The Oncosearch | Oncotarget

A tumor-promoting mechanism mediated by retrotransposon-encoded reverse transcriptase is active in human transformed cell lines Research Paper

Ilaria Sciamanna, Alberto Gualtieri, Cristina Cossetti, Emanuele Felice Osimo, Manuela Ferracin, Gianfranco Macchia, Eleonora Arico, Gianni Prosseda, Patrizia Vitullo, Tom Misteli, Corrado Spadafora

Published Oct 14, 2013 · Vol. 4, No. 12 · pp. 2271-2287

Keywords: LINE-1 retrotransposons, reverse transcriptase, transcriptome, miRNAs, DNA:RNA hybrids, cancer genome, reverse transcriptase inhibitor.

Insights into therapeutic resistance from whole-genome analyses of circulating tumor DNA Letters to the Editor

Luis A. Diaz, Jr, Mark Sausen, George A. Fisher, Victor E. Velculescu

Published Oct 8, 2013 · Vol. 4, No. 10 · pp. 1856-1857

p53 regulates the transcription of the anti-inflammatory molecule developmental endothelial locus-1 (Del-1) Research Paper

Hyesoon Kim, Seung-Hwan Lee, Mi-Ni Lee, Goo Taeg Oh, Kyung-Chul Choi, Eun Young Choi

Published Oct 3, 2013 · Vol. 4, No. 11 · pp. 1976-1985

Keywords: p53, inflammation, endothelial cell, Del-1

Broad-spectrum anti-tumor and anti-metastatic DNA vaccine based on p62-encoding vector Research Paper

Franco Venanzi, Victor Shifrin, Michael Y. Sherman, Vladimir Gabai, Oleg Kisilev, Andrey Komissarov, Mikhail Grudinin, Maria Shartakova, Ekaterina Romanovskaya-Romanko, Yuri Kudryavets, Natalya Bezdenezhnykh, Oleksandra Lykhova, Nadiia Semesyuk, Antonio Concetti, Anatoly Tsyb, Marina Filimonova, Victoria Makarchuk, Raisa Yakubovsky, Andrey Chursov, Vita Shcherbinina, Alexander Shneider

Published Oct 2, 2013 · Vol. 4, No. 10 · pp. 1829-1835

Keywords: cancer immunotherapy, DNA vaccine, autophagy, metastases

Combinatorial antitumor effect of HDACs and the PI3K-Akt-mTOR pathway inhibition in a Pten deficient model of prostate cancer Research Paper

Leigh Ellis, ShengYu Ku, Swathi Ramakrishnan, Elena Lasorsa, Gizzou Azabdaftari, Alejandro Godoy, Roberto Pili

Published Sep 27, 2013 · Vol. 4, No. 12 · pp. 2225-2236

Keywords: prostate cancer, BEZ235, panobinostat, DNA damage, ATM, therapy

5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft Research Paper

Alexandra Borodovsky, Vafi Salmasi, Sevin Turcan, Armida W. M. Fabius, Gilson Baia, Charles G Eberhart, Jon D. Weingart, Gary L Gallia, Stephen B Baylin, Timothy A Chan, Gregory J Riggins

Published Sep 16, 2013 · Vol. 4, No. 10 · pp. 1737-1747

Keywords: IDH, 5-azacytidine, progressive glioma, xenograft, astrocytoma, methylation

Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine. Research Paper

Sevin Turcan, Armida WM Fabius, Alexandra Borodovsky, Alicia Pedraza, Cameron Brennan, Jason Huse, Agnes Viale, Gregory J Riggins, Timothy A Chan

Published Sep 16, 2013 · Vol. 4, No. 10 · pp. 1729-1736

Keywords: IDH, glioma, decitabine, DNMT

Isolation and genome-wide expression and methylation characterization of CD31+ cells from normal and malignant human prostate tissue Research Paper

Wei Luo, Hu Qiang, Dan Wang, Kristin K Deeb, Yingyu Ma, Carl D Morrison, Song Liu, Candace S Johnson, Donald L Trump

Published Aug 21, 2013 · Vol. 4, No. 9 · pp. 1472-1483

Keywords: Endothelial cell, Gene expression, DNA methylation, Prostate cancer

Galectin-7 is epigenetically-regulated tumor suppressor in gastric cancer Research Paper

Seok-Jun Kim, Jung-Ah Hwang, Jae Y. Ro, Yeon-Su Lee, Kyung-Hee Chun

Published Aug 20, 2013 · Vol. 4, No. 9 · pp. 1461-1471

Keywords: Galectin-7, Gastric cancer, DNA hypermethylation, Epigenetic mechanisms

