The Oncosearch | Oncotarget

BRAF Mutant Gastrointestinal Stromal Tumor: First report of regression with BRAF inhibitor dabrafenib (GSK2118436) and whole exomic sequencing for analysis of acquired resistance Research Paper

Gerald S. Falchook, Jonathan C. Trent, Michael C. Heinrich, Carol Beadling, Janice Patterson, Christel C. Bastida, Samuel C. Blackman, Razelle Kurzrock

Published Feb 25, 2013 · Vol. 4, No. 2 · pp. 310-315

Keywords: Gastrointestinal stromal tumor, Dabrafenib, GSK2118436, BRAF mutation, BRAF inhibition, V600E

Ras inhibition boosts galectin-7 at the expense of galectin-1 to sensitize cells to apoptosis Research Paper

Batya Barkan, Adrienne D. Cox, Yoel Kloog

Published Feb 24, 2013 · Vol. 4, No. 2 · pp. 256-268

Keywords: : apoptosis, c-jun, farnesylthiosalicylic acid, FTS, galectin-1, galectin -7, JDP2, NF1, p53, Ras, Salirasib, neurofibromin, NF1

TRAIL induces apoptosis in oral squamous carcinoma cells: a crosstalk with oncogenic Ras regulated cell surface expression of death receptor 5 Research Paper

Jun-jie Chen, Constantinos M. Mikelis, Yaqin Zhang, J. Silvio Gutkind, Baolin Zhang

Published Feb 23, 2013 · Vol. 4, No. 2 · pp. 206-217

Keywords: oral cancer, TRAIL, death receptors, apoptosis, Ras, oncotarget

Calcein-effluxing human colon cancer cells are enriched for self-renewal capacity and depend on Î²-catenin Research Paper

Joshua E. Allen, Wafik S. El-Deiry

Published Feb 18, 2013 · Vol. 4, No. 2 · pp. 184-191

Stress Response of Glioblastoma Cells Mediated by miR-17-5p Targeting PTEN and the Passenger Strand miR-17-3p Targeting MDM2 Research Paper

Haoran Li, Burton B Yang

Published Dec 31, 2012 · Vol. 3, No. 12 · pp. 1653-1668

Keywords: microRNA, stem cell, miR-17, stress response, drug resistance

Advances in Targeting Signal Transduction Pathways. Review

James Andrew McCubrey, Linda S Steelman, William H Chappell, Lin Sun, Nicole M Davis, Stephen L Abrams, Richard A Franklin, Lucio Cocco, Camilla Evangelisti, Francesca Chiarini, Alberto M Martelli, Massimo Libra, Saverio Candido, Grazia Malaponte, Maria C Mazzarino, Paolo Fagone, Marco Donia, Ferdinando Nicoletti, Jerry Polesel, Renato Talamini, Jorg Basecke, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Michele Milella, Agostino Tafuri, Joanna DuliÅ„ska-Litewka, Piotr Laidler, Antonio B D'Assoro, Lyudmyla Drobot, Kazuo Umezawa, Giuseppe Montalto, Melchiorre Cervello, Zoya N Demidenko

Published Dec 30, 2012 · Vol. 3, No. 12 · pp. 1505-1521

Keywords: Targeted Therapy, Therapy Resistance, Cancer Stem Cells, Raf, Akt, PI3K, mTOR, AMPK, Metformin

A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia Research Paper

Francesca Chiarini, Annalisa Lonetti, Gabriella Teti, Ester Orsini, Daniela Bressanin, Alessandra Cappellini, Francesca Ricci, Pier Luigi Tazzari, Andrea Ognibene, Mirella Falconi, Pasqualepaolo Pagliaro, Ilaria Iacobucci, Giovanni Martinelli, Sergio Amadori, James A McCubrey, Alberto M Martelli

Published Dec 18, 2012 · Vol. 3, No. 12 · pp. 1615-1628

Keywords: AML, PI3K/Akt/mTOR signaling, apoptosis, autophagy combination therapy, leukemia initiating cells

