The Oncosearch | Oncotarget

Gefitinib resistance resulted from STAT3-mediated Akt activation in lung cancer cells Research Paper

Kai Wu, Qingshan Chang, Yongju Lu, Ping Qiu, Bailing Chen, Chitra Thakur, Jiaying Sun, Lingzhi Li, Anjaneyulu Kowluru, Fei Chen

Published Nov 24, 2013 · Vol. 4, No. 12 · pp. 2430-2438

Keywords: Gefitinib, EGFR, STAT3, Akt recovery

Drug resistance in multiple myeloma: latest findings and new concepts on molecular mechanisms Review

Jahangir Abdi, Guoan Chen, Hong Chang

Published Nov 24, 2013 · Vol. 4, No. 12 · pp. 2186-2207

Keywords: multiple myeloma, drug resistance, signaling pathways, oncogenes

The proto-oncogene KRAS is targeted by miR-200c Research Paper

Florian Kopp, Ernst Wagner, Andreas Roidl

Published Nov 24, 2013 · Vol. 5, No. 1 · pp. 185-195

Keywords: breast cancer, lung cancer, miRNA, K-ras, cell cycle, proliferation

Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-ÐºB target genes in human breast cancer Research Paper

Alba Dalmases, Irene Gonzalez-Navarrete, Silvia Menendez, Oriol ArpÃ, Josep Maria Coromines, Sonia Servitja, Ignasi Tusquets, Cristina Chamizo, RaÃºl RincÃ³n, LluÃs Espinosa, Anna Bigas, Pilar Eroles, Jessica Furriol, Anna Lluch, Ana Rovira, Joan Albanell, Federico Rojo

Published Nov 23, 2013 · Vol. 5, No. 1 · pp. 196-210

Keywords: breast cancer, chemoresistance, NF-ÐºB, p53, prognosis

EI24 regulates epithelial-to-mesenchymal transition and tumor progression by suppressing TRAF2-mediated NF-ÎºB activity Research Paper

Jung-Min Choi, Sushil Devkota, Young Hoon Sung, Han-Woong Lee

Published Nov 17, 2013 · Vol. 4, No. 12 · pp. 2383-2396

Keywords: EI24, EMT, NF-ÎºB, tumor progression

Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic re-programming Research Paper

Veronica Martinez-Marignac, Nader Toban, Miguel Bazile, Raquel Aloyz

Published Nov 7, 2013 · Vol. 4, No. 12 · pp. 2550-2566

Keywords: CLL, AMPK, Dasatinib, kinase inhibitor, metabolism, glycolysis, OXPHOS

Enrichment of human osteosarcoma stem cells based on hTERT transcriptional activity Research Paper

Ling Yu, Shiqing Liu, Chun Zhang, Bo Zhang, Bruno M. Simoes, Rachel Eyre, Yi Liang, Huichao Yan, Zheng Wu, Weichun Guo, Robert B. Clarke

Published Nov 5, 2013 · Vol. 4, No. 12 · pp. 2326-2338

Keywords: osteosarcoma, stem cells, sarcospheres, telomerase

14-3-3Ïƒ attenuates RhoGDI2-induced cisplatin resistance through activation of Erk and p38 in gastric cancer cells Research Paper

In-Kyu Kim, Sun-Mi Park, Hee Jun Cho, Kyoung Eun Baek, In-Koo Nam, Seung-Ho Park, Ki-Jun Ryu, Jinhyun Ryu, Jungil Choi, Soon-Chan Hong, Jae Won Kim, Chang Won Lee, Sang Soo Kang, Jiyun Yoo

Published Oct 19, 2013 · Vol. 4, No. 11 · pp. 2045-2056

Keywords: RhoGDI2, 14-3-3Ïƒ, gastric cancer, chemoresistance, metastasis

Reduction of MLH1 and PMS2 confers temozolomide resistance and is associated with recurrence of glioblastoma Research Paper

Yoshinari Shinsato, Tatsuhiko Furukawa, Shunji Yunoue, Hajime Yonezawa, Kentarou Minami, Yukihiko Nishizawa, Ryuji Ikeda, Kohichi Kawahara, Masatatsu Yamamoto, Hirofumi Hirano, Hiroshi Tokimura, Kazunori Arita

Published Oct 14, 2013 · Vol. 4, No. 12 · pp. 2261-2270

Keywords: temozolomide, MLH1, PMS2, MutL-alphaï€, resistance, recurrence, glioblastoma

Insights into therapeutic resistance from whole-genome analyses of circulating tumor DNA Letters to the Editor

Luis A. Diaz, Jr, Mark Sausen, George A. Fisher, Victor E. Velculescu

Published Oct 8, 2013 · Vol. 4, No. 10 · pp. 1856-1857

Chemoresistance to gemcitabine in hepatoma cells induces epithelial-mesenchymal transition and involves activation of PDGF-D pathway Research Paper

