The Oncosearch | Oncotarget

Retaining MKP1 expression and attenuating JNK-mediated apoptosis by RIP1 for cisplatin resistance through miR-940 inhibition Research Paper

Qiong Wang, Shaoqing Shi, Weiyang He, Mabel T. Padilla, Lin Zhang, Xia Wang, Bin Zhang, Yong Lin

Published Feb 25, 2014 · Vol. 5, No. 5 · pp. 1304-1314

A DNA repair pathway score predicts survival in human multiple myeloma: the potential for therapeutic strategy Research Paper

Alboukadel Kassambara, Claire Gourzones-Dmitriev, Surinder Sahota, Thierry RÃ¨me, JÃ©rÃ´me Moreaux, Hartmut Goldschmidt, Angelos Constantinou, Phillipe Pasero, Dirk Hose, Bernard Klein

Published Feb 24, 2014 · Vol. 5, No. 9 · pp. 2487-2498

Keywords: DNA repair, Multiple Myeloma, prognosis

Rapamycin downregulates thymidylate synthase and potentiates the activity of pemetrexed in non-small cell lung cancer Research Paper

Shigeru Kawabata, Chun-Te Chiang, Junji Tsurutani, Hideaki Shiga, Matthew L. Arwood, Takefumi Komiya, Joell J. Gills, Regan M. Memmott, Phillip A. Dennis

Published Feb 16, 2014 · Vol. 5, No. 4 · pp. 1062-1070

Keywords: Rapamycin, Pemetrexed, Drug synergy, mTOR, Thymidylate Synthase, Lung Cancer

MUC1-C nuclear localization drives invasiveness of renal cancer cells through a sheddase/gamma secretase dependent pathway Research Paper

Audrey Bouillez, Viviane Gnemmi, Kelly Gaudelot, Brigitte HÃ©mon, BÃ©linda Ringot, Nicolas Pottier, FranÃ§ois Glowacki, Caroline Butruille, Christelle Cauffiez, Malika Hamdane, Nicolas Sergeant, Isabelle Van Seuningen, Xavier Leroy, SÃ©bastien Aubert, MichaÃ«l Perrais

Published Feb 2, 2014 · Vol. 5, No. 3 · pp. 754-763

microRNA expression profiling identifies a four microRNA signature as a novel diagnostic and prognostic biomarker in triple negative breast cancers Priority Research Paper

Pierluigi Gasparini, Luciano Cascione, Matteo Fassan, Francesca Lovat, Gulnur Guler, Serdar Balci, Cigdem Irkkan, Carl Morrison, Carlo M. Croce, Charles L. Shapiro, Kay Huebner

Published Jan 21, 2014 · Vol. 5, No. 5 · pp. 1174-1184

Keywords: Triple Negative breast cancer, microRNA, five markers, prognosis, treatments, outcome

Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor. Research Paper

Paul MÃ©sange, Virginie Poindessous, MichÃ¨le Sabbah, Alexandre E. Escargueil, Aimery de Gramont, Annette K. Larsen

Published Jan 20, 2014 · Vol. 5, No. 13 · pp. 4709-4721

Keywords: resistance, angiogenesis inhibition, vascular endothelial growth factor (VEGF)-signaling, hypoxia, bevacizumab, nintedanib

Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity Research Paper

Adrienne L. Watson, Bryant J. Keller, Kyle A. Williams, Namrata N. Damle, Samuel J. Finnerty, Leah K. Anderson, Andrew D. Greeley, Vincent W. Keng, Eric P. Rahrmann, Amanda L. Halfond, Natasha M. Powell, Margaret H. Collins, Tilat Rizvi, Christopher L. Moertel, Nancy Ratner, David A. Largaespada

Published Jan 20, 2014 · Vol. 5, No. 6 · pp. 1502-1514

Keywords: Malignant peripheral nerve sheath tumors, plexiform neurofibromas, Schwann cells, neurofibromatosis type 1 syndrome, neurofibromin 1, PI3K/AKT/mTOR signaling, MAPK signaling, targeted therapies, genetically engineered mouse models, combination therapy

MicroRNA-17-5p promotes chemotherapeutic drug resistance and tumour metastasis of colorectal cancer by repressing PTEN expression Research Paper

Lekun Fang, Haoran Li, Lei Wang, Jun Hu, Tianru Jin, Jianping Wang, Burton B. Yang

Published Jan 19, 2014 · Vol. 5, No. 10 · pp. 2974-2987

Keywords: microRNA, stem cell, miR-17, colon cancer, drug resistance

Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response Research Paper

Marcella Salzano, Marta VÃ¡zquez-Cedeira, Marta Sanz-GarcÃa, Alberto Valbuena, Sandra Blanco, Isabel F. FernÃ¡ndez, Pedro A. Lazo

