The Oncosearch | Oncotarget

Targeting CDC25C, PLK1 and CHEK1 to overcome Docetaxel resistance induced by loss of LZTS1 in prostate cancer Research Paper

Nader Al Nakouzi, Sophie Cotteret, FrÃ©dÃ©ric Commo, Catherine Gaudin, Shanna Rajpar, Philippe Dessen, Philippe Vielh, Karim Fizazi, Anne Chauchereau

Published Jan 6, 2014 · Vol. 5, No. 3 · pp. 667-678

Keywords: Prostate cancer, chemoresistance, LZTS1, CDC25C, PLK1, CHEK1

C-kit induces epithelialâ€“mesenchymal transition and contributes to salivary adenoid cystic cancer progression Research Paper

Ya-ling Tang, Yun-long Fan, Jian Jiang, Kai-de Li, Min Zheng, Wei Chen, Xiang-rui Ma, Ning Geng, Qian-ming Chen, Yu Chen, Xinhua Liang

Published Jan 6, 2014 · Vol. 5, No. 6 · pp. 1491-1501

Keywords: salivary adenoid cystic cancer, epithelialâ€“mesenchymal transition (EMT), c-kit, cancer stem cell, metastasis

Preferred binding of gain-of-function mutant p53 to bidirectional promoters with coordinated binding of ETS1 and GABPA to multiple binding sites Research Paper

Catherine A. Vaughan, Swati P. Deb, Sumitra Deb, Brad Windle

Published Jan 2, 2014 · Vol. 5, No. 2 · pp. 417-427

Keywords: mutant p53, ChIP-Seq, ETS1, bi-directional promoter

Frequent amplification of ORAOV1 gene in esophageal squamous cell cancer promotes an aggressive phenotype via proline metabolism and ROS production Research Paper

Yosuke Togashi, Tokuzo Arao, Hiroki Kato, Kazuko Matsumoto, Masato Terashima, Hidetoshi Hayashi, Marco A. de Velasco, Yoshihiko Fujita, Hideharu Kimura, Takushi Yasuda, Hitoshi Shiozaki, Kazuto Nishio

Published Dec 30, 2013 · Vol. 5, No. 10 · pp. 2962-2973

Keywords: oral cancer overexpressed 1, esophageal squamous cell cancer, pyrroline-5-carboxylate reductase, proline metabolism, reactive oxygen species

Poly (ADP-ribose) polymerase 1 transcriptional regulation: A novel crosstalk between histone modification H3K9ac and ETS1 motif hypomethylation in BRCA1-mutated ovarian cancer Research Paper

Da Li, Fang-Fang Bi, Ji-Min Cao, Chen Cao, Chun-Yan Li, Bo Liu, Qing Yang

Published Dec 29, 2013 · Vol. 5, No. 1 · pp. 291-297

Keywords: PARP1, H3K9ac, ETS1, BRCA1, Ovarian cancer

CITED1 confers stemness to Wilms tumor and enhances tumorigenic responses when enriched in the nucleus Research Paper

Andrew J. Murphy, Janene Pierce, Christian de Caestecker, Gregory D. Ayers, Alex Zhao, Jonathan R. Krebs, Vincente Kenyi Saito-Diaz, Ethan Lee, Alan O. Perantoni, Mark P. de Caestecker, Harold N. Lovvorn, III

Published Dec 28, 2013 · Vol. 5, No. 2 · pp. 386-402

Keywords: CITED1, Wilms tumor, WNT, WiT49, cancer stem cell

Survivin promoter-regulated oncolytic adenovirus with Hsp70 gene exerts effective antitumor efficacy in gastric cancer immunotherapy Research Paper

Weiguo Wang, Weidan Ji, Huanzhang Hu, Juming Ma, Xiaoya Li, Weiqun Mei, Yang Xu, Hui-Zhen Hu, Yan Yan, Qizhe Song, Zhigang Li, Changqing Su

