The Oncosearch | Oncotarget

Genome-wide comparison of the transcriptomes of highly enriched normal and chronic myeloid leukemia stem and progenitor cell populations Research Paper

Jonathan M. Gerber, Jessica L. Gucwa, David Esopi, Meltem Gurel, Michael C. Haffner, Milada Vala, William G. Nelson, Richard J. Jones, Srinivasan Yegnasubramanian

Published May 6, 2013 · Vol. 4, No. 5 · pp. 715-728

Keywords: chronic myeloid leukemia, CML, leukemic stem cell, LSC, normal hematopoietic stem cell, HSC, myeloid progenitor cells, CD34, CD38, ALDH, IL2RA, CD25, DPP4, CD26, GAS2

Nuclear DNA Methylation and Chromatin Condensation Phenotypes Are Distinct Between Normally Proliferating/Aging, Rapidly Growing/Immortal, and Senescent Cells Research Paper

Jin Ho Oh, Arkadiusz Gertych, Jian Tajbakhsh

Published Mar 26, 2013 · Vol. 4, No. 3 · pp. 474-493

Keywords: DNA methylation, chromatin condensation, cell proliferation, aging, senescence, cancer, 3D imaging, cell-by-cell analysis

DNA-intercalators Causing Rapid Re-expression of Methylated and Silenced Genes in Cancer Cells Research Paper

M. Zulfiquer Hossain, Megan A. Healey, Calvin Lee, Weijie Poh, Sashidhar R. Yerram, Kalpesh Patel, Nilofer S. Azad, James G. Herman, Scott E. Kern

Published Feb 26, 2013 · Vol. 4, No. 2 · pp. 298-309

Keywords: cancer, gene methylation, demethylation, DNA-intercalator, quinacrine, DNMT inhibitor, epigenetics, silencing and re-activation of gene expression, small molecule-DNA interactions

The limited contribution of DNA methylation to PML-RARÎ± induced leukemia Editorial

Christian Rohde, Till Schoofs, Carsten MÃ¼ller-Tidow

Published Feb 15, 2013 · Vol. 4, No. 1 · pp. 5-6

Altered transcriptome signature of phenotypically normal skin fibroblasts heterozygous for CDKN2A in familial melanoma: relevance to early intervention Research Paper

Meiyun Fan, Susan R. Pfeffer, Henry T. Lynch, Pamela Cassidy, Sancy Leachman, Lawrence M. Pfeffer, Levy Kopelovich

Published Jan 19, 2013 · Vol. 4, No. 1 · pp. 128-141

Keywords: Familial Melanoma, gene expression, CDKN2A, p16, Mutations, Melanoma

STAT5 triggers BCR-ABL1 mutation by mediating ROS production in chronic myeloid leukaemia Research Paper

Wolfgang Warsch, Eva Grundschober, Angelika Berger, Lars Gille, Sabine Cerny-Reiterer, Anca-Sarmiza Tigan, Andrea Hoelbl-Kovacic, Peter Valent, Richard Moriggl, Veronika Sexl

Published Dec 31, 2012 · Vol. 3, No. 12 · pp. 1669-1687

Keywords: BCR-ABL1, Chronic Myeloid Leukaemia, Reactive Oxygen Species, STAT5, mutation

Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes Review

Albert E. Berman, Olga V. Leontieva, Venkatesh Natarajan, James A. McCubrey, Zoya N. Demidenko, Mikhail A. Nikiforov

Published Dec 30, 2012 · Vol. 3, No. 12 · pp. 1522-1532

A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia Research Paper

Francesca Chiarini, Annalisa Lonetti, Gabriella Teti, Ester Orsini, Daniela Bressanin, Alessandra Cappellini, Francesca Ricci, Pier Luigi Tazzari, Andrea Ognibene, Mirella Falconi, Pasqualepaolo Pagliaro, Ilaria Iacobucci, Giovanni Martinelli, Sergio Amadori, James A McCubrey, Alberto M Martelli

Published Dec 18, 2012 · Vol. 3, No. 12 · pp. 1615-1628

Keywords: AML, PI3K/Akt/mTOR signaling, apoptosis, autophagy combination therapy, leukemia initiating cells

The Maintenance of Epigenetic States by p53: The Guardian of the Epigenome Commentary

Arnold J. Levine, Benjamin Greenbaum

Published Dec 11, 2012 · Vol. 3, No. 12 · pp. 1503-1504

PIK3CA Mutations in Advanced Cancers: Characteristics and Outcomes Research Paper

Filip Janku, Jennifer J. Wheler, Aung Naing, Vanda M. T. Stepanek, Gerald S. Falchook, Siqing Fu, Ignacio Garrido-Laguna, Apostolia M. Tsimberidou, Sarina A. Piha-Paul, Stacy L. Moulder, J. Jack Lee, Rajyalakshmi Luthra, David S. Hong, Razelle Kurzrock

