The Oncosearch | Oncotarget

Cell-based high-throughput screens for the discovery of chemotherapeutic agents Research Perspective

Jennifer T Fox, Kyungiae Myung

Published May 29, 2012 · Vol. 3, No. 5 · pp. 581-585

Keywords: ATAD5-luciferase, genotoxins, DNA repair mutants, cancer, drug discovery

Dramatic reduction of sequence artefacts from DNA isolated from formalin-fixed cancer biopsies by treatment with uracil-DNA glycosylase. Research Paper

Hongdo Do, Alexander Dobrovic

Published May 24, 2012 · Vol. 3, No. 5 · pp. 546-558

Keywords: FFPE, cancer biopsies, sequencing artefacts, EGFR mutation, BRAF mutation, closed-tube analysis

On the presence and role of human gene-body DNA methylation Research Paper

Daudi Jjingo, Andrew B. Conley, Soojin V. Yi, Victoria V. Lunyak, I. King Jordan

Published May 9, 2012 · Vol. 3, No. 4 · pp. 462-474

Keywords: genome-wide methylation, epigenetic mark, intragenic transcription, methylating enzyme complexes

Singular v Dual Inhibition of SNF2L and Its Isoform, SNF2LT, Have Similar Effects on DNA Damage but Opposite Effects on the DNA Damage Response, Cancer Cell Growth Arrest and Apoptosis Research Paper

Yin Ye, Yi Xiao, Wenting Wang, Jian-Xin Gao, Kurtis Yearsley, Quintao Yan, Sanford H. Barsky

Published May 9, 2012 · Vol. 3, No. 4 · pp. 475-489

Keywords: SNF2LT, chromatin remodelling ATPase, cell cycle checkpoints

Methylation profiling of normal individuals reveals mosaic promoter methylation of cancer-associated genes. Research Paper

Lasse S. Kristensen, Michael P. Raynor, Ida L. Candiloro, Alexander Dobrovic

Published May 8, 2012 · Vol. 3, No. 4 · pp. 450-461

Keywords: DNA methylation, epigenetics, biomarkers, high-resolution melting (HRM), methylation-specific PCR (MSP), constitutional methylation

Aggressiveness of human melanoma xenograft models is promoted by aneuploidy-driven gene expression deregulation Research Paper

Veronique Mathieu, Christine Pirker, Wolfgang M Schmidt, Sabine Spiegl-Kreinecker, Daniela LÃ¶tsch, Petra Heffeter, Balazs Hegedus, Michael Grusch, Robert Kiss, Walter Berger

Published Apr 24, 2012 · Vol. 3, No. 4 · pp. 399-413

Keywords: malignant melanoma, aneuploidy, xenograft, aggressiveness, integrative genomics

Comprehensive Assessment of Potential Multiple Myeloma Immunoglobulin Heavy Chain V-D-J Intraclonal Variation Using Massively Parallel Pyrosequencing Methodological Reports

Renee C. Tschumper, Yan W. Asmann, Asif Hossain, Paul M. Huddleston, Xiaosheng Wu, Angela Dispenzieri, Bruce W. Eckloff, Diane F. Jelinek

Published Apr 20, 2012 · Vol. 3, No. 4 · pp. 502-513

Keywords: IGHV, multiple myeloma, massively parallel sequencing

Regulation of p53: a collaboration between Mdm2 and Mdmx Review

Dongsheng Pei, Yanping Zhang, Junnian Zheng

Published Mar 10, 2012 · Vol. 3, No. 3 · pp. 228-235

Inhibition of p53 expression modifies the specificity of chromatin binding by the androgen receptor Research Paper

Natalya V. Guseva, Oskar W. Rokhlin, Thomas B. Bair, Rebecca B. Glover, Michael B. Cohen

Published Feb 29, 2012 · Vol. 3, No. 2 · pp. 183-194

Keywords: androgen receptor, p53, FoxA1, prostate cancer

Gain-of-function p53 mutants have widespread genomic locations partially overlapping with p63. Brief Reports

Elena Martynova, Silvia Pozzi, Valentina Basile, Diletta Dolfini, Federico Zambelli, Carol Imbriano, Giulio Pavesi, Roberto Mantovani

