The Oncosearch | Oncotarget

Human PIF1 helicase supports DNA replication and cell growth under oncogenic-stress Research Paper

Mary E. Gagou, Anil Ganesh, Geraldine Phear, Darren Robinson, Eva Petermann, Angela Cox, Mark Meuth

Published Nov 5, 2014 · Vol. 5, No. 22 · pp. 11381-11398

Keywords: helicases, replication stress, oncogenes, human cells

Development and prospective multicenter evaluation of the long noncoding RNA MALAT-1 as a diagnostic urinary biomarker for prostate cancer Clinical Research Papers

Fubo Wang, Shancheng Ren, Rui Chen, Ji Lu, Xiaolei Shi, Yasheng Zhu, Wei Zhang, Taile Jing, Chao Zhang, Jian Shen, Chuanliang Xu, Huiqing Wang, Haifeng Wang, Yang Wang, Bin Liu, Yaoming Li, Ziyu Fang, Fei Guo, Meng Qiao, Chengyao Wu, Qiang Wei, Danfeng Xu, Dan Shen, Xin Lu, Xu Gao, Jianguo Hou, Yinghao Sun

Published Nov 4, 2014 · Vol. 5, No. 22 · pp. 11091-11102

Molecular profiling of endometrial carcinoma precursor, primary and metastatic lesions suggests different targets for treatment in obese compared to non-obese patients Clinical Research Papers

Anna Berg, Erling A. Hoivik, Siv MjÃ¸s, Frederik Holst, Henrica M. J. Werner, Ingvild L. Tangen, Amaro Taylor-Weiner, William J. Gibson, Kanthida Kusonmano, Elisabeth Wik, Jone Trovik, Mari K. Halle, Anne M. Ã˜yan, Karl-Henning Kalland, Andrew D. Cherniack, Rameen Beroukhim, Ingunn Stefansson, Gordon B. Mills, Camilla Krakstad, Helga B. Salvesen

Published Nov 4, 2014 · Vol. 6, No. 2 · pp. 1327-1339

Targeted PI3K/AKT/mTOR therapy for metastatic carcinomas of the cervix: A phase I clinical experience Clinical Research Papers

Ming-Mo Hou, Xiaochun Liu, Jennifer Wheler, Aung Naing, David Hong, Robert L. Coleman, Apostolia Tsimberidou, Filip Janku, Ralph Zinner, Karen Lu, Razelle Kurzrock, Siqing Fu

Published Oct 29, 2014 · Vol. 5, No. 22 · pp. 11168-11179

Preclinical efficacy of maternal embryonic leucine-zipper kinase (MELK) inhibition in acute myeloid leukemia Research Paper

Houda Alachkar, Martin B.G. Mutonga, Klaus H. Metzeler, Noreen Fulton, Gregory Malnassy, Tobias Herold, Karsten Spiekermann, Stefan K. Bohlander, Wolfgang Hiddemann, Yo Matsuo, Wendy Stock, Yusuke Nakamura

Published Oct 28, 2014 · Vol. 5, No. 23 · pp. 12371-12382

Msi1 promotes tumor growth and cell proliferation by targeting cell cycle checkpoint proteins p21, p27 and p53 in cervical carcinomas Research Paper

Xian Liu, Wen-Ting Yang, Peng-Sheng Zheng

Published Oct 24, 2014 · Vol. 5, No. 21 · pp. 10870-10885

Keywords: Msi1, cervical cancer, cell cycle, oncogene

A phase 1b, open-label study of trebananib plus bevacizumab or motesanib in patients with solid tumours Clinical Research Papers

David S. Hong, Razelle Kurzrock, Marilyn Mulay, Erik Rasmussen, Benjamin M. Wu, Michael B. Bass, Zhandong D. Zhong, Greg Friberg, Lee S. Rosen

Published Oct 23, 2014 · Vol. 5, No. 22 · pp. 11154-11167

microRNA-29b prevents liver fibrosis by attenuating hepatic stellate cell activation and inducing apoptosis through targeting PI3K/AKT pathway Research Paper