Qiong Wu, Rui Wang, Qingling Yang, Xin Hou, Sulian Chen, Yueyue Hou, Changjie Chen, Yan Yang, Lucio Miele, Fazlul Sarkar, Yuqing Chen, Zhiwei Wang

Published Oct 7, 2013 · Vol. 4, No. 11 · pp. 1999-2009

Keywords: Hepatocellular carcinoma, chemoresistance, PDGF-D, EMT, gemcitabine

Mitochondrial oxidative stress is the achilleâ€™s heel of melanoma cells resistant to Braf-mutant inhibitor Research Paper

Paola Corazao-Rozas, Pierre Guerreschi, Manel Jendoubi, Fanny AndrÃ©, AurÃ©lie Jonneaux, Camille Scalbert, Guillaume GarÃ§on, Myriam Mallet-Martino, StÃ©phane Balayssac, Stephane Rocchi, Ariel Savina, Pierre Formstecher, Laurent Mortier, Jerome Kluza, Philippe Marchetti

Published Oct 6, 2013 · Vol. 4, No. 11 · pp. 1986-1998

Keywords: metabolism, oxidative phosphorylation, elesclomol, ROS

Broad-spectrum anti-tumor and anti-metastatic DNA vaccine based on p62-encoding vector Research Paper

Franco Venanzi, Victor Shifrin, Michael Y. Sherman, Vladimir Gabai, Oleg Kisilev, Andrey Komissarov, Mikhail Grudinin, Maria Shartakova, Ekaterina Romanovskaya-Romanko, Yuri Kudryavets, Natalya Bezdenezhnykh, Oleksandra Lykhova, Nadiia Semesyuk, Antonio Concetti, Anatoly Tsyb, Marina Filimonova, Victoria Makarchuk, Raisa Yakubovsky, Andrey Chursov, Vita Shcherbinina, Alexander Shneider

Published Oct 2, 2013 · Vol. 4, No. 10 · pp. 1829-1835

Keywords: cancer immunotherapy, DNA vaccine, autophagy, metastases

Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX Research Paper

Marissa V Powers, Melanie Valenti, Susana Mirander, Alison Maloney, Suzanne A Eccles, George Thomas, Paul A Clarke, Paul Workman

Published Sep 29, 2013 · Vol. 4, No. 11 · pp. 1963-1975

Keywords: 17-AAG, HSP90, BAX, Apoptosis, Colon cancer

Immunological targeting of tumor cells undergoing an epithelial-mesenchymal transition via a recombinant brachyury-yeast vaccine Research Paper

Duane H. Hamilton, Mary T. Litzinger, Alessandra Jales, Bruce Huang, Romaine I. Fernando, James W. Hodge, Andressa Ardiani, David Apelian, Jeffrey Schlom, Claudia Palena

Published Sep 26, 2013 · Vol. 4, No. 10 · pp. 1777-1790

Keywords: epithelial-mesenchymal transition, brachyury, T-box transcription factor, cancer vaccine, T-cell immunotherapy

Major vault protein supports glioblastoma survival and migration by upregulating the EGFR/PI3K signalling axis Research Paper

Daniela Loetsch, Elisabeth Steiner, Klaus Holzmann, Sabine Spiegl-Kreinecker, Christine Pirker, Juraj Hlavaty, Helga Petznek, Balazs Hegedus, Tamas Garay, Thomas Mohr, Wolfgang Sommergruber, Walter Berger, Michael Grusch

Published Sep 1, 2013 · Vol. 4, No. 11 · pp. 1904-1918

Keywords: major vault protein, vault particles, glioblastoma multiforme, EGFR, PI3K, migration, invasion

Lung cancer tumorigenicity and drug resistance are maintained through ALDH^hi CD44^hi tumor initiating cells Research Paper

Jing Liu, Zhijie Xiao, Sunny Kit-Man Wong, Vicky Pui-Chi Tin, Ka-Yan Ho, Junwen Wang, Mai-Har Sham, Maria Pik Wong

Published Aug 30, 2013 · Vol. 4, No. 10 · pp. 1698-1711

Keywords: lung cancer, tumor initiating cell, aldehyde dehydrogenase, CD44, drug resistance

Notch3 inhibition enhances sorafenib cytotoxic efficacy by promoting GSK3Î² phosphorylation and p21 down-regulation in hepatocellular carcinoma Research Paper

Catia Giovannini, Michele Baglioni, Marco Baron Toaldo, Cristiano Ventrucci, Stefania D'Adamo, Mario Cipone, Pasquale Chieco, Laura Gramantieri, Luigi Bolondi

Published Aug 24, 2013 · Vol. 4, No. 10 · pp. 1618-1631

Keywords: ERK, drug resistance, angiogenesis, cell proliferation, Notch3

Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype. Research Paper

MickaÃ«l Ohanna, Yann Cheli, Caroline Bonet, Vanessa F Bonazzi, Marylin Allegra, Sandy Giuliano, Karine Bille, Philippe Bahadoran, Damien Giacchero, Jean Philippe Lacour, Glen M Boyle, Nicholas F Hayward, Corine Bertolotto, Robert Ballotti