Autophagy-related gene 12 (ATG12) is a novel determinant of primary resistance to HER2-targeted therapies: Utility of transcriptome analysis of the autophagy interactome to guide breast cancer treatment Research Paper

SÃlvia CufÃ, Alejandro Vazquez-Martin, Ceistina Oliveras-Ferraros, Bruna Corominas-Faja, Ander Urruticoechea, BegoÃ±a Martin-Castillo, Javier A Menendez

Published Nov 17, 2012 · Vol. 3, No. 12 · pp. 1600-1614

Keywords: Autophagy, ATG genes, HER2, trastuzumab, lapatinib

Epigenetic Regulation of miRNA-211 by MMP-9 Governs Glioma Cell Apoptosis, Chemosensitivity and Radiosensitivity Research Paper

Swapna Asuthkar, Kiran Kumar Velpula, Chandramu Chetty, Bharathi Gorantla, Jasti S. Rao

Published Nov 16, 2012 · Vol. 3, No. 11 · pp. 1439-1454

Keywords: Matrix metalloproteinase-9 (MMP-9), microRNA-211 (miR-211), Cancer Stem Cells (CSC), Ionizing radiation (IR) and Temozolomide (Tem)

All tyrosine kinase inhibitor-resistant chronic myelogenous cells are highly sensitive to Ponatinib Research Paper

Ophelie Cassuto, Maeva Dufies, Arnaud Jacquel, Alexandre Puissant, Clemence Ginet, Amine Hamouda, Frederic Luciano, Guillaume Robert, Jean-Michel Karsenti, Laurence Legros, Jill Patrice Cassuto, Pascal Lenain, Patrick Auberger

Published Nov 14, 2012 · Vol. 3, No. 12 · pp. 1557-1565

Keywords: CML, resistance, ITK, Ponatinib

Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity Research Paper

Hung-Ju Shih, Hsiao-Huei Chen, Yen-An Chen, Meng-Hsun Wu, Gan-Guang Liou, Wei-Wen Chang, Linyi Chen, Lu-Hai Wang, Hsin-Ling Hsu

Published Nov 9, 2012 · Vol. 3, No. 11 · pp. 1401-1415

Keywords: MCT-1, Shc, Ras, ERK, apoptosis, tumor

High-Throughput Chemical Screens Identify Disulfiram as an Inhibitor of Human Glioblastoma Stem Cells Research

Parvinder Hothi, Timothy J. Martins, LiPing Chen, Loic Deleyrolle, Jae-Geun Yoon, Brent Reynolds, Greg Foltz

Published Oct 23, 2012 · Vol. 3, No. 10 · pp. 1124-1136

Keywords: disulfiram, glioblastoma, high-throughput chemical screens, stem cells

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance Review

James Andrew McCubrey, Linda S. Steelman, William H. Chappell, Stephen L. Abrams, Richard A. Franklin, Giuseppe Montalto, Melchiorre Cervello, Massimo Libra, Saverio Candido, Grazia Malaponte, Maria C. Mazzarino, Paolo Fagone, Ferdinando Nicoletti, JÃ¶rg BÃ¤secke, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Michele Milella, Agostino Tafuri, Francesca Chiarini, Camilla Evangelisti, Lucio Cocco, Alberto M. Martelli

Published Oct 20, 2012 · Vol. 3, No. 10 · pp. 1068-1111

Keywords: Targeted Therapy, Therapy Resistance, Cancer Stem Cells, Raf, Akt, PI3K, mTOR

Effects of Ectopic Expression of NGAL on Doxorubicin Sensitivity. Research Paper

William H Chappell, Stephen L. Abrams, Richard A Franklin, Giuseppe Montalto, Melchiorre Cervello, Alberto M Martelli, Saverio Candido, Massimo Libra, Jerry Polesel, Renato Talamini, Ralph Arlinghaus, Linda S Steelman, James A McCubrey

