The Oncosearch | Oncotarget

The AKT Inhibitor MK-2206 is Cytotoxic in Hepatocarcinoma Cells Displaying Hyperphosphorylated AKT-1 and Synergizes with Conventional Chemotherapy Research Paper

Carolina Simioni, Alberto M. Martelli, Alice Cani, Rengul Cetin-Atalay, James A. McCubrey, Silvano Capitani, Luca M. Neri

Published Aug 24, 2013 · Vol. 4, No. 9 · pp. 1496-1506

Keywords: Hepatocellular carcinoma, MK-2206, Akt-1, targeted therapy, apoptosis, autophagy

Crucial Role for Early Growth Response-1 in the Transcriptional Regulation of miR-20b in Breast Cancer Research Paper

Dongping Li, Yaroslav Ilnytskyy, Anna Kovalchuk, Levon M. Khachigian, Roderick T. Bronson, Bo Wang, Olga Kovalchuk

Published Jul 28, 2013 · Vol. 4, No. 9 · pp. 1373-1387

Keywords: EGR1, miR-20b, transcription, PTEN, BRCA1, breast cancer, proliferation, migration, cell cycle arrest

Targeting mixed lineage kinases in ER-positive breast cancer cells leads to G2/M cell cycle arrest and apoptosis. Research Paper

Limin Wang, Kathleen A Gallo, Susan E Conrad

Published Jul 7, 2013 · Vol. 4, No. 8 · pp. 1158-1171

Keywords: breast cancer, kinase inhibitors, cell cycle, apoptosis

Targeting Mutant p53 by a SIRT1 Activator YK-3-237 Inhibits the Proliferation of Triple-Negative Breast Cancer Cells Research Paper

Yong Weon Yi, Hyo Jin Kang, Hee Jeong Kim, Yali Kong, Milton M. Brown, Insoo Bae

Published Jul 5, 2013 · Vol. 4, No. 7 · pp. 984-994

Keywords: mutant p53 (mtp53), deacetylation, SIRT1, activator, triple-negative breast cancer (TNBC)

Blockade of the PDGFR family together with SRC leads to diminished proliferation of colorectal cancer cells Research Paper

Silke KaulfuÃŸ, Henning Seemann, Rovena Kampe, Julia Meyer, Ralf Dressel, Britta KÃ¶nig, Jens-Gerd Scharf, Peter Burfeind

Published Jun 30, 2013 · Vol. 4, No. 7 · pp. 1037-1049

Keywords: colorectal cancer, PDGF receptor, c-KIT, SRC, cell proliferation, apoptosis, RNA interference, targeted therapy

Myeloablative Anti-CD20 Radioimmunotherapy +/- High-Dose Chemotherapy Followed by Autologous Stem Cell Support for Relapsed/Refractory B-Cell Lymphoma Results in Excellent Long-Term Survival Research Paper

Julia Y. Wagner, Kathleen Schwarz, Susanne Schreiber, Burkhard Schmidt, Hans-JÃ¼rgen Wester, Markus Schwaiger, Christian Peschel, Christoph von Schilling, Klemens Scheidhauer, Ulrich Keller

Published Jun 12, 2013 · Vol. 4, No. 6 · pp. 899-910

Keywords: Non-Hodgkin lymphoma, CD20, Radioimmunotherapy, High-dose chemotherapy, Autologous stem cell transplantation

Thymoma Patients Treated in a Phase I Clinic at MD Anderson Cancer Center: Responses to mTOR Inhibitors and Molecular Analyses Research Paper

Jennifer J. Wheler, David Hong, Stephen G. Swisher, Gerald S. Falchook, Apostolia Maria Tsimberidou, Thorunn Helgason, Aung Naing, Bettzy Stephen, Filip Janku, Philip J. Stephens, Roman Yelensky, Razelle Kurzrock

Published Jun 10, 2013 · Vol. 4, No. 6 · pp. 890-898

Keywords: advanced thymoma, mTOR inhibitors, targeted therapy, thymic carcinoma

Germline PTPRD Mutations in Ewing Sarcoma: Biologic and Clinical Implications Research Paper

Yunyun Jiang, Filip Janku, Vivek Subbiah, Laura S. Angelo, Aung Naing, Peter M. Anderson, Cynthia E. Herzog, Siqing Fu, Robert S. Benjamin, Razelle Kurzrock