Published Dec 28, 2013 · Vol. 5, No. 1 · pp. 150-160

Keywords: Gastric cancer, Survivin gene, Heat shock protein, Oncolytic adenovirus, Gene therapy

Celecoxib suppresses hepatoma stemness and progression by up-regulating PTEN Research Paper

Tian-Huei Chu, Hoi-Hung Chan, Hsiao-Mei Kuo, Li-Fen Liu, Tsung-Hui Hu, Cheuk-Kwan Sun, Mei-Lang Kung, Shih-Wei Lin, E-Ming Wang, Yi-Ling Ma, Kwan-Hung Cheng, Kwok-Hung Lai, Zhi-Hong Wen, Ping-I Hsu, Ming-Hong Tai

Published Dec 28, 2013 · Vol. 5, No. 6 · pp. 1475-1490

Keywords: hepatocellular carcinoma, hepatic cancer stem cells, celecoxib, prostaglandin E2, phosphatase and tensin homolog

Rac1b negatively regulates TGF-Î²1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling Research Paper

Hendrik Ungefroren, Susanne Sebens, Klaudia Giehl, Ole Helm, Stephanie Groth, Fred Faendrich, Christoph Roecken, Bence Sipos, Hendrik Lehnert, Frank Gieseler

Published Dec 23, 2013 · Vol. 5, No. 1 · pp. 277-290

Keywords: Rac1b, Rac1, Smad, TGF-beta1, pancreatic ductal adenocarcinoma, cell migration

Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-ÎºB regulated gene products in multiple myeloma xenograft mouse model Research Paper

Kodappully Sivaraman Siveen, Nurulhuda Mustafa, Feng Li, Radhamani Kannaiyan, Kwang Seok Ahn, Alan Prem Kumar, Wee-Joo Chng, Gautam Sethi

Published Dec 18, 2013 · Vol. 5, No. 3 · pp. 634-648

Keywords: Thymoquinone, MM, bortezomib, apoptosis, NF-ÎºB

NF2/Merlin in hereditary neurofibromatosis 2 versus cancer: biologic mechanisms and clinical associations Review

Rebecca Dunbar Schroeder, Laura S. Angelo, Razelle Kurzrock

Published Dec 17, 2013 · Vol. 5, No. 1 · pp. 67-77

Keywords: NF2, Nuerofibromatosis 2, Cancer, Mutations

Capturing the biological impact of CDKN2A and MC1R genes as an early predisposing event in melanoma and non melanoma skin cancer. Research Paper

MarÃa JosÃ© Escamez, Francisco Garcia-Garcia, Gemma Tell-Marti, Angels Fabra, LucÃa MartÃnez-SantamarÃa, Celia Badenas, Paula Aguilera, Marta Pevida, JoaquÃn Dopazo, Marcela del RÃo, Susana Puig

Published Dec 16, 2013 · Vol. 5, No. 6 · pp. 1439-1451

Keywords: Familial Melanoma, CDKN2A, MC1R, gene expression, p16, mutations

Anti-oxidative stress response genes: bioinformatic analysis of their expression and relevance in multiple cancers Research Perspective

Barak Rotblat, Thomas G. P. Grunewald, Gabriel Leprivier, Gerry Melino, Richard A. Knight

Published Dec 15, 2013 · Vol. 4, No. 12 · pp. 2577-2590

Keywords: anti-oxidant genes, glutathione, thioredoxin, breast cancer, lung cancer, NRF2, G6PD

LZTS1 downregulation confers paclitaxel resistance and is associated with worse prognosis in breast cancer Research Paper

Francesca Lovat, Hideshi Ishii, Monica Schiappacassi, Matteo Fassan, Mattia Barbareschi, Enzo Galligioni, Pierluigi Gasparini, Gustavo Baldassarre, Carlo M. Croce, Andrea Vecchione