Published Oct 20, 2012 · Vol. 3, No. 10 · pp. 1236-1245

Keywords: NGAL, Lcn2, Doxorubicin, lipocalins, siderocalins, iron transport, MMP-9, drug resistance

Disulfiram, a drug widely used to control alcoholism, suppresses self-renewal of glioblastoma and overrides resistance to temozolomide Research

Joanna Triscott, Cathy Lee, Kaiji Hu, Abbas Fotovati, Rachel Berns, Mary Pambid, Margaret Luk, Richard E Kast, Esther Kong, Eric Toyota, Stephen Yip, Brian Toyota, Sandra E Dunn

Published Oct 8, 2012 · Vol. 3, No. 10 · pp. 1112-1123

Keywords: glioblastoma, disulfiram, temozolomide, brain tumor, drug resistance

High cytidine deaminase expression in the liver provides sanctuary for cancer cells from decitabine treatment effects Research Paper

Quteba Ebrahem, Reda Z Mahfouz, Kwok Peng Ng, Yogen Saunthararajah

Published Sep 27, 2012 · Vol. 3, No. 10 · pp. 1137-1145

Keywords: cytidine analogues, decitabine, cytidine deaminase, chemotherapy resistance, sanctuary

Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response. Review

James Andrew McCubrey, Linda Steeman, William Chappell, Stephen Abrams, Giuseppe Montalto, Melchiorre Cervello, Ferdinando Nicoletti, Paolo Fagone, Grazia Malaponte, Maria Mazzarino, Saverio Candido, Massimo Libra, Jorg Basecke, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Michele Milella, Agostino Tafuri, Lucio Cocco, Camilla Evangelisti, Francesca Chiarini, Alberto Martelli

Published Sep 20, 2012 · Vol. 3, No. 9 · pp. 954-987

Keywords: targeted therapy, therapy resistance, mutations, Raf, Akt, PI3K, mTOR

Modulating Antiangiogenic Resistance by Inhibiting the Signal Transducer and Activator of Transcription 3 Pathway in Glioblastoma Research Paper

John de Groot, Ji Liang, Ling-Yuan Kong, Jun Wei, Yuji Piao, Gregory Fuller, Wei Qiao, Amy B Heimberger

Published Sep 19, 2012 · Vol. 3, No. 9 · pp. 1036-1048

Keywords: bevacizumab, anti-vascular endothelial growth factor, signal transducer and activator of transcription 3, treatment failure, invasion

Antagonists of growth hormone-releasing hormone suppress in vivo tumor growth and gene expression in triple negative breast cancers Research Paper

Roberto Perez, Andrew V Schally, Irving Vidaurre, Ricardo Rincon, Norman L Block, Ferenc G Rick

Published Aug 30, 2012 · Vol. 3, No. 9 · pp. 988-997

Keywords: neuropeptide analog, tumor gene expression, receptor silencing, targeted therapy, inflammation

Mislocalization of death receptors correlates with cellular resistance to their cognate ligands in human breast cancer cells Research Paper

Baolin Zhang, Jun-Jie Chen, Jennifer H.-C. Shen, Leslie Rivera Rosado, Yaqin Zhang, Xu Di

Published Aug 19, 2012 · Vol. 3, No. 8 · pp. 833-842

Keywords: death receptors, cellular localization, breast cancer, targeted cancer therapy, drug resistance

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BRAF Mutant Gastrointestinal Stromal Tumor: First report of regression with BRAF inhibitor dabrafenib (GSK2118436) and whole exomic sequencing for analysis of acquired resistance Research Paper

Ras inhibition boosts galectin-7 at the expense of galectin-1 to sensitize cells to apoptosis Research Paper

TRAIL induces apoptosis in oral squamous carcinoma cells: a crosstalk with oncogenic Ras regulated cell surface expression of death receptor 5 Research Paper

Calcein-effluxing human colon cancer cells are enriched for self-renewal capacity and depend on Î²-catenin Research Paper

