The Oncosearch | Oncotarget

Targeting cellular respiration as a therapeutic strategy in glioblastoma Research Perspective

Enyuan Shang, Trang Thi Thu Nguyen, Mike-Andrew Westhoff, Georg Karpel-Massler, Markus D. Siegelin

Published May 2, 2023 · Vol. 14, No. 1 · pp. 419-425

Keywords: glioblastoma, metabolism, lactate, carbon tracing, central carbon metabolism

HER3- A key survival pathway and an emerging therapeutic target in metastatic colorectal cancer and pancreatic ductal adenocarcinoma Research Perspective

Omkar Desai, Rui Wang

Published Apr 28, 2023 · Vol. 14, No. 1 · pp. 439-443

Keywords: HER3, colorectal, pancreatic cancer, metastasis, microenvironment

Using cancer proteomics data to identify gene candidates for therapeutic targeting Research Perspective

Diana Monsivais, Sydney E. Parks, Darshan S. Chandrashekar, Sooryanarayana Varambally, Chad J. Creighton

Published Apr 28, 2023 · Vol. 14, No. 1 · pp. 399-412

Keywords: proteomics, proteogenomics, multi-omics, cancer, TTK protein kinase

Attenuation of cancer proliferation by suppression of glypican-1 and its pleiotropic effects in neoplastic behavior Research Paper

Fang Cheng, Victor Chérouvrier Hansson, Grigorios Georgolopoulos, Katrin Mani

Published Mar 13, 2023 · Vol. 14, No. 1 · pp. 219-235

Keywords: Glypican-1, TCGA, bladder carcinoma, hepatocellular carcinoma, glioma

Oncogenic driver FGFR3-TACC3 requires five coiled-coil heptads for activation and disulfide bond formation for stability Research Paper

Clark G. Wang, Malalage N. Peiris, April N. Meyer, Katelyn N. Nelson, Daniel J. Donoghue

Published Feb 6, 2023 · Vol. 14, No. 1 · pp. 133-145

Keywords: oncogenic fusion protein, chromosomal translocation, glioblastoma, FGFR3-TACC3, coiled-coil

WNT-pathway medulloblastoma: what constitutes low-risk and how low can one go? Research Perspective

Shakthivel Mani, Abhishek Chatterjee, Archya Dasgupta, Neelam Shirsat, Sridhar Epari, Girish Chinnaswamy, Tejpal Gupta

Published Feb 2, 2023 · Vol. 14, No. 1 · pp. 105-110

Keywords: de-intensification, medulloblastoma, molecular, survival, toxicity

The “extreme phenotype approach” applied to male breast cancer allows the identification of rare variants of ATR as potential breast cancer susceptibility alleles Research Paper

Martin Chevarin, Diana Alcantara, Juliette Albuisson, Marie-Agnès Collonge-Rame, Céline Populaire, Zohair Selmani, Amandine Baurand, Caroline Sawka, Geoffrey Bertolone, Patrick Callier, Yannis Duffourd, Philippe Jonveaux, Yves-Jean Bignon, Isabelle Coupier, François Cornelis, Christophe Cordier, Monique Mozelle-Nivoix, Jean-Baptiste Rivière, Paul Kuentz, Christel Thauvin, Romain Boidot, François Ghiringhelli, Marc O'Driscoll, Laurence Faivre, Sophie Nambot

Published Feb 1, 2023 · Vol. 14, No. 1 · pp. 111-125

Keywords: male breast cancer, genetic predisposition to cancer, exome sequencing, ATR, extreme phenotype

Novel inflammation-combined prognostic index to predict survival outcomes in patients with gastric cancer Research Paper

Noriyuki Hirahara, Takeshi Matsubara, Shunsuke Kaji, Hikota Hayashi, Yohei Sasaki, Koki Kawakami, Ryoji Hyakudomi, Tetsu Yamamoto, Yoshitsugu Tajima

Published Jan 25, 2023 · Vol. 14, No. 1 · pp. 71-82

Keywords: gastric cancer, laparoscopic gastrectomy, novel predictive index, inflammation-combined prognostic index, cancer-specific survival

Anti-tumor effect of antibody drug conjugate ASP1235 targeting Fms-like tyrosine kinase 3 with venetoclax plus azacitidine in an acute myeloid leukemia xenograft mouse model Research Paper

Hirofumi Tsuzuki, Tatsuya Kawase, Taisuke Nakazawa, Masamichi Mori, Taku Yoshida

Published Dec 13, 2022 · Vol. 13, No. 1 · pp. 1359-1368

Keywords: acute myeloid leukemia (AML), ASP1235, antibody drug conjugate (ADC), venetoclax, azacitidine

MK256 is a novel CDK8 inhibitor with potent antitumor activity in AML through downregulation of the STAT pathway Research Paper

Jen-Chieh Lee, Shu Liu, Yucheng Wang, You Liang, David M. Jablons

Published Oct 26, 2022 · Vol. 13, No. 1 · pp. 1217-1236

Keywords: AML, CDK8, kinase inhibitor, STAT pathway, xenograft

Tumor hyaluronan as a novel biomarker in non-small cell lung cancer: A retrospective study Research Paper

