The Oncosearch | Oncotarget

Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas Research Paper

Yuchen Jiao, Patrick J. Killela, Zachary J. Reitman, B.Ahmed Rasheed, Christopher M. Heaphy, Roeland F. de Wilde, Fausto J. Rodriguez, Sergio Rosemberg, Sueli Meiko Obashinjo, Suely Kazue Nagahashi Marie, Chetan Bettegowda, Nishant Agrawal, Eric Lipp, Christopher Pirozzi, Giselle Lopez, Yiping He, Henry Friedman, Allan H. Friedman, Gregory J. Riggins, Matthias Holdhoff, Peter Burger, Roger McLendon, Darell D. Bigner, Bert Vogelstein, Alan K. Meeker, Kenneth W. Kinzler, Nickolas Papadopoulos, Luis A. Diaz, Jr., Hai Yan

Published Aug 3, 2012 · Vol. 3, No. 7 · pp. 709-722

Keywords: ALT, IDH1, IDH2, Mixed Gliomas

The response to PAK1 inhibitor IPA3 distinguishes between cancer cells with mutations in BRAF and Ras oncogenes Research Paper

Ruchi Singhal, Eugene S. Kandel

Published Jul 31, 2012 · Vol. 3, No. 7 · pp. 700-708

Keywords: IPA3, PAK1, BRAF, NRAS, KRAS, melanoma, colon cancer, GDC-0879, AZD6244

Computer-Based Identification of a Novel LIMK1/2 Inhibitor that Synergizes with Salirasib to Destabilize the Actin Cytoskeleton Research Paper

Efrat Mashiach Farkash, Roni Rak, Galit Elad-Sfadia, Roni Haklai, Shmuel Carmeli, Yoel Kloog, Haim Wolfson

Published Jul 7, 2012 · Vol. 3, No. 6 · pp. 629-639

Keywords: Cofilin, Ras, Rac, Rho, LIMK

Methylation profiling of normal individuals reveals mosaic promoter methylation of cancer-associated genes. Research Paper

Lasse S. Kristensen, Michael P. Raynor, Ida L. Candiloro, Alexander Dobrovic

Published May 8, 2012 · Vol. 3, No. 4 · pp. 450-461

Keywords: DNA methylation, epigenetics, biomarkers, high-resolution melting (HRM), methylation-specific PCR (MSP), constitutional methylation

Aggressiveness of human melanoma xenograft models is promoted by aneuploidy-driven gene expression deregulation Research Paper

Veronique Mathieu, Christine Pirker, Wolfgang M Schmidt, Sabine Spiegl-Kreinecker, Daniela LÃ¶tsch, Petra Heffeter, Balazs Hegedus, Michael Grusch, Robert Kiss, Walter Berger

Published Apr 24, 2012 · Vol. 3, No. 4 · pp. 399-413

Keywords: malignant melanoma, aneuploidy, xenograft, aggressiveness, integrative genomics

Targeted therapy for hepatocellular carcinoma: novel agents on the horizon Review

Melchiorre Cervello, James A McCubrey, Antonella Cusimano, Nadia Lampiasi, Antonina Azzolina, Giuseppe Montalto

Published Mar 31, 2012 · Vol. 3, No. 3 · pp. 236-260

Keywords: HCC, signaling pathways, EGF/EGFR, Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR, Wnt/Î²-catenin

Targeting Mnks for Cancer Therapy Review

Jinqiang Hou, Frankie Kam, Christopher G Proud, Shudong Wang

Published Mar 3, 2012 · Vol. 3, No. 2 · pp. 118-131

Keywords: eIF4E, Mnk, Ras, Raf, MAPK, Akt, PI3K, mTOR, Targeted Cancer Therapy, Structure based drug design, Mnk Inhibitors

Ras inhibition by FTS attenuates brain tumor growth in mice directly and by enhancing reactivity of cytotoxic lymphocytes Research Paper