Published Dec 14, 2013 · Vol. 5, No. 4 · pp. 970-977

Keywords: Lzts1/Fez1, breast cancer, taxanes

A loss-of-function mutation in PTCH1 suggests a role for autocrine hedgehog signaling in colorectal tumorigenesis Brief Reports

Jon H. Chung, Fred Bunz

Published Dec 11, 2013 · Vol. 4, No. 12 · pp. 2208-2211

Keywords: Hedgehog, colorectal cancer, Patched, vismodegib, autocrine

EFEMP1 induces Î³-secretase/Notch-mediated temozolomide resistance in glioblastoma Research Paper

Lotte Hiddingh, Bakhos A. Tannous, Jian Teng, Bas Tops, Judith Jeuken, Esther Hulleman, Sandra H. Boots-Sprenger, W. Peter Vandertop, David P. Noske, Gertjan J.L. Kaspers, Pieter Wesseling, Thomas Wurdinger

Published Dec 7, 2013 · Vol. 5, No. 2 · pp. 363-374

Keywords: Temozolomide resistance, glioblastoma, EFEMP1, Î³-secretase, Notch, GSI

ERG induces a mesenchymal-like state associated with chemoresistance in leukemia cells Research Paper

Liliana H. Mochmann, Martin Neumann, Eva K. von Der Heide, Verena Nowak, Anja A. KÃ¼hl, Jutta Ortiz-Tanchez, Juliane Bock, Wolf K Hofmann, Claudia D Baldus

Published Dec 4, 2013 · Vol. 5, No. 2 · pp. 351-362

Keywords: ERG, ERK, EMT, Chemoresistance

FAM83D promotes cell proliferation and motility by downregulating tumor suppressor gene FBXW7 Research Paper

Zeran Wang, Yueyong Liu, Pengju Zhang, Weiguo Zhang, Weijing Wang, Kenneth Curr, Guangwei Wei, Jian-Hua Mao

Published Nov 25, 2013 · Vol. 4, No. 12 · pp. 2476-2486

Keywords: FAM83D, FBXW7, breast cancer, epithelial-mesenchymal transition, invasion

Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-ÐºB target genes in human breast cancer Research Paper

Alba Dalmases, Irene Gonzalez-Navarrete, Silvia Menendez, Oriol ArpÃ, Josep Maria Coromines, Sonia Servitja, Ignasi Tusquets, Cristina Chamizo, RaÃºl RincÃ³n, LluÃs Espinosa, Anna Bigas, Pilar Eroles, Jessica Furriol, Anna Lluch, Ana Rovira, Joan Albanell, Federico Rojo

Published Nov 23, 2013 · Vol. 5, No. 1 · pp. 196-210

Keywords: breast cancer, chemoresistance, NF-ÐºB, p53, prognosis

Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer. Research Paper

Anastasia Wyce, Yan Degenhardt, Yuchen Bai, BaoChau Le, Susan Korenchuk, Ming-Chih Crouthamel, Charles McHugh, Robert Vessella, Caretha Creasy, Peter Tummino, Olena Barbash

Published Nov 23, 2013 · Vol. 4, No. 12 · pp. 2419-2429

Keywords: BET inhibitor, prostate cancer, c-Myc

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Targeting CDC25C, PLK1 and CHEK1 to overcome Docetaxel resistance induced by loss of LZTS1 in prostate cancer Research Paper

C-kit induces epithelialâ€“mesenchymal transition and contributes to salivary adenoid cystic cancer progression Research Paper

Preferred binding of gain-of-function mutant p53 to bidirectional promoters with coordinated binding of ETS1 and GABPA to multiple binding sites Research Paper

Frequent amplification of ORAOV1 gene in esophageal squamous cell cancer promotes an aggressive phenotype via proline metabolism and ROS production Research Paper

Poly (ADP-ribose) polymerase 1 transcriptional regulation: A novel crosstalk between histone modification H3K9ac and ETS1 motif hypomethylation in BRCA1-mutated ovarian cancer Research Paper

