The Oncosearch | Oncotarget

The proto-oncogene KRAS is targeted by miR-200c Research Paper

Florian Kopp, Ernst Wagner, Andreas Roidl

Published Nov 24, 2013 · Vol. 5, No. 1 · pp. 185-195

Keywords: breast cancer, lung cancer, miRNA, K-ras, cell cycle, proliferation

Dietary protein restriction inhibits tumor growth in human xenograft models of prostate and breast cancer Research Paper

Luigi Fontana, Remi M. Adelaiye, Antonella L. Rastelli, Kiersten Marie Miles, Eric Ciamporcero, Valter D. Longo, Holly Nguyen, Robert Vessella, Roberto Pili

Published Nov 23, 2013 · Vol. 4, No. 12 · pp. 2451-2461

Keywords: Protein diet restriction, prostate cancer, breast cancer

Chloroquine synergizes with FTS to enhance cell growth inhibition and cell death Research Paper

Eran Schmukler, Eya Wolfson, Roni Haklai, Galit Elad-Sfadia, Yoel Kloog, Ronit Pinkas-Kramarski

Published Nov 20, 2013 · Vol. 5, No. 1 · pp. 173-184

Keywords: Autophagy, Ras, Transformation, signal transduction.

A novel androgen-regulated isoform of the TSC2 tumour suppressor gene increases cell proliferation Research Paper

Jennifer Munkley, Prabhakar Rajan, Nicholas P. Lafferty, Caroline Dalgliesh, Robert M. Jackson, Craig N. Robson, Hing Y. Leung, David J. Elliott

Published Oct 21, 2013 · Vol. 5, No. 1 · pp. 131-139

Keywords: TSC2, mTOR, mRNA isoform, androgen, prostate cancer

The genetic landscape of anaplastic astrocytoma Research Paper

Patrick J. Killela, Christopher J. Pirozzi, Zachary J. Reitman, Sian Jones, B. Ahmed Rasheed, Eric Lipp, Henry Friedman, Allan H. Friedman, Yiping He, Roger E. McLendon, Darell D. Bigner, Hai Yan

Published Oct 16, 2013 · Vol. 5, No. 6 · pp. 1452-1457

Keywords: Exome sequencing, Anaplastic Astrocytoma, Notch

Broad-spectrum anti-tumor and anti-metastatic DNA vaccine based on p62-encoding vector Research Paper

Franco Venanzi, Victor Shifrin, Michael Y. Sherman, Vladimir Gabai, Oleg Kisilev, Andrey Komissarov, Mikhail Grudinin, Maria Shartakova, Ekaterina Romanovskaya-Romanko, Yuri Kudryavets, Natalya Bezdenezhnykh, Oleksandra Lykhova, Nadiia Semesyuk, Antonio Concetti, Anatoly Tsyb, Marina Filimonova, Victoria Makarchuk, Raisa Yakubovsky, Andrey Chursov, Vita Shcherbinina, Alexander Shneider

Published Oct 2, 2013 · Vol. 4, No. 10 · pp. 1829-1835

Keywords: cancer immunotherapy, DNA vaccine, autophagy, metastases

DHH-RHEBL1 fusion transcript: a novel recurrent feature in the new landscape of pediatric CBFA2T3-GLIS2-positive acute myeloid leukemia Research Paper

Riccardo Masetti, Marco Togni, Annalisa Astolfi, Martina Pigazzi, Elena Manara, Valentina Indio, Carmelo Rizzari, Sergio Rutella, Giuseppe Basso, Andrea Pession, Franco Locatelli

Published Sep 7, 2013 · Vol. 4, No. 10 · pp. 1712-1720

Keywords: pediatric acute myeloid leukemia, citogenetically normal acute myeloid leuekemia, whole-transcriptome massively parallel sequencing, CBFA2T3-GLIS2 fusion transcript, DHH-RHEBL1 fusion transcript.

Exomic Sequencing of Four Rare Central Nervous System Tumor Types Research Paper

Chetan Bettegowda, Nishant Agrawal, Yuchen Jiao, Yuxuan Wang, Laura D. Wood, Fausto J. Rodriguez, Ralph H. Hruban, Gary L. Gallia, Zev A. Binder, Callen J. Riggins, Vafi Salmasi, Gregory J. Riggins, Zachary J. Reitman, Ahmed Rasheed, Stephen Keir, Sueli Shinjo, Suely Marie, Roger McLendon, George Jallo, Bert Vogelstein, Darrell Bigner, Hai Yan, Kenneth W. Kinzler, Nickolas Papadopoulos

Published Apr 6, 2013 · Vol. 4, No. 4 · pp. 572-583

Keywords: CNS tumors, PXA, GBM, ependymoma, exomic sequencing, BRAF, mTOR

Tumorigenic potential of circulating prostate tumor cells Research Paper

Filipe LF. Carvalho, Brian W. Simons, Emmanuel S. Antonarakis, Zeshaan Rasheed, Nora Douglas, Daniela Villegas, William Matsui, David M. Berman