Published Jun 5, 2013 · Vol. 4, No. 6 · pp. 884-889

Keywords: Ewing sarcoma, PTPRD, mutation, germline

Revisiting Clinical Trials Using EGFR Inhibitor-Based Regimens in Patients with Advanced Non-Small Cell Lung Cancer: A Retrospective Analysis of an MD Anderson Cancer Center Phase I Population Research Paper

Jennifer Wheler, Gerald Falchook, Apostolia M. Tsimberidou, David Hong, Aung Naing, Sarina Piha-Paul, Su S. Chen, John Heymach, Siqing Fu, Su S. Chen, Bettzy Stephen, Jansina Y. Fok, Filip Janku, Razelle Kurzrock

Published Jun 4, 2013 · Vol. 4, No. 5 · pp. 772-784

Keywords: EGFR mutation, EGFR wild-type, non-small cell lung cancer, phase I trials, resistance, squamous cell

P53 Mutations in Advanced Cancers: Clinical Characteristics, Outcomes, and Correlation between Progression-Free Survival and Bevacizumab-Containing Therapy Research Paper

Rabih Said, David S. Hong, Carla L. Warneke, J. Jack Lee, Jennifer J. Wheler, Filip Janku, Aung Naing, Gerald S. Falchook, Siqing Fu, Sarina Piha-Paul, Apostolia M. Tsimberidou, Razelle Kurzrock

Published May 1, 2013 · Vol. 4, No. 5 · pp. 705-714

Keywords: P53 mutations, PTEN loss, bevacizumab, Li-Fraumeni syndrome

A kinase-independent biological activity for insulin growth factor-1 receptor (IGF-1R) : implications for inhibition of the IGF-1R signal Research Paper

Filip Janku, Helen J. Huang, Laura S. Angelo, Razelle Kurzrock

Published Mar 23, 2013 · Vol. 4, No. 3 · pp. 463-473

Keywords: IGF-1R, OSI-906, intracellular glucose, autophagy, MCF7, HEK293

BRAF Mutant Gastrointestinal Stromal Tumor: First report of regression with BRAF inhibitor dabrafenib (GSK2118436) and whole exomic sequencing for analysis of acquired resistance Research Paper

Gerald S. Falchook, Jonathan C. Trent, Michael C. Heinrich, Carol Beadling, Janice Patterson, Christel C. Bastida, Samuel C. Blackman, Razelle Kurzrock

Published Feb 25, 2013 · Vol. 4, No. 2 · pp. 310-315

Keywords: Gastrointestinal stromal tumor, Dabrafenib, GSK2118436, BRAF mutation, BRAF inhibition, V600E

In Vitro and in Vivo Anti-tumor Activity of miR-221/222 Inhibitors in Multiple Myeloma Research Paper

Maria Teresa Di Martino, Annamaria GullÃ, Maria Eugenia Gallo Cantafio, Marta Lionetti, Emanuela Leone, Nicola Amodio, Pietro Hiram Guzzi, Umberto Foresta, Francesco Conforti, Mario Cannataro, Antonino Neri, Antonio Giordano, Pierosandro Tagliaferri, Pierfrancesco Tassone

Published Feb 24, 2013 · Vol. 4, No. 2 · pp. 242-255

Keywords: miR-221, miR-222, microRNA, miRNA, multiple myeloma, plasma cell leukemia

Targeted Therapy of Advanced Gallbladder Cancer and Cholangiocarcinoma with Aggressive Biology: Eliciting Early Response Signals from Phase 1 trials Research Paper

Ishwaria Subbiah, Vivek Subbiah, Apostolia M Tsimberidou, Aung Naing, Ahmed Kaseb, Javle Milind, Siqing Fu, David S Hong, Sarina Piha-Paul, Jenifer Wheler, Kenneth Hess, Filip Janku, Gerald Falchook, Robert A Wolff, Razelle Kurzrock

Published Jan 27, 2013 · Vol. 4, No. 1 · pp. 153-162

Keywords: Gallbladder Cancer, Cholangiocarcinoma, Phase 1 trials

Dual EGFR inhibition in combination with anti-VEGF treatment: A phase I clinical trial in non-small cell lung cancer Research Paper