Published Jan 17, 2014 · Vol. 5, No. 7 · pp. 1770-1778

Keywords: Breast cancer, VRK1, Radiation, doxorubicin, chemotherapy, DNA damage, 53BP1

Antitumor activity of the c-Myc inhibitor KSI-3716 in gemcitabine-resistant bladder cancer Research Paper

Ho Kyung Seo, Kyung-Ohk Ahn, Nae-Rae Jung, Ji-Sun Shin, Weon Seo Park, Kang-Hyun Lee, Sang-Jin Lee, Kyung-Chae Jeong

Published Jan 16, 2014 · Vol. 5, No. 2 · pp. 326-337

Keywords: Bladder cancer, c-Myc, inhibitor, gemcitabine, gemcitabine resistance

Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo Research Paper

John T. Heap, Jan Theys, Muhammad Ehsaan, Aleksandra M Kubiak, Ludwig Dubois, Kim Paesmans, Lieve Van Mellaert, Richard Knox, Sarah A. Kuehne, Phillipe Lambin, Nigel P. Minton

Published Jan 12, 2014 · Vol. 5, No. 7 · pp. 1761-1769

Targeting CDC25C, PLK1 and CHEK1 to overcome Docetaxel resistance induced by loss of LZTS1 in prostate cancer Research Paper

Nader Al Nakouzi, Sophie Cotteret, FrÃ©dÃ©ric Commo, Catherine Gaudin, Shanna Rajpar, Philippe Dessen, Philippe Vielh, Karim Fizazi, Anne Chauchereau

Published Jan 6, 2014 · Vol. 5, No. 3 · pp. 667-678

Keywords: Prostate cancer, chemoresistance, LZTS1, CDC25C, PLK1, CHEK1

Bak and Mcl-1 are essential for Temozolomide induced cell death in human glioma Research Paper

Catherine Gratas, Quentin SÃ©ry, Marion RabÃ©, Lisa Oliver, FranÃ§ois M. Vallette

Published Jan 1, 2014 · Vol. 5, No. 9 · pp. 2428-2435

Keywords: cell death, Bcl-2 family, glioma, temozolomide

Inhibition of the vacuolar ATPase induces Bnip3-dependent death of cancer cells and a reduction in tumor burden and metastasis Priority Research Paper

Regina M. Graham, John W. Thompson, Keith A. Webster

Published Dec 29, 2013 · Vol. 5, No. 5 · pp. 1162-1173

Keywords: hypoxia, cancer, xenograft, programmed cell death, bafilomycin A1

SERPINB3 protects from oxidative damage by chemotherapeutics through inhibition of mitochondrial respiratory complex I Research Paper

Francesco Ciscato, Marco Sciacovelli, Gianmarco Villano, Cristian Turato, Paolo Bernardi, Andrea Rasola, Patrizia Pontisso

Published Dec 24, 2013 · Vol. 5, No. 9 · pp. 2418-2427

Keywords: SERPINB3, chemotherapeutics, mitochondria, respiratory complexes, reactive oxygen species, cell death

Anti-oxidative stress response genes: bioinformatic analysis of their expression and relevance in multiple cancers Research Perspective

Barak Rotblat, Thomas G. P. Grunewald, Gabriel Leprivier, Gerry Melino, Richard A. Knight

Published Dec 15, 2013 · Vol. 4, No. 12 · pp. 2577-2590

Keywords: anti-oxidant genes, glutathione, thioredoxin, breast cancer, lung cancer, NRF2, G6PD

LZTS1 downregulation confers paclitaxel resistance and is associated with worse prognosis in breast cancer Research Paper

Francesca Lovat, Hideshi Ishii, Monica Schiappacassi, Matteo Fassan, Mattia Barbareschi, Enzo Galligioni, Pierluigi Gasparini, Gustavo Baldassarre, Carlo M. Croce, Andrea Vecchione

Published Dec 14, 2013 · Vol. 5, No. 4 · pp. 970-977

Keywords: Lzts1/Fez1, breast cancer, taxanes

EFEMP1 induces Î³-secretase/Notch-mediated temozolomide resistance in glioblastoma Research Paper

Lotte Hiddingh, Bakhos A. Tannous, Jian Teng, Bas Tops, Judith Jeuken, Esther Hulleman, Sandra H. Boots-Sprenger, W. Peter Vandertop, David P. Noske, Gertjan J.L. Kaspers, Pieter Wesseling, Thomas Wurdinger

Published Dec 7, 2013 · Vol. 5, No. 2 · pp. 363-374

Keywords: Temozolomide resistance, glioblastoma, EFEMP1, Î³-secretase, Notch, GSI

ERG induces a mesenchymal-like state associated with chemoresistance in leukemia cells Research Paper

Liliana H. Mochmann, Martin Neumann, Eva K. von Der Heide, Verena Nowak, Anja A. KÃ¼hl, Jutta Ortiz-Tanchez, Juliane Bock, Wolf K Hofmann, Claudia D Baldus