Published Mar 5, 2013 · Vol. 4, No. 3 · pp. 413-421

Keywords: Circulating tumor cells, EpCAM, prostate cancer, prostate-specific antigen, TRAMP mouse

Growth of poorly differentiated endometrial carcinoma is inhibited by combined action of medroxyprogesterone acetate and the Ras inhibitor Salirasib Research Paper

Raya Faigenbaum, Roni Haklai, Gilad Ben-Baruch, Yoel Kloog

Published Feb 27, 2013 · Vol. 4, No. 2 · pp. 316-328

Keywords: Endometrial cancer, medroxyprogesterone acetate, FTS, Ras, ERÎ±, ERÎ²

Ras inhibition boosts galectin-7 at the expense of galectin-1 to sensitize cells to apoptosis Research Paper

Batya Barkan, Adrienne D. Cox, Yoel Kloog

Published Feb 24, 2013 · Vol. 4, No. 2 · pp. 256-268

Keywords: : apoptosis, c-jun, farnesylthiosalicylic acid, FTS, galectin-1, galectin -7, JDP2, NF1, p53, Ras, Salirasib, neurofibromin, NF1

TRAIL induces apoptosis in oral squamous carcinoma cells: a crosstalk with oncogenic Ras regulated cell surface expression of death receptor 5 Research Paper

Jun-jie Chen, Constantinos M. Mikelis, Yaqin Zhang, J. Silvio Gutkind, Baolin Zhang

Published Feb 23, 2013 · Vol. 4, No. 2 · pp. 206-217

Keywords: oral cancer, TRAIL, death receptors, apoptosis, Ras, oncotarget

Ras inhibition enhances autophagy, which partially protects cells from death Research Paper

Eran Schmukler, Efrat Grinboim, Sari Schokoroy, Adva Amir, Eya Wolfson, Yoel Kloog, Ronit Pinkas-Kramarski

Published Jan 19, 2013 · Vol. 4, No. 1 · pp. 142-152

Keywords: autophagy, Ras, transformation, signal transduction

Dual EGFR inhibition in combination with anti-VEGF treatment: A phase I clinical trial in non-small cell lung cancer Research Paper

Gerald S. Falchook, Aung Naing, David S. Hong, Ralph G. Zinner, Siqing Fu, Sarina A. Piha-Paul, Apostolia M. Tsimberidou, Sonia K. Morgan-Linnell, Yunfang Jiang, Christel C. Bastida, Jennifer J. Wheler, Razelle Kurzrock

Published Jan 14, 2013 · Vol. 4, No. 1 · pp. 118-127

Simalikalactone E (SkE), a new weapon in the armamentarium of drugs targeting cancers that exhibit constitutive activation of the ERK pathway Research Paper

Guillaume Robert, ValÃ©rie Jullian, Arnaud Jacquel, ClÃ©mence Ginet, Maeva Dufies, Stephanie Torino, AnaÃ¯s Pottier, Frederic Peyrade, Sophie Tartare-Deckert, GeneviÃ¨ve Bourdy, Eric Deharo, Patrick Auberger

Published Dec 30, 2012 · Vol. 3, No. 12 · pp. 1688-1699

Keywords: Simalikalactone E, B-Raf inhibitor, CML, Melanoma, Hairy Cell Leukemia, ERK pathway

Superior efficacy of co-treatment with dual PI3K/mTOR inhibitor NVP-BEZ235 and pan-histone deacetylase inhibitor against human pancreatic cancer Research Paper

Sreedhar Venkannagari, Warren Fiskus, Karissa Peth, Peter Atadja, Manuel Hidalgo, Anirban Maitra, Kapil N Bhalla

Published Nov 15, 2012 · Vol. 3, No. 11 · pp. 1416-1427

Keywords: Pancreatic cancer, pan-HDAC inhibitor, BEZ235, mTOR, AKT

Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity Research Paper

Hung-Ju Shih, Hsiao-Huei Chen, Yen-An Chen, Meng-Hsun Wu, Gan-Guang Liou, Wei-Wen Chang, Linyi Chen, Lu-Hai Wang, Hsin-Ling Hsu

Published Nov 9, 2012 · Vol. 3, No. 11 · pp. 1401-1415

Keywords: MCT-1, Shc, Ras, ERK, apoptosis, tumor

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance Review

James Andrew McCubrey, Linda S. Steelman, William H. Chappell, Stephen L. Abrams, Richard A. Franklin, Giuseppe Montalto, Melchiorre Cervello, Massimo Libra, Saverio Candido, Grazia Malaponte, Maria C. Mazzarino, Paolo Fagone, Ferdinando Nicoletti, JÃ¶rg BÃ¤secke, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Michele Milella, Agostino Tafuri, Francesca Chiarini, Camilla Evangelisti, Lucio Cocco, Alberto M. Martelli