Published Aug 19, 2013 · Vol. 4, No. 12 · pp. 2212-2224

Keywords: melanoma, senescence, secretome, STAT3

Understanding the role of NRF2-regulated miRNAs in human malignancies Review

Niraj M Shah, Stuart A Rushworth, Megan Y Murray, Kristian M Bowles, David J MacEwan

Published Aug 8, 2013 · Vol. 4, No. 8 · pp. 1130-1142

Keywords: NRF2, miRNA, transcription factor, oncogenesis, drug resistance

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Gefitinib resistance resulted from STAT3-mediated Akt activation in lung cancer cells Research Paper

Drug resistance in multiple myeloma: latest findings and new concepts on molecular mechanisms Review

The proto-oncogene KRAS is targeted by miR-200c Research Paper

Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-ÐºB target genes in human breast cancer Research Paper

EI24 regulates epithelial-to-mesenchymal transition and tumor progression by suppressing TRAF2-mediated NF-ÎºB activity Research Paper

Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic re-programming Research Paper

Enrichment of human osteosarcoma stem cells based on hTERT transcriptional activity Research Paper

14-3-3Ïƒ attenuates RhoGDI2-induced cisplatin resistance through activation of Erk and p38 in gastric cancer cells Research Paper

Reduction of MLH1 and PMS2 confers temozolomide resistance and is associated with recurrence of glioblastoma Research Paper

Insights into therapeutic resistance from whole-genome analyses of circulating tumor DNA Letters to the Editor

Chemoresistance to gemcitabine in hepatoma cells induces epithelial-mesenchymal transition and involves activation of PDGF-D pathway Research Paper

Mitochondrial oxidative stress is the achilleâ€™s heel of melanoma cells resistant to Braf-mutant inhibitor Research Paper

Broad-spectrum anti-tumor and anti-metastatic DNA vaccine based on p62-encoding vector Research Paper

Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX Research Paper

Immunological targeting of tumor cells undergoing an epithelial-mesenchymal transition via a recombinant brachyury-yeast vaccine Research Paper

Major vault protein supports glioblastoma survival and migration by upregulating the EGFR/PI3K signalling axis Research Paper

Lung cancer tumorigenicity and drug resistance are maintained through ALDH^hi CD44^hi tumor initiating cells Research Paper

Notch3 inhibition enhances sorafenib cytotoxic efficacy by promoting GSK3Î² phosphorylation and p21 down-regulation in hepatocellular carcinoma Research Paper

Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype. Research Paper

Understanding the role of NRF2-regulated miRNAs in human malignancies Review

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Gefitinib resistance resulted from STAT3-mediated Akt activation in lung cancer cells Research Paper

Drug resistance in multiple myeloma: latest findings and new concepts on molecular mechanisms Review

The proto-oncogene KRAS is targeted by miR-200c Research Paper

Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-ÐºB target genes in human breast cancer Research Paper

EI24 regulates epithelial-to-mesenchymal transition and tumor progression by suppressing TRAF2-mediated NF-ÎºB activity Research Paper

Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic re-programming Research Paper

Enrichment of human osteosarcoma stem cells based on hTERT transcriptional activity Research Paper

14-3-3Ïƒ attenuates RhoGDI2-induced cisplatin resistance through activation of Erk and p38 in gastric cancer cells Research Paper

Reduction of MLH1 and PMS2 confers temozolomide resistance and is associated with recurrence of glioblastoma Research Paper

Insights into therapeutic resistance from whole-genome analyses of circulating tumor DNA Letters to the Editor

Chemoresistance to gemcitabine in hepatoma cells induces epithelial-mesenchymal transition and involves activation of PDGF-D pathway Research Paper

Mitochondrial oxidative stress is the achilleâ€™s heel of melanoma cells resistant to Braf-mutant inhibitor Research Paper

Broad-spectrum anti-tumor and anti-metastatic DNA vaccine based on p62-encoding vector Research Paper

Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX Research Paper

Immunological targeting of tumor cells undergoing an epithelial-mesenchymal transition via a recombinant brachyury-yeast vaccine Research Paper

Major vault protein supports glioblastoma survival and migration by upregulating the EGFR/PI3K signalling axis Research Paper

Lung cancer tumorigenicity and drug resistance are maintained through ALDHhi CD44hi tumor initiating cells Research Paper

Notch3 inhibition enhances sorafenib cytotoxic efficacy by promoting GSK3Î² phosphorylation and p21 down-regulation in hepatocellular carcinoma Research Paper

Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype. Research Paper

Understanding the role of NRF2-regulated miRNAs in human malignancies Review

Lung cancer tumorigenicity and drug resistance are maintained through ALDH^hi CD44^hi tumor initiating cells Research Paper