Published Dec 4, 2013 · Vol. 5, No. 2 · pp. 351-362

Keywords: ERG, ERK, EMT, Chemoresistance

AID downregulation is a novel function of the DNMT inhibitor 5-aza-deoxycytidine Research Paper

Chiou-Tsun Tsai, Pei-Ming Yang, Ting-Rong Chern, Shu-Hui Chuang, Jung-Hsin Lin, Lars Klemm, Markus MÃ¼schen, Ching-Chow Chen

Published Nov 25, 2013 · Vol. 5, No. 1 · pp. 211-223

Keywords: AID, 5-aza-CdR, Zebularine, DNMT1

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Retaining MKP1 expression and attenuating JNK-mediated apoptosis by RIP1 for cisplatin resistance through miR-940 inhibition Research Paper

A DNA repair pathway score predicts survival in human multiple myeloma: the potential for therapeutic strategy Research Paper

Rapamycin downregulates thymidylate synthase and potentiates the activity of pemetrexed in non-small cell lung cancer Research Paper

MUC1-C nuclear localization drives invasiveness of renal cancer cells through a sheddase/gamma secretase dependent pathway Research Paper

microRNA expression profiling identifies a four microRNA signature as a novel diagnostic and prognostic biomarker in triple negative breast cancers Priority Research Paper

Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor. Research Paper

Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity Research Paper

MicroRNA-17-5p promotes chemotherapeutic drug resistance and tumour metastasis of colorectal cancer by repressing PTEN expression Research Paper

Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response Research Paper

Antitumor activity of the c-Myc inhibitor KSI-3716 in gemcitabine-resistant bladder cancer Research Paper

Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo Research Paper

Targeting CDC25C, PLK1 and CHEK1 to overcome Docetaxel resistance induced by loss of LZTS1 in prostate cancer Research Paper

Bak and Mcl-1 are essential for Temozolomide induced cell death in human glioma Research Paper

Inhibition of the vacuolar ATPase induces Bnip3-dependent death of cancer cells and a reduction in tumor burden and metastasis Priority Research Paper

SERPINB3 protects from oxidative damage by chemotherapeutics through inhibition of mitochondrial respiratory complex I Research Paper

Anti-oxidative stress response genes: bioinformatic analysis of their expression and relevance in multiple cancers Research Perspective

LZTS1 downregulation confers paclitaxel resistance and is associated with worse prognosis in breast cancer Research Paper

EFEMP1 induces Î³-secretase/Notch-mediated temozolomide resistance in glioblastoma Research Paper

ERG induces a mesenchymal-like state associated with chemoresistance in leukemia cells Research Paper

AID downregulation is a novel function of the DNMT inhibitor 5-aza-deoxycytidine Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Retaining MKP1 expression and attenuating JNK-mediated apoptosis by RIP1 for cisplatin resistance through miR-940 inhibition Research Paper

A DNA repair pathway score predicts survival in human multiple myeloma: the potential for therapeutic strategy Research Paper

Rapamycin downregulates thymidylate synthase and potentiates the activity of pemetrexed in non-small cell lung cancer Research Paper

MUC1-C nuclear localization drives invasiveness of renal cancer cells through a sheddase/gamma secretase dependent pathway Research Paper

microRNA expression profiling identifies a four microRNA signature as a novel diagnostic and prognostic biomarker in triple negative breast cancers Priority Research Paper

Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor. Research Paper

Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity Research Paper

MicroRNA-17-5p promotes chemotherapeutic drug resistance and tumour metastasis of colorectal cancer by repressing PTEN expression Research Paper

Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response Research Paper

Antitumor activity of the c-Myc inhibitor KSI-3716 in gemcitabine-resistant bladder cancer Research Paper

Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo Research Paper

Targeting CDC25C, PLK1 and CHEK1 to overcome Docetaxel resistance induced by loss of LZTS1 in prostate cancer Research Paper

Bak and Mcl-1 are essential for Temozolomide induced cell death in human glioma Research Paper

Inhibition of the vacuolar ATPase induces Bnip3-dependent death of cancer cells and a reduction in tumor burden and metastasis Priority Research Paper

SERPINB3 protects from oxidative damage by chemotherapeutics through inhibition of mitochondrial respiratory complex I Research Paper

Anti-oxidative stress response genes: bioinformatic analysis of their expression and relevance in multiple cancers Research Perspective

LZTS1 downregulation confers paclitaxel resistance and is associated with worse prognosis in breast cancer Research Paper

EFEMP1 induces Î³-secretase/Notch-mediated temozolomide resistance in glioblastoma Research Paper

ERG induces a mesenchymal-like state associated with chemoresistance in leukemia cells Research Paper

AID downregulation is a novel function of the DNMT inhibitor 5-aza-deoxycytidine Research Paper