Jia Wang, Eagle S.H . Chu, Hai-Yong Chen, Kwan Man, Minnie Y.Y. Go, Xiao Ru Huang, Hui Yao Lan, Joseph J.Y. Sung, Jun Yu

Published Oct 22, 2014 · Vol. 6, No. 9 · pp. 7325-7338

Proscillaridin A is cytotoxic for glioblastoma cell lines and controls tumor xenograft growth in vivo Research Paper

Emilie DenicolaÃ¯, Nathalie Baeza-Kallee, AurÃ©lie Tchoghandjian, Manon CarrÃ©, Carole Colin, Carine Jiguet Jiglaire, Sandy Mercurio, Christophe Beclin, Dominique Figarella-Branger

Published Oct 21, 2014 · Vol. 5, No. 21 · pp. 10934-10948

Keywords: Proscillaridin A, glioblastoma, cytotoxicity, tumor growth control, Na+/K+ ATPase Î±1 subunit

AMACR amplification and overexpression in primary imatinib-naÃ¯ve gastrointestinal stromal tumors: a driver of cell proliferation indicating adverse prognosis Research Paper

Chien-Feng Li, Li-Tzong Chen, Jui Lan, Fong-Fu Chou, Ching-Yih Lin, Yen-Yang Chen, Tzu-Ju Chen, Shau-Hsuan Li, Shih-Chen Yu, Fu-Ming Fang, Hui-Chun Tai, Hsuan-Ying Huang

Published Oct 18, 2014 · Vol. 5, No. 22 · pp. 11588-11603

MicroRNA-638 inhibits cell proliferation, invasion and regulates cell cycle by targeting tetraspanin 1 in human colorectal carcinoma Research Paper

Jiwei Zhang, Bojian Fei, Qifeng Wang, Mingxu Song, Yuan Yin, Binbin Zhang, Shujuan Ni, Weijie Guo, Zehua Bian, Chao Quan, Zhihui Liu, Yugang Wang, Jian Yu, Xiang Du, Dong Hua, Zhaohui Huang

Published Oct 7, 2014 · Vol. 5, No. 23 · pp. 12083-12096

Keywords: microRNA-638, TSPAN1, cell proliferation, colorectal carcinoma, cell cycle

HS-133, a novel fluorescent phosphatidylinositol 3-kinase inhibitor as a potential imaging and anticancer agent for targeted therapy Research Paper

Ju-Hee Lee, Kyung Hee Jung, Hyunseung Lee, Mi Kwon Son, Sun-Mi Yun, Sung-Hoon Ahn, Kyeong-Ryoon Lee, Soyoung Lee, Donghee Kim, Sungwoo Hong, Soon-Sun Hong

Published Sep 29, 2014 · Vol. 5, No. 20 · pp. 10180-10197

Simultaneous targeting of PI3KÎ´ and a PI3KÎ´-dependent MEK1/2-Erk1/2 pathway for therapy in pediatric B-cell acute lymphoblastic leukemia Research Paper

Xiang Wang, Xi Zhang, Ben-shang Li, Xiaowen Zhai, Zhuo Yang, Li-xia Ding, Hongsheng Wang, Chris Liang, Weiliang Zhu, Jian Ding, Ling-hua Meng

Published Sep 26, 2014 · Vol. 5, No. 21 · pp. 10732-10744

Down-regulation of miRNA-106b inhibits growth of melanoma cells by promoting G1-phase cell cycle arrest and reactivation of p21/WAF1/Cip1 protein Research Paper

Ram Prasad, Santosh K. Katiyar

Published Sep 25, 2014 · Vol. 5, No. 21 · pp. 10636-10649

Targeting the DNA replication checkpoint by pharmacologic inhibition of Chk1 kinase: a strategy to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapy Research Paper

Estefania Martino-Echarri, Beric R. Henderson, Mariana G. Brocardo

Published Sep 16, 2014 · Vol. 5, No. 20 · pp. 9889-9900

Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation Research Paper

Carolina Simioni, Alice Cani, Alberto M. Martelli, Giorgio Zauli, Giovanna Tabellini, James McCubrey, Silvano Capitani, Luca M. Neri