A Hidden Role of the Inactivated FANCD2: Upregulating Î”Np63 Research Paper

Jayabal Panneerselvam, Anna Pickering, Jun Zhang, Hong Wang, Hui Tian, Junnian Zheng, Peiwen Fei

Published Aug 11, 2013 · Vol. 4, No. 9 · pp. 1416-1426

Keywords: P63, Fanconi Anemia tumor supressor pathway, oncogene delta N p63, FANCD2, tumorigenicity, transactivation

Mdig de-represses H19 large intergenic non-coding RNA (lincRNA) by down-regulating H3K9me3 and heterochromatin Research Paper

Bailing Chen, Miaomiao Yu, Qingshan Chang, Yongju Lu, Chitra Thakur, Danjun Ma, Zhengping Yi, Fei Chen

Published Aug 10, 2013 · Vol. 4, No. 9 · pp. 1427-1437

Keywords: mdig, H19, demethylation, prognosis

Tissue-specific isoform switch and DNA hypomethylation of the pyruvate kinase PKM gene in human cancers Research Paper

Shruti Desai, Minming Ding, Bin Wang, Zhimin Lu, Qi Zhao, Kenna Shaw, W K Alfred Yung, John N Weinstein, Ming Tan, Jun Yao

Published Aug 7, 2013 · Vol. 5, No. 18 · pp. 8202-8210

Keywords: PKM2, alternative splicing, DNA methylation

The predictive value of 53BP1 and BRCA1 mRNA expression in advanced non-small-cell lung cancer patients treated with first-line platinum-based chemotherapy Research Paper

Laura Bonanno, Carlota Costa, Margarita Majem, Jose Javier Sanchez, Ana Gimenez-Capitan, Ignacio Rodriguez, Alain Vergenegre, Bartomeu Massuti, Adolfo Favaretto, Massimo Rugge, Cinta Pallares, Miquel Taron, Rafael Rosell

Published Jul 31, 2013 · Vol. 4, No. 10 · pp. 1572-1581

Keywords: BRCA1, 53BP1, DNA repair, predictive modeling, platinum

High imatinib dose overcomes insufficient response associated with ABCG2 haplotype in chronic myelogenous leukemia patients Research Paper

Marc Delord, Philippe Rousselot, Jean-Michel Cayuela, FranÃ§ois Sigaux, JoÃ«lle Guilhot, Claude Preudhomme, FranÃ§ois Guilhot, Pascale Loiseau, Emmanuel Raffoux, Daniela Geromin, Emmanuelle Genin, Fabien Calvo, Heriberto Bruzzoni-Giovanelli

Published Jul 18, 2013 · Vol. 4, No. 10 · pp. 1582-1591

Keywords: CML, Imatinib, SNPs, ABCG2, Pharmacogenetic, molecular response, BCR-ABL

Cancer detection using whole-genome sequencing of cell free DNA Editorial

Rebecca J. Leary, Mark Sausen, Luis A. Diaz, Jr., Victor E. Velculescu

Published Jul 15, 2013 · Vol. 4, No. 8 · pp. 1119-1120

Battle of the eternal rivals: restoring functional p53 and inhibiting Polo-like kinase 1 as cancer therapy Review

Frank Louwen, Juping Yuan

Published Jul 13, 2013 · Vol. 4, No. 7 · pp. 958-971

Keywords: Polo-like kinase 1, p53, Plk1 inhibitor

STAT6-mediated BCL6 repression in primary mediastinal B-cell lymphoma (PMBL) Research Paper

Olga Ritz, Karolin Rommel, Karola Dorsch, Elena Kelsch, Julia Melzner, Michaela Buck, Karen Leroy, Vasiliki Papadopoulou, Simon Wagner, Jochen K Lennerz, Peter MÃ¶ller

Published Jul 13, 2013 · Vol. 4, No. 7 · pp. 1093-1102

Keywords: intratumoral heterogenity, PMBL, BCL6, pSTAT6

DNA damage-induced ubiquitylation of proteasome controls its proteolytic activity Research Paper

Tatiana N Moiseeva, Andrew Bottrill, Gerry Melino, Nickolai A Barlev

Published Jun 29, 2013 · Vol. 4, No. 9 · pp. 1338-1348

Keywords: proteasome, DNA damage, proteolytic activities, ubiquitylation

Radiation therapy induces the DNA damage response in peripheral blood Research Paper

Christopher J Bakkenist, R Kenneth Czambel, David A Clump, Joel S Greenberger, Jan H Beumer, John C Schmitz