Published Feb 22, 2012 · Vol. 3, No. 2 · pp. 132-143

Keywords: mutant p53, p63, keratinocytes

Novel targeted therapies for mantle cell lymphoma Research Perspective

Lapo Alinari, Beth Christian, Robert Baiocchi

Published Feb 22, 2012 · Vol. 3, No. 2 · pp. 203-211

Regulation of glucose metabolism by p53: Emerging new roles for the tumor suppressor Review

Esha Madan, Rajan Gogna, Madan Bhatt, Uttam Pati, Periannan Kuppusamy, Abbas Ali Mahdi

Published Dec 31, 2011 · Vol. 2, No. 12 · pp. 948-957

Keywords: p53, TIGAR, SCO2, metabolism, senescence, aging

Metformin: Multi-faceted protection against cancer Review

Sonia Del Barco, Alejandro Vazquez-Martin, SÃlvia CufÃ, Cristina Oliveras-Ferraros, Joaquim Bosch-Barrera, Jorge Joven, BegoÃ±a Martin-Castillo, Javier A Menendez

Published Dec 24, 2011 · Vol. 2, No. 12 · pp. 896-917

Keywords: Diabetes, cancer, metformin, cancer stem cells, senescence

TAp73alpha protects small cell lung carcinoma cells from caspase-2 induced mitochondrial mediated apoptotic cell death Research Paper

Naveen Muppani, Ulrika Nyman, Bertrand Joseph

Published Dec 22, 2011 · Vol. 2, No. 12 · pp. 1145-1154

Keywords: p73, caspase-2, cancer, apoptosis

DNA-PKCS binding to p53 on the p21WAF1/CIP1 promoter blocks transcription resulting in cell death Research Paper

Richard Hill, Patricia A. Madureira, David M. Waisman, Patrick W.K. Lee

Published Dec 20, 2011 · Vol. 2, No. 12 · pp. 1094-1108

Keywords: DNA-PKCS, p53, p21 transcription suppression

Targeting Autophagy Addiction in Cancer Research Perspective

Joseph D. Mancias, Alec C. Kimmelman

Published Dec 19, 2011 · Vol. 2, No. 12 · pp. 1302-1306

Keywords: Autophagy, Ras, Metabolism, Cancer, tumor, therapy

PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation Research Paper

Dannis Gilbert Van Vuurden, Esther Hulleman, Olga L.M. Meijer, Laurine E. Wedekind, Marcel Kool, Hendrik Witt, W. Peter Vandertop, Thomas WÃ¼rdinger, David P. Noske, Gertjan J.L. Kaspers, Jacqueline Cloos

Published Dec 15, 2011 · Vol. 2, No. 12 · pp. 984-996

Keywords: PARP, radiation, medulloblastoma, ependymoma, glioma, pediatric

Do AML patients with DNMT3A exon 23 mutations benefit from idarubicin as compared to daunorubicin? A single center experience. Research Paper

Olivier LaRochelle, Sarah Bertoli, FranÃ§ois Vergez, Jean Emmanuel Sarry, VÃ©ronique Mansat-De Mas, Sophie Dobbelstein, Nicole Dastugue, Anne-Claire Strzelecki, Cindy Cavelier, Laurent Creancier, Arnaud Pillon, Anna Kruczynski, Cecile Demur, Audrey Sarry, FranÃ§oise Huguet, Anne Huynh, Christian RÃ©cher, Eric Delabesse

Published Nov 9, 2011 · Vol. 2, No. 11 · pp. 850-861

Keywords: leukemia, DNMT3A, anthracyclins, idarubicin, AML

Expression of FACT in mammalian tissues suggests its role in maintaining of undifferentiated state of cells Research Paper

Henry Garcia, Daria Fleyshman, Kateryna Kolesnikova, Alfiya Safina, Mairead Commane, Geraldine Paszkiewicz, Angela Omelian, Carl Morrison, Katerina Gurova

Published Oct 13, 2011 · Vol. 2, No. 10 · pp. 783-796

Keywords: Key words: chromatin remodeling, transcription, SPT16, SSRP1, cancer, differentiation, proliferation, oncotarget

Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers Research Paper

Michael Christoph Haffner, Alcides Chaux, Alan K Meeker, David Esopi, Jonathan Gerber, Laxmi G. Pellakuru, Antoun Toubaji, Pedram Argani, Christine Iacobuzio-Donahue, William G. Nelson, George J. Netto, Angelo DeMarzo, Srinivasan Yegnasubramanian