Elizabeta Aizman, Adi Mor, Ayelet Levy, Jacob George, Yoel Kloog

Published Feb 7, 2012 · Vol. 3, No. 2 · pp. 144-157

Keywords: Ras, Glioblastoma, CTL, FTS, Salirasib

Identification of a chrXq27.3 microRNA cluster associated with early relapse in advanced stage ovarian cancer patients Research Paper

Marina Bagnoli, Loris De Cecco, Anna Granata, Roberta Nicoletti, Edoardo Marchesi, Paola Alberti, Barbara Valeri, Massimo Libra, Mattia Barbareschi, Francesco Raspagliesi, Delia Mezzanzanica, Silvana Canevari

Published Dec 31, 2011 · Vol. 2, No. 12 · pp. 1265-1278

Keywords: advanced-stage ovarian cancer, early relapse, microRNA profiling, miR-506, cisplatin, miR-513a-5p, miR-513b.

Targeting Autophagy Addiction in Cancer Research Perspective

Joseph D. Mancias, Alec C. Kimmelman

Published Dec 19, 2011 · Vol. 2, No. 12 · pp. 1302-1306

Keywords: Autophagy, Ras, Metabolism, Cancer, tumor, therapy

Cooperative Effects of Akt-1 and Raf-1 on the Induction of Cellular Senescence in Doxorubicin or Tamoxifen Treated Breast Cancer Cells Research Paper

Jackson R. Taylor, Brian D. Lehmann, William H. Chappell, Stephen L. Abrams, Linda S. Steelman, James A. McCubrey

Published Aug 30, 2011 · Vol. 2, No. 8 · pp. 610-626

Keywords: Akt, ERK, mTOR, Senescence, Drug Resistance, Tamoxifen

The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer Research Perspective

Tapati Mazumdar, Jennifer DeVecchio, Akwasi Agyeman, Ting Shi, Janet A. Houghton

Published Aug 21, 2011 · Vol. 2, No. 8 · pp. 638-645

Keywords: Hedgehog signaling, Colon carcinoma, DNA damage

Involvement of Akt-1 and mTOR in Sensitivity of Breast Cancer to Targeted Therapy Research Paper

Melissa L. Sokolosky, Kristin M. Stadelman, William H. Chappell, Stephen L. Abrams, Alberto M. Martelli, Franca Stivala, Massimo Libra, Ferdinando Nicoletti, Lyudmyla B. Drobot, Richard A. Franklin, Linda S. Steelman, James A. McCubrey

Published Jul 1, 2011 · Vol. 2, No. 7 · pp. 538-550

Keywords: Akt, mTOR, Targeted Therapy, Drug Resistance

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health Review

William H. Chappell, Linda S. Steelman, Jacquelyn M. Long, Ruth C. Kempf, Stephen L. Abrams, Richard A. Franklin, JÃ¶rg BÃ¤secke, Franca Stivala, Marco Donia, Paolo Fagone, Graziella Malaponte, Maria C. Mazzarino, Ferdinando Nicoletti, Massimo Libra, Danijela Maksimovic-Ivanic, Sanja Mijatovic, Giuseppe Montalto, Melchiorre Cervello, Piotr Laidler, Michele Milella, Agostino Tafuri, Antonio Bonati, Camilla Evangelisti, Lucio Cocco, Alberto M. Martelli, James A. McCubrey

Published Mar 11, 2011 · Vol. 2, No. 3 · pp. 135-164

Keywords: Targeted Therapy, Combination Therapy, Drug Resistance, Cancer Stem Cells, Aging, Senescence, Raf, Akt, PI3K, mTOR

Role of dual PI3/Akt and mTOR inhibition in Waldenstrom's Macroglobulinemia Review

Antonio Sacco, Aldo Roccaro, Irene M. Ghobrial

Published Nov 17, 2010 · Vol. 1, No. 7 · pp. 578-582

Addiction of MYCN amplified tumours to B-MYB underscores a reciprocal regulatory loop Research Paper