Gerald S. Falchook, Aung Naing, David S. Hong, Ralph G. Zinner, Siqing Fu, Sarina A. Piha-Paul, Apostolia M. Tsimberidou, Sonia K. Morgan-Linnell, Yunfang Jiang, Christel C. Bastida, Jennifer J. Wheler, Razelle Kurzrock

Published Jan 14, 2013 · Vol. 4, No. 1 · pp. 118-127

Stress Response of Glioblastoma Cells Mediated by miR-17-5p Targeting PTEN and the Passenger Strand miR-17-3p Targeting MDM2 Research Paper

Haoran Li, Burton B Yang

Published Dec 31, 2012 · Vol. 3, No. 12 · pp. 1653-1668

Keywords: microRNA, stem cell, miR-17, stress response, drug resistance

A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia Research Paper

Francesca Chiarini, Annalisa Lonetti, Gabriella Teti, Ester Orsini, Daniela Bressanin, Alessandra Cappellini, Francesca Ricci, Pier Luigi Tazzari, Andrea Ognibene, Mirella Falconi, Pasqualepaolo Pagliaro, Ilaria Iacobucci, Giovanni Martinelli, Sergio Amadori, James A McCubrey, Alberto M Martelli

Published Dec 18, 2012 · Vol. 3, No. 12 · pp. 1615-1628

Keywords: AML, PI3K/Akt/mTOR signaling, apoptosis, autophagy combination therapy, leukemia initiating cells

PIK3CA Mutations in Advanced Cancers: Characteristics and Outcomes Research Paper

Filip Janku, Jennifer J. Wheler, Aung Naing, Vanda M. T. Stepanek, Gerald S. Falchook, Siqing Fu, Ignacio Garrido-Laguna, Apostolia M. Tsimberidou, Sarina A. Piha-Paul, Stacy L. Moulder, J. Jack Lee, Rajyalakshmi Luthra, David S. Hong, Razelle Kurzrock

Published Nov 30, 2012 · Vol. 3, No. 12 · pp. 1566-1575

Keywords: PIK3CA mutation, phenotypic taxonomy, clinical outcome

Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2 Research Perspective

Zhiwei Wang, Hiroyuki Inuzuka, Jiateng Zhong, Pengda Liu, Fakul H Sarkar, Yi Sun, Wenyi Wei

Published Nov 16, 2012 · Vol. 3, No. 11 · pp. 1294-1300

Keywords: acetylation, cancer, deacetylation, SIRT3, oncoprotein, ubiquitination, phosphorylation, F-box protein, Skp2, therapy

Regulation of DNA Damage Following Termination of Hedgehog (HH) Survival Signaling at the level of the GLI Genes in Human Colon Cancer Research Paper

AKWASI AGYEMAN, Tapati Mazumdar, Janet A Houghton

Published Aug 20, 2012 · Vol. 3, No. 8 · pp. 854-868

Keywords: Hedgehog, GLI1/2 inhibition, GANT61, DNA damage, colon cancer

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The AKT Inhibitor MK-2206 is Cytotoxic in Hepatocarcinoma Cells Displaying Hyperphosphorylated AKT-1 and Synergizes with Conventional Chemotherapy Research Paper

Crucial Role for Early Growth Response-1 in the Transcriptional Regulation of miR-20b in Breast Cancer Research Paper

Targeting mixed lineage kinases in ER-positive breast cancer cells leads to G2/M cell cycle arrest and apoptosis. Research Paper

Targeting Mutant p53 by a SIRT1 Activator YK-3-237 Inhibits the Proliferation of Triple-Negative Breast Cancer Cells Research Paper

Blockade of the PDGFR family together with SRC leads to diminished proliferation of colorectal cancer cells Research Paper

Myeloablative Anti-CD20 Radioimmunotherapy +/- High-Dose Chemotherapy Followed by Autologous Stem Cell Support for Relapsed/Refractory B-Cell Lymphoma Results in Excellent Long-Term Survival Research Paper

Thymoma Patients Treated in a Phase I Clinic at MD Anderson Cancer Center: Responses to mTOR Inhibitors and Molecular Analyses Research Paper

Germline PTPRD Mutations in Ewing Sarcoma: Biologic and Clinical Implications Research Paper

Revisiting Clinical Trials Using EGFR Inhibitor-Based Regimens in Patients with Advanced Non-Small Cell Lung Cancer: A Retrospective Analysis of an MD Anderson Cancer Center Phase I Population Research Paper

