7 · pp. 497-514

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Mechanisms of AXL overexpression and function in Imatinib-resistant chronic myeloid leukemia cells Research Paper

Chronic myeloid leukemia stem cells in the era of targeted therapies: resistance, persistence and long-term dormancy Research Perspective

Protection of acute myeloid leukaemia cells from apoptosis induced by front-line chemotherapeutics is mediated by haem oxygenase-1 Research Paper

Assessment of EGFR/HER2 dimerization by FRET-FLIM utilizing Alexa-conjugated secondary antibodies in relation to targeted therapies in cancers Methodological Reports

Cooperative Effects of Akt-1 and Raf-1 on the Induction of Cellular Senescence in Doxorubicin or Tamoxifen Treated Breast Cancer Cells Research Paper

Aurora Kinase Inhibition Overcomes Cetuximab Resistance in Squamous Cell Cancer of the Head and Neck Research Paper

Involvement of Akt-1 and mTOR in Sensitivity of Breast Cancer to Targeted Therapy Research Paper

Phosphorylation of AKT: a Mutational Analysis. Research Paper

Class III Î²-Tubulin Counteracts the Ability of Paclitaxel to Inhibit Cell Migration Research Paper

Netrin-1 overexpression is predictive of ovarian malignancies Research Paper

Potential Therapeutic Strategies to Overcome Acquired Resistance to BRAF or MEK Inhibitors in BRAF Mutant Cancers Research Perspective

Using quantitative proteomic analysis to understand genotype specific intrinsic drug resistance in melanoma Research Perspective

Association of Mycoplasma hominis infection with prostate cancer Research Paper

Caveolin-1 in sarcomas: friend or foe? Research Perspective

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health Review

Inhibition of SREBP1 sensitizes cells to death ligands Research Paper

Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence Research Perspective

Targeting tumor angiogenesis with TSP-1-based compounds: rational design of antiangiogenic mimetics of endogenous inhibitors Research Perspective

Refractory chronic lymphocytic leukemia â€“ new therapeutic strategies Review

EGFR-mutated lung cancer: a paradigm of molecular oncology Review

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Mechanisms of AXL overexpression and function in Imatinib-resistant chronic myeloid leukemia cells Research Paper

Chronic myeloid leukemia stem cells in the era of targeted therapies: resistance, persistence and long-term dormancy Research Perspective

Protection of acute myeloid leukaemia cells from apoptosis induced by front-line chemotherapeutics is mediated by haem oxygenase-1 Research Paper

Assessment of EGFR/HER2 dimerization by FRET-FLIM utilizing Alexa-conjugated secondary antibodies in relation to targeted therapies in cancers Methodological Reports

Cooperative Effects of Akt-1 and Raf-1 on the Induction of Cellular Senescence in Doxorubicin or Tamoxifen Treated Breast Cancer Cells Research Paper

Aurora Kinase Inhibition Overcomes Cetuximab Resistance in Squamous Cell Cancer of the Head and Neck Research Paper

Involvement of Akt-1 and mTOR in Sensitivity of Breast Cancer to Targeted Therapy Research Paper

Phosphorylation of AKT: a Mutational Analysis. Research Paper

Class III Î²-Tubulin Counteracts the Ability of Paclitaxel to Inhibit Cell Migration Research Paper

Netrin-1 overexpression is predictive of ovarian malignancies Research Paper

Potential Therapeutic Strategies to Overcome Acquired Resistance to BRAF or MEK Inhibitors in BRAF Mutant Cancers Research Perspective

Using quantitative proteomic analysis to understand genotype specific intrinsic drug resistance in melanoma Research Perspective

Association of Mycoplasma hominis infection with prostate cancer Research Paper

Caveolin-1 in sarcomas: friend or foe? Research Perspective

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health Review

Inhibition of SREBP1 sensitizes cells to death ligands Research Paper

Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence Research Perspective

Targeting tumor angiogenesis with TSP-1-based compounds: rational design of antiangiogenic mimetics of endogenous inhibitors Research Perspective

Refractory chronic lymphocytic leukemia â€“ new therapeutic strategies Review

EGFR-mutated lung cancer: a paradigm of molecular oncology Review