Jun Gong, Michelle Guan, Haesoo Kim, Natalie Moshayedi, Sejal Mehta, Galen Cook-Wiens, Brent K. Larson, Jenny Zhou, Rishi Patel, Isaac Lapite, Veronica R. Placencio-Hickok, Richard Tuli, Ronald B. Natale, Andrew E. Hendifar

Published Oct 25, 2022 · Vol. 13, No. 1 · pp. 1202-1214

Keywords: hyaluronan, hyaluronic acid, biomarker, prognostic, predictive

FSP1, a novel KEAP1/NRF2 target gene regulating ferroptosis and radioresistance in lung cancers Research Perspective

Nsengiyumva Emmanuel, Hongen Li, Jing Chen, Yilei Zhang

Published Oct 17, 2022 · Vol. 13, No. 1 · pp. 1136-1139

Keywords: KEAP1/NRF2, lung cancer, ferroptosis, radioresistance, therapy

The serine protease matriptase inhibits migration and proliferation in multiple myeloma cells Research Paper

Ida Steiro, Esten N. Vandsemb, Samah Elsaadi, Kristine Misund, Anne-Marit Sponaas, Magne Børset, Pegah Abdollahi, Tobias S. Slørdahl

Published Oct 15, 2022 · Vol. 13, No. 1 · pp. 1175-1186

Keywords: matriptase, multiple myeloma, tumor suppressor, migration, Src

Addendum: BCMab1-Ra, a novel immunotoxin that BCMab1 antibody coupled to Ricin A chain, can eliminate bladder tumor Addendum

Chong Li, Ruping Yan, Zhao Yang, Haifeng Wang, Ruiyun Zhang, Haige Chen, Jiansong Wang

Published Oct 11, 2022

Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-ribose polymerase inhibitors and low-dose alkylating chemotherapy Research Paper

Daiki Ueno, Juan C. Vasquez, Amrita Sule, Jiayu Liang, Jinny van Doorn, Ranjini Sundaram, Sam Friedman, Randy Caliliw, Shinji Ohtake, Xun Bao, Jing Li, Huihui Ye, Karla Boyd, Rong Rong Huang, Jack Dodson, Paul Boutros, Ranjit S. Bindra, Brian Shuch

Published Sep 3, 2022 · Vol. 13, No. 1 · pp. 1054-1067

Keywords: FH, SDHB, renal cell carcinoma, PARP inhibitor, temozolomide

A novel mechanism of regulation of the oncogenic transcription factor GLI3 by toll-like receptor signaling Priority Research Paper

Stephan J. Matissek, Mona Karbalivand, Weiguo Han, Ava Boutilier, Estefania Yzar-Garcia, Laura L. Kehoe, Devin Storm Gardner, Adam Hage, Krista Fleck, Vicki Jeffers, Ricardo Rajsbaum, Sherine F. Elsawa

Published Jul 29, 2022 · Vol. 13, No. 1 · pp. 944-959

Keywords: GLI3, inflammation, TLR

Are anaplastic lymphoma kinase (ALK) and O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation driver biomarkers of pulmonary neuroendocrine tumors (NETs) and carcinomas (NECs)? Research Paper

Birgitta Hiddinga, Karen Zwaenepoel, Annelies Janssens, Jan Van Meerbeeck, Patrick Pauwels

Published May 13, 2022 · Vol. 13, No. 1 · pp. 800-809

Keywords: MGMT promoter methylation, anaplastic lymphoma kinase, neuroendocrine tumor, neuroendocrine carcinoma, small cell lung cancer

HOXB9 mediates resistance to chemotherapy and patient outcomes through the TGFβ pathway in pancreatic cancer Research Paper

Naokazu Chiba, Shigeto Ochiai, Takahiro Gunji, Toshimichi Kobayashi, Toru Sano, Koichi Tomita, Shigeyuki Kawachi

Published May 11, 2022 · Vol. 13, No. 1 · pp. 747-754

Keywords: HOXB9, pancreatic cancer, epithelial mesenchymal transition, TGFβ

CancerOmicsNet: a multi-omics network-based approach to anti-cancer drug profiling Research Paper

Limeng Pu, Manali Singha, Jagannathan Ramanujam, Michal Brylinski

Published May 9, 2022 · Vol. 13, No. 1 · pp. 695-706

Keywords: cancer growth rate, kinase inhibitors, differential gene expression, gene-disease association, cancer-specific networks

NF-κB over-activation portends improved outcomes in HPV-associated head and neck cancer Research Paper

Travis P. Schrank, Andrew C. Prince, Tejas Sathe, Xiaowei Wang, Xinyi Liu, Damir T. Alzhanov, Barbara Burtness, Albert S. Baldwin, Wendell G. Yarbrough, Natalia Issaeva