P53 Mutations in Advanced Cancers: Clinical Characteristics, Outcomes, and Correlation between Progression-Free Survival and Bevacizumab-Containing Therapy Research Paper

A kinase-independent biological activity for insulin growth factor-1 receptor (IGF-1R) : implications for inhibition of the IGF-1R signal Research Paper

BRAF Mutant Gastrointestinal Stromal Tumor: First report of regression with BRAF inhibitor dabrafenib (GSK2118436) and whole exomic sequencing for analysis of acquired resistance Research Paper

In Vitro and in Vivo Anti-tumor Activity of miR-221/222 Inhibitors in Multiple Myeloma Research Paper

Targeted Therapy of Advanced Gallbladder Cancer and Cholangiocarcinoma with Aggressive Biology: Eliciting Early Response Signals from Phase 1 trials Research Paper

Dual EGFR inhibition in combination with anti-VEGF treatment: A phase I clinical trial in non-small cell lung cancer Research Paper

Stress Response of Glioblastoma Cells Mediated by miR-17-5p Targeting PTEN and the Passenger Strand miR-17-3p Targeting MDM2 Research Paper

A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia Research Paper

PIK3CA Mutations in Advanced Cancers: Characteristics and Outcomes Research Paper

Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2 Research Perspective

Regulation of DNA Damage Following Termination of Hedgehog (HH) Survival Signaling at the level of the GLI Genes in Human Colon Cancer Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

The AKT Inhibitor MK-2206 is Cytotoxic in Hepatocarcinoma Cells Displaying Hyperphosphorylated AKT-1 and Synergizes with Conventional Chemotherapy Research Paper

Crucial Role for Early Growth Response-1 in the Transcriptional Regulation of miR-20b in Breast Cancer Research Paper

Targeting mixed lineage kinases in ER-positive breast cancer cells leads to G2/M cell cycle arrest and apoptosis. Research Paper

Targeting Mutant p53 by a SIRT1 Activator YK-3-237 Inhibits the Proliferation of Triple-Negative Breast Cancer Cells Research Paper

Blockade of the PDGFR family together with SRC leads to diminished proliferation of colorectal cancer cells Research Paper

Myeloablative Anti-CD20 Radioimmunotherapy +/- High-Dose Chemotherapy Followed by Autologous Stem Cell Support for Relapsed/Refractory B-Cell Lymphoma Results in Excellent Long-Term Survival Research Paper

Thymoma Patients Treated in a Phase I Clinic at MD Anderson Cancer Center: Responses to mTOR Inhibitors and Molecular Analyses Research Paper

Germline PTPRD Mutations in Ewing Sarcoma: Biologic and Clinical Implications Research Paper

Revisiting Clinical Trials Using EGFR Inhibitor-Based Regimens in Patients with Advanced Non-Small Cell Lung Cancer: A Retrospective Analysis of an MD Anderson Cancer Center Phase I Population Research Paper

P53 Mutations in Advanced Cancers: Clinical Characteristics, Outcomes, and Correlation between Progression-Free Survival and Bevacizumab-Containing Therapy Research Paper

A kinase-independent biological activity for insulin growth factor-1 receptor (IGF-1R) : implications for inhibition of the IGF-1R signal Research Paper

BRAF Mutant Gastrointestinal Stromal Tumor: First report of regression with BRAF inhibitor dabrafenib (GSK2118436) and whole exomic sequencing for analysis of acquired resistance Research Paper

In Vitro and in Vivo Anti-tumor Activity of miR-221/222 Inhibitors in Multiple Myeloma Research Paper

Targeted Therapy of Advanced Gallbladder Cancer and Cholangiocarcinoma with Aggressive Biology: Eliciting Early Response Signals from Phase 1 trials Research Paper

Dual EGFR inhibition in combination with anti-VEGF treatment: A phase I clinical trial in non-small cell lung cancer Research Paper

Stress Response of Glioblastoma Cells Mediated by miR-17-5p Targeting PTEN and the Passenger Strand miR-17-3p Targeting MDM2 Research Paper

A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia Research Paper

PIK3CA Mutations in Advanced Cancers: Characteristics and Outcomes Research Paper

Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2 Research Perspective

Regulation of DNA Damage Following Termination of Hedgehog (HH) Survival Signaling at the level of the GLI Genes in Human Colon Cancer Research Paper