Published Sep 2, 2011 · Vol. 2, No. 8 · pp. 627-637

Keywords: 5-hydroxymethylcytosine, 5hmC, DNA methylation, differentiation, cancer, tissue stem / progenitor cells

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Search Oncotarget

Cell-based high-throughput screens for the discovery of chemotherapeutic agents Research Perspective

Dramatic reduction of sequence artefacts from DNA isolated from formalin-fixed cancer biopsies by treatment with uracil-DNA glycosylase. Research Paper

On the presence and role of human gene-body DNA methylation Research Paper

Singular v Dual Inhibition of SNF2L and Its Isoform, SNF2LT, Have Similar Effects on DNA Damage but Opposite Effects on the DNA Damage Response, Cancer Cell Growth Arrest and Apoptosis Research Paper

Methylation profiling of normal individuals reveals mosaic promoter methylation of cancer-associated genes. Research Paper

Aggressiveness of human melanoma xenograft models is promoted by aneuploidy-driven gene expression deregulation Research Paper

Comprehensive Assessment of Potential Multiple Myeloma Immunoglobulin Heavy Chain V-D-J Intraclonal Variation Using Massively Parallel Pyrosequencing Methodological Reports

Regulation of p53: a collaboration between Mdm2 and Mdmx Review

Inhibition of p53 expression modifies the specificity of chromatin binding by the androgen receptor Research Paper

Gain-of-function p53 mutants have widespread genomic locations partially overlapping with p63. Brief Reports

Novel targeted therapies for mantle cell lymphoma Research Perspective

Regulation of glucose metabolism by p53: Emerging new roles for the tumor suppressor Review

Metformin: Multi-faceted protection against cancer Review

TAp73alpha protects small cell lung carcinoma cells from caspase-2 induced mitochondrial mediated apoptotic cell death Research Paper

DNA-PKCS binding to p53 on the p21WAF1/CIP1 promoter blocks transcription resulting in cell death Research Paper

Targeting Autophagy Addiction in Cancer Research Perspective

PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation Research Paper

Do AML patients with DNMT3A exon 23 mutations benefit from idarubicin as compared to daunorubicin? A single center experience. Research Paper

Expression of FACT in mammalian tissues suggests its role in maintaining of undifferentiated state of cells Research Paper

Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Cell-based high-throughput screens for the discovery of chemotherapeutic agents Research Perspective

Dramatic reduction of sequence artefacts from DNA isolated from formalin-fixed cancer biopsies by treatment with uracil-DNA glycosylase. Research Paper

On the presence and role of human gene-body DNA methylation Research Paper

Singular v Dual Inhibition of SNF2L and Its Isoform, SNF2LT, Have Similar Effects on DNA Damage but Opposite Effects on the DNA Damage Response, Cancer Cell Growth Arrest and Apoptosis Research Paper

Methylation profiling of normal individuals reveals mosaic promoter methylation of cancer-associated genes. Research Paper

Aggressiveness of human melanoma xenograft models is promoted by aneuploidy-driven gene expression deregulation Research Paper

Comprehensive Assessment of Potential Multiple Myeloma Immunoglobulin Heavy Chain V-D-J Intraclonal Variation Using Massively Parallel Pyrosequencing Methodological Reports

Regulation of p53: a collaboration between Mdm2 and Mdmx Review

Inhibition of p53 expression modifies the specificity of chromatin binding by the androgen receptor Research Paper

Gain-of-function p53 mutants have widespread genomic locations partially overlapping with p63. Brief Reports

Novel targeted therapies for mantle cell lymphoma Research Perspective

Regulation of glucose metabolism by p53: Emerging new roles for the tumor suppressor Review

Metformin: Multi-faceted protection against cancer Review

TAp73alpha protects small cell lung carcinoma cells from caspase-2 induced mitochondrial mediated apoptotic cell death Research Paper

DNA-PKCS binding to p53 on the p21WAF1/CIP1 promoter blocks transcription resulting in cell death Research Paper

Targeting Autophagy Addiction in Cancer Research Perspective

PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation Research Paper

Do AML patients with DNMT3A exon 23 mutations benefit from idarubicin as compared to daunorubicin? A single center experience. Research Paper

Expression of FACT in mammalian tissues suggests its role in maintaining of undifferentiated state of cells Research Paper

Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers Research Paper