Published Jun 26, 2013 · Vol. 4, No. 8 · pp. 1143-1148

Keywords: DNA damage response, ATM

Mechanism of DNA damage responses induced by exposure to an oligonucleotide homologous to the telomere overhang in melanoma Research Paper

Ryan T Pitman, Luke Wojdyla, Neelu Puri

Published Jun 3, 2013 · Vol. 4, No. 5 · pp. 761-771

Keywords: T-oligo, Tankyrase, TRF1, telomere, p53, melanoma

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A tumor-promoting mechanism mediated by retrotransposon-encoded reverse transcriptase is active in human transformed cell lines Research Paper

Insights into therapeutic resistance from whole-genome analyses of circulating tumor DNA Letters to the Editor

p53 regulates the transcription of the anti-inflammatory molecule developmental endothelial locus-1 (Del-1) Research Paper

Broad-spectrum anti-tumor and anti-metastatic DNA vaccine based on p62-encoding vector Research Paper

Combinatorial antitumor effect of HDACs and the PI3K-Akt-mTOR pathway inhibition in a Pten deficient model of prostate cancer Research Paper

5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft Research Paper

Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine. Research Paper

Isolation and genome-wide expression and methylation characterization of CD31+ cells from normal and malignant human prostate tissue Research Paper

Galectin-7 is epigenetically-regulated tumor suppressor in gastric cancer Research Paper

A Hidden Role of the Inactivated FANCD2: Upregulating Î”Np63 Research Paper

Mdig de-represses H19 large intergenic non-coding RNA (lincRNA) by down-regulating H3K9me3 and heterochromatin Research Paper

Tissue-specific isoform switch and DNA hypomethylation of the pyruvate kinase PKM gene in human cancers Research Paper

The predictive value of 53BP1 and BRCA1 mRNA expression in advanced non-small-cell lung cancer patients treated with first-line platinum-based chemotherapy Research Paper

High imatinib dose overcomes insufficient response associated with ABCG2 haplotype in chronic myelogenous leukemia patients Research Paper

Cancer detection using whole-genome sequencing of cell free DNA Editorial

Battle of the eternal rivals: restoring functional p53 and inhibiting Polo-like kinase 1 as cancer therapy Review

STAT6-mediated BCL6 repression in primary mediastinal B-cell lymphoma (PMBL) Research Paper

DNA damage-induced ubiquitylation of proteasome controls its proteolytic activity Research Paper

Radiation therapy induces the DNA damage response in peripheral blood Research Paper

Mechanism of DNA damage responses induced by exposure to an oligonucleotide homologous to the telomere overhang in melanoma Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

A tumor-promoting mechanism mediated by retrotransposon-encoded reverse transcriptase is active in human transformed cell lines Research Paper

Insights into therapeutic resistance from whole-genome analyses of circulating tumor DNA Letters to the Editor

p53 regulates the transcription of the anti-inflammatory molecule developmental endothelial locus-1 (Del-1) Research Paper

Broad-spectrum anti-tumor and anti-metastatic DNA vaccine based on p62-encoding vector Research Paper

Combinatorial antitumor effect of HDACs and the PI3K-Akt-mTOR pathway inhibition in a Pten deficient model of prostate cancer Research Paper

5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft Research Paper

Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine. Research Paper

Isolation and genome-wide expression and methylation characterization of CD31+ cells from normal and malignant human prostate tissue Research Paper

Galectin-7 is epigenetically-regulated tumor suppressor in gastric cancer Research Paper

A Hidden Role of the Inactivated FANCD2: Upregulating Î”Np63 Research Paper

Mdig de-represses H19 large intergenic non-coding RNA (lincRNA) by down-regulating H3K9me3 and heterochromatin Research Paper

Tissue-specific isoform switch and DNA hypomethylation of the pyruvate kinase PKM gene in human cancers Research Paper

The predictive value of 53BP1 and BRCA1 mRNA expression in advanced non-small-cell lung cancer patients treated with first-line platinum-based chemotherapy Research Paper

High imatinib dose overcomes insufficient response associated with ABCG2 haplotype in chronic myelogenous leukemia patients Research Paper

Cancer detection using whole-genome sequencing of cell free DNA Editorial

Battle of the eternal rivals: restoring functional p53 and inhibiting Polo-like kinase 1 as cancer therapy Review

STAT6-mediated BCL6 repression in primary mediastinal B-cell lymphoma (PMBL) Research Paper

DNA damage-induced ubiquitylation of proteasome controls its proteolytic activity Research Paper

Radiation therapy induces the DNA damage response in peripheral blood Research Paper

Mechanism of DNA damage responses induced by exposure to an oligonucleotide homologous to the telomere overhang in melanoma Research Paper