Published Oct 20, 2012 · Vol. 3, No. 10 · pp. 1068-1111

Keywords: Targeted Therapy, Therapy Resistance, Cancer Stem Cells, Raf, Akt, PI3K, mTOR

Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer Research Paper

Lydia Kriegl, Michael Vieth, Thomas Kirchner, Antje Menssen

Published Oct 3, 2012 · Vol. 3, No. 10 · pp. 1182-1193

Keywords: Serrated route, colorectal cancer, SIRT1, c-MYC, BRAF and KRAS mutation, wnt signalling

Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response. Review

James Andrew McCubrey, Linda Steeman, William Chappell, Stephen Abrams, Giuseppe Montalto, Melchiorre Cervello, Ferdinando Nicoletti, Paolo Fagone, Grazia Malaponte, Maria Mazzarino, Saverio Candido, Massimo Libra, Jorg Basecke, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Michele Milella, Agostino Tafuri, Lucio Cocco, Camilla Evangelisti, Francesca Chiarini, Alberto Martelli

Published Sep 20, 2012 · Vol. 3, No. 9 · pp. 954-987

Keywords: targeted therapy, therapy resistance, mutations, Raf, Akt, PI3K, mTOR

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The proto-oncogene KRAS is targeted by miR-200c Research Paper

Dietary protein restriction inhibits tumor growth in human xenograft models of prostate and breast cancer Research Paper

Chloroquine synergizes with FTS to enhance cell growth inhibition and cell death Research Paper

A novel androgen-regulated isoform of the TSC2 tumour suppressor gene increases cell proliferation Research Paper

The genetic landscape of anaplastic astrocytoma Research Paper

Broad-spectrum anti-tumor and anti-metastatic DNA vaccine based on p62-encoding vector Research Paper

DHH-RHEBL1 fusion transcript: a novel recurrent feature in the new landscape of pediatric CBFA2T3-GLIS2-positive acute myeloid leukemia Research Paper

Exomic Sequencing of Four Rare Central Nervous System Tumor Types Research Paper

Tumorigenic potential of circulating prostate tumor cells Research Paper

Growth of poorly differentiated endometrial carcinoma is inhibited by combined action of medroxyprogesterone acetate and the Ras inhibitor Salirasib Research Paper

Ras inhibition boosts galectin-7 at the expense of galectin-1 to sensitize cells to apoptosis Research Paper

TRAIL induces apoptosis in oral squamous carcinoma cells: a crosstalk with oncogenic Ras regulated cell surface expression of death receptor 5 Research Paper

Ras inhibition enhances autophagy, which partially protects cells from death Research Paper

Dual EGFR inhibition in combination with anti-VEGF treatment: A phase I clinical trial in non-small cell lung cancer Research Paper

Simalikalactone E (SkE), a new weapon in the armamentarium of drugs targeting cancers that exhibit constitutive activation of the ERK pathway Research Paper

Superior efficacy of co-treatment with dual PI3K/mTOR inhibitor NVP-BEZ235 and pan-histone deacetylase inhibitor against human pancreatic cancer Research Paper

Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity Research Paper

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance Review

Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer Research Paper

Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response. Review

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

The proto-oncogene KRAS is targeted by miR-200c Research Paper

Dietary protein restriction inhibits tumor growth in human xenograft models of prostate and breast cancer Research Paper

Chloroquine synergizes with FTS to enhance cell growth inhibition and cell death Research Paper

A novel androgen-regulated isoform of the TSC2 tumour suppressor gene increases cell proliferation Research Paper

The genetic landscape of anaplastic astrocytoma Research Paper

Broad-spectrum anti-tumor and anti-metastatic DNA vaccine based on p62-encoding vector Research Paper

DHH-RHEBL1 fusion transcript: a novel recurrent feature in the new landscape of pediatric CBFA2T3-GLIS2-positive acute myeloid leukemia Research Paper

Exomic Sequencing of Four Rare Central Nervous System Tumor Types Research Paper

Tumorigenic potential of circulating prostate tumor cells Research Paper

Growth of poorly differentiated endometrial carcinoma is inhibited by combined action of medroxyprogesterone acetate and the Ras inhibitor Salirasib Research Paper

Ras inhibition boosts galectin-7 at the expense of galectin-1 to sensitize cells to apoptosis Research Paper

TRAIL induces apoptosis in oral squamous carcinoma cells: a crosstalk with oncogenic Ras regulated cell surface expression of death receptor 5 Research Paper

Ras inhibition enhances autophagy, which partially protects cells from death Research Paper

Dual EGFR inhibition in combination with anti-VEGF treatment: A phase I clinical trial in non-small cell lung cancer Research Paper

Simalikalactone E (SkE), a new weapon in the armamentarium of drugs targeting cancers that exhibit constitutive activation of the ERK pathway Research Paper

Superior efficacy of co-treatment with dual PI3K/mTOR inhibitor NVP-BEZ235 and pan-histone deacetylase inhibitor against human pancreatic cancer Research Paper

Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity Research Paper

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance Review

Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer Research Paper

Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response. Review