Stress Response of Glioblastoma Cells Mediated by miR-17-5p Targeting PTEN and the Passenger Strand miR-17-3p Targeting MDM2 Research Paper

Advances in Targeting Signal Transduction Pathways. Review

A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia Research Paper

Autophagy-related gene 12 (ATG12) is a novel determinant of primary resistance to HER2-targeted therapies: Utility of transcriptome analysis of the autophagy interactome to guide breast cancer treatment Research Paper

Epigenetic Regulation of miRNA-211 by MMP-9 Governs Glioma Cell Apoptosis, Chemosensitivity and Radiosensitivity Research Paper

All tyrosine kinase inhibitor-resistant chronic myelogenous cells are highly sensitive to Ponatinib Research Paper

Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity Research Paper

High-Throughput Chemical Screens Identify Disulfiram as an Inhibitor of Human Glioblastoma Stem Cells Research

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance Review

Effects of Ectopic Expression of NGAL on Doxorubicin Sensitivity. Research Paper

Disulfiram, a drug widely used to control alcoholism, suppresses self-renewal of glioblastoma and overrides resistance to temozolomide Research

High cytidine deaminase expression in the liver provides sanctuary for cancer cells from decitabine treatment effects Research Paper

Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response. Review

Modulating Antiangiogenic Resistance by Inhibiting the Signal Transducer and Activator of Transcription 3 Pathway in Glioblastoma Research Paper

Antagonists of growth hormone-releasing hormone suppress in vivo tumor growth and gene expression in triple negative breast cancers Research Paper

Mislocalization of death receptors correlates with cellular resistance to their cognate ligands in human breast cancer cells Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

BRAF Mutant Gastrointestinal Stromal Tumor: First report of regression with BRAF inhibitor dabrafenib (GSK2118436) and whole exomic sequencing for analysis of acquired resistance Research Paper

Ras inhibition boosts galectin-7 at the expense of galectin-1 to sensitize cells to apoptosis Research Paper

TRAIL induces apoptosis in oral squamous carcinoma cells: a crosstalk with oncogenic Ras regulated cell surface expression of death receptor 5 Research Paper

Calcein-effluxing human colon cancer cells are enriched for self-renewal capacity and depend on Î²-catenin Research Paper

Stress Response of Glioblastoma Cells Mediated by miR-17-5p Targeting PTEN and the Passenger Strand miR-17-3p Targeting MDM2 Research Paper

Advances in Targeting Signal Transduction Pathways. Review

A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia Research Paper

Autophagy-related gene 12 (ATG12) is a novel determinant of primary resistance to HER2-targeted therapies: Utility of transcriptome analysis of the autophagy interactome to guide breast cancer treatment Research Paper

Epigenetic Regulation of miRNA-211 by MMP-9 Governs Glioma Cell Apoptosis, Chemosensitivity and Radiosensitivity Research Paper

All tyrosine kinase inhibitor-resistant chronic myelogenous cells are highly sensitive to Ponatinib Research Paper

Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity Research Paper

High-Throughput Chemical Screens Identify Disulfiram as an Inhibitor of Human Glioblastoma Stem Cells Research

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance Review

Effects of Ectopic Expression of NGAL on Doxorubicin Sensitivity. Research Paper

Disulfiram, a drug widely used to control alcoholism, suppresses self-renewal of glioblastoma and overrides resistance to temozolomide Research

High cytidine deaminase expression in the liver provides sanctuary for cancer cells from decitabine treatment effects Research Paper

Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response. Review

Modulating Antiangiogenic Resistance by Inhibiting the Signal Transducer and Activator of Transcription 3 Pathway in Glioblastoma Research Paper

Antagonists of growth hormone-releasing hormone suppress in vivo tumor growth and gene expression in triple negative breast cancers Research Paper

Mislocalization of death receptors correlates with cellular resistance to their cognate ligands in human breast cancer cells Research Paper