Published May 7, 2022 · Vol. 13, No. 1 · pp. 707-722

Keywords: HPV, head and neck cancer, CYLD, TRAF3, NF-κB

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European Cancer and Oncology Congress

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Targeting cellular respiration as a therapeutic strategy in glioblastoma Research Perspective

HER3- A key survival pathway and an emerging therapeutic target in metastatic colorectal cancer and pancreatic ductal adenocarcinoma Research Perspective

Using cancer proteomics data to identify gene candidates for therapeutic targeting Research Perspective

Attenuation of cancer proliferation by suppression of glypican-1 and its pleiotropic effects in neoplastic behavior Research Paper

Oncogenic driver FGFR3-TACC3 requires five coiled-coil heptads for activation and disulfide bond formation for stability Research Paper

WNT-pathway medulloblastoma: what constitutes low-risk and how low can one go? Research Perspective

The “extreme phenotype approach” applied to male breast cancer allows the identification of rare variants of ATR as potential breast cancer susceptibility alleles Research Paper

Novel inflammation-combined prognostic index to predict survival outcomes in patients with gastric cancer Research Paper

Anti-tumor effect of antibody drug conjugate ASP1235 targeting Fms-like tyrosine kinase 3 with venetoclax plus azacitidine in an acute myeloid leukemia xenograft mouse model Research Paper

MK256 is a novel CDK8 inhibitor with potent antitumor activity in AML through downregulation of the STAT pathway Research Paper

Tumor hyaluronan as a novel biomarker in non-small cell lung cancer: A retrospective study Research Paper

FSP1, a novel KEAP1/NRF2 target gene regulating ferroptosis and radioresistance in lung cancers Research Perspective

The serine protease matriptase inhibits migration and proliferation in multiple myeloma cells Research Paper

Addendum: BCMab1-Ra, a novel immunotoxin that BCMab1 antibody coupled to Ricin A chain, can eliminate bladder tumor Addendum

Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-ribose polymerase inhibitors and low-dose alkylating chemotherapy Research Paper

A novel mechanism of regulation of the oncogenic transcription factor GLI3 by toll-like receptor signaling Priority Research Paper

Are anaplastic lymphoma kinase (ALK) and O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation driver biomarkers of pulmonary neuroendocrine tumors (NETs) and carcinomas (NECs)? Research Paper

HOXB9 mediates resistance to chemotherapy and patient outcomes through the TGFβ pathway in pancreatic cancer Research Paper

CancerOmicsNet: a multi-omics network-based approach to anti-cancer drug profiling Research Paper

NF-κB over-activation portends improved outcomes in HPV-associated head and neck cancer Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Targeting cellular respiration as a therapeutic strategy in glioblastoma Research Perspective

HER3- A key survival pathway and an emerging therapeutic target in metastatic colorectal cancer and pancreatic ductal adenocarcinoma Research Perspective

Using cancer proteomics data to identify gene candidates for therapeutic targeting Research Perspective

Attenuation of cancer proliferation by suppression of glypican-1 and its pleiotropic effects in neoplastic behavior Research Paper

Oncogenic driver FGFR3-TACC3 requires five coiled-coil heptads for activation and disulfide bond formation for stability Research Paper

WNT-pathway medulloblastoma: what constitutes low-risk and how low can one go? Research Perspective

The “extreme phenotype approach” applied to male breast cancer allows the identification of rare variants of ATR as potential breast cancer susceptibility alleles Research Paper

Novel inflammation-combined prognostic index to predict survival outcomes in patients with gastric cancer Research Paper

Anti-tumor effect of antibody drug conjugate ASP1235 targeting Fms-like tyrosine kinase 3 with venetoclax plus azacitidine in an acute myeloid leukemia xenograft mouse model Research Paper

MK256 is a novel CDK8 inhibitor with potent antitumor activity in AML through downregulation of the STAT pathway Research Paper

Tumor hyaluronan as a novel biomarker in non-small cell lung cancer: A retrospective study Research Paper

FSP1, a novel KEAP1/NRF2 target gene regulating ferroptosis and radioresistance in lung cancers Research Perspective

The serine protease matriptase inhibits migration and proliferation in multiple myeloma cells Research Paper

Addendum: BCMab1-Ra, a novel immunotoxin that BCMab1 antibody coupled to Ricin A chain, can eliminate bladder tumor Addendum

Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-ribose polymerase inhibitors and low-dose alkylating chemotherapy Research Paper

A novel mechanism of regulation of the oncogenic transcription factor GLI3 by toll-like receptor signaling Priority Research Paper

Are anaplastic lymphoma kinase (ALK) and O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation driver biomarkers of pulmonary neuroendocrine tumors (NETs) and carcinomas (NECs)? Research Paper

HOXB9 mediates resistance to chemotherapy and patient outcomes through the TGFβ pathway in pancreatic cancer Research Paper

CancerOmicsNet: a multi-omics network-based approach to anti-cancer drug profiling Research Paper

NF-κB over-activation portends improved outcomes in HPV-associated head and neck cancer Research Paper