Published Nov 30, 2012 · Vol. 3, No. 12 · pp. 1566-1575

Keywords: PIK3CA mutation, phenotypic taxonomy, clinical outcome

Epigenetic Regulation of miRNA-211 by MMP-9 Governs Glioma Cell Apoptosis, Chemosensitivity and Radiosensitivity Research Paper

Swapna Asuthkar, Kiran Kumar Velpula, Chandramu Chetty, Bharathi Gorantla, Jasti S. Rao

Published Nov 16, 2012 · Vol. 3, No. 11 · pp. 1439-1454

Keywords: Matrix metalloproteinase-9 (MMP-9), microRNA-211 (miR-211), Cancer Stem Cells (CSC), Ionizing radiation (IR) and Temozolomide (Tem)

Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN Research Paper

Andrew D Beggs, Enric Domingo, Megan McGregor, Mikael Presz, Elaine Johnstone, Rachel Midgley, David Kerr, Dahmane Oukrif, Marco Novelli, Muti Abulafi, Shirley V Hodgson, Wakkas Fadhil, Mohammed Ilyas, Ian P Tomlinson

Published Oct 28, 2012 · Vol. 3, No. 11 · pp. 1348-1355

Keywords: Double strand break repair, ATM, g-H2AX, colorectal cancer, prognosis

DNA-demethylating and anti-tumor activity of synthetic miR-29b mimics in multiple myeloma Research Paper

Nicola Amodio, Marzia Leotta, Dina Bellizzi, Maria Teresa Di Martino, Patrizia D'Aquila, Marta Lionetti, Fernanda Fabiani, Emanuela Leone, Anna Maria GullÃ, Giuseppe Passarino, Michele Caraglia, Massimo Negrini, Antonino Neri, Antonio Giordano, Pierosandro Tagliaferri, Pierfrancesco Tassone

Published Oct 21, 2012 · Vol. 3, No. 10 · pp. 1246-1258

Keywords: miRNA, miR-29b, multiple myeloma, DNMT

DNA damage-induced activation of ATM promotes Î²-TRCP-mediated Mdm2 ubiquitination and destruction Research Paper

Zhiwei Wang, Hiroyuki Inuzuka, Jiateng Zhong, Hidefumi Fukushima, Lixin Wan, Pengda Liu, Wenyi Wei

Published Sep 11, 2012 · Vol. 3, No. 9 · pp. 1026-1035

Keywords: Mdm2, ATM, CKI, phosphorylation, beta-TRCP, ubiquitination, DNA damage

Genetic and epigenetic loss of microRNA-31 leads to feed-forward expression of EZH2 in melanoma Research Paper

Irfan A Asangani, Paul W Harms, Lois Dodson, Mithil Pandhi, Lakshmi P Kunju, Christopher A Maher, Douglas R Fullen, Timothy M Johnson, Thomas J Giordano, Nallasivam Palanisamy, Arul M Chinnaiyan

Published Aug 31, 2012 · Vol. 3, No. 9 · pp. 1011-1025

Keywords: microRNA-31, melanoma, tumor suppressor, EZH2, DZNep

Regulation of DNA Damage Following Termination of Hedgehog (HH) Survival Signaling at the level of the GLI Genes in Human Colon Cancer Research Paper

AKWASI AGYEMAN, Tapati Mazumdar, Janet A Houghton

Published Aug 20, 2012 · Vol. 3, No. 8 · pp. 854-868

Keywords: Hedgehog, GLI1/2 inhibition, GANT61, DNA damage, colon cancer

Systemic shRNA mediated knock-down of S100A4 in colorectal cancer xenografted mice reduces metastasis formation Research Paper

Mathias Dahlmann, Ulrike Sack, Pia Herrmann, Margit Lemm, Iduna Fichtner, Peter M. Schlag, Ulrike Stein

Published Aug 7, 2012 · Vol. 3, No. 8 · pp. 783-797

Keywords: colorectal, cancer, metastasis, S100A4, RNAi

Circulating tumor-derived mutant mitochondrial DNA: a predictive biomarker of clinical prognosis in human squamous cell carcinoma. Brief Reports

Katsuhiro Uzawa, Takao Baba, Fumihiko Uchida, Masanobu Yamatoji, Atsushi Kasamatsu, Yosuke Sakamoto, Katsunori Ogawara, Masashi Shiiba, Hiroki Bukawa, Hideki Tanzawa

Published Jul 25, 2012 · Vol. 3, No. 7 · pp. 670-677

Keywords: squamous cell carcinoma, mitochondrial DNA, high-resolution melting curve analysis, circulating tumor-derived DNA, prognosis