CITED1 confers stemness to Wilms tumor and enhances tumorigenic responses when enriched in the nucleus Research Paper

Survivin promoter-regulated oncolytic adenovirus with Hsp70 gene exerts effective antitumor efficacy in gastric cancer immunotherapy Research Paper

Celecoxib suppresses hepatoma stemness and progression by up-regulating PTEN Research Paper

Rac1b negatively regulates TGF-Î²1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling Research Paper

Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-ÎºB regulated gene products in multiple myeloma xenograft mouse model Research Paper

NF2/Merlin in hereditary neurofibromatosis 2 versus cancer: biologic mechanisms and clinical associations Review

Capturing the biological impact of CDKN2A and MC1R genes as an early predisposing event in melanoma and non melanoma skin cancer. Research Paper

Anti-oxidative stress response genes: bioinformatic analysis of their expression and relevance in multiple cancers Research Perspective

LZTS1 downregulation confers paclitaxel resistance and is associated with worse prognosis in breast cancer Research Paper

A loss-of-function mutation in PTCH1 suggests a role for autocrine hedgehog signaling in colorectal tumorigenesis Brief Reports

EFEMP1 induces Î³-secretase/Notch-mediated temozolomide resistance in glioblastoma Research Paper

ERG induces a mesenchymal-like state associated with chemoresistance in leukemia cells Research Paper

FAM83D promotes cell proliferation and motility by downregulating tumor suppressor gene FBXW7 Research Paper

Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-ÐºB target genes in human breast cancer Research Paper

Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer. Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Targeting CDC25C, PLK1 and CHEK1 to overcome Docetaxel resistance induced by loss of LZTS1 in prostate cancer Research Paper

C-kit induces epithelialâ€“mesenchymal transition and contributes to salivary adenoid cystic cancer progression Research Paper

Preferred binding of gain-of-function mutant p53 to bidirectional promoters with coordinated binding of ETS1 and GABPA to multiple binding sites Research Paper

Frequent amplification of ORAOV1 gene in esophageal squamous cell cancer promotes an aggressive phenotype via proline metabolism and ROS production Research Paper

Poly (ADP-ribose) polymerase 1 transcriptional regulation: A novel crosstalk between histone modification H3K9ac and ETS1 motif hypomethylation in BRCA1-mutated ovarian cancer Research Paper

CITED1 confers stemness to Wilms tumor and enhances tumorigenic responses when enriched in the nucleus Research Paper

Survivin promoter-regulated oncolytic adenovirus with Hsp70 gene exerts effective antitumor efficacy in gastric cancer immunotherapy Research Paper

Celecoxib suppresses hepatoma stemness and progression by up-regulating PTEN Research Paper

Rac1b negatively regulates TGF-Î²1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling Research Paper

Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-ÎºB regulated gene products in multiple myeloma xenograft mouse model Research Paper

NF2/Merlin in hereditary neurofibromatosis 2 versus cancer: biologic mechanisms and clinical associations Review

Capturing the biological impact of CDKN2A and MC1R genes as an early predisposing event in melanoma and non melanoma skin cancer. Research Paper

Anti-oxidative stress response genes: bioinformatic analysis of their expression and relevance in multiple cancers Research Perspective

LZTS1 downregulation confers paclitaxel resistance and is associated with worse prognosis in breast cancer Research Paper

A loss-of-function mutation in PTCH1 suggests a role for autocrine hedgehog signaling in colorectal tumorigenesis Brief Reports

EFEMP1 induces Î³-secretase/Notch-mediated temozolomide resistance in glioblastoma Research Paper

ERG induces a mesenchymal-like state associated with chemoresistance in leukemia cells Research Paper

FAM83D promotes cell proliferation and motility by downregulating tumor suppressor gene FBXW7 Research Paper

Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-ÐºB target genes in human breast cancer Research Paper

Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer. Research Paper