Francesco Gualdrini, Daisy Corvetta, Sandra Cantilena, Olesya Chayka, Barbara Tanno, Giuseppe RaschellÃ, Arturo Sala

Published Aug 4, 2010 · Vol. 1, No. 4 · pp. 278-288

Smooth muscle Î±-actin is a direct target of PLZF: effects on the cytoskeleton and on susceptibility to oncogenic transformation Research Paper

Jin Shi, Minghao Sun, Peter K. Vogt

Published May 1, 2010 · Vol. 1, No. 1 · pp. 9-21

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Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas Research Paper

The response to PAK1 inhibitor IPA3 distinguishes between cancer cells with mutations in BRAF and Ras oncogenes Research Paper

Computer-Based Identification of a Novel LIMK1/2 Inhibitor that Synergizes with Salirasib to Destabilize the Actin Cytoskeleton Research Paper

Methylation profiling of normal individuals reveals mosaic promoter methylation of cancer-associated genes. Research Paper

Aggressiveness of human melanoma xenograft models is promoted by aneuploidy-driven gene expression deregulation Research Paper

Targeted therapy for hepatocellular carcinoma: novel agents on the horizon Review

Targeting Mnks for Cancer Therapy Review

Ras inhibition by FTS attenuates brain tumor growth in mice directly and by enhancing reactivity of cytotoxic lymphocytes Research Paper

Identification of a chrXq27.3 microRNA cluster associated with early relapse in advanced stage ovarian cancer patients Research Paper

Targeting Autophagy Addiction in Cancer Research Perspective

Cooperative Effects of Akt-1 and Raf-1 on the Induction of Cellular Senescence in Doxorubicin or Tamoxifen Treated Breast Cancer Cells Research Paper

The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer Research Perspective

Involvement of Akt-1 and mTOR in Sensitivity of Breast Cancer to Targeted Therapy Research Paper

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health Review

Role of dual PI3/Akt and mTOR inhibition in Waldenstrom's Macroglobulinemia Review

Addiction of MYCN amplified tumours to B-MYB underscores a reciprocal regulatory loop Research Paper

Smooth muscle Î±-actin is a direct target of PLZF: effects on the cytoskeleton and on susceptibility to oncogenic transformation Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas Research Paper

The response to PAK1 inhibitor IPA3 distinguishes between cancer cells with mutations in BRAF and Ras oncogenes Research Paper

Computer-Based Identification of a Novel LIMK1/2 Inhibitor that Synergizes with Salirasib to Destabilize the Actin Cytoskeleton Research Paper

Methylation profiling of normal individuals reveals mosaic promoter methylation of cancer-associated genes. Research Paper

Aggressiveness of human melanoma xenograft models is promoted by aneuploidy-driven gene expression deregulation Research Paper

Targeted therapy for hepatocellular carcinoma: novel agents on the horizon Review

Targeting Mnks for Cancer Therapy Review

Ras inhibition by FTS attenuates brain tumor growth in mice directly and by enhancing reactivity of cytotoxic lymphocytes Research Paper

Identification of a chrXq27.3 microRNA cluster associated with early relapse in advanced stage ovarian cancer patients Research Paper

Targeting Autophagy Addiction in Cancer Research Perspective

Cooperative Effects of Akt-1 and Raf-1 on the Induction of Cellular Senescence in Doxorubicin or Tamoxifen Treated Breast Cancer Cells Research Paper

The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer Research Perspective

Involvement of Akt-1 and mTOR in Sensitivity of Breast Cancer to Targeted Therapy Research Paper

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health Review

Role of dual PI3/Akt and mTOR inhibition in Waldenstrom's Macroglobulinemia Review

Addiction of MYCN amplified tumours to B-MYB underscores a reciprocal regulatory loop Research Paper

Smooth muscle Î±-actin is a direct target of PLZF: effects on the cytoskeleton and on susceptibility to oncogenic transformation Research Paper