Mutations in circulating mitochondrial DNA: Cassandra of oral cancer? Editorial

Eugene S. Kandel

Published Jul 24, 2012 · Vol. 3, No. 7 · pp. 664-665

Keywords: mitochondrial DNA, oral cancer, biomarker

Wt p53 impairs response to chemotherapy: make lemonade to spare normal cells Research Perspective

Mikhail V. Blagosklonny

Published Jul 12, 2012 · Vol. 3, No. 6 · pp. 601-607

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Genome-wide comparison of the transcriptomes of highly enriched normal and chronic myeloid leukemia stem and progenitor cell populations Research Paper

Nuclear DNA Methylation and Chromatin Condensation Phenotypes Are Distinct Between Normally Proliferating/Aging, Rapidly Growing/Immortal, and Senescent Cells Research Paper

DNA-intercalators Causing Rapid Re-expression of Methylated and Silenced Genes in Cancer Cells Research Paper

The limited contribution of DNA methylation to PML-RARÎ± induced leukemia Editorial

Altered transcriptome signature of phenotypically normal skin fibroblasts heterozygous for CDKN2A in familial melanoma: relevance to early intervention Research Paper

STAT5 triggers BCR-ABL1 mutation by mediating ROS production in chronic myeloid leukaemia Research Paper

Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes Review

A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia Research Paper

The Maintenance of Epigenetic States by p53: The Guardian of the Epigenome Commentary

PIK3CA Mutations in Advanced Cancers: Characteristics and Outcomes Research Paper

Epigenetic Regulation of miRNA-211 by MMP-9 Governs Glioma Cell Apoptosis, Chemosensitivity and Radiosensitivity Research Paper

Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN Research Paper

DNA-demethylating and anti-tumor activity of synthetic miR-29b mimics in multiple myeloma Research Paper

DNA damage-induced activation of ATM promotes Î²-TRCP-mediated Mdm2 ubiquitination and destruction Research Paper

Genetic and epigenetic loss of microRNA-31 leads to feed-forward expression of EZH2 in melanoma Research Paper

Regulation of DNA Damage Following Termination of Hedgehog (HH) Survival Signaling at the level of the GLI Genes in Human Colon Cancer Research Paper

Systemic shRNA mediated knock-down of S100A4 in colorectal cancer xenografted mice reduces metastasis formation Research Paper

Circulating tumor-derived mutant mitochondrial DNA: a predictive biomarker of clinical prognosis in human squamous cell carcinoma. Brief Reports

Mutations in circulating mitochondrial DNA: Cassandra of oral cancer? Editorial

Wt p53 impairs response to chemotherapy: make lemonade to spare normal cells Research Perspective

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Genome-wide comparison of the transcriptomes of highly enriched normal and chronic myeloid leukemia stem and progenitor cell populations Research Paper

Nuclear DNA Methylation and Chromatin Condensation Phenotypes Are Distinct Between Normally Proliferating/Aging, Rapidly Growing/Immortal, and Senescent Cells Research Paper

DNA-intercalators Causing Rapid Re-expression of Methylated and Silenced Genes in Cancer Cells Research Paper

The limited contribution of DNA methylation to PML-RARÎ± induced leukemia Editorial

Altered transcriptome signature of phenotypically normal skin fibroblasts heterozygous for CDKN2A in familial melanoma: relevance to early intervention Research Paper

STAT5 triggers BCR-ABL1 mutation by mediating ROS production in chronic myeloid leukaemia Research Paper

Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes Review

A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia Research Paper

The Maintenance of Epigenetic States by p53: The Guardian of the Epigenome Commentary

PIK3CA Mutations in Advanced Cancers: Characteristics and Outcomes Research Paper

Epigenetic Regulation of miRNA-211 by MMP-9 Governs Glioma Cell Apoptosis, Chemosensitivity and Radiosensitivity Research Paper

Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN Research Paper

DNA-demethylating and anti-tumor activity of synthetic miR-29b mimics in multiple myeloma Research Paper

DNA damage-induced activation of ATM promotes Î²-TRCP-mediated Mdm2 ubiquitination and destruction Research Paper

Genetic and epigenetic loss of microRNA-31 leads to feed-forward expression of EZH2 in melanoma Research Paper

Regulation of DNA Damage Following Termination of Hedgehog (HH) Survival Signaling at the level of the GLI Genes in Human Colon Cancer Research Paper

Systemic shRNA mediated knock-down of S100A4 in colorectal cancer xenografted mice reduces metastasis formation Research Paper

Circulating tumor-derived mutant mitochondrial DNA: a predictive biomarker of clinical prognosis in human squamous cell carcinoma. Brief Reports

Mutations in circulating mitochondrial DNA: Cassandra of oral cancer? Editorial

Wt p53 impairs response to chemotherapy: make lemonade to spare normal cells Research Perspective