Published Sep 16, 2014 · Vol. 5, No. 20 · pp. 10034-10047

Melanoma patient-derived xenografts accurately model the disease and develop fast enough to guide treatment decisions Clinical Research Papers

Berglind O. Einarsdottir, Roger Olofsson Bagge, Joydeep Bhadury, Henrik Jespersen, Jan Mattsson, Lisa M. Nilsson, Katarina TruvÃ©, Marcela DÃ¡vila LÃ³pez, Peter Naredi, Ola Nilsson, Ulrika Stierner, Lars Ny, Jonas A. Nilsson

Published Sep 8, 2014 · Vol. 5, No. 20 · pp. 9609-9618

A novel action mechanism for MPT0G013, a derivative of arylsulfonamide, inhibits tumor angiogenesis through up-regulation of TIMP3 expression Research Paper

Chih-Ya Wang, Jing-Ping Liou, An-Chi Tsai, Mei-Jung Lai, Yi-Min Liu, Hsueh-Yun Lee, Jing-Chi Wang, Shiow-Lin Pan, Che-Ming Teng

Published Sep 8, 2014 · Vol. 5, No. 20 · pp. 9838-9850

A phase I trial of the HIV protease inhibitor nelfinavir in adults with solid tumors Clinical Research Papers

Gideon M. Blumenthal, Joell J. Gills, Marc S. Ballas, Wendy B. Bernstein, Takefumi Komiya, Roopa Dechowdhury, Betsy Morrow, Hyejeong Root, Guinevere Chun, Cynthia Helsabeck, Seth M. Steinberg, Jaclyn LoPiccolo, Shigeru Kawabata, Erin R. Gardner, William D. Figg, Phillip A. Dennis

Published Sep 5, 2014 · Vol. 5, No. 18 · pp. 8161-8172

Anti-rheumatic agent auranofin induced apoptosis in chronic myeloid leukemia cells resistant to imatinib through both Bcr/Abl-dependent and -independent mechanisms Research Paper

Xin Chen, Xianping Shi, Chong Zhao, Xiaofen Li, Xiaoying Lan, Shouting Liu, Hongbiao Huang, Ningning Liu, Siyan Liao, Dan Zang, Wenbin Song, Quentin Liu, Bing Z. Carter, Ping Q. Dou, Xuejun Wang, Jinbao Liu

Published Aug 22, 2014 · Vol. 5, No. 19 · pp. 9118-9132

Keywords: Auranofin, proteasome, chronic myelogenous leukemia, imatinib resistance, Bcr-Abl

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Human PIF1 helicase supports DNA replication and cell growth under oncogenic-stress Research Paper

Development and prospective multicenter evaluation of the long noncoding RNA MALAT-1 as a diagnostic urinary biomarker for prostate cancer Clinical Research Papers

Molecular profiling of endometrial carcinoma precursor, primary and metastatic lesions suggests different targets for treatment in obese compared to non-obese patients Clinical Research Papers

Targeted PI3K/AKT/mTOR therapy for metastatic carcinomas of the cervix: A phase I clinical experience Clinical Research Papers

Preclinical efficacy of maternal embryonic leucine-zipper kinase (MELK) inhibition in acute myeloid leukemia Research Paper

Msi1 promotes tumor growth and cell proliferation by targeting cell cycle checkpoint proteins p21, p27 and p53 in cervical carcinomas Research Paper

A phase 1b, open-label study of trebananib plus bevacizumab or motesanib in patients with solid tumours Clinical Research Papers

microRNA-29b prevents liver fibrosis by attenuating hepatic stellate cell activation and inducing apoptosis through targeting PI3K/AKT pathway Research Paper

Proscillaridin A is cytotoxic for glioblastoma cell lines and controls tumor xenograft growth in vivo Research Paper

AMACR amplification and overexpression in primary imatinib-naÃ¯ve gastrointestinal stromal tumors: a driver of cell proliferation indicating adverse prognosis Research Paper

MicroRNA-638 inhibits cell proliferation, invasion and regulates cell cycle by targeting tetraspanin 1 in human colorectal carcinoma Research Paper

HS-133, a novel fluorescent phosphatidylinositol 3-kinase inhibitor as a potential imaging and anticancer agent for targeted therapy Research Paper

Simultaneous targeting of PI3KÎ´ and a PI3KÎ´-dependent MEK1/2-Erk1/2 pathway for therapy in pediatric B-cell acute lymphoblastic leukemia Research Paper

Down-regulation of miRNA-106b inhibits growth of melanoma cells by promoting G1-phase cell cycle arrest and reactivation of p21/WAF1/Cip1 protein Research Paper

Targeting the DNA replication checkpoint by pharmacologic inhibition of Chk1 kinase: a strategy to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapy Research Paper

Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation Research Paper

Melanoma patient-derived xenografts accurately model the disease and develop fast enough to guide treatment decisions Clinical Research Papers

A novel action mechanism for MPT0G013, a derivative of arylsulfonamide, inhibits tumor angiogenesis through up-regulation of TIMP3 expression Research Paper

A phase I trial of the HIV protease inhibitor nelfinavir in adults with solid tumors Clinical Research Papers

Anti-rheumatic agent auranofin induced apoptosis in chronic myeloid leukemia cells resistant to imatinib through both Bcr/Abl-dependent and -independent mechanisms Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Human PIF1 helicase supports DNA replication and cell growth under oncogenic-stress Research Paper

Development and prospective multicenter evaluation of the long noncoding RNA MALAT-1 as a diagnostic urinary biomarker for prostate cancer Clinical Research Papers

Molecular profiling of endometrial carcinoma precursor, primary and metastatic lesions suggests different targets for treatment in obese compared to non-obese patients Clinical Research Papers

Targeted PI3K/AKT/mTOR therapy for metastatic carcinomas of the cervix: A phase I clinical experience Clinical Research Papers

Preclinical efficacy of maternal embryonic leucine-zipper kinase (MELK) inhibition in acute myeloid leukemia Research Paper

Msi1 promotes tumor growth and cell proliferation by targeting cell cycle checkpoint proteins p21, p27 and p53 in cervical carcinomas Research Paper

A phase 1b, open-label study of trebananib plus bevacizumab or motesanib in patients with solid tumours Clinical Research Papers

microRNA-29b prevents liver fibrosis by attenuating hepatic stellate cell activation and inducing apoptosis through targeting PI3K/AKT pathway Research Paper

Proscillaridin A is cytotoxic for glioblastoma cell lines and controls tumor xenograft growth in vivo Research Paper

AMACR amplification and overexpression in primary imatinib-naÃ¯ve gastrointestinal stromal tumors: a driver of cell proliferation indicating adverse prognosis Research Paper

MicroRNA-638 inhibits cell proliferation, invasion and regulates cell cycle by targeting tetraspanin 1 in human colorectal carcinoma Research Paper

HS-133, a novel fluorescent phosphatidylinositol 3-kinase inhibitor as a potential imaging and anticancer agent for targeted therapy Research Paper

Simultaneous targeting of PI3KÎ´ and a PI3KÎ´-dependent MEK1/2-Erk1/2 pathway for therapy in pediatric B-cell acute lymphoblastic leukemia Research Paper

Down-regulation of miRNA-106b inhibits growth of melanoma cells by promoting G1-phase cell cycle arrest and reactivation of p21/WAF1/Cip1 protein Research Paper

Targeting the DNA replication checkpoint by pharmacologic inhibition of Chk1 kinase: a strategy to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapy Research Paper

Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation Research Paper

Melanoma patient-derived xenografts accurately model the disease and develop fast enough to guide treatment decisions Clinical Research Papers

A novel action mechanism for MPT0G013, a derivative of arylsulfonamide, inhibits tumor angiogenesis through up-regulation of TIMP3 expression Research Paper

A phase I trial of the HIV protease inhibitor nelfinavir in adults with solid tumors Clinical Research Papers

Anti-rheumatic agent auranofin induced apoptosis in chronic myeloid leukemia cells resistant to imatinib through both Bcr/Abl-dependent and -